Role of Interferon-γ in Mediating the Antitumor Efficacy of Interleukin-12

Journal of Immunotherapy

Volumn 17, Issue 2, 1995, Pages 71-77

  Brunda, Michael J ^a   Luistro, Leopoldo ^a   Hendrzak, Jill A ^a   Fountoulakis, Michael ^b   Garotta, Gianni ^b   Gately, Maurice K ^c  

^a Departments of Oncology   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c HOFFMANN LA ROCHE INC   (United States)

Author keywords

Antitumor activity; Cytokine; Interferon ; Interleukin 12

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; MONOCLONAL ANTIBODY XMG1 2; NEUTRALIZING ANTIBODY; RECOMBINANT GAMMA INTERFERON; RECOMBINANT INTERLEUKIN 12; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CARCINOMA CELL; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EUTHYROIDISM; INTERFERON INDUCTION; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY CARCINOMA; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SURVIVAL;

ANIMAL; ANTIBODIES, MONOCLONAL; CELL DIVISION; COMPARATIVE STUDY; CYTOKINES; INTERFERON TYPE II; INTERLEUKIN-12; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0028987902     PISSN: 15249557     EISSN: 15374513     Source Type: Journal    
DOI: 10.1097/00002371-199502000-00001     Document Type: Article

References (22)

1. Brunda MJ, Luistro L, Warrier RR, et al. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med 1993;178:1223-30.
2. Nastala CL, Edington HD, McKinney TG, et al. Recombinant interleukin-12 (IL-12) administration induces tumor regression in association with interferon-gamma production. J Immunol 1994;153:1697-706.
3. Brunda MJ. Interleukin-12. J Leukocyte Biol 1994;55:280-8.
4. Gately MK, Gubler U, Brunda MJ, et al. Interleukin-12: a cytokine with therapeutic potential in oncology and infectious diseases. Ther Immunol 1994;1:187-96.
5. Wolf SF, Temple PA, Kobayashi M, et al. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol 1991;146:3074-81.
6. Gubler U, Chua AO, Schoenhaut DS, et al. Coexpression of two distinct genes is required to generate secreted, bioactive cytotoxic lymphocyte maturation factor. Proc Natl Acad Sci USA 1991;88:4143-7.
7. Chan SH, Perussia B, Gupta JW, et al. Induction of inter-feron production by natural killer cell stimulatory factor: characterization of the responding cells and synergy with other inducers. J Exp Med 1991;173:869-79.
8. Schoenhaut DS, Chua AO, Wolitzky AG, et al. Cloning and expression of murine IL-12. J Immunol 1992;148:3433-40.
9. Gately MK, Warrier RR, Honasoge S, et al. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo. Ini Immunol 1994;6:157-67.
10. Ratliff TL, Kadmon D, Shapiro A, Jacobs AJ, Heston WDW. Inhibition of mouse bladder tumor proliferation by murine interferon-γ and its synergism with interferon-β. Cancer Res 1984;44:4377-81.
11. Brunda MJ, Wright RB. Differential antiproliferative effects of combinations of recombinant interferons alpha and gamma on two murine tumor cell lines. Int J Cancer 1986; 37:287-91.
12. Brunda MJ, Sulich V, Bellantoni D. The anti-tumor effect of recombinant interferon alpha or gamma is influenced by tumor location. Int J Cancer 1987;40:807-10.
13. Truitt GA, Bontempo JM, Stern LL, et al. Efficacy and toxicity elicited by recombinant interferons alpha and gamma when administered in combination to tumor-bearing mice. Biotech Ther 1989;1:1-16.
14. Salup RR, Back TC, Wiltrout RH. Successful treatment of advanced murine renal cell cancer by bicompartmental adoptive chemoimmunotherapy. J Immunol 1987;138:641-7.
15. Gately MK, Chizzonite R. Measurement of human and mouse interleukin 12. In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W, eds. Current protocols in immunology, vol 1. New York: Wiley, 1992;6.16.1-8.
16. Gray PW, Goeddel D. Cloning and expression of murine immune interferon cDNA. Proc Natl Acad Sci USA 1983; 80:5842-6.
17. Familetti PC, Rubenstein S, Pestka S. A convenient and rapid cytopathic effect inhibition assay for interferon. Methods Enzymol 1981;78:387-94.
18. Kohler J, Heumann D, Garetta G, et al. IFN-7 involvement in the severity of gram-negative infections in mice. J Immunol 1993;151:916-21.
19. Wong GHW, Clark-Lewis I, McKimm-Breschkin JL, Harris AW, Schrader JW. Interferon gamma induces enhanced expression of la and H-2 antigens on B-lymphoid, macrophage and myeloid cell lines. J Immunol 1983;131:788-93.
20. Sayers TJ, Mason AT, Ortaldo JR. Regulation of human natural killer cell activity by interferon-γ: lack of a role in interleukin 2-mediated augmentation. J Immunol 1986;136: 2176-80.
21. Varesio L, Blasi E, Thurman GB, Talmadge JE, Wiltrout RH, Herberman RB. Potent activation of mouse macrophages by recombinant interferon-gamma. Cancer Res 1984; 44:4465-70.
22. Giovarelli M, Santoni A, Jemma C, et al. Obligatory role of IFN-γ in induction of lymphokine-activated and T lymphocyte killer activity, but not in boosting of natural cytotoxic-ity. J Immunol 1988;141:2831-6.