Structure-based design of the first dotent and selective inhibitor of human non-pancreatic secretory phospholipase A2

Nature Structural Biology

Volumn 2, Issue 6, 1995, Pages 458-465

  Schevitz, R W ^a   Bach, N J ^a   Carlson, D G ^a   Chirgadze, N Y ^a   Clawson, D K ^a   Dillard, R D ^a   Drahelm, S E ^a   Hartley, L W ^a   Jones, N D ^a,b   Mihelich, E D ^a   Olkowski, J L ^a   Snyder, D W ^a   Sommers, C ^a,c   Wery, J P ^a  

^a ELI LILLY AND COMPANY   (United States)

^b Molecular Structure Corporation   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDOLE DERIVATIVE; INDOMETACIN; LY 14024; LY 311727; PHOSPHOLIPASE INHIBITOR; PHOSPHOLIPSE A2; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME SPECIFICITY; GUINEA PIG; LUNG; NONHUMAN; PANCREAS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SWINE;

ANIMAL; BINDING SITES; BIOLOGICAL ASSAY; CALCIUM; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; GUINEA PIGS; HUMAN; INDOLES; INFLAMMATION; KINETICS; LUNG; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHOLIPASES A; POTASSIUM CHLORIDE; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0028997717     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb0695-458     Document Type: Article

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