Interleukin 12: A new clinical player in cytokine therapy

British Journal of Cancer

Volumn 71, Issue 4, 1995, Pages 655-659

  Banks, R E ^a   Patel, P M ^a   Selby, P J ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Cancer; Cytokine; Immunotherapy; Interleukin 12; Review

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN RECEPTOR; PROTEIN SUBUNIT;

ANTINEOPLASTIC ACTIVITY; B LYMPHOCYTE; CANCER CELL CULTURE; CANCER IMMUNOTHERAPY; CELLULAR IMMUNITY; EDITORIAL; LYMPHOBLASTOID CELL LINE; LYMPHOKINE ACTIVATED KILLER CELL; MACROPHAGE; MONOCYTE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR BINDING; T LYMPHOCYTE;

CYTOKINES; HUMAN; INTERLEUKIN-12; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; NEOPLASMS; RECEPTORS, INTERLEUKIN; TUMOR CELLS, CULTURED;

EID: 0028987027     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.1995.130     Document Type: Editorial

References (73)

1. ANDREWS JV, SCHOOF DD, BERTAGNOLLI MM, PEOPLES GE, OEDEGEBUURE PS AND EBERLEIN TJ. (1993). Immunomodulatory effects of interleukin-12 on human tumor-infiltrating lymphocytes. J. Immunother., 14, 1–10.
2. ASTE-AMEZAGA M, D’ANDREA A, KUBIN M AND TRINCHIERI G. (1994). Cooperation of natural killer cell stimulatory factor/ interleukin-12 with other stimuli in the induction of cytokines and cytotoxic cell-associated molecules in human T and NK cells. Cell. Immunol., 156, 480–492.
3. BELLONE G AND TRINCHIERI G. (1994). Dual stimulatory and inhibitory effect of NK cell stimulatory factor/IL-12 on human hematopoiesis. J. Immunol., 153, 930–937.
4. BERTAGNOLLI MM, LIN BY, YOUNG D AND HERRMANN SH. (1992). IL-12 augments antigen-dependent proliferation of activated T lymphocytes. J. Immunol., 149, 3778–3783.
5. BLOOM ET AND HORVATH JA. (1994). Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T cell activity: implications for the age-related decline in CTL. J. Immunol., 152, 4242–4254.
6. BONNEMA JD, RIVLIN KA, TING AT, SCHOON RA, ABRAHAM RT AND LEIBSON PJ. (1994). Cytokine-enhanced NK cell-mediated cytotoxicity: positive modulatory effects of IL-2 and IL-12 on stimulus-dependent granule exocytosis. J. Immunol., 152, 2098–2104.
7. BRUNDA MJ. (1994). Interleukin-12. J. Leuk. Biol., 55, 280–288.
8. BRUNDA MJ, LUISTRO L, WARRIER RR, WRIGHT RB, HUBBARD BR, MURPJIY M, WOLF SF AND GATELY MK. (1993). Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J. Exp. Med., 178, 1223–1230.
9. CESANO A, VISONNEAU S, CLARK SC AND SANTOLI D. (1993). Cellular and molecular mechanisms of activation of MHC nonrestricted cytotoxic cells by IL-12. J. Immunol., 151, 2943–2957.
10. CHAN SH, PERUSSIA B, GUPTA JW, KOBAYASHI M, POSPISIL M, YOUNG HA, WOLF SF, YOUNG D, CLARK SC AND TRINCHIERI G. (1991). Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J. Exp. Med., 173, 869–879.
11. CHEHIMI J, VALIANTE NM, D’ANDREA A, RENGARAJU M, ROSADO Z, KOBAYASHI M, PERUSSIA B, WOLF SF, STARR SE AND TRINCHIERI G. (1993). Enhancing effect of natural killer cell stimulatory factor (NKSF/interleukin-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells. Eur. J. Immunol., 23, 1826–1830.
12. CHIZZONITE R, TRUITT T, PODLASKI FJ, WOLITZKY AG, QUINN PM, NUNES P, STERN AS AND GATELY MK. (1991). IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts. J. Immunol., 147, 1548–1556.
13. CHIZZONITE R, TRUITT T, DESAI BB, NUNES P, PODLASKI FJ, STERN AS AND GATELY MK. (1992). IL-12 receptor. I. Characterization of the receptor on phytohemagglutinin-activated human lymphoblasts. J. Immunol., 148, 3117–3124.
14. CHUA AO, CHIZZONITE R, DESAI BB, TRUITT TP, NUNES P, MINETTI U, WARRIER RR, PRESKY DH, LEVINE JF, GATELY MK AND GUBLER U. (1994). Expression cloning of a human IL-12 receptor component: a new member of the cytokine receptor superfamily with strong homology to gpl30. J. Immunol., 153, 128–136.
