Relative sensitivity of the endogenous hprt gene and lacl transgene in ENU‐treated big blue™ B6C3F1 mice

Environmental and Molecular Mutagenesis

Volumn 26, Issue 1, 1995, Pages 9-15

  Skopek, Thomas R ^a   Kort, Kristy L ^a   Marino, Deborah R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Big Blue mice; ENU; hprt; lacl

Indexed keywords

ETHYLNITROSOUREA; BACTERIAL PROTEIN; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LACI PROTEIN; REPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; MUTAGENICITY; MUTATION; MUTATION RATE; NONHUMAN; T LYMPHOCYTE; TRANSGENE; ANIMAL; BIOSYNTHESIS; COMPARATIVE STUDY; DOSE RESPONSE; FEMALE; GENETICS; METABOLISM; MOUSE STRAIN; MUTAGENESIS; SPECIES DIFFERENCE; TRANSGENIC MOUSE;

ANIMALIA;

ANIMAL; BACTERIAL PROTEINS; COMPARATIVE STUDY; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLNITROSOUREA; FEMALE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, TRANSGENIC; MUTAGENESIS; REPRESSOR PROTEINS; SPECIES SPECIFICITY; T-LYMPHOCYTES;

EID: 0028991066     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.2850260103     Document Type: Article

References (21)

1. Induction of 6‐thioguanine‐resistant lymphocytes in Fischer 344 rats following in vivo exposure to N‐ethyl‐N‐nitro‐sourea and cyclophosphamide
2. Heterogeneous DNA damage and repair in the mammalian genome
3. Human HPRT mutant database: Software for data entry and retrieval
4. Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo
5. Measurement of in vivo mutant frequency in lymphocytes in the mouse
6. Sequence of the lacl gene
7. Efficient rescue of integrated shuttle vectors from transgenic mice: A model for studying mutations in vivo
8. Cloned mouse lymphocytes permit analysis of somatic mutations that occur in vivo
9. Chemical induction of somatic gene mutations and chromosomal aberrations in lung fibroblasts of rats
10. Development of a short term in vivo mutagenesis assay: The effects of methylation on recovery of a lambda phage shuttle vector from transgenic mice
11. Spectra of spontaneous and mutagen‐induced mutations in the lacl gene in transgenic mice
12. Evidence that the pattern of spontaneous somatic mutation can differ dramatically with tissue type
13. Structure, expression, and mutation of the hypoxanthine phosphoribosyl‐transferase gene
14. Characterization of mutations induced by ethylnitrosourea in seminiferous germ cells of transgenic B6C3F1 mice
15. Mutational spectrum of N‐ethyl‐N‐nitrosourea at the HPRT locus in splenic T‐cells of exposed B6C3F1 mice
16. Molecular analysis of hypoxanthine phosphoribosyl transferase mutants induced by glycidyl 1‐naphthyl ether in mouse spleen cells in vivo
17. The accumulation and persistence of somatic mutations in vivo
18. Comparison of somatic mutation in a transgenic vs. host locus
19. TM mice
20. A clonal marker induced by mutation in mouse intestinal epithelium
21. Enumeration of 6‐thioguanine‐resistant T‐lymphocytes in the peripheral blood of nonhuman primates (cynomolgus monkeys)