Potent vitamin D3 analogs: Their abilities to enhance transactivation and to bind to the vitamin D3 response element

Leukemia Research

Volumn 19, Issue 3, 1995, Pages 147-158

  Imai, Yasufumi ^a   Pike, J Wesley ^b   Koeffler, H Phillip ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b LIGAND PHARMACEUTICALS INC   (United States)

Author keywords

gel retardation; transactivations; Vitamin D3 analogs

Indexed keywords

CALCITRIOL; CALCITRIOL RECEPTOR; CHLORAMPHENICOL ACETYLTRANSFERASE; COLECALCIFEROL; OSTEOCALCIN; VITAMIN RECEPTOR; DNA BINDING PROTEIN; DNA BINDING PROTEINS; DRUG DERIVATIVE; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; TRANSCRIPTION FACTOR;

ARTICLE; BINDING AFFINITY; BLAST CELL; CELL STRAIN HL 60; ELECTROPHORETIC MOBILITY; HUMAN; POTENTIAL DIFFERENCE; PRIORITY JOURNAL; REPORTER GENE; TRANSACTIVATION; VITAMIN D METABOLISM; BINDING COMPETITION; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CULTURE MEDIUM; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; REGULATORY SEQUENCE;

BASE SEQUENCE; BINDING, COMPETITIVE; CALCITRIOL; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CULTURE MEDIA; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMAN; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECEPTORS, CALCITRIOL; RECEPTORS, RETINOIC ACID; REGULATORY SEQUENCES, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 0028988421     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/0145-2126(94)00127-V     Document Type: Article

References (53)

1. Basic and clinical concepts related to vitamin D metabolism and action
2. The role of vitamin D endocrine system in health and disease
3. 3 and its fluorinated analogues
4. 3
5. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML
6. Induction of differentiation of the human histiocytic lymphoma cell line U 937 by 1α,25-dihydrocholecalciferol
7. 3: in vivo and in vitro effects on human preleukemic and leukemic cells
8. Effects of a novel vitamin D analogue MC903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo
9. 3 is a potent modulator of in vivo immunoregulating activity without inducing hypercalcemia in mice
10. Vitamin D-mediated gene expression
11. 3 receptors
12. 3 signaling
13. The vitamin D-responsive element in the human osteocalcin gene
14. 3-modulated heterodimer
15. 3
16. A 55-kilodalton accessory factor facilitates vitamin D receptor DNA binding
17. 3
18. Reconstitution of the vitamin D-responsive osteocalcin transcription unit in Saccharomyces cerevisiae
19. Expression of human vitamin D receptor in Saccharomyces cerevisiae: purification, properties and generation of polyclonal antibodies
20. Vitamin D compounds: effect on clonal proliferation and differentiation of human myeloid cells
21. 3 in a single two milliliter plasma sample
22. 3 to its chick intestinal mucosa receptor using a hydroxyapatite batch assay
23. 3
24. Novel vitamin D analogs that modulate leukemic cell growth and differentiation with little effect on either intestinal calcium absorption or bone calcium mobilization
25. 3: differential effects on leukemic cell growth, differentiation, and intestinal calcium absorption
26. 3 prolongs survival time of leukemic mice
27. 3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism
28. 3 analogs
29. 3 and dihydrotachysterols and dihydrostasterol in the chick
30. 3 analogs: effect on leukemic clonal growth and differentiation, and on serum calcium levels
31. 3: an extraordinarily potent inhibitor of leukemic cell growth in vitro
32. On the mechanisms for the selective action of vitamin D analogs
33. The activity of 22-Oxacalcitriol in osteoblastlike (ROS 17/2.8) cells
34. Vitamin D analogs with low affinity for the vitamin D binding protein: enhanced in vitro and decreased in vivo activity
35. Structure function analysis of vitamin D analogs with C-ring modifications
36. 3
37. 3 analogs potently induce the human osteocalcin gene promoter stably transfected into rat osteosarcoma cells (ROSCO-2)
38. 3, a novel bioactive metabolite
39. 1,25-dihydroxy-vitamin D-responsive element and glucocorticoid repression in the osteocalcin gene
40. 3 enhancement of mouse secreted phosphoprotein 1 (Spp-1 or osteopontin) gene expression
41. Two nuclear signalling pathways for vitamin D
42. 3-activated expression of the rat osteocalcin gene
43. 3 regulation
44. Jun-Fos and receptors for vitamin A and D recognize a common responsive element in the human osteocalcin gene
45. The glucocorticoid receptor binds to a sequence overlapping the TATA box of the human osteocalcin promoter: a potential mechanism for negative regulation
46. Postproliferative transcription of the rat osteocalcin gene is reflected by vitamin D-responsive developmental modifications in protein interactions at basal and enhancer promoter elements
47. 9-Cis retinoic acid is a high affinity ligand for the retinoid X receptor
48. 3 stimulates membrane phosphoinositide turnover, activates protein kinase C, and increases cytosolic calcium in rat colonic epithelium
49. 3 on cytosolic calcium in two human cell lines (HL-60 and U-937)
50. 3 in HL- 60 cells
51. 3 modulate the hormone-induced increases in osteocalcin gene transcription in osteoblast-like cells
52. 3 receptor