Polyamine regulation of N-methyl-D-aspartate receptor channels

Annual Review of Pharmacology and Toxicology

Volumn 35, Issue , 1995, Pages 463-482

  Rock, David M ^a,b   Macdonald, Robert L ^b  

^a PFIZER INC   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

NMDA; polyamine pharmacology; spermidine; spermine

Indexed keywords

1 (1 THIENYLCYCLOHEXYL) PIPERIDINE; ARCAINE; DIAMINODECANE; DIETHYLENETRIAMINE; DIZOCILPINE; GLYCINE; ION CHANNEL; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER; PHENCYCLIDINE; POLYAMINE; PUTRESCINE; RECEPTOR SUBUNIT; SPERMIDINE; SPERMINE; UNCLASSIFIED DRUG;

CENTRAL NERVOUS SYSTEM; ELECTROPHYSIOLOGY; LIGAND BINDING; MOLECULAR BIOLOGY; NEUROTRANSMISSION; NONHUMAN; POLYAMINE METABOLISM; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW;

EID: 0028987875     PISSN: 00664251     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.pa.35.040195.002335     Document Type: Review

References (122)

1. Seiler N. 1991. Pharmacological properties of the natural polyamines and their depletion by biosynthesis inhibitors as a therapeutic approach. Prog. Drug Res. 37:107-60
2. Styrer L. 1981. Biochemistry, pp. 411-15. San Francisco: Freeman
3. Bredt DS, Snyder SH. 1992. Nitric oxide, a novel neuronal messenger. Neuron 8:3-11
4. Tabor CW, Tabor H. 1984. Polyamines. Annu. Rev. Biochem. 53:749-90
5. Paschen W. 1992. Polyamine metabolism in reversible cerebral ischemia. Cerebrovasc. Brain Metab. Rev. 4:59-88
6. Porcella A, Fage D, Voltz C, Carter C, Scatton B, et al. 1991. Difluoromethyl ornithine protects against the neurotoxic effects of intrastriatally administered N-methyl-D-aspartate in vivo. Eur. J. Pharmacol. 199:267-69
7. Kish SJ, Wilson JM, Fletcher PJ. 1991. The polyamine synthesis inhibitor α-difluoromethylorinithine is neuroprotective against N-methyl-D-aspartate-induced brain damage in vivo. Eur. J. Pharmacol. 209:101-03
8. Williams K, Romano C, Dichter MA, Molinoff PB. 1991. Modulation of the NMDA receptor by polyamines. Life Sci. 48:469-98
9. Harman RJ, Shaw GG. 1981. The spontaneous and evoked release of spermine from rat brain in vitro. Br. J. Pharmacol. 73:165-74
10. Gilad GM, Gilad VH. 1991. Polyamine uptake, binding and release in rat brain. Eur. J. Pharmacol. 193:41-46
11. Fage D, Voltz C, Scatton B, Carter C. 1992. Selective release of spermine and spermidine from the rat strialum by N-methyl-D-aspartale receptor activation in vivo. J. Neurochem. 58:2170-75
12. Harman RJ, Shaw GG. 1981. High-affinity uptake of spermine by slices of rat cerebral cortex. J. Neurochem. 36: 1609-15
13. Herman MD, Reuveny E, Narahashi T. 1993. The effect of polyamines on voltage-activated calcium channels in mouse neuroblastoma cells. J. Physiol. 462: 645-60
14. Scott RH, Sweeney MI, Kobrinsky EM, Pearson HA, Timms GH, et al. 1992. Actions of arginine polyamine on voltage and ligand-activated whole cell currents recorded from cultured neurones. Br. J. Pharmacol. 106:199-207
15. Scott RH, Sutton KG, Dolphin AC. 1993. Interactions of polyamines with neuronal ion channels. Trends Neurosci. 16:153-59
16. Curtis DR, Phillis JW, Watkins JC. 1959. Chemical excitation of spinal neurones. Nature. 183:611-12
17. Curtis DR, Phillis JW, Watkins JC. 1960. The chemical excitation of spinal neurones by certain acidic amino acids. J. Physiol. 150:656-82
18. Monaghan DT, Bridges RJ, Cotman CW. 1989. The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 29:345-402
19. Watkins JC, Krogsgaard-Larsen P, Honore T. 1990. Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. Trends Pharmacol. Sci. 11:25-33
20. Collingridge GL, Lester RAJ. 1989. Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol. Rev. 40:143-210
21. Patneau DK, Mayer ML. 1990. Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors. J. Neurosci. 10:2385-99
