The Histamine H1-Receptor Antagonist Binding Site. A Stereoselective Pharmacophoric Model Based upon (Semi-)Rigid H1-Antagonists and Including a Known Interaction Site on the Receptor

Journal of Medicinal Chemistry

Volumn 38, Issue 17, 1995, Pages 3351-3360

  Laak, Anton M ter ^a   Venhorst, Jennifer ^a   den Kelder, Gabriëlle M Donné Op ^a   Timmerman, Hendrik ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

5 (3 QUINUCLIDINYL) 5H DIBENZO[B,E]THIAZINE; CYPROHEPTADINE; DIPHENHYDRAMINE; EPINASTINE; HISTAMINE H1 RECEPTOR; HISTAMINE H1 RECEPTOR ANTAGONIST; MEQUITAZINE; MIANSERIN; PHENINDAMINE; TRIPROLIDINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; DRUG CONFORMATION; DRUG RECEPTOR BINDING; GUINEA PIG; HYDROGEN BOND; MOLECULAR INTERACTION; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR AFFINITY; STEREOCHEMISTRY; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; METABOLISM; STEREOISOMERISM;

BINDING SITES; HISTAMINE H1 ANTAGONISTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STEREOISOMERISM; SUPPORT, NON-U.S. GOV'T;

EID: 0028991759     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00017a019     Document Type: Article

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