The γ-aminobutyric acid receptor γ3 subunit gene (GABRG3) is tightly linked to the α5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation

Genomics

Volumn 26, Issue 2, 1995, Pages 258-264

  Greger, V ^a,c,d   Knoll, J H M ^a,b,d   Woolf, E ^a,d   Glatt, K ^a   Tyndale, R F ^e   Delorey, T M ^e   Olsen, R W ^e   Tobin, A J ^e   Sikela, J M ^f   Nakatsu, Y ^g   Brilliant, M H ^g   Whiting, P J ^h   Lalande, M ^a,c,d  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF COLORADO   (United States)

^g FOX CHASE CANCER CENTER   (United States)

^h Merck Sharp & Dohme Limited   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR;

ARTICLE; CHROMOSOME 15Q; GENE ISOLATION; GENE LOCATION; GENETIC LINKAGE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANIMAL; BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, ARTIFICIAL, YEAST; CHROMOSOMES, HUMAN, PAIR 15; CLONING, MOLECULAR; COMPARATIVE STUDY; GENES, STRUCTURAL; HUMAN; IN SITU HYBRIDIZATION, FLUORESCENCE; LINKAGE (GENETICS); MICE; MOLECULAR SEQUENCE DATA; POLARITY OF TRANSLATION; RECEPTORS, GABA-A; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028987721     PISSN: 08887543     EISSN: 10898646     Source Type: Journal    
DOI: 10.1016/0888-7543(95)80209-5     Document Type: Article

References (39)

1. A strategy to reveal high-frequency RFLPs along the human X chromosome
2. The mouse pink-eyed dilution locus: A model for aspects of Prader—Willi syndrome, Angelman syndrome, and a form of hypomelanosis of Ito
3. Mouse chromosome 7
4. A receptor subunit genes: Relationship to human genetic disease
5. Microdissection of the Prader—Willi syndrome chromosome region and identification of potential gene sequences
6. Parental origin of chromosome 15 deletion in Prader—Willi syndrome
7. Angelman syndrome associated with a maternal 15q11–13 deletion of less than 200 kb
8. The syntenic relationship between the critical deletion region for the Prader—Willi/Angelman syndromes and proximal mouse chromosome 7
9. Angelman syndrome
10. Phenotypic consequences of deletion of the γ3 α5 or β3 subunit of the type A γ-aminobutyric acid receptor in mice
11. Cloning of the γ-aminobutyric acid (GABA) ϱ1 cDNA: A GABA receptor subunit highly expressed in the retina
12. Identification of a putative γ-aminobutyric acid (GABA) receptor subunit ϱ2 cDNA and colocalization of the genes encoding ϱ2 (GABRR2) and ϱ1 (GABRR1) to human chromosome 6q14–q21 and mouse chromosome 4
13. Genetic mapping of the β1 GABA receptor gene to human chromosome 4, using a tetranucleotide repeat polymorphism
14. Isolation of molecular probes associated with the chromosome 15 instability in the Prader—Willi syndrome
15. A receptor α5 (GABRA5) locus at chromosome 15q11–q13
16. A receptor subunit genes: Localization of the α6-subunit gene (GABRA6) to distal chromosome 5q by linkage analysis
17. A receptor (GABRB1)
18. Allele-specific replication timing of imprinted gene regions
19. Angelman and Prader—Willi syndromes share a common chromosome 15 deletion but differ in parental origin of the deletion
20. FISH ordering of reference markers and of the gene for the α5 subunit of the γ-aminobutyric acid receptor (GABRA5) within the Angelman and Prader—Willi syndrome chromosomal regions
21. Allele specificity of DNA replication timing in the Angelman/Prader—Willi syndrome imprinted chromosomal region
22. Isolation of human chromosome 13-specific DNA sequences cloned from flow sorted chromosomes and potentially linked to the retinoblastoma locus
23. Deletions of chromosome 15 as a cause of the Prader—Willi syndrome
24. Hybridization fingerprinting in genome mapping and sequencing
25. A receptor channels
26. Is Angelman syndrome an alternate result of del(15)(q11–13)?
27. A receptor subunit genes is deleted in a neurological mutant of the mouse p locus
28. Restriction fragment length polymorphisms within proximal 15q and their use in molecular cytogenetics and the Prader—Willi syndrome
29. Evaluation of potential models for imprinted and nonimprinted components of human chromosome 15q11–q13 syndromes by fine-structure homology mapping in the mouse
30. A receptors
31. A-receptor β3 subunit gene as the Angelman's syndrome gene
32. A receptor isoform
33. High-resolution mapping of the γ-aminobutyric acid receptor subunit β3 and α5 gene cluster on chromosome 15q11–q13 and localization of breakpoints in two Angelman syndrome patients
34. Cloning high molecular weight DNA fragments by the bacteriophage P1 system
35. The P1 cloning system: Past and future
36. A receptors
37. A receptor β3 subunit to the Angelman/Prader—Willi region of human chromosome 15
38. A receptor β3 subunit gene: Characterization of a human cDNA from chromosome 15q11q13 and mapping to a region of conserved synteny on mouse chromosome 7
39. Human chromosomal localization of the genes encoding the γ1 and γ2 subunits of the γ-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome