Amyotrophic lateral sclerosis is a multifactorial disease

Muscle & Nerve

Volumn 18, Issue 7, 1995, Pages 741-752

  Eisen, Andrew ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

amyotrophic lateral sclerosis; corticomotoneuron; excitotoxicity; multifactorial; pathogenesis

Indexed keywords

EXCITOTOXIN; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTROPHIC FACTOR; SUPEROXIDE DISMUTASE;

AGING; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; ENVIRONMENTAL FACTOR; GLIA CELL; HUMAN; NEUROTROPISM; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; SECOND MESSENGER;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 21; GLUTAMIC ACID; HUMAN; MUTATION; NERVE GROWTH FACTORS; NEUROFILAMENT PROTEINS; NEUROTOXINS; RECEPTORS, N-METHYL-D-ASPARTATE; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; SUPEROXIDE DISMUTASE;

EID: 0028998398     PISSN: 0148639X     EISSN: 10974598     Source Type: Journal    
DOI: 10.1002/mus.880180711     Document Type: Article

References (108)

1. Neurofilaments, free radicals, excitotoxins and amyotrophic lateral sclerosis
2. Marked depletion of ciliary neurotrophic factor in ventral horn of spinal cord but not cerebral motor cortex in amyotrophic lateral sclerosis
3. Immunological models of amyotrophic lateral sclerosis
4. Evidence for autoimmunity in amyotrophic lateral sclerosis
5. A pilot trial of dextromethorphan in amyotrophic lateral sclerosis
6. Abnormal EPSPs evoked by magnetic brain stimulation in hands muscle motoneurons of patients with amyotrophic lateral sclerosis
7. A controlled trial of riluzole in amyotrophic lateral sclerosis
8. Fast axonal transport in amyotrophic lateral sclerosis: an intra‐axonal organelle traffic analysis
9. Design of clinical therapeutic trials in amyotrophic lateral sclerosis
10. Corticospinal projections to upper and lower limb spinal motoneurons in man
11. Proximal enlargement in motor neuron diseases
12. Insulin‐like growth factor I increases brain growth and central nervous system myelination in transgenic mice
13. Sclerose des cordons lateraux de la moelle epinere chez femme hysterique atteinte de contracture peranemte des quatre membres
14. Risk factors in motor neuron disease: a case control study
15. Local circuit neurons immunoreactive for calretinin, calbindin D‐28k or parvalbumin in monkey prefrontal cortex: distribution and morphology
16. Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis
17. Protein kinase C activation inhibits glutamate‐induced cytotoxicity in a neural cell line
18. Electrical and magnetic stimulation of human motor cortex: surface EMG and single unit responses
19. Motor cortex stimulation in intact man: II. Multiple descending volleys
20. Amyotrophic lateral sclerosis and structural defects in Cu, Zn superoxide dismutase
21. Neurotrophic factors in the treatment of motor neuron disease and trauma
22. Trial of immunosuppression in amyotrophic lateral sclerosis using total lymphoid irradiation
23. Amyotrophic lateral sclerosis, Parkinson's disease and Alzheimer's disease: phylogenetic disordres of the human neocortex sharing many characteristics
24. Amyotrophic lateral sclerosis (ALS): a phylogenetic disease of the corticomotoneuron?
25. Pathogenic mechanisms in amyotrophic lateral sclerosis
26. Cortical excitability in amyotrophic lateral sclerosis: a clue to pathogenesis
27. Duration of amyotrophic lateral sclerosis is age dependent
28. Antiglutamate therapy in amyotrophic lateral sclerosis using Lamotrigine
29. There are characteristic features of fasciculation in amyotrophic lateral sclerosis
30. Neurodegeneration in amyotrophic lateral sclerosis: neurotrophic factors and monoamine oxidase B
31. An application of cumulative sum technique (cusums) to neurophysiology
32. The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1‐22.1 in the vicinity of the gene for amyotrophic lateral sclerosis
33. Hypothesis: interference with axonal transport of neurofilament as a common mechanism in certain diseases of the central nervous system
34. Fibroblast growth factors, proteins with a broad spectrum of biological activities
35. Glutamate and Parkinson's disease
36. Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders in mice and humans
37. Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation
38. Astrocytes: vital components of the central nervous system
39. Trial of immunosuppression in amyotrophic lateral sclerosis using total lymphoid irradiation
40. Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33‐q35
41. Members of several gene families influence survival of rat motor neurons in vitro and in vivo
42. Parvalbumin and calbindin D‐28k in the human motor system and in motor neuron disease
43. Signal loss in the motor cortex on magnetic images in amyotrophic lateral sclerosis
44. Corticofungal projections to the motor nuclei of the brainstem and spinal cord in humans
45. Amyotrophic lateral sclerosis: what makes the direct corticospinal tract so vulnerable