15. D’ANDREA A, RENGARAJU M, VALIANTE NM, CHEHIMI J, KUBIN M, ASTE M, CHAN SH, KOBAYASHI M, YOUNG D, NICKBARG E, CHIZZONITE R, WOLF SF AND TRINCHIERI G. (1992). Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med., 176, 1387–1398.
16. D’ANDREA A, ASTE-AMEZAGA M, VALIANTE NM, MA X, KUBIN M AND TRINCHIERI G. (1993). Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med., 178, 1041–1048.
17. DESAI BB, QUINN PM, WOLITZKY AG, MONGINI PK, CHIZZONITE R AND GATELY MK. (1992). IL-12 receptor. II. Distribution and regulation of receptor expression. J. Immunol., 148, 3125–3132.
18. GATELY MK. (1993). Interleukin-12: a recently discovered cytokine with potential for enhancing cell-mediated immune responses to tumors. Cancer Invest., 11, 500–506.
19. GATELY MK, WILSON DE AND WONG HL. (1986). Synergy between recombinant interleukin 2 (rIL 2) and IL 2-depleted lymphokine- containing supernatants in facilitating allogeneic human cytolytic T lymphocyte responses in vitro. J. Immunol., 136, 1274–1282.
20. GATELY MK, DESAI BB, WOLITZKY AG, QUINN PM, DWYER CM, PODLASKI FJ, FAMILLETTI PC, SINIGAGLIA F, CHIZONNITE R, GUBLER U AND STERN AS. (1991). Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J. Immunol, 147, 874–882.
21. GATELY MK, WOLITZKY AG, QUINN PM AND CHIZZONITE R. (1992). Regulation of human cytolytic lymphocyte responses by interleukin-12. Cell. Immunol., 143, 127–142.
22. GATELY MK, WARRIER RR, HONASOGE S, CARVAJAL DM, FAHERTY DA, CONNAUGHTON SE, ANDERSON TD, SARMIENTO U, HUBBARD BR AND MURPHY M. (1994). Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo. Int. Immunol., 6, 157–167.
23. GEARING DP AND COSMAN D. (1991). Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. Cell, 66, 9–10.
24. GERMANN T, GATELY MK, SCHOENHAUT DS, LOHOFF M, MATTNER F, FISCHER S, JIN SC, SCHMITT E AND RUDE E. (1993). Interleukin-12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Thl) but not on Th2 cells. Eur. J. Immunol., 23, 1762–1770.
25. GODFREY DI, KENNEDY J, GATELY MK, HAKIMI J, HUBBARD BR AND ZLOTNIK A. (1994). IL-12 influences intrathymic T cell development. J. Immunol, 152, 2729–2735.
26. GUBLER U, CHUA AO, SCHOENHAUT DS, DWYER CM, McCOMAS W, MOTYKA R, NABAVI N, WOLITZKY AG, QUINN PM, FAMILLETTI PC AND GATELY MK. (1991). Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl Acad. Sei. USA, 88, 4143–4147.
27. HENDRZAK JA, LUISTRO L, GATELY MK, GAROTTA G AND BRUNDA MJ. (1994). Role of interferon gamma in mediating the antitumor effects of interleukin-12 (abstract 3125). Proc. Am. Assoc. Cancer Res., 35, 524.
28. HILL LL, PERUSSIA B, McCUE PA AND KORNGOLD R. (1994). Effect of human natural killer cells on the metastatic growth of human melanoma xenografts in mice with severe combined immunodeficiency. Cancer Res., 54, 763–770.
29. + T cells through IL-12 produced by Listeria-induced macrophages. Science, 260, 547–549.
30. JACOBSEN SE, VEIBY OP AND SMELAND EB. (1993). Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells. J. Exp. Med., 178, 413–418.
31. JEWETT A AND BONA VIDA B. (1994). Activation of the human immature natural killer cell subset by IL-12 and its regulation by endogenous TNF-a and IFN-gamma secretion. Cell. Immunol., 154, 273–286.
32. KINIWA M, GATELY M, GUBLER U, CHIZZONITE R, FARGEAS C AND DELESPESSE G. (1992). Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes. J. Clin. Invest., 90, 262–266.
33. KOBAYASHI M, FITZ L, RYAN M, HEWICK RM, CLARK SC, CHAN S, LOUDON R, SHERMAN F, PERUSSIA B AND TRINCHIERI G. (1989). Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med., 170, 827–845.
34. KUBIN M, KAMOUN M AND TRINCHIERI G. (1994). Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med., 180, 211–222.
35. KUSHER DI, RASHLEIGH SR, ENDICOTT JN AND DJEU JY. (1994). Interleukins 2 and 12 activate natural killer cell cytolytic responses of peripheral blood mononuclear cells from patients with advanced head and neck squamous cell carcinoma (abstract 3119). Proc. Am. Assoc. Cancer Res., 35, 523.
