Endothelin: Potential role in hypertension and vascular hypertrophy

Hypertension

Volumn 25, Issue 6, 1995, Pages 1135-1143

  Schiffrin, E L ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

aorta; arterioles; endothelium; hypertension, malignant; hypertension, mineralocorticoid; receptors, endothelin; RNA, messenger

Indexed keywords

DEOXYCORTICOSTERONE ACETATE; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST;

GENE DISRUPTION; HUMAN; HYPERTENSION; HYPERTROPHY; MOLECULAR GENETICS; MOUSE; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SHORT SURVEY; SPONTANEOUSLY HYPERTENSIVE RAT; VASCULAR DISEASE;

EID: 0029001207     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.25.6.1135     Document Type: Short Survey

References (99)

1. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332:411-415.
2. Vanhoutte PM. Is endothelin involved in the pathogenesis of hypertension? Hypertension. 1993;21:747-751.
3. Lüscher TF, Seo B, Bühler FR. Potential role of endothelin in hypertension. Hypertension. 1993;21:752-757.
4. Inoue A, Yanagisawa M, Kimura S, Kasuya Y, Miyauchi T. The human endothelin family - 3 structurally and pharmacologically distinct isopeptides predicted by 3 separate genes. Proc Natl Acad Sci U S A. 1989;86:2863-2867.
5. Haynes WG, Webb DJ. The endothelin family of peptides: local hormones with diverse roles in health and disease? Clin Sci. 1993;84:485-500.
6. Lüscher TF, Oemar BS, Boulanger CM, Hahn AWA. Molecular and cellular biology of endothelin and its receptors, part I. J Hypertens. 1993;11:7-11.
7. Lüscher TF, Oemar BS, Boulanger CM, Hahn AWA. Molecular and cellular biology of endothelin and its receptors, part II. J Hypertens. 1993;11:121-126.
8. Hahn AWA, Resink TJ, Scott-Burden T, Powell J, Dohi Y, Buhler FR. Stimulation of endothelin mRNA and secretion in rat vascular smooth muscle cells: a novel autocrine function. Cell Regul. 1990;1:649-659.
9. Yoshizumi M, Kurihara H, Sugiyama T, Takaku F, Yanagisawa M, Masaki T, Yasako Y. Hemodynamic shear stress stimulates endothelin production by cultured endothelial cells. Biochem Biophys Res Commun. 1989;161:859-864.
10. Malek A, Izumo S. Physiological fluid shear stress causes down-regulation of endothelin-1 mRNA in bovine aortic endothelium. Am J Physiol. 1992;263:C389-C396.
11. Kurihara H, Yoshizumi M, Sugiyama T, Takaku F, Yanagisawa M, Masaki T, Hamaoki M, Kato H, Yazaki Y. Transforming growth factor-beta stimulates the expression of endothelin mRNA by vascular endothelial cells. Biochem Biophys Res Commun. 1989;159: 1435-1440.
12. Imai T, Hirata Y, Emori T, Yanagisawa M, Masaki T, Marumo F. Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells. Hypertension. 1992;19:753-757.
13. Sakurai T, Yanagisawa M, Masaki T. Molecular characterization of endothelin receptors. Trends Pharmacol Sci. 1992;13:103-108.
14. Arai H, Hori S, Aramori I, Ohkubo H, Nakanishi S. Cloning and expression of a cDNA encoding an endothelin receptor. Nature. 1990;348:730-732.
15. Sakurai T, Yanagisawa M, Takuwa Y, Miyazaki H, Kimura S, Goto K, Masaki T. Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature. 1990; 348:732-735.
16. B receptor mediates both vasodilation and vasoconstriction in vivo. Biochem Biophys Res Commun. 1992;186:867-873.
17. Panek RL, Major TC, Hirigorani GP, Doherty AM, Taylor DG. Endothelin and structurally related analogs distinguish between endothelin receptor subtypes. Biochem Biophys Res Commun. 1992;183:566-571.
18. B receptors on aortic smooth muscle cells of spontaneously hypertensive rats. Am J Physiol. 1993;264:C479-C484.
