Probing the Mechanism of Bioactivation of MPTP Type Analogs by Monoamine Oxidase B: Structure-Activity Studies on Substituted 4-Phenoxy-, 4-Phenyl-, and 4-Thiophenoxy-1-cyclopropyl-1,2,3,6-tetrahydropyridines

Chemical Research in Toxicology

Volumn 8, Issue 5, 1995, Pages 703-710

  Rimoldi, John M ^a   Wane, You Xiong ^a   Nimkar, Sandeep K ^a   Anderson, Andrea H ^a   Burch, Heidi ^a   Castagnoli, Neal ^a   Kuttab, Simon H ^b  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b BIRZEIT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 CYCLOPROPYL 1,2,3,6 TETRAHYDRO 4 (2 METHYLPHENYL)PYRIDINE; 1 CYCLOPROPYL 1,2,3,6 TETRAHYDRO 4 PHENOXYPYRIDINE; 1 CYCLOPROPYL 1,2,3,6 TETRAHYDRO 4 PHENYLPYRIDINE; 1 CYCLOPROPYL 1,2,3,6 TETRAHYDRO 4 THIOPHENOXYPYRIDINE; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 4 BENZYL 1 CYCLOPROPYL 1,2,3,6 TETRAHYDROPYRIDINE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CATION; HYDROGEN; PYRIDINE DERIVATIVE; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CATTLE; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME SUBSTRATE; LIVER MITOCHONDRION; NONHUMAN; OXIDATION; SPECTROPHOTOMETRY; STRUCTURE ACTIVITY RELATION;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; BIOTRANSFORMATION; MONOAMINE OXIDASE; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

ANIMALIA; BOS TAURUS; FELIS CATUS; GYMNOMYZA SAMOENSIS;

EID: 0029001364     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx00047a010     Document Type: Article

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