22. 3H]MK-801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines. J. Neurochem. 51:830-36
23. 3H]MK-801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site. Mol. Pharmacol. 36:575-81
24. 3H]N-(1-[thienyl]cyclohexyl)piperdidine binding to the N-methyl-D-aspartate receptor ionophore complex. Mol. Pharmacol. 37:572-77
25. Reynolds U, Miller RJ. 1989. Ifenprodil is a novel type of NMDA receptor antagonist: interaction with polyamines. Mol. Pharmacol. 36:758-65
26. 3H](+)-5-methyl-10,11-dihidro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) binding in brain synaptic membranes treated with triton X-100. J. Pharmacol. Exp. Ther. 256:1161-72
27. 3H]MK-801 binding to the NMDA receptor complex in human cortical membranes. Eur. J. Pharmacol. 189:195-200
28. 3H]MK-801 to the solubilized N-methyl-D-aspartate receptor. J. Neurochem. 57:811-18
29. 3H]MK-801 binding to N-methyl-D-aspartate receptors solubilized from rat brain: effects of glycine site ligands, polyamines, ifenprodil, and desipramine. J. Neurochem. 57:39-45
30. Yoneda Y, Ogita K. 1991. Heterogeneity of the N-methyl-D-aspartate receptor ionophore complex in rat brain, as revealed by ligand binding techniques. J. Pharmacol. Exp. Ther. 259:86-96
31. 3H]MK-801) in rat brain: regional effects of polyamines. J. Pharmacol. Exp. Ther. 256:811-19
32. Subramaniam S, McGonigle P. 1993. Regional heterogeneity of polyamine effects on the N-methyl-D-aspartate receptor in rat brain. J. Neurochem. 60: 2276-84
33. McGurk JF, Bennett MLV, Zukin RS. 1990. Polyamines potentiate the responses of N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Proc. Natl. Acad. Sci. USA 87:9971-74
34. Brackely P, Goodnow RJ, Nakanishi K, Sudan HL, Usherwood PNR. 1990. Spermine and philanthotoxin potentiate excitatory amino acid responses of Xenopus oocytes injected with rat and chick brain RNA. Neurosci. Lett. 114: 51-56
35. Maciver CR, Bednar DL, Karbon W. 1991. Opposite effects of spermine and arcaine on responses of N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Neurosci. Lett. 132: 146-50
36. Sprosen T, Woodruff GN. 1990. Polyamines potentiate NMDA induced whole-cell currents in cultured striatal neurons. Eur. J. Pharmacol. 179:477-78
37. Williams K, Dawson VL, Romano C, Dichter MA, Molinoff PB. 1990. Characterization of polyamines having agonist, antagonist and inverse agonist effects at the polyamine recognition site of the NMDA receptor. Neuron 5:199-208
38. Rock DM, Macdonald RL. 1992. The polyamine spermine has multiple actions on N-methyl-D-aspartate receptor single-channel currents in cultured cortical neurons. Mol. Pharmacol. 41:83-88
39. Rock DM, Macdonald RL. 1992. Spermine and related polyamines produce a voltage-dependent reduction of N-methyl-D-aspartate receptor single-channel conductance. Mol. Pharmacol. 42: 157-64
40. Lerma J. 1992. Spermine regulates N-methyl-D-aspartate receptor desensitization. Neuron 8:343-52
41. Benveniste M, Mayer ML. 1993. Multiple effects of spermine on N-methyl-D-aspartic acid receptor responses of rat cultured hippocampal neurones. J. Physiol. 464:131-63
42. Araneda RC, Zukin RS, Bennett MLV. 1993. Effects of polyamines on NMDA-induced currents in rat hippocampal neurons: a whole-cell and single-channel study. Neurosci. Lett. 152:107-12
43. Vorobjev VS, Sharonova IN, Walsh IB, Haas HL. 1993. Histamine potentiates N-methyl-D-aspartate responses in acutely isolated hippocampal neurons. Neuron 11:837-44
44. Robichaud LJ, Boxer PA. 1993. Polyamine modulation of excitatory amino acid responses in the rat cortical wedge. Neuropharmacology 32:1025-35
45. Chida N, Saito H, Abe K. 1992. Spermine facilitates the generation of long-term potentiation of evoked potential in the dentate gyrus of anesthetized rats. Brain Res. 593:57-62
