-
1
-
-
0025069924
-
Induction chemotherapy with cisplatin, fluorouracil and high-dose leucovorin for locally advanced head and neck cancer: A clinical and pharmacological analysis
-
Vokes EE, Schilsky RL, Weichselbaum RR, et al: Induction chemotherapy with cisplatin, fluorouracil and high-dose leucovorin for locally advanced head and neck cancer: A clinical and pharmacological analysis. J Clin Oncol 8:214-247, 1990
-
(1990)
J Clin Oncol
, vol.8
, pp. 214-247
-
-
Vokes, E.E.1
Schilsky, R.L.2
Weichselbaum, R.R.3
-
2
-
-
0024413739
-
Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer
-
Swain SM, Lippman ME, Egan EG, et al: Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer. J Clin Oncol 7:890-899, 1989
-
(1989)
J Clin Oncol
, vol.7
, pp. 890-899
-
-
Swain, S.M.1
Lippman, M.E.2
Egan, E.G.3
-
3
-
-
0025815823
-
Clinical relevance of biochemical modulation of 5-fluorouracil
-
Peters GJ, Van Groeningen CJ: Clinical relevance of biochemical modulation of 5-fluorouracil. Ann Oncol 2:469-480, 1991
-
(1991)
Ann Oncol
, vol.2
, pp. 469-480
-
-
Peters, G.J.1
Van Groeningen, C.J.2
-
4
-
-
0025261244
-
Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy
-
Doroshow JH, Multhauf P, Leong L, et al: Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy. J Clin Oncol 8:491-501, 1990
-
(1990)
J Clin Oncol
, vol.8
, pp. 491-501
-
-
Doroshow, J.H.1
Multhauf, P.2
Leong, L.3
-
5
-
-
0025068882
-
Continuous infusion high-dose leucovorin with 5-fluorouracil and cisplatin for untreated stage IV carcinoma of the head and neck
-
Dreyfuss AI, Clark JR, Wright JR, et al: Continuous infusion high-dose leucovorin with 5-fluorouracil and cisplatin for untreated stage IV carcinoma of the head and neck. Ann Intern Med 112:167-172, 1990
-
(1990)
Ann Intern Med
, vol.112
, pp. 167-172
-
-
Dreyfuss, A.I.1
Clark, J.R.2
Wright, J.R.3
-
6
-
-
0022345778
-
Treatment of squamous cell carcinoma of the head and neck with cisplatin and 5 fluorouracil
-
Amrein PC, Weitzman SA: Treatment of squamous cell carcinoma of the head and neck with cisplatin and 5 fluorouracil. J Clin Oncol 3:1632-1639, 1985
-
(1985)
J Clin Oncol
, vol.3
, pp. 1632-1639
-
-
Amrein, P.C.1
Weitzman, S.A.2
-
7
-
-
0019979498
-
Clinical trial of cisplatin and 5FU infusion as initial treatment for advanced squamous cell carcinoma of the head and neck
-
Kish J, Drelichman A, Jacobs J, et al: Clinical trial of cisplatin and 5FU infusion as initial treatment for advanced squamous cell carcinoma of the head and neck. Cancer Treat Rep 66:471-476, 1982
-
(1982)
Cancer Treat Rep
, vol.66
, pp. 471-476
-
-
Kish, J.1
Drelichman, A.2
Jacobs, J.3
-
8
-
-
0023009728
-
Induction chemotherapy with cis platinum and 5-fluorouracil for squamous cell carcinoma of the head and neck
-
Thyss A, Schneider M, Santini J, et al: Induction chemotherapy with cis platinum and 5-fluorouracil for squamous cell carcinoma of the head and neck. Br J Cancer 54:755-760, 1986
-
(1986)
Br J Cancer
, vol.54
, pp. 755-760
-
-
Thyss, A.1
Schneider, M.2
Santini, J.3
-
9
-
-
0025611018
-
Metabolism and mechanism of action of 5-fluorouracil
-
Parker WB, Cheng YC: Metabolism and mechanism of action of 5-fluorouracil. Pharm Ther 48:381-395, 1990
-
(1990)
Pharm Ther
, vol.48
, pp. 381-395
-
-
Parker, W.B.1
Cheng, Y.C.2
-
10
-
-
0002685062
-
Fluorinated pyrimidine
-
Chabner BA, Collins JM (eds) Philadelphia, PA, Lippincott
-
Grem JL: Fluorinated pyrimidine, in Chabner BA, Collins JM (eds): Cancer Chemotherapy, Principles and Practice. Philadelphia, PA, Lippincott 1990, pp 180-225
-
(1990)
Cancer Chemotherapy, Principles and Practice
, pp. 180-225
-
-
Grem, J.L.1
-
11
-
-
0008865908
-
Studies on resistance against 5-fluorouracil. Enzymes of the uracil pathway during development of resistance
-
Reichard, Sköld O, Klein G, Revesz L, et al: Studies on resistance against 5-fluorouracil. Enzymes of the uracil pathway during development of resistance. Cancer Res 22:235-243, 1962
-
(1962)
Cancer Res
, vol.22
, pp. 235-243
-
-
Reichard1
Sköld, O.2
Klein, G.3
Revesz, L.4
-
12
-
-
0018886366
-
Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil
-
Ardalan B, Cooney DA, Jayaram HN, et al: Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil. Cancer Res 40:1431-1437, 1980
-
(1980)
Cancer Res
, vol.40
, pp. 1431-1437
-
-
Ardalan, B.1
Cooney, D.A.2
Jayaram, H.N.3
-
13
-
-
0019349301
-
Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinoma in mice
-
