Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

Cell

Volumn 81, Issue 4, 1995, Pages 641-650

  MacMicking, John D ^a   Nathan, Carl ^a   Hom, Gary ^b   Chartrain, Nicole ^b   Fletcher, Daniel S ^b   Trumbauer, Myrna ^b   Stevens, Karla ^b   Xie, Qiao wen ^a   Sokol, Karen ^c   Hutchinson, Nancy ^b   Chen, Howard ^b   Mudget, John S ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; DEATH; ENDOTOXEMIA; ENZYME DEFECT; LISTERIA MONOCYTOGENES; LIVER INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROPIONIBACTERIUM ACNES; SEPTIC SHOCK;

AMINO ACID OXIDOREDUCTASES; ANIMAL; BACTERIAL INFECTIONS; BASE SEQUENCE; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; NITRIC-OXIDE SYNTHASE; SHOCK, SEPTIC; SUPPORT, U.S. GOV'T, P.H.S.;

ANIMALIA; BACTERIA (MICROORGANISMS); CORYNEBACTERIUM; LISTERIA MONOCYTOGENES; PROPIONIBACTERIUM ACNES;

EID: 0028999596     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(95)90085-3     Document Type: Article

References (82)

1. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium
2. Release of nitric oxide during the T cell-independent pathway of macrophage activation: its role in resistance to Listeria monocytogenes
3. Nitric oxide synthase inhibitors attenuate human monocyte chemotaxis in vitro
4. MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia
5. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin
6. Passive immunization of mice against D factor blocks lethality and cytokine release during endotoxemia
7. Phospholipids and their inhibitors: a critical evaluation of their role in the treatment of sepsis
8. Nitric oxide produced during murine listeriosis is protective
9. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase
10. Nitric oxide: a physiologic mediator of penile erection
11. Kinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophils
12. Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase
13. N-ω-amino-L-arginine an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin
14. Neutrophils are essential for early anti-listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody
15. Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock
16. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production
17. Effect of in vivo inhibition of nitric oxide production in murine leishmaniasis
18. The molecular cell biology of interferon-γ and its receptor
19. Negative inotropic effects of cytokines on the heart mediated by nitric oxide
20. A synthetic inhibitor of interleukin-1β converting enzyme prevents endotoxin-induced interleukin-1β production in vitro and in vivo
21. The protective role of endogenously synthesized nitric oxide in staphylococcal enterotoxin B-induced shock in mice
22. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes
23. Urinary nitrate excretion in relation to murine macrophage activation: influence of dietary L-arginine and oral NG-monomethyl-l-arginine
24. Reactive nitrogen intermediates suppress the primary immunologic response to listeria
25. Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury
26. Tumor necrosis factor-α regulates in vivo nitric oxide synthesis and induces liver injury during endotoxemia
27. Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite
28. Synthesis of nitric-oxide from a guanidino nitrogen of L-arginine: a molecular mechanism that targets intracellular iron
29. Targeted disruption of the neuronal nitric oxide synthase gene
30. Mice that lack the interferon-γ receptor have profoundly altered responses to infection with bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide
31. Requirement for transcription factor IRF-1 in NO synthase induction in macrophages
32. Inhibition of viral replication by interferon-γ-induced nitric oxide synthase
33. NG-methyl-l-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide
34. Reversal of endotoxin-mediated shock by NG-methyl-l-arginine an inhibitor of nitric oxide synthesis
35. IFN-γ involvement in the severity of gram-negative infections in mice
36. Spin trapping of nitric oxide produced in vivo in septic-shock mice
37. L-arginine pathway in the sepsis syndrome
38. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme
39. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line
40. Differential expression of iNOS and cNOS mRNA in human vascular smooth muscle cells and endothelial cells under normal and inflammatory conditions
41. Role of interferon regulatory factor 1 in induction of nitric oxide synthase
42. Inhibition of nitric oxide synthesis is detrimental during endotoxemia
43. Differential expression and induction of mRNAs encoding two inducible nitric oxide syntheses in rat kidney
44. Nitric oxide: physiology, pathophysiology, and pharmacology
45. Electroporation of embryonic stem cells for generating transgenic mice and studying in vitro differentiation
46. Isolation of the functional human excision repair gene ERCC5 by intercosmid recombination
47. Tissue injury caused by deposition of immune complexes is l-arginine dependent
48. Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis
49. Role of nitric oxide synthesis in macrophage antimicrobial activity
50. Regulation of biosynthesis of nitric oxide
51. Nitric oxide syntheses: roles, tolls, and controls
52. Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?
53. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase
54. Nitrogen oxide levels in patients after trauma and during sepsis
55. Interleukin-1 receptor antagonist reduces mortality from endotoxin shock
56. Pathogenetic mechanisms of septic shock
57. Effects of l-arginine and l-nitro-arginine treatment on blood pressure and cardiac output in a rabbit endotoxin shock model
58. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock
59. Effects of a nitric oxide synthase inhibitor in humans with septic shock
60. Mice deficient forthe 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
61. Nitric oxide as a mediator of relaxation of the corpus cavernosum in responseto nonadrenergic, noncholinergic neurotransmission
62. Role of nitric oxide in antagonistic effects of transforming growth factor-β and interleukin-1 β on the beating rate of cultured cardiac myocytes
63. Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes
64. Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide
65. Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide
66. A new approach in the treatment of hypotension in human septic shock by NG-monomethyl-l-arginine, an inhibitor of the nitric oxide synthelase
67. Nitric oxide synthase activity in pregnant rabbit uterus decreases on the last day of pregnancy
68. Lymphokine enhances the expression and synthesis of la antigens on cultured mouse peritoneal macrophages
69. Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide
70. Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-y
71. Nitric oxide: a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
72. Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD-and FMN-containing flavoprotein
73. Beneficial effect and improved survival in rodent models of septic shock with S-methylisothiourea sulfate a potent and selective inhibitor of inducible nitric oxide synthase
74. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytoxicity by macrophages
75. Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon
76. Inhibition of nitric oxide synthesis improves survival in a murine peritonitis model of sepsis that is not cured by antibiotics alone
77. The role of the L-arginine:nitric oxide pathway in circulatory shock
78. Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo
79. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages
80. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide
81. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice
82. An l-arginine-nitric oxide-cyclic guanosine monophosphate system exists in the uterus and inhibits contractility during pregnancy