Suppression of intestinal neoplasia by DNA hypomethylation

Cell

Volumn 81, Issue 2, 1995, Pages 197-205

  Laird, Peter W ^a   Jackson Grusby, Laurie ^a   Fazeli, Amin ^a   Dickinson, Stephanie L ^a   Edward Jung, W ^a   Li, En ^b   Weinberg, Robert A ^a   Jaenisch, Rudolf ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE;

ALLELE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARCINOGENESIS; DNA METHYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE REPRESSION; HETEROZYGOSITY; INTESTINE CANCER; INTESTINE POLYP; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA;

EID: 0029001154     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(95)90329-1     Document Type: Article

References (75)

1. DNA methylation in eukaryotes
2. CpG islands
3. Methylation and imprinting: from host defense to gene regulation?
4. Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression
5. Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases
6. Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers
7. Somatic allelic loss at the DCC, APC, nm23-Hi and p53 tumor suppressor gene loci in human prostatic carcinoma
8. G/U lesions are efficiently corrected to G/C in SV40 DNA
9. Cell lineage-specific undermethylation of mouse repetitive DNA
10. A genetic linkage map of the mouse: current applications and future prospects
11. Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse
12. DNA cytosine methylation and heat-induced deamination
13. High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer
14. Hypomethylation distinguishes genes of some human cancers from their normal counterparts
15. Hypomethylation of ras oncogenes in primary human cancers
16. Reduced genomic 5-methylcytosine content in human colonic neoplasia
17. A sensitive genetic assay for the detection of cytosine deamination: determination of rate constants and the activation energy
18. The 5-methylcytosine content of DNA from human tumors
19. CpG islands in vertebrate genomes
20. Folate, methionine, and alcohol intake and risk of colorectal adenoma
21. Hypomethylation of DNA from benign and malignant human colon neoplasms
22. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis
23. Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma
24. Identification and characterization of the familial adenomatous polyposis coli gene
25. bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia
26. Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP)
27. Increased cytosine DNA-methyltransferase activity during colon cancer progression
28. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
29. The role of DNA methylation in cancer
30. Methylation, mutation and cancer
31. Identification of deletion mutations and three new genes at the familial polyposis locus
32. Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
33. Inactive chromatin spreads from a focus of methylation
34. DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture
35. DNA methylation affects the formation of active chromatin
36. The DNA (cytosine-5) methyltransferases
37. DNA methylation and cancer
38. Simplified mammalian DNA isolation procedure
39. Cytosinespecific type II DNA methyltransferases. A conserved enzyme core with variable target-recognizing domains
40. Structure, function and regulation of mammalian DNA methyltransferase
41. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei
42. The tumor suppressor genes
43. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
44. Role for DNA methylation in genomic imprinting
45. Mapping of multipleintestinal neoplasia (Min) to proximal chromosome 18 of the mouse
46. + in intestinal adenomas from Min mice
47. Hepatocarcinogenesis in rats fed methyl-deficient, amino acid-defined diets
48. Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients
49. Preferential X-chromosome inactivation, DNA methylation and imprinting
50. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
51. The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system
52. The role of the adenomatous polyposis coli (APC) gene in human cancers
53. CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene
54. Predictive motifs derived from cytosine methyltransferases
55. APC mutations occur early during colorectal tumorigenesis
56. Studies on hypomethylation of liver DNA during early stages of chemical carcinogenesis in rat liver
57. On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs
58. Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine
59. Genetic and epigenetic losses of heterozygosity in cancer predisposition and progression
60. Regulation of mouse satellite DNA replication time
61. High frequency mutagenesis by a DNA methyltransferase
62. The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA
63. Repair of thymine.guanine and uracil.guanine mismatched base-pairs in bacteriophage M13mp18 DNA heteroduplexes
64. Hepatic DNA methylation and liver tumor formation in male C3H mice fed methionine- and choline-deficient diets
65. Abnormal methylation of the calcitonin gene in human colonic neoplasms
66. X chromosome inactivation and DNA methylation
67. DNA methylation and cancer
68. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
69. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene
70. Mutations of the APC gene occur during early stages of gastric adenoma development
71. Alternative chromatin structure at CpG islands
72. Hypomethylation of ras oncogenes in chemically induced and spontaneous B6C3F1 mouse liver tumors
73. Heat- and alkali-induced deamination of 5-methylcytosine and cytosine residues in DNA
74. Tumor suppressor genes
75. Gene methylation patterns and expression