46. Nicoll RA, Kauer JA, Malenka RC. 1988. The current excitement about long-term potentiation. Neuron 1:97-103
47. Choi DW. 1988. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1:623-34
48. Rothman SM, Olney JW. 1987. Excitotoxicity and the NMDA receptor. Trends Neurosci. 10:299-302
49. Rogawski MA. 1992. The NMDA receptor, NMDA antagonists and epilepsy therapy: a status report. Drugs 44:279-92
50. Lipton SA. 1992. Models of neuronal injury in AIDS: another role for the NMDA receptor. Trends Neurosci. 15: 75-79
51. Olney JW. 1990. Excitotoxic amino acids and neuropsychiatric disorders. Annu. Rev. Pharmacol. Toxicol. 30:47-71
52. Ascher P, Nowak L. 1988. The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurons. J. Physiol. 399:247-66
53. Ascher P. 1988. Divalent cations and the NMDA channel. Biomed. Res. 9 (Suppl. 2):31-37
54. Mayer ML, Westbrook GL. 1987. Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones. J. Physiol. 394:501-27
55. Mayer ML, Westbrook GL. 1985. The action of N-methyl-D-aspartic acid on mouse spinal cord neurones in culture. J. Physiol. 361:65-90
56. Mayer ML, Vyklicky L, Westbrook GL. 1989. Modulation of excitatory amino acid receptors by group IIB metal cations in cultured mouse hippocampal neurones. J. Physiol. 415:329-50
57. MacDermott AB, Mayer ML, Westbrook GL, Smith SJ, Barker JL. 1986. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 321:519-22
58. Mayer ML, Westbrook GL. 1984. Mixed-agonist action of excitatory amino acids on mouse spinal cord neurones under voltage clamp. J. Physiol. 354:29-53
59. Cull-Candy SG, Usowicz MM. 1987. Multiple-conductance channels activated by excitatory amino acids in cerebellar neurons. Nature 325:525-28
60. Jahr CE, Stevens CF. 1987. Glutamate activates multiple single channel conductances in hippocampal neurons. Nature 325:522-25
61. Cull-Candy SG, Usowicz MM. 1989. On the multiple-conductance single channels activated by excitatory amino acids in large cerebellar neurones of (he rat. J. Physiol. 415:555-82
62. Howe JE, Cull-Candy SG, Colquhoun D. 1992. Currents through single gluta mate receptor channels in outside-out patches from rat cerebellar granule cells. J. Physiol. 432:143-202
63. Nowak L, Bregestovski P, Ascher P, Herbert A, Prochiantz A. 1984. Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307: 462-65
64. 2+ antagonize NMDA and GABA responses of hippocampal neurons. Nature 328:640-43
65. 2+ of NMDA responses in spinal cord neurones. Nature 309:261-63
66. MacDonald JF, Nowak LM. 1990. Mechanism of blockade of excitatory amino acid receptor channels. Trends Pharmacol. Sci. 11:167-72
67. Ault B, Evans RH, Francis AA, Oakes DJ, Watkins JC. 1980. Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations. J. Physiol. 307:413-28
68. Johnson JW, Ascher P. 1987. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325: 529-31
69. Kleckner N, Dingledine R. 1988. Requirement for glycine for activation of NMDA-receptors in Xenopus oocytes. Science. 241:835-37
70. +. Proc. Natl. Acad. Sci. USA 87:6445-49
71. Traynelis SF, Cull-Candy SG. 1990. Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons. Nature 345:347-50
72. Vyklicky L, Vlachova V, Krusek J. 1990. The effect of external pH changes on responses to excitatory amino acids in mouse hippocampal neurons. J. Physiol. 430:497-517
73. Aizenman E, Lipton SA, Loring RH. 1989. Selective modulation of NMDA responses by reduction and oxidation. Neuron 2:1257-63
74. Aizenman E, Hartnett KA, Reynolds IJ. 1992. Oxygen free radicals regulate NMDA receptor function via a redox modulatory site. Neuron 5:841-46
75. Christine CW, Choi DW. 1990. Effect of zinc on NMDA receptor-mediated channel currents in cortical neurons. J. Neurosci. 10:108-16
