Protein kinase C involvement in apoptosis

General Pharmacology

Volumn 26, Issue 5, 1995, Pages 881-887

  Lucas, Miguel ^a   Sánchez Margalet, Victor ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN MACARENA   (Spain)

Author keywords

bcl 2; calcium; ceramide; p34cdc2; Programmed cell death

Indexed keywords

CALCIUM; CERAMIDE; DNA; ONCOPROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATASE; PROTEIN; PROTEIN KINASE C; SPHINGOMYELIN; STAUROSPORINE; THAPSIGARGIN;

AGED; ANIMAL CELL; APOPTOSIS; CALCIUM TRANSPORT; CELL CYCLE PHASE; CELL TYPE; DNA REPLICATION; ETIOLOGY; HUMAN; HUMAN CELL; MITOSIS; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMAL; APOPTOSIS; HUMAN; PROTEIN KINASE C; SIGNAL TRANSDUCTION;

EID: 0029001975     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(94)00295-X     Document Type: Review

References (73)

1. Role of protein kinase C in neutrophil survival enhanced by granulocyte colony-stimulating factor
2. Apoptosis. The role of endonuclease
3. Induction of mouse thymocyte apoptosis by inhibitors of tyrosine kinases is associated with dephosphorylation of nuclear proteins
4. Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production
5. 2+ concentration and DNA fragmentation
6. Induction of a common pathway of apoptosis by staurosporine
7. High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells
8. Apoptotic cell death induced by C-myc is inhibited by bcl-2
9. The phosphoprotein phosphatase calcineurin controls calcium-dependent apoptosis in B cell lines
10. Cascade induction of c-fos, c-myc and heat shock 70 K transcripts during the regression of the ventral prostate glan
11. Thymocyte apoptosis is induced by p53-dependent and independent pathways
12. V-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells
13. The control of apoptosis in mammalian cells
14. Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines
15. Ceramide stimulates a cytosolic protein phosphatase
16. Cooperative interaction between C-myc and bcl-2 protooncogenes
17. Apoptosis: molecular mechanisms in programmed cell death
18. Cell death mechanism and the immune system
19. Implication of protein kinase C in IL-2-Mediated proliferation and apoptosis in a murine T cell clone
20. Activation-induced apoptosis in lymphocytes
21. A mutant of the WEHI-231 B lymphocyte line that is resistant to phorbol esters is still sensitive to antigen receptor-mediated growth inhibition
22. Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis
23. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis
24. Sphingolipid breakdown products: and anti-proliferative and tumorsuppressor lipids
25. Human Weel maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
26. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
27. 2+ is not required for glucocorticoid-induced apoptosis in thymocytes
28. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA
29. Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway
30. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C
31. Effects of bryotstatin 1 and other pharmacological activators of protein kinase C on 1-[beta-D-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells
32. Thapsigargin-induced persistent intracellular calcium pool depletion and apoptosis in human hepatoma cells
33. Apoptosis: a basic biological phenomenon with wideranging implications in tissue kinetics
34. Protein tyrosine kinases couple the surface immunoglobulin of germinal center B cells to phosphatidylinositol-dependent and -independent pathways of rescue from apoptosis
35. Distribution of cAMP in secondary follicles and its expression in B cell apoptosis and CD40-mediated survival
36. 2+ fluxes
37. The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis
38. 2+ are not required to trigger apoptosis in human leukaemia cells
39. p53 is required for radiation-induced apoptosis in mouse thymocytes
40. Induction of programmed cell death (apoptosis) in mature lymphocytes
41. Protein kinase C activation promotes cell survival in mature lymphocytes prone to apoptosis
42. Phorbol ester induces apoptosis in HL-60 promyelocytic leukemia cells but not in HL-60 PET mutant
43. Activation of beta-isozyme of protein kinase C (PKC beta) is necessary and sufficient for phorbol ester-induced differentiation of HL-60 promyelocytes
44. A common pathway mediates retinoic acid and PMA-dependent programmed cell death (apoptosis of neuronal cells)
45. Role for serine phosphorylation of Bcl-2 in an antiapoptotic signaling pathways triggered by IL-3, EPO and bryostain
46. 2+ concentration
47. Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C
48. Cellular signaling in programmed cell death (apoptosis)
49. Activation of cyclin A-dependent protein kinases during apoptosis
50. 2+ requirements and sensitivity to cyclosporine A
51. Dexamethasone induces apoptosis in mouse natural killer cells and cytotoxic T lymphocytes
52. 2+ entry pathway in human neutrophils
53. 2+ concentration in isolated liver nuclei
54. IL-2 protects T lymphocytes from glucocorticoid-induced DNA fragmentation and cell death
55. Universal control mechanism regulating onset of M-phase
56. Programmed cell death induced by ceramide
57. Chromatin condensation during apoptosis is accompanied by degradation of lamin A + B without activation of cdc2 kinase
58. Protein kinase C involvement in thymocyte apoptosis induced by hydrocortisone
59. Tyrosine kinase(s) regulate apoptosis and bcl-2 expression in a growth factor-dependent cell line
60. Phorbol esters can protect mouse pre-T cell lines from radiation-induced rapid interphase apoptosis
61. Social controls on cell survival and cell death
62. Phorbol esters inhibits apoptosis in IL-2-dependent T lymphocytes
63. Decrease protein kinase C activity is associated with programmed cell death (apoptosis) in freshly isolated rat hepatocytes
64. Sensitivity of insulin-secreting RIN m5F cells to undergoing apoptosis by the protein kinase C inhibitor staurosporine
65. Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells
66. Gene activation is required for developmentally programmed cell death
67. cdc2 activation required for apoptosis
68. 2
69. Inhibition of radiation-produced apoptosis in vitro by tumor promoters
70. Role of protein phosphorylation in TNF-induced apoptosis: phosphatase inhibitors synergize with TNF to activate DNA fragmentation in normal as well as TNF-resistant U937 variants
71. Inhibition of apoptosis as a mechanism of tumor promotion
72. Apoptosis
73. Cell death: the significance of apoptosis