36. LIEBERMAN MD, SIGAL RK, WILLIAMS NN AND DALY JM. (1991). Natural killer cell stimulatory factor (NKSF) augments natural killer cell and antibody-dependent tumoricidal response against colon carcinoma cell lines. J. Surg. Res., 50, 410–415.
37. MACATONIA SE, HSIEH CS, MURPHY KM AND O’GARRA A. (1993). Dendritic cells and macrophages are required for Thl development of CD4 + T cells from alpha beta TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-gamma production is IFN-gamma-dependent. Int. Immunol., 5, 1119–1128.
38. MCKNIGHT AJ, ZIMMER GJ, FOGELMAN I, WOLF SF AND ABBAS AK. (1994). Effects of IL-12 on helper T cell-dependent immune responses in vivo. J. Immunol., 152, 2172–2179.
39. MANETTI R, PARRONCHI P, GIUDIZI MG, PICCINNI MP, MAGGI E, TRINCHIERI G AND ROMAGNANI S. (1993). Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Thl)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med., III, 1199–1204.
40. MATTNER F, FISCHER S, GUCKES S, JIN S, KAULEN H, SCHMITT E, RUDE E AND GERMANN T. (1993). The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur. J. Immunol., 23, 2202–2208.
41. MAYOR S, O’DONNELL M AND CLINTON SK. (1994). Interleukin-12 (IL-12) immunotherapy of experimental bladder cancer (abstract 2827). Proc. Am. Assoc. Cancer Res., 35, 474.
42. MEHROTRA PT, WU D, CRIM JA, MOSTOWSKI HS AND SIEGEL JP. (1993). Effects of IL-12 on the generation of cytotoxic activity in human CD8 + T lymphocytes. J. Immunol., 151, 2444–2452.
43. MERBERG DM, WOLF SF AND CLARK SC. (1992). Sequence similarity between NKSF and the IL-6/G-CSF family. Immunol. Today, 13, 77–78.
44. MORRIS SC, MADDEN KB, ADAMOVICZ JJ, GAUSE WC, HUBBARD BR, GATELY MK AND FINKELMAN FD. (1994). Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J. Immunol., 152, 1047–1056.
45. MURPHY EE, TERRES G, MACATONIA SE, HSIEH C-S, MATTSON J, LANIER L, WYSOCKA M, TRINCHIERI G, MURPHY K AND O’GARRA A. (1994). B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med., 180, 223–231.
46. NASTALA CL, EDINGTON HD, MCKINNEY TG, TAHARA H, NALESNIK MA, BRUNDA MJ, GATELY MK, WOLF SF, SCHREIBER RD, STORKUS WJ AND LOTZE MT. (1994). Recombinant IL-12 administration induces tumor regression in association with IFN- gamma production. J. Immunol., 153, 1697–1706.
47. NAUME B, GATELY M AND ESPEVIK T. (1992). A comparative study of IL-12 (cytotoxic lymphocyte maturation factor)-, IL-2-, and IL-7-induced effects on immunomagnetically purified CD56+ NK cells. J. Immunol., 148, 2429–2436.
48. NAUME B, JOHNSEN AC, ESPEVIK T AND SUNDAN A. (1993). Gene expression and secretion of cytokines and cytokine receptors from highly purified CD56 + natural killer cells stimulated with interleukin-2, interleukin-7 and interleukin-12. Eur. J. Immunol., 23, 1831–1838.
49. O’TOOLE M, WOLF SF, O’BRIEN C, HUBBARD N AND HERMANN S. (1993). Effect of in vivo IL-12 administration on murine tumor cell growth (abstract 1679). J. Immunol., 150, 294A.
50. PERUSSIA B, CHAN SH, D’ANDREA A, TSUJI K, SANTOLI D, POSPI-SIL M YOUNG D, WOLF SF AND TRINCHIERI G. (1992). Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta +, TCR-gamma delta + T lymphocytes, and NK cells. J. Immunol., 149, 3495–3502.
51. PLOEMACHER RE, VAN SOEST PL, BOUDEWIJN A AND NEBEN S. (1993a). Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor. Leukemia, 7, 1374–1380.
52. PLOEMACHER RE, VAN SOEST PL, VOORWINDEN H AND BOUDEWIJN A. (1993b). Interleukin-12 synergizes with interleukin-3 and steel factor to enhance recovery of murine hemopoietic stem cells in liquid culture. Leukemia, 7, 1381–1388.
53. PODLASKI FJ, NANDURI VB, HULMES JD, PAN YC, LEVIN W, DANHO W, CHIZZONITE R, GATELY MK AND STERN AS. (1992). Molecular characterization of interleukin 12. Arch. Biochem. Biophys., 294, 230–237.