76. Legendre P, Westbrook GL. 1990. The inhibition of single N-methyl-D-aspartate-activated channels by zinc ions on cultured rat neurones. J. Physiol. 429: 429-49
77. Huettner JE, Bean BP. 1988. Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels. Proc. Natl. Acad. Sci. USA 85:1307-11
78. Lodge D, Johnson KM. 1990. Noncompetitive excitatory amino acid receptor antagonists. Trends Pharmacol. Sci. 11: 81-86
79. Williams K, Pullan LM, Romano C, Powel RJ, Salama AI, et al. 1992. An antagonist/partial agonist at the polyamine recognition site of the N-methyl-D-aspartate receptor that alters the properties of the glutamate recognition site. J. Pharmacol. Exp. Ther. 262:539-44
80. Romano C, Williams K, DePriest S, Seshadri R, Marshall GR, et al. 1992. Effects of mono-, di-, and triamines on the N-methyl-D-aspartate receptor complex: a model of the polyamine recognition site. Mol. Pharmacol. 41:785-92
81. Reynolds IJ. 1992. 1,5-(diethylamino)piperidine, a novel spermidine analogue that more specifically activates the N-methyl-D-aspartate receptor-associated polyamine site. Mol. Pharmacol. 41:989-92
82. Pullan LM, Stumpo RJ, Powel RJ, Paschetto KA, Britt M. 1992. Neomycin is an agonist at a polyamine site on the N-methyl-D-aspartate receptor. J. Neurochem. 59:2087-93
83. Reynolds IJ. 1990. Arcaine is a competitive antagonist of the polyamine site of the NMDA receptor. Eur. J. Pharmacol. 177:215-16
84. Reynolds IJ. 1990. Arcaine uncovers dual interactions of polyamines with the N-methyl-D-aspartate receptor. J. Pharmacol. Exp. Ther. 255:1001-7
85. Reynolds IJ, Baron BM, Edwards ML. 1991. 1,10-bis(guanidino)decane inhibits N-methyl-D-aspartate responses in vitro and in vivo. J. Pharmacol. Exp. Ther. 259:626-32
86. 3H]N-(1-[thienyl]cyclohexyl)-piperidine binding by arcaine: evidence for a shared spermidine-magnesium binding site. Mol. Pharmacol. 38:705-10
87. Reynolds IJ. 1992. Interactions between zinc and spermidine on the N-methyl-D-aspartate receptor complex: clues to the mechanism of action of 1,10-bis(guanidino)decane and pentamidine. J. Pharmacol. Exp. Ther. 263:632-38
88. Berger ML, Seifriz I, Letschnig M, Schodl C, Noe CR. 1992. Interaction of long chain n-alkyl diamines with the NMDA receptor complex. Neurosci. Lett. 142:85-88
89. 3H]MK-801 binding to the NMDA receptor/ionophore complex is regulated by divalent cations: evidence of multiple regulatory sites. Eur. J. Pharmacol. 151: 103-12
90. 125I]Iododizocilpine binding to the N-methyl-D-aspartate receptor of rat brain membranes. J. Neurochem. 58: 1469-76
91. 3H]MK-801 binding in brain synaptic membranes. J. Neurochem. 59:473-81
92. Pullan LM, Powel RJ. 1991. Spermine reciprocally changes the affinity of NMDA receptor agonists and antagonists. Eur. J. Pharmacol. 207:173-74
93. 2+ and polyamines independently of the arcaine-sensitive polyamine site. J. Neurochem. 62:54-62
94. Ransom RW. 1991. Polyamine and ifenprodil interactions with the NMDA receptor's glycine site. Eur. J. Pharmacol. 208:67-71
95. Sacaan AI, Johnson KM. 1989. Spermine enhances binding to the glycine site associated with the N-methyl-D-aspartate receptor complex. Mol. Pharmacol. 36:836-39
96. Yoneda Y, Suzuki T, Ogita K. 1994. Differential profiles of binding of a radiolabeled agonist and antagonist at a glycine recognition domain of the N-methyl-D-aspartate receptor ionophore complex in rat brain. J. Neurochem. 62:102-12
97. Donevan SD, Jones SM, Rogawski MA. 1992. Arcaine blocks N-methyl-D-aspartate receptor responses by an open channel mechanism: whole-cell and single-channel recording studies in cultured hippocampal neurons. Mol. Pharmacol. 41:727-35
98. Rock DM, Macdonald RL. 1992. The polyamine diaminodecane (DA-10) produces a voltage-dependent flickery block of single NMDA receptor channels. Neurosci. Lett. 144:111-15
