Isomorphous Crystal Structures of Escherichia coli Dihydrofolate Reductase Complexed with Folate, 5-Deazafolate, and 5,10-Dideazatetrahydrofolate: Mechanistic Implications

Biochemistry

Volumn 34, Issue 8, 1995, Pages 2710-2723

  Reyes, Vicente M ^a   Sawaya, Michael R ^a   Brown, Katherine A ^a   Kraut, Joseph ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 DEAZAFOLIC ACID; DIHYDROFOLATE REDUCTASE; FOLIC ACID; FOLIC ACID DERIVATIVE; LOMETREXOL; NICOTINAMIDE; PTERIDINE; PYRIDINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; WATER;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ESCHERICHIA COLI; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT;

BINDING SITES; CLONING, MOLECULAR; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; FOLIC ACID; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; SUPPORT, U.S. GOV'T, P.H.S.; TETRAHYDROFOLATE DEHYDROGENASE; TETRAHYDROFOLATES;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; VERTEBRATA;

EID: 0028985318     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00008a039     Document Type: Article

References (36)

1. Anderson, D. H. (1987) Ph.D. Dissertation, Department of Physics, University of California, San Diego, La Jolla, CA 92037.
2. Blakley, R. L. (1984) in Chemistry and Biochemistry of Folates, Vol. I: Folates and Pterins (Blakley, R. L. & Benkovic, S. J., Eds.) pp 191-253, John Wiley & Sons, New York.
3. Blakley, R. L., & Appleman, J. R. (1994) Adv. Enzymol. (in press).
4. Blakley, R. L., Appleman, J. R., Freisheim, J. H., & Jablonsky, M. J. (1993) Arch. Biochem. Biophys. 306, 501-509.
5. Bolin, J. T., Filman, D. J., Matthews, D. A., Hamlin, R. C., & Kraut, J. (1982) J. Biol. Chem. 257, 13650-13662.
6. Brown, K. A., & Kraut, J. (1992) Faraday Discuss. Chem. Soc. 93, 217-224.
7. Bystroff, C., & Kraut, J. (1991) Biochemistry 30, 2227-2239.
8. Bystroff, C., Oatley, S. J., & Kraut, J. (1990) Biochemistry 29, 3263-3277.
9. Chen, Y. Q., Kraut, J., Blakley, R. L., & Callender, R. (1994) Biochemistry 33, 7021-7026.
10. Davies, J. F., II, Delcamp, T. J., Prendergast, N. J., Ashford, V. A., Freisheim, J. H., & Kraut, J. (1990) Biochemistry 29, 9467-9479.
11. Fierke, C. A., Johnson, K. A., & Benkovic, S. J. (1987) Biochemistry 26, 4085-4092.
12. Freisheim, J. H., & Matthews, D. A. (1984) in Folate Antagonists as Therapeutic Agents (Sirotnak, F. M., Burchall, J. J., Ens-minger, W. D., & Montgomery, J. A., Eds.) Vol. 1, pp 69-131, Academic Press, Inc., Orlando, FL.
13. Candour, R. D. (1981) Bioinorg. Chem. 10, 169-170.
14. Hamlin, R. (1985) Methods Enzymol. 114, 416-452.
15. Howell, E. E., Villafranca, J. E., Warren, M. S., Oatley, S. J., & Kraut, J. (1986) Science 231, 1123-1128.
16. Kraut, J. (1988) Science 242, 533-540.
17. Kraut, J., & Matthews, D. A. (1987) in Biological Macromolecules and Assemblies (Jumak, F. A., & McPherson, A., Eds.) Vol. 3, pp 1-72, John Wiley & Sons, New York.
18. Kuyper, L. F. (1989) in Computer-Aided Drug Design: Methods and Applications (Perun, T. J., & Propst, C. L., Eds.) pp 327-369, Marcel Dekker, Inc., New York.
19. Li, L., Falzone, C. J., Wright, P. E., & Benkovic, S. J. (1992) Biochemistry 31, 7826-7833.
20. Luzzati, V. (1952) Acta Crystallogr. 5, 802-810.
21. Maharaj, G., Selinsky, B. S., Appleman, J. R., Perlman, M., London, R. E., & Blakley, R. L. (1990) Biochemistry 29, 4554-4560.
22. McTigue, M. A., Davies, J. F.,, Kaufman, B. T., & Kraut, J. (1992) Biochemistry 31, 7264-7273.
23. Morrison, J. F., & Stone, S. R. (1988) Biochemistry 27, 5499-5506.
24. Penner, M. H., & Frieden, C. (1987) J. Biol. Chem. 262, 15908-15914.
25. Rossmann, M. G., & Argos, P. (1975) J. Biol. Chem. 250, 7525-7532.
26. Sawaya, M. R. (1994) Ph.D. Dissertation, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92037.
27. Smith, D. R., & Calvo, J. M. (1980) Nucleic Acids Res. 8, 2255-2274.
28. Smith, D. R., & Calvo, J. M. (1982) Mol. Gen. Genet. 187, 72-78.
29. Stone, S. R., & Morrison, J. F. (1988) Biochemistry 27, 5493-5499.
30. Tronrud, D. E., Ten Eyck, L. F., & Matthews, B. W. (1987) Acta Crystallogr. A43, 489-501.
31. Warren, M. S., Brown, K. A., Famum, M. F., Howell, E. E., & Kraut, J. (1991) Biochemistry 30, 11092-11103.
32. Weast, R. C., Ed. (1968) CRC Handbook of Chemistry and Physics, 49th ed., p D-88, The Chemical Rubber Co., Cleveland, OH.
33. Williams, E. A., & Morrison, J. M. (1992) Biochemistry 31, 6801-6811.
34. Wu, Y. D., & Houk, K. N. (1987a) J. Am. Chem. Soc. 109, 906-908.
35. Wu, Y. D., & Houk, K. N. (1987b) J. Am. Chem. Soc. 109, 2226-2227.
36. Xuong, N. H., Nielsen, C. P., Hamlin, R., & Anderson, D. H. (1985) J. Appl. Crystallogr. 18, 342-350.