19. B-receptor-mediated vasoconstriction in rat pulmonary arteries and arterioles. J Cardiovasc Pharmacol. 1994;23:838-845.
20. B receptors in canine coronary arteries. Circ Res. 1994;74:105-114.
21. B-like receptors. Biochem Biophys Res Commun. 1992;184:100-106.
22. Gray GA, Löffler B-M, Clozel M. Characterization of endothelin receptors mediating contraction of rabbit saphenous vein. Am J Physiol. 1994;266:H959-H966.
23. B receptors mediate contraction to endothelin-1 in human blood vessels. Circulation. 1994;89:1203-1208.
24. Deng LY, Li J-S, Schiffrin EL. Endothelin receptor subtypes in resistance arteries from humans and from rats. Cardiovasc Res. 1995;29:532-535.
25. Tschudi MR, Lüscher TF. Characterization of contractile endothelin and angiotensin receptors in human resistance arteries: evidence for two endothelin and one angiotensin receptor. Biochem Biophys Res Commun. 1994;204:685-690.
26. Hirata Y, Takagi Y, Fukuda Y, Marumo F. Endothelin is a potent mitogen for rat vascular smooth muscle cells. Atherosclerosis. 1989;78:225-228.
27. Bobik A, Grooms A, Millar JA, Mitchell A, Grinpukel S. Growth factor activity of endothelin on vascular smooth muscle. Am J Physiol. 1990;258:C408-C415.
28. King AJ, Brenner BM. Endothelium-derived vasoactive factors and the renal vasculature. Am J Physiol. 1991;260:R653-R662.
29. Suzuki N, Miyauchi T, Tomobe Y, Matsumoto H, Goto K, Masaki T, Fujino M. Plasma concentrations of endothelin-1 in spontaneously hypertensive rats and DOCA-salt hypertensive rats. Biochem Biophys Res Commun. 1990;167:941-947.
30. Kohno M, Yasumari K, Murakawa KI, Yokokawa K, Horio T, Fukui T, Takeda T. Plasma immunoreactive endothelin in essential hypertension. Am J Med. 1990;88:614-618.
31. Davenport AP, Ashby MJ, Easton P, Ella S, Bedford J, Dickerson C, Nunez DJ, Capper SJ, Brown MJ. A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: comparison of levels in patients with essential hypertension and normotensive control subjects. Clin Sci. 1990;78:261-264.
32. Shichiri M, Hirata Y, Ando K, Emori T, Ohta K, Kimoto S, Ogura M, Inoue A, Marumo F. Plasma endothelin levels in hypertension and chronic renal failure. Hypertension. 1990;15:493-496.
33. Schiffrin EL, Thibault G. Plasma endothelin in human essential hypertension. Am J Hypertens. 1991;4:303-308.
34. Kohno M, Murakawa K-i, Horio T, Yokokawa K, Yasunari K, Fukui T, Takeda T. Plasma immunoreactive endothelin-1 in experimental malignant hypertension. Hypertension. 1991;18:93-100.
35. Wagner OF, Christ G, Wojta J, Vierhapper H, Parzer S, Nowotny PJ, Schneider B, Waldhäusl W, Binder BR. Polar secretion of endothelin-1 by cultured endothelial cells. J Biol Chem. 1992;267: 16066-16068.
36. Yokokawa K, Tahara H, Kohno M, Murakawa K-i, Yasunari K, Nakagawa K, Hamada T, Otani S, Yanagisawa M, Takeda T. Hypertension associated with endothelin-secreting malignant hemangioendothelioma. Ann Intern Med. 1991;114:213-215.
37. Amico JA, Clarke MR, Watson CG, Kim NB, Bonomi PL, Crowley RS, Horowitz MJ. Endothelin-1 gene expression in human pheochromocytoma. J Lab Clin Med. 1993;122:667-672.
38. Edwards BS, Hunt SA, Fowler MB, Valantine HA, Anderson LM, Lerman A. Effect of cyclosporine on plasma endothelin levels in humans after cardiac transplantation. Am J Cardiol. 1991;67: 782-784
39. Stockenhuber F, Gottsauner-Wolf M, Marosi L, Liebisch B, Kurz RW, Balcke P. Plasma levels of endothelin in chronic renal failure and after renal transplantation: impact on hypertension and cyclosporin A-associated nephrotoxicity. Clin Sci. 1991;82:255-258.
40. Naruse M, Nakamura N, Naruse K, Kubo K, Kato M, Hagiwara H, Sugino N, Demura H. Plasma immunoreactive endothelin levels are increased in hemodialysis patients with hypertension following erythropoietin therapy. Hypertens Res. 1992;15:11-16.
