Antibiotic-Induced Release of Endotoxin: A Therapeutic Paradox

Drug Safety

Volumn 12, Issue 3, 1995, Pages 183-195

  Hurley, James ^a,b  

^a Division of Pulmonology   (United States)

^b ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMOXICILLIN; AMPICILLIN; ANTIBIOTIC AGENT; AZTREONAM; BACTERICIDE; BETA LACTAM ANTIBIOTIC; CEFOTAXIME; CEFPIROME; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CHLORAMPHENICOL; CIPROFLOXACIN; CYTOKINE; ENDOTOXIN; GENTAMICIN; IMIPENEM; MEROPENEM; PENICILLIN G; POLYMYXIN B; TOBRAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC THERAPY; ANTIMICROBIAL ACTIVITY; BIOAVAILABILITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOLYSIS; DRUG HYPERSENSITIVITY; GRAM NEGATIVE BACTERIUM; HERXHEIMER REACTION; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; MENINGITIS; META ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; SEPSIS; TOXIN ANALYSIS;

ANIMALS; ANTI-BACTERIAL AGENTS; ENDOTOXINS; GRAM-NEGATIVE BACTERIA; HUMANS; SEPSIS;

EID: 0028987840     PISSN: 01145916     EISSN: 11791942     Source Type: Journal    
DOI: 10.2165/00002018-199512030-00004     Document Type: Review

References (79)

