Histamine H1 receptor occupancy in human brains after single oral doses of histamine H1 antagonists measured by positron emission tomography

British Journal of Pharmacology

Volumn 116, Issue 1, 1995, Pages 1649-1655

  Yanai, Kazuhiko ^a   Ryu, Jong Hoon ^a   Watanabe, Takehiko ^a   Iwata, Ren ^b   Ido, Tatsuo ^b   Sawai, Yoneichi ^c   Ito, Kazumi ^c   Itoh, Masatoshi ^b  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c Hirakata Center ^*  (Japan)

Author keywords

Antihistamines; brain; H1 receptor antagonists: chlorpheniramine; receptor occupancy; sedation in man: positron emission tomography; terfenadine

Indexed keywords

4 (1 HYDROXY 4 (4 (HYDROXYDIPHENYLMETHYL) 1 PIPERIDINYL)BUTYL) ALPHA,ALPHA DIMETHYLBENZENEACETIC ACID; 4-(1-HYDROXY-4-(4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINYL)BUTYL)-ALPHA,ALPHA-DIMETHYLBENZENEACETIC ACID; CARBON; CHLORPHENIRAMINE; DIAGNOSTIC AGENT; DOXEPIN; DRUG DERIVATIVE; HISTAMINE H1 RECEPTOR; HISTAMINE H1 RECEPTOR ANTAGONIST; TERFENADINE; ANTIHISTAMINIC AGENT; CARBON 11; DRUG METABOLITE;

ADULT; ANIMAL; ARTICLE; BLOOD; BRAIN; COMPUTER ASSISTED EMISSION TOMOGRAPHY; GUINEA PIG; HUMAN; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; SCINTISCANNING; ULTRASTRUCTURE; ANIMAL TISSUE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DROWSINESS; DRUG BLOOD LEVEL; FRONTAL CORTEX; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR OCCUPANCY;

ADMINISTRATION, ORAL; ADULT; ANIMAL; BRAIN; CARBON RADIOISOTOPES; CHLORPHENIRAMINE; DOXEPIN; GUINEA PIGS; HISTAMINE H1 ANTAGONISTS; HUMAN; MALE; RECEPTORS, HISTAMINE H1; SUPPORT, NON-U.S. GOV'T; TERFENADINE; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0028984069     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1995.tb16386.x     Document Type: Article

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