Influence of etomoxir on the expression of several genes in liver, testis and heart

General Pharmacology

Volumn 26, Issue 5, 1995, Pages 897-904

  Hegardt, Fausto G ^a   Serra, Dolors ^a   Asins, Guillermina ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

cholesterogenesis L FABP; CPT I; Etomoxir; Ketogenesis; mitochondrial HMG CoA synthase; POCA; TDGA

Indexed keywords

2 TETRADECYL GLYCIDIC ACID; CARNITINE PALMITOYLTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE 2; CLOMOXIR; CYTOCHROME P450 ISOENZYME; DI (2 ETHYLHEXYL)PHTHALATE; ETHYLENE OXIDE DERIVATIVE; ETOMOXIR; FATTY ACID BINDING PROTEIN; FATTY ACID SYNTHASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ISOENZYME; MESSENGER RNA; MYOSIN; OXYGENASE; PEROXISOME PROLIFERATOR; UNCLASSIFIED DRUG;

CARBOHYDRATE METABOLISM; CHOLESTEROL SYNTHESIS; CYTOSOL; ENZYME ACTIVITY; FATTY ACID OXIDATION; GENE EXPRESSION; HEART; HEART PERFORMANCE; KETOGENESIS; LIPID DIET; LIPID METABOLISM; LIVER; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; REVIEW; TESTIS;

ANIMAL; EPOXY COMPOUNDS; GENE EXPRESSION; HEART; HUMAN; HYPOGLYCEMIC AGENTS; LIVER; MALE; MYOCARDIUM; SUPPORT, NON-U.S. GOV'T; TESTIS;

EID: 0029001357     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(94)00281-Q     Document Type: Review

References (33)

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3. Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl CoA synthases are encoded by two different genes
4. Regulation of the expression of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene
5. Rate limiting function of 3-hydroxy-3-methylglutaryl coenzyme A synthase in ketogenesis
6. Cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase from the hamster. Isolation of the gene and characterization of the 5′ flanking region
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11. Identification of 2-tetradecylglycidyl coenzyme A as the active form of methyl 2-tetradecylglycidate (methyl palmoxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyl transferase A in isolated rat liver mitochondria
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14. The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia
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16. Glucose and palmitate oxidation in isolated working rate reperfused after a period of transient global ischemia
17. Etomoxir, a carnitine palmitoyltransferase inhibitor, protects hearts from fatty acid-induced ischemic injury independent of changes in long chain acylcarnitine
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20. Inhibition by etomoxir of carnitine palmitoyltransferase I reduces hepatic glucose production and plasma lipids in non-insulin dependent diabetes mellitus
21. Influence of carnitine acyltransferase inhibitors on the performance and metabolism of rat cardiac muscle
22. Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids
23. Testis and ovary express the gene for the ketogenic mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase
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27. Substituted 2-oxiranecarboxylic acids: a new group of candidate hypoglycaemic drugs
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29. Hepatic and adipose tissue lipogenic enzyme mRNA levels are suppressed by high fat diets in the rat
30. Glucose oxidation rates in fatty acid-perfused isolated working hearts from diabetic rats
31. Rat heart expresses two forms of mitochondrial carnitine palmitoyl transferase I. The minor component is identical to the liver enzyme
32. Aryl-substituted 2-oxirane carboxylic acids: a new group of antidiabetic drugs
33. Decrease of fatty acid oxidation, ketogenesis and gluconeogenesis in isolated perfused rat liver by phenyl alkyl oxirane carboxylate (B807-27) due to inhibition of CPT I