41. Takahashi K, Totsune K, Imai Y, Sone M, Nozuki M, Murakami O, Sekino H, Mouri T. Plasma concentrations of immunoreactive-endothelin in patients with chronic renal failure treated with recombinant human erythropoietin. Clin Sci. 1993;84:47-50.
42. Carlini R, Obialo CI, Rothstein M. Intravenous erythropoietin (rHuEPO) administration increases plasma endothelin and blood pressure in hemodialysis patients. Am J Hypertens. 1993;6:103-107.
43. Greer IA, Leask R, Hodson BA, Dawes J, Kilpatrick DC, Liston WA. Endothelin, elastase, and endothelial dysfunction in preeclampsia. Lancet. 1991;337:558. Letter.
44. Clozel M. Endothelin sensitivity and receptor binding in the aorta of spontaneously hypertensive rats. J Hypertens. 1989;17:913-917.
45. Nguyen PV, Yang X-P, Li G, Deng LY, Flückiger J-P, Schiffrin EL. Contractile responses and signal transduction of endothelin-1 in aorta and mesenteric vasculature of adult spontaneously hypertensive rats. Can J Physiol Pharmacol. 1993;71:473-483.
46. Bolger GT, Liard F, Jodoin A, Jaramillo J. Vascular reactivity, tissue levels and binding sites for endothelin: a comparison in the spontaneously hypertensive and Wistar-Kyoto rats. Can J Physiol Pharmacol. 1991;69:406-413.
47. Tomobe Y, Ishikawa T, Yanagisawa M, Kimura S, Masaki T, Goto K. Mechanisms of altered sensitivity to endothelin-1 between aortic smooth muscles of spontaneously hypertensive and Wistar-Kyoto rats. J Pharmacol Exp Ther. 1991;257:555-561.
48. Küng CF, Lüscher TF. Different mechanisms of endothelial dysfunction with aging and hypertension in rat aorta. Hypertension. 1995;25:194-200.
49. Nguyen PV, Parent A, Deng LY, Flückiger JP, Thibault G, Schiffrin EL. Endothelin vascular receptors and responses in DOCA-salt hypertensive rats. Hypertension. 1992;19(suppl II):II-98-II-104.
50. Flückiger JP, Nguyen PV, Li G, Yang XP, Schiffrin EL. Phosphoinositide, calcium and 1,2 diacylglycerol response of blood vessels of DOCA-salt hypertensive rats to endothelin-1. Hypertension. 1992;19:743-749.
51. Deng LY, Schiffrin EL. Effects of endothelin-1 and vasopressin on resistance arteries of spontaneously hypertensive rats. Am J Hypertens. 1992;5:817-822.
52. Dohi Y, Luscher TF. Endothelin in hypertensive resistance arteries: intraluminal and extraluminal dysfunction. Hypertension. 1991; 18:543-549.
53. 2+ responses to angiotensin II but not to endothelin-1. J Hypertens. 1994;12:663-673.
54. Tomobe Y, Miyauchi T, Saito A, Yanagisawa M, Kimura S, Goto K, Masaki T. Effects of endothelin on the renal artery of spontaneously hypertensive and Wistar-Kyoto rats. Eur J Pharmacol. 1988;152:373-374.
55. Miyauchi T, Ishikawa T, Tomobe Y, Yanagisawa M, Kimura S, Sugishita Y, Ito I, Goto K, Masaki T. Characteristics of the pressor response to endothelin in spontaneously hypertensive and Wistar-Kyoto rats. Hypertension. 1989;14:427-434.
56. MacLean MR, McGrath JC. Effect of endothelin-1 on isolated vascular beds from normotensive and spontaneously hypertensive rats. Eur J Pharmacol. 1990;190:263-267.
57. Dohi Y, Criscione L, Lüscher TF. Renovascular hypertension impairs formation of endothelium-derived relaxing factors and sensitivity to endothelin-1 in resistance arteries. Br J Pharmacol. 1991;104:349-354.
58. Deng LY, Schiffrin EL. Effects of endothelin on resistance arteries of DOCA-salt hypertensive rats. Am J Physiol. 1992;262:H1782-H1787.
59. Deng LY, Schiffrin EL. Effect of antihypertensive treatment on response to endothelin of resistance arteries of hypertensive rats. J Cardiovasc Pharmacol. 1993;21:725-731.