46. Cortical function in amyotrophic lateral sclerosis. A positron emission study
47. Cortical function in progressive lower motor neuron disorders and amyotrophic lateral sclerosis: a comparative PET study
48. + channel al subunit
49. Activation of PKC reverses apparent NMDA receptor reduction in ALS
50. Pathogenic mechanisms in amyotrophic lateral sclerosis and other motor neuron disorders
51. Ubiquitinimmunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis. Morphology, distribution and specificity
52. The iron‐binding protein lactotransferrin is present in pathological lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis
53. Rising mortality from motoneuron disease in the USA, 1982–84
54. Excitatory amino acids as a final common pathway for neurologic disorders
55. IgG from amyotrophic lateral sclerosis patients increases current through P‐type calcium channels in mammalian cerebellar Purkinje cells and in isolated channel protein in lipid bilayer
56. Will ciliary neurotrophic factor slow progression of motor neuron disease?
57. Disruption of the CNTF gene results in motor neuron degeneration
58. Neurodegeneration and the immune system
59. Genetic basis of familial amyotrophic lateral sclerosis
60. Structural similarities between ganglioside GM1 and antigens of the P2 phenotype
61. Sporadic ALS and chromosome 22: evidence for a possible neurofilament gene defect
62. The firing probability of single motor units following transcranial magnetic stimulation in healthy subjects and patients with neurological disease
63. The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease
64. Arrest of motor neuron disease in wobbler mice cotreated with CBTF and BDNF
65. Immunocytochemical and ultrastructural studies of upper motor neurons in amyotrophic lateral sclerosis
66. Reactive astrocytes are widespread in the cortical gray matter of amyotrophic lateral sclerosis
67. Late onset selective damage in the rat spinal cord induced by continuous intrathecal administration of AMPA
68. Neurotrophic factors: two are better than one
69. Amyotrophic lateral sclerosis: the clinical disorder
70. Multifocal motor neuropathy
71. Detection of cortical neuron loss in motor neuron disease by proton magnetic resonance spectroscopy imaging in vivo
72. Blood group investigations on Carolinians and Chamorros of Saipan
73. Primary lateral sclerosis. Clinical features, neuropathology and diagnostic criteria
74. Cu/Zn superoxide dismutase activity in familial and sporasdic amyotrophic lateral sclerosis
75. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
76. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
77. Glutamate transporter subtypes: role in excitotoxicity and amyotrophic lateral sclerosis
78. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
79. Stimulation of the human motor cortex through the scalp
80. Amyotrophic lateral sclerosis and autoimmunity
81. Amyotrophic lateral sclerosis: theories and therapies
82. Amyotrophic lateral sclerosis and lymphoma: bone marrow examination and other diagnostic tests
83. Androgen concentration in motor neurons of cranial nerves and spinal cord
84. Aluminum pretreatment impairs the ability of astrocytes to protect neurons from glutamate mediated toxicity
85. Ubiquitinated dystrophic neurites suggest corticospinal derangement in patients with amyotrophic lateral sclerosis
86. Experimental rationale for the therapeutic use of neurotrophins in amyotrophic lateral sclerosis
87. Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motoneuronopathy
88. Excitatory amino acid receptors, excitotoxicity, and the human nervous system
89. 3H]D‐Aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study
90. 3H]kainate
91. N‐methyl‐D‐aspartate (NMDA) receptors in the spinal cord and motor cortex in motor neuron disease: a quantitative autoradiographic study using [3H]MK‐801
92. Androgen receptor systems in the brain stem of the primate
93. Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic‐locus heterogeneity
94. Animal models of amyotrophic lateral sclerosis and the spinal muscular atrophies
95. Experimental immune‐mediated motor neuron disease: models for human ALS
96. Serum antibodies to L‐type calcium channels in patients with amyotrophic lateral sclerosis
97. Chronic aluminum‐induced motor neurondegeneration: clinical, neuropathological and molecular biological aspects
98. Antibodies to L‐type calcium channels in amyotrophic lateral sclerosis
99. Sequences specific for enterovirus detected in spinal cord from patients with MND
100. Increased experssion of neurofilament subunit NF‐L produces morphologic alterations that resemble the pathology of human motor neuron disease
101. Disruption of the CNTF gene results in motor neuron degeneration
102. Lymphoma, motor neuron diseases and amyotrophic lateral sclerosis
103. Excitatory amino acids, free radicals and the pathogenesis of motor neuron disease