Local application of γ-linolenic acid in the treatment of human gliomas

Cancer Letters

Volumn 94, Issue 2, 1995, Pages 147-155

  Das, U N ^a   Prasad, V V S K ^a   Reddy, D Raia ^a  

^a NIZAM'S INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Free radicals; Human gliomas; Tumoricidal; Linolenic acid

Indexed keywords

ANTINEOPLASTIC AGENT; GAMMA LINOLENIC ACID;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN CELL; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CYTOTOXICITY; DOG; DRUG EFFECT; DRUG SAFETY; FEMALE; GLIOBLASTOMA; GLIOMA; HISTOPATHOLOGY; HUMAN; INTRACEREBRAL DRUG ADMINISTRATION; MALE; NONHUMAN; PATIENT CARE; PRIORITY JOURNAL; TUMOR REGRESSION;

ADULT; AGED; AGED, 80 AND OVER; ANIMAL; ASTROCYTOMA; BRAIN NEOPLASMS; DOGS; FEMALE; GAMMA-LINOLENIC ACID; GLIOBLASTOMA; GLIOMA; HUMAN; INJECTIONS, INTRALESIONAL; MALE; MIDDLE AGE; TOMOGRAPHY, X-RAY COMPUTED;

ANIMALIA; CANIS FAMILIARIS;

EID: 0028983419     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(95)03844-M     Document Type: Article

References (29)

1. The appearance of phospholipase activity in the human macrophage-like cell line U937 during dimethyl-sulfoxide induced differentiation
2. The appearance of phospholipase and cyclo-oxygenase activities in the human promyelocytic leukemia cell line HL-60 during dimethyl sulfoxide induced differentiation
3. Prostaglandins and immune response in cancer
4. Inhibition of sensitized lymphocyte response to sperm antigen(s) by prostaglandins
5. Enzyme deletions and essential fatty acid metabolism in cultured cells
6. Growth related lipid peroxidation in tumor microsomal membranes and mitochondria
7. Selective killing of human cancer cells by polyunsaturated fatty acids
8. Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyunsaturated fatty acids
9. Cytotoxic effects of free fatty acids on ascites tumor cells
10. Some effects of gamma-linolenic acid on cultured human esophageal carcinoma cells
11. Gamma-linolenic acid, arachidonic acid and eicosapentaenoic acid as potential anti-cancer drugs
12. Tumoricidal action of cis-unsaturated fatty acids and its relationship to free radicals and lipid peroxidation
13. Cytotoxic action of cis-unsaturated fatty acids on human cervical carcinoma (HeLa) cells: relationship to free radicals and lipid peroxidation and its modulation by calmodulin antagonists
14. Polyunsaturated fatty acids augment free radical generation in tumor cells in vitro
15. Uptake and distribution of cis-unsaturated fatty acids and their effect on free radical generation in normal and tumor cells in vitro
16. Cis-unsaturated fatty acids as potential anti-mutagenic, tumoricidal and anti-metastatic agents
17. Reactive oxygen species leading to lipid peroxidation and DNA lesions implicated in the cytotoxic action of certain anti-tumor antibiotics
18. Effect of prostaglandins and their precursors on the proliferation of human lymphocytes and their secretion of tumor necrosis factor and various interleukins
19. Suppression of interleukin-2-dependent T cell growth in vitro by prostaglandin E (PGE) and their precursors
20. Cis-polyunsaturated fatty acids induce high levels of superoxide production by human neutrophils
21. Free radical generation in human leukocytes by cis-unsaturated fatty acids is a calmodulin dependent process
22. Role of macrophage lipids in regulating tumoricidal activity
23. Brain tumours
24. Randomised comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery
25. Intratumoral gamma-linolenic acid therapy of human gliomas
26. Photoradiation therapy and its potential in the management of neurological tumors
27. Adjuvant treatment of malignant brain tumors
28. Chemotherapy for malignant gliomas