60. Schiffrin EL, Deng LY, Larochelle P. Blunted effects of endothelin on small subcutaneous resistance arteries of mild essential hypertensive patients. J Hypertens. 1992; 10:437-444.
61. Schiffrin EL, Deng LY, Larochelle P. Morphology of resistance arteries and comparison of effects of vasoconstrictors in mild essential hypertensive patients. Clin Invest Med. 1993;16:177-186.
62. Schiffrin EL, Deng LY, Larochelle P. Effects of a beta blocker or converting enzyme inhibitor on resistance arteries in essential hypertension. Hypertension. 1994;23:83-91.
63. Schini VB, Kim ND, Vanhoutte PM. The basal and stimulated release of EDRF inhibits the contractions evoked by endothelin-1 and endothelin-3 in aortae of normotensive and spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1991;17:S266-S270.
64. Winquist RJ, Bunting PB, Garsky VM, Lumma PK, Schofield TL. Prominent depressor response to endothelin in spontaneously hypertensive rats. Eur J Pharmacol. 1989;163:199-203.
65. Hirata Y, Matsuoka H, Kimura K, Fukui K, Hayakawa H, Suzuki E, Sugimoto T, Sugimoto T, Yanagisawa M, Masaki T. Renal vasoconstriction by the endothelial cell-derived peptide endothelin in spontaneously hypertensive rats. Circ Res. 1989;65:1370-1379.
66. Wu CC, Bohr DF. Role of endothelium in the response to endothelin in hypertension. Hypertension. 1990;16:677-681.
67. Dohi Y, Hahn AWA, Boulanger CM, Bühler FR, Lüscher TF. Endothelin stimulated by angiotensin II augments contractility of spontaneously hypertensive rat resistance arteries. Hypertension. 1992;19:131-137.
68. Haynes WG, Hand MF, Johnstone HA, Padfield PL, Webb DJ. Direct and sympathetically mediated venoconstriction in essential hypertension: enhanced responses to endothelin-1. J Clin Invest. 1994;94:1359-1364.
69. Larivière R, Thibault G. Schiffrin EL. Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats. Hypertension. 1993;21:294-300.
70. Larivière R, Day R, Schiffrin EL. Increased expression of endothelin-1 gene in blood vessels of deoxycorticosterone acetate-salt hypertensive rats. Hypertension. 1993;21:916-920.
71. Day R, Larivière R, Schiffrin EL. In situ hybridization shows increased endothelin-1 mRNA levels in endothelial cells of blood vessels of deoxycorticosterone acetate-salt hypertensive rats. Am J Hypertens. 1995;8:294-300.
72. Chua BHL, Krebs CJ, Chua CC, Diglio CA. Endothelin stimulates protein synthesis in smooth muscle cells. Am J Physiol. 1992;262: E412-E416.
73. Larivière R, Deng LY, Day R, Sventek P, Thibault G, Schiffrin EL. Increased endothelin-1 gene expression in the endothelium of coronary arteries and in the endocardium of DOCA-salt hypertensive rats. J Mol Cell Cardiol. In press.
74. Larivière R, Sventek P, Schiffrin EL. Expression of endothelin-1 gene in blood vessels of spontaneously hypertensive rats. Life Sci. 1995;56:1889-1896.
75. Schiffrin EL, Larivière R, Li J-S, Sventek P, Touyz RM. Deoxycorticosterone acetate plus salt induce overexpression of vascular endothelin-1 and severe vascular hypertrophy in spontaneously hypertensive rats. Hypertension. 1995;25(part 2):769-773.
76. Hasegawa K, Fujiwara H, Doyama K, Inada T, Ohtani S, Fujiwara T, Hosoda K, Nakao K, Sasayama S. Endothelin-1-selective receptor in the arterial intima of patients with hypertension. Hypertension. 1994;23:288-293.
77. Lerman A, Edwards BS, Hallet JW, Heublein DM, Sandberg SM, Burnett JC Jr. Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis. N Engl J Med. 1991;325:997-1001.
78. Zeiher AM, Ihling C, Pistorius K, Schächinger V, Schaefer H-E. Increased tissue endothelin immunoreactivity in atherosclerotic lesions associated with acute coronary syndromes. Lancet. 1994;344:1405-1406.