54. QUILL H, BHANDOOLA A, TRINCHIERI G, HALUSKEY J AND PERITT D. (1994). Induction of interleukin 12 responsiveness is impaired in anergic T lymphocytes. J. Exp. Med., 179, 1065–1070.
55. RABINOWICH H, HERBERMAN RB AND WHITESIDE TL. (1993). Differential effects of IL12 and IL2 on expression and function of cellular adhesion molecules on purified human natural killer cells. Cell. Immunol., 152, 481–498.
56. ROBERTSON MJ, SOIFFER RJ, WOLF SF, MANLEY TJ, DONAHUE C, YOUNG D, HERRMANN SH AND RITZ J. (1992). Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF. J. Exp. Med., 175, 779–788.
57. ROMAGNANI S. (1992). Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response? Immunol. Today, 13, 379–381.
58. ROMANI L, MENCACCI A, TONNETTI L, SPACCAPELO R, CENCI E, WOLF S, PUCCETTI P AND BISTONI F. (1994). Interleukin-12 but not interferon-gamma production correlates with induction of T helper type-1 phenotype in murine candidiasis. Eur. J. Immunol., 24, 909–915.
59. ROSSI AR, PERICLE F, RASHLEIGH S, JANIEC J AND DJEU JY. (1994). Lysis of neuroblastoma cell lines by human natural killer cells activated by interleukin-2 and interleukin-12. Blood, 83, 1323–1328.
60. SALCEDO TW, AZZONI L, WOLF SF AND PERUSSIA B. (1993). Modulation of perforin and granzyme messenger RNA expression in human natural killer cells. J. Immunol., 151, 2511–2520.
61. + T cells. Eur. J. Immunol., 24, 343–347.
62. SCHOENHAUT DS, CHUA AO, WOLITZKY AG, QUINN PM, DWYER CM, MCCOMAS W, FAMILLETTI PC, GATELY MK AND GUBLER U. (1992). Cloning and expression of murine IL-12. J. Immunol., 148, 3433–3440.
63. SIEBURTH D, JABS EW, WARRINGTON JA, LI X, LASOTA J, LAFORGIA S, KELLEHER K, HUEBNER K, WASMUTH JJ AND WOLF SF. (1992). Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. Genomics, 14, 59–62.
64. SOIFFER RJ, ROBERTSON MJ, MURRAY C, COCHRAN K AND RITZ J. (1993). Interleukin-12 augments cytolytic activity of peripheral blood lymphocytes from patients with hematologic and solid malignancies. Blood, 82, 2790–2796.
65. STERN AS, PODLASKI FJ, HULMES JD, PAN YC, QUINN PM, WOLITZKY AG, FAMILLETTI PC, STREMLO DL, TRUITT T, CHIZZONITE R AND GATELY MK. (1990). Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc. Natl Acad. Sci. USA, 87, 6808–6812.
66. STERN LL, TARBY CM, TAMBORINI B AND TRUITT GA. (1994). Preclinical development of IL-12 as an anticancer drug: comparison to IL-2 (abstract 3100). Proc. Am. Assoc. Cancer Res., 35, 520.
67. TAHARA H, ZEH III HJ, STORKUS WJ, PAPPO I, WATKINS SC, GUBLER U, WOLF SF, ROBBINS PD AND LOTZE MT. (1994). Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo. Cancer Res., 54, 182–189.
68. TRINCHIERI G. (1993). Interleukin-12 and its role in the generation of TH1 cells. Immunol. Today, 14, 335–338.
69. WOLF SF, TEMPLE PA, KOBAYASHI M, YOUNG D, DICIG M, LOWE L, DZIALO R, FITZ L, FERENZ C, HEWICK RM, KELLEHER K, HERRMANN SH, CLARK SC, AZZONI L, CHAN SH, TRINCHIERI G AND PERUSSIA B. (1991). Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol., 146, 3074–3081.
70. WONG HL, WILSON DE, JENSON JC, FAMILLETTI PC, STREMLO DL AND GATELY MK. (1988). Characterization of a factor(s) which synergizes with recombinant interleukin 2 in promoting allogeneic human cytolytic T-lymphocyte responses in vitro. Cell. Immunol., III, 39–54.
71. WU CY, DEMEURE C, KINIWA M, GATELY M AND DELESPESSE G. (1993). IL-12 induces the production of IFN-gamma by neonatal human CD4 T cells. J. Immunol., 151, 1938–1949.
72. YANAGIDA T, KATO T, IGARASHI O, INOUE T AND NARIUCHI H. (1994). Second signal activity of IL-12 on the proliferation and IL-2R expression of T helper cell-1 clone. J. Immunol., 152, 4919–4928.
73. ZEH HJ, HURD S, STORKUS WJ AND LOTZE MT. (1993). Interleukin- 12 promotes the proliferation and cytolytic maturation of immune effectors: implications for the immunotherapy of cancer. J. Immunother., 14, 14, 155–161.