1. Antibiotic-induced release of endotoxin: a reappraisal
2. ACCP/SCCM consensus conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
3. Reappraisal of the role of endotoxin in the sepsis syndrome
4. Plasma endotoxin as a predictor of multiple organ failure and death in systemic meningococcal disease
5. Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways
6. Release of endotoxin from bacteria exposed to ciprofloxacin and its prevention with polymyxin B
7. Effects of different types and combinations of antimicrobial agents on endotoxin release from gram negative bacteria: an in vitro and in vivo study
8. Effect of penicillin and chloramphenicol on the growth and endotoxin release by N. meningitidis
9. Beta-lactam antibiotic-induced release of free endotoxin: in vitro comparison of penicillin-binding protein (PBP) 2-specific imipenem and PBP 3-specific ceftazidime
10. Bactericidal activity of beta-lactams against Haemophilus influenzae: effect on endotoxin release
11. Delayed antibiotic-induced lysis of Escherichia coli in vitro is correlated with enhancement of LPS release
12. Endotoxin concentrations in cerebrospinal fluid correlate with clinical severity and neurological outcome of Haemophilus influenzae type B meningitis
13. A randomized trial of a recombinant endotoxin neutralizing protein versus a monoclonal antibody to endotoxin for the treatment of E. coli sepsis in a rat model [abstract 1043]
14. Mortality rate and bacteremia, endotoxin, and endothelin-1 levels in antibiotic therapy for E. coli septic peritonitis
15. Comparison of endotoxin release by different antimicrobial agents and the effects on inflammation in experimental Escherichia coli meningitis
16. Antibiotic-induced bacterial killing stimulates tumor necrosis factor-alpha release in whole blood
17. The endotoxin-liberating effect of antibiotics on meningococci in vitro
18. The release of endotoxin from antibiotic treated Escherichia coli and the production of tumour necrosis factor by human monocytes
19. Cerebrospinal fluid endotoxin levels in children with H. influenzae meningitis before and after administration of intravenous ceftriaxone
20. Serial quantitation of endotoxaemia and bacteraemia during therapy for Gram-negative bacterial sepsis
21. Effect of antibiotic class and concentration on the release of lipopolysaccharide from Escherichia coli
22. Susceptibility tests: special tests
23. Free endotoxin — a review
24. Cerebrospinal fluid endotoxin levels with ceftriaxone therapy for Haemophilus influenzae meningitis [letter]
25. Endotoxaemia: an early predictor of septicaemia in febrile patients
26. Antibiotics versus cardiovascular support in a canine model of human septic shock
27. Antibiotic therapy, endotoxin concentration in cerebrospinal fluid, and brain edema in experimental Escherichia coli meningitis in rabbits
28. Effect of antibiotics on endotoxin release from gram negative bacteria
29. Release of lipopolysaccharide during Bordetella pertussis growth
30. Antibiotic-induced release of endotoxin in chronically bacteriuric patients
31. Influence of antimicrobial therapy on kinetics of tumour necrosis factor levels in experimental endocarditis caused by Klebsiella pneumoniae
32. The biological activities of peptidoglycan in experimental Haemophilus influenzae meningitis
33. Endotoxin shedding by enterobacteria: free and cell bound endotoxin differ in Limulus activity
34. Bacterial components and the pathophysiology of injury to the blood-brain barrier: does cell wall add to the effects of endotoxin in Gram-negative meningitis?
35. Differences in release of tumor necrosis factor from THP-1 cells stimulated by filtrates of antibiotic-killed Escherichia coli
36. Antibiotic induced release of endotoxin form bacteria in vitro
37. Post-antibiotic effect of beta-lactam antibiotics on gram-negative bacteria in relation to morphology, initial killing and MIC
38. Influence of sub-inhibitory levels of antibiotics on expression of Escherichia coli lipopolysaccharide and binding of anti-lipopolysaccharide monoclonal antibodies
39. Reactivity and protective capacity of a polyclonal antiserum derived from mice immunized with antibiotic exposed Escherichia coli
40. Antibiotics enhance binding by human lipid A-reactive monoclonal antibody HA-1A to smooth gram negative bacteria
41. Effect of antibiotics on gram negative sepsis in the rat. Lack of endotoxin burst
42. The Jarisch-Herxheimer reaction complicating syphilotherapy in pregnancy
43. Changes in circulating immune complexes during the Jarisch-Herxheimer reaction in secondary syphilis
44. The spectrum of relapsing fever in the Rocky Mountains
45. Comparison of cefuroxime axetil and doxycycline in the treatment of early Lyme disease
46. Activation of protein mediators of inflammation and evidence for endotoxemia in Borrelia recurrentis infection
47. Detection of plasma tumor necrosis factor, interleukins 6, and 8 during the Jarisch-Herxheimer reaction of relapsing fever
48. Studies on the mechanism of the Jarisch-Herxheimer reaction in louse-borne relapsing fever: evidence for the presence of circulating Borrelia endotoxin
49. Endotoxemia associated with the Jarisch-Herxheimer reaction
50. Reaction following treatment of murine borreliosis and Shwartzman type reaction with borrelial sonicates
51. Studies on the pathogenesis of the Jarisch-Herxheimer reaction: development of an animal model and evidence against a role for classic endotoxin
52. Lack of endotoxin in Borrelia hispanica and Treponema pallidum
53. Evaluation for endotoxemia in patients receiving penicillin therapy for secondary syphilis
54. Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis: analysis using a CAT reporter construct
55. Borrelia burgdorferi and Escherichia coli lipopolysaccharides induce nitric oxide and interleukin-6 production in cultured rat brain cells
56. Tumor lysis syndrome
57. Uterine contractions after antibiotic therapy for pyelonephritis in pregnancy
58. Meningococcal septicaemia in a C6-deficient patient and effects of plasma transfusion on lipopolysaccharide release
59. Extreme plasminogen activator inhibitor and endotoxin values in patients with meningococcal disease
60. Quantitation of endotoxin in blood from patients with meningococcal disease using a limulus lysate test in combination with chromogenic substrate
61. Endotoxin liberation and invasivity of Neisseria meningitidis
62. Endotoxin liberation by strains of N. meningitidis isolated from patients and healthy carriers
63. Meningococcal endotoxin in lethal septic shock plasma studied by gas chromatography, mass-spectrometry, ultracentrifugation, and electron microscopy
64. Concordance of endotoxemia with gram negative bacteremia in patients with gram negative sepsis: a meta-analysis
65. Pseudomonas aeruginosa compared with Escherichia coli produces less endotoxemia but more cardiovascular dysfunction and mortality in a canine model of septic shock
66. Choice of bacteria in animal models of sepsis
67. Louse-borne relapsing fever in Ethiopia
68. Penicillin versus tetracycline in the treatment of louse borne relapsing fever
69. Borrelia recurrentis infection: single-dose antibiotic regimens and management of the Jarisch-Herxheimer reaction
70. Pathophysiology and immunology of the Jarisch-Herxheimer-like reaction in louse-borne relapsing fever: comparison of tetracycline and slow-release penicillin
71. Tetracycline versus penicillin in the treatment of louse-borne relapsing fever
72. Antibiotic therapy of bacterial meningitis: lessons wes’ve learned
73. Treatment of pneumococcic meningitis with penicillin compared with penicillin plus aureomycin: studies including observations on an apparent antagonism between penicillin and aureomycin
74. A comparison of ceftriaxone and cefuroxime for the treatment of bacterial meningitis in children
75. Randomised comparison of chloramphenicol, ampicillin, cefotaxime, and ceftriaxone for childhood bacterial meningitis
76. Treatment of typhoid fever with ceftriaxone for 5 days or chloramphenicol for 14 days: a randomized clinical trial