79. Kurihara H, Yoshizumi M, Sugiyama T, Takaku F, Yanagisawa M, Masaki T, Hamaoki M, Kato H, Yazaki Y. Transforming growth factor-beta stimulates the expression of endothelin mRNA by vascular endothelial cells. Biochem Biophys Res Commun. 1989;159: 1435-1440.
80. Sarzani R, Brecher P, Chobanian AV. Growth factor expression in aorta of normotensive and hypertensive rats. J Clin Invest. 1989; 83:1404-1408.
81. Ohno A, Naruse M, Kato S, Hosaka M, Naruse K, Demura H, Sugino N. Endothelin-specific antibodies decrease blood pressure and increase glomerular filtration rate and renal plasma flow in spontaneously hypertensive rats. J Hypertens. 1992;10:781-785.
82. McMahon EG, Palomo MA, Brown MA, Bertenshaw ST, Carter JS. Effect of phosphoramidon (endothelin converting enzyme inhibitor) and BQ-123 (endothelin receptor subtype A antagonist) on blood pressure in hypertensive rats. Am J Hypertens. 1993; 6:667-673.
83. A receptor. Life Sci. 1992;50:247-255.
84. A receptor antagonist. J Pharmacol Exp Ther. 1993;264: 1040-1046.
85. A) receptor antagonist in conscious rats. J Cardiovasc Pharmacol. 1992;20:940-948.
86. Nishikibe M, Tsuchida S, Okada M, Fukuroda T, Shimamoto K, Yano M, Ishikawa K, Ikemoto F. Antihypertensive effect of newly synthesized endothelin antagonist, BQ-123, in a genetic hypertensive model. Life Sci. 1993;52:717-724.
87. Clozel M, Breu V, Burri K, Cassal J-M, Fischli W, Gray GA, Hirth G, Löffler B-M, Müller M, Neidhart W, Ramuz H. Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist. Nature. 1993;365:759-761.
88. Clozel M, Clozel JP, Hess P. Endothelin receptor antagonism: a new therapeutic approach in experimental hypertension. Circulation. 1993; 88(suppl I):I-316. Abstract.
89. Li J-S, Larivière R, Schiffrin EL. Effect of a nonselective endothelin antagonist on vascular remodeling in DOCA-salt hypertensive rats: evidence for a role of endothelin in vascular hypertrophy. Hypertension. 1994;24:183-188.
90. Li J-S, Schiffrin EL. Effect of chronic treatment of adult spontaneously hypertensive rats with an endothelin receptor antagonist. Hypertension. 1995;25(part 1):495-500.
91. Li J-S, Schiffrin EL. Chronic endothelin receptor antagonist treatment of young spontaneously hypertensive rats. J Hypertens. In press.
92. A receptor antagonist, in spontaneously hypertensive rats treated with DOCA-salt. Eur J Pharmacol. 1994; 259:339-342.
93. Haynes WG, Webb DJ. Contribution of endogenous generation of endothelin-1 to basal vascular tone. Lancet. 1994;344:852-854.
94. Wenzel RR, Noll G, Lüscher TF. Endothelin receptor antagonists inhibit endothelin in human skin microcirculation. Hypertension. 1994;23:581-586.
95. Kurihara Y, Kurihara H, Suzuki H, Kodama T, Maemura K, Nagai R, Oda H, Kuwaki T, Cao W-H, Kamada N, Jishage K, Ouchi Y, Azuma S, Toyoda Y, Ishikawa T, Kumada M, Yazaki Y. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature. 1994;368:703-710.
96. De Nucci G, Thomas R, D'Orléans-Juste P, Antunes E, Walder C, Warner TD, Vane JR. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc Natl Acad Sci U S A. 1988;85:9797-9800.
97. Mortensen LH, Fink GD. Salt-dependency of endothelin-induced chronic hypertension in conscious rats. Hypertension. 1992; 19:549-554.
98. Cicila GT, Rapp JP, Bloch KD, Kurtz TW, Pravenec M, Kren V, Hong CC, Quertermous T, Ng SC. Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in inbred Dahl rats. J Hypertens. 1994;12:643-651.
99. Deng LY, Dene H, Pravenec M, Rapp JP. Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. J Clin Invest. 1994;93:2701-2709.