99. Subramaniam S, Donevan SD, Rogawski MA. 1992. 1,10-diaminodecane and 1,12-diaminododecane block NMDA receptor currents by an open channel block mechanism. Neurosci. Lett. 147:213-16
100. Subramaniam S, Donevan SD, Rogawski MA. 1994. Hydrophobic interactions of n-alkyl diamines with the N-methyl-D-aspartate receptor: voltage-dependent and -independent blocking sites. Mol Pharmacol 45:117-24
101. Stone TW. 1993. Subtypes of NMDA receptors. Gen. Pharmacol. 24:825-32
102. Moriyoshi K, Masu M, Ishii T, Shigemoto R, Mizuno N, et al. 1991. Molecular cloning and charcterization of the rat NMDA receptor. Nature 354: 31-37
103. Imoto K, Busch C, Sakmann B, Mishina M, Konno T, et al. 1988. Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance. Nature 335:645-48
104. Verdoorn TA, Burnashev N, Monyer H, Seeburg PH, Sakmann B. 1991. Structural determinants of ion flow through recombinant glutamate receptor channels. Science 252:1715-18
105. Hume RI, Dingledine R, Heinemann S. 1991. Identification of a site in glutamate receptor subunits that controls calcium permeability. Science 253:1028-31
106. Nakanishi N, Axel R, Shneider NA. 1992. Alternative splicing generates functionally distinct N-methyl-D-aspartate receptors. Proc. Natl. Acad. Sci. USA 89:8552-56
107. Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, et al. 1992. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256:1217-21
108. Meguro H, Mori H, Araki K, Kushlya E, Kutsuwada T, et al. 1992. Functional characterization of a heteromeric NMDA receptor channel expressed from cDNAs. Nature 357:70-74
109. 2+-block site of the NMDA receptor channel. Nature 358: 673-75
110. Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, et al. 1992. Molecular diversity of the NMDA receptor channel. Nature 358:36-41
111. Monyer H, Burnashev N, Laurie DJ, Sakmann B, Seeburg PH. 1994. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12:529-40
112. Tolle TR, Berthele A, Zieglgansberger W, Seeburg PH, Wisden W. 1993. The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J. Neurosci. 13:5009-28
113. Durand GM, Gregor P, Zheng X, Bennett MLV, Uhl GR, et al. 1992. Cloning of an apparent splice variant of the rat N-methyl-D-aspartate receptor NMDAR1 with altered sensitivity to polyamines and activators of protein kinase C. Proc. Natl. Acad. Sci. USA 89:9359-63
114. Durand GM, Bennett MLV, Zukin RS. 1993. Splice variants of the N-methyl-D-aspartate receptor NR1 identify domains involved in regulation by polyamines and protein kinase C. Proc. Natl. Acad Sci. USA 90:6731-35
115. Anantharam V, Panchal RG, Wilson A, Kolchine VV, Treistman SN, et al. 1992. Combinatorial RNA splicing alters the surface charge on the NMDA receptor. FEBS Lett. 305:27-30
116. Stern P, Béhé P, Schoepfer R, Colquhoun D. 1992. Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors. Proc. R. Soc. London Ser. B 250:271-77
117. Gibb AJ, Colquhoun D. 1992. Activation of N-methyl-D-aspartate receptors by L-glutamate in cells dissociated from adult rat hippocampus. J. Physiol. 456: 143-79
118. Burnashev N, Schoepfer R, Monyer H, Ruppersberg JP, Gunther W, et al. 1992. Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor. Science 257:1415-19
119. 2+ potentiation of recombinant NMDA receptors. Neuron 12:811-18
120. Williams K, Zappia AM, Pritchett DB, Shen YM, Molinoff PB. 1994. Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits. Mol. Pharmacol. 45:803-9
121. Lynch DR, Anegawa NJ, Verdoorn TA, Pritchett DB. 1994. N-methyl-D-aspartate receptors: different subunit requirements for binding of glutamate antagonist, glycine antagonists and channel-blocking agents. Mol. Pharmacol. 45:540-45
122. Zhong J, Russell SL, Pritchett DB, Molinoff PB, Williams K. 1994. Expression of mRNAs encoding subunits of the N-methyl-D-aspartate receptor in cultured cortical neurons. Mol. Pharmacol. 45:846-53