Houghton JA, Maroda SJ, Phillips JO, et al: Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinoma in mice. Cancer Res 41:144-149, 1981
-
(1981)
Cancer Res
, vol.41
, pp. 144-149
-
-
Houghton, J.A.1
Maroda, S.J.2
Phillips, J.O.3
-
14
-
-
0020027506
-
Biochemical characterisation of fluoropyrimidine-resistant murine leukemic cell lines
-
Mulkins MA, Heidelberg C: Biochemical characterisation of fluoropyrimidine-resistant murine leukemic cell lines. Cancer Res 42:965-972, 1982
-
(1982)
Cancer Res
, vol.42
, pp. 965-972
-
-
Mulkins, M.A.1
Heidelberg, C.2
-
15
-
-
0023111335
-
Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy
-
Clark JL, Berger SH, Mittelman A, et al: Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy. Cancer Treat Rep 71:261-265, 1987
-
(1987)
Cancer Treat Rep
, vol.71
, pp. 261-265
-
-
Clark, J.L.1
Berger, S.H.2
Mittelman, A.3
-
16
-
-
10544225765
-
Thymidylate synthase gene expression predicts response of primary gastric cancer to 5-fluorouracil-leucovorin-cisplatin
-
abstr
-
Lenz HJ, Leichman CG, Danenberg P, et al: Thymidylate synthase gene expression predicts response of primary gastric cancer to 5-fluorouracil-leucovorin-cisplatin. Proc Am Soc Clin Oncol 199:585, 1993 (abstr)
-
(1993)
Proc Am Soc Clin Oncol
, vol.199
, pp. 585
-
-
Lenz, H.J.1
Leichman, C.G.2
Danenberg, P.3
-
17
-
-
85035154792
-
Thymidylate synthase protein and gene expression predicts for response to 5fluorouracil-leucovorin chemotherapy in patients with colorectal and gastric cancer
-
abstr
-
Johnston PG, Lenz HJ, Danenberg KD, et al: Thymidylate synthase protein and gene expression predicts for response to 5fluorouracil-leucovorin chemotherapy in patients with colorectal and gastric cancer. Proc Am Soc Clin Oncol 196:569, 1994 (abstr)
-
(1994)
Proc Am Soc Clin Oncol
, vol.196
, pp. 569
-
-
Johnston, P.G.1
Lenz, H.J.2
Danenberg, K.D.3
-
18
-
-
84921211131
-
Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer resistance to protracted infusion 5-fluorouracil and weekly leucovorin
-
abstr
-
Leichman CG, Lenz HJ, Leichman L, et al: Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer resistance to protracted infusion 5-fluorouracil and weekly leucovorin. Proc Am Soc Clin Oncol 201:592, 1994 (abstr)
-
(1994)
Proc Am Soc Clin Oncol
, vol.201
, pp. 592
-
-
Leichman, C.G.1
Lenz, H.J.2
Leichman, L.3
-
19
-
-
85035154300
-
Thymidylate synthase gene expression in normal and malignant gastrointestinal tissues in relation to in vivo response to 5FU based therapy
-
abstr
-
Ardalan B, Reddy KR, Livingstone A, et al: Thymidylate synthase gene expression in normal and malignant gastrointestinal tissues in relation to in vivo response to 5FU based therapy. Proc Am Assoc Cancer Res 549:3271, 1994 (abstr)
-
(1994)
Proc Am Assoc Cancer Res
, vol.549
, pp. 3271
-
-
Ardalan, B.1
Reddy, K.R.2
Livingstone, A.3
-
20
-
-
0026560328
-
Quantification of thymidylate synthase, dihydrofolate reductase and DT-diaphorase gene expression in human tumors using the polymerase chain reaction
-
Horikoshi T, Danenberg KD, Stadlbauer THW, et al: Quantification of thymidylate synthase, dihydrofolate reductase and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Res 52:108-116, 1992
-
(1992)
Cancer Res
, vol.52
, pp. 108-116
-
-
Horikoshi, T.1
Danenberg, K.D.2
Stadlbauer, T.H.W.3
-
21
-
-
0022656553
-
Sensitivity of human, murine and rat cells to 5-fluorouracil and 5′-deoxy-5fluorouridine in relation to drug metabolizing enzymes
-
Peters GJ, Laurensse E, Leyva A, et al: Sensitivity of human, murine and rat cells to 5-fluorouracil and 5′-deoxy-5fluorouridine in relation to drug metabolizing enzymes. Cancer Res 46:20-28, 1986
-
(1986)
Cancer Res
, vol.46
, pp. 20-28
-
-
Peters, G.J.1
Laurensse, E.2
Leyva, A.3
-
22
-
-
0026637845
-
Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules
-
Aschele C, Sobrero A, Faderan MA, et al: Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules. Cancer Res 52:1855-1864, 1992
-
(1992)
Cancer Res
, vol.52
, pp. 1855-1864
-
-
Aschele, C.1
Sobrero, A.2
Faderan, M.A.3
-
23
-
-
0022400840
-
Enzymes of uracil catabolism in normal and neoplastic human tissues
-
Naguib FNM, El Kouni AM, Cha S: Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res 45:5405-5412, 1985
-
(1985)
Cancer Res
, vol.45
, pp. 5405-5412
-
-
Naguib, F.N.M.1
El Kouni, A.M.2
Cha, S.3
-
24
-
-
0028097137
-
A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to fluorouracil
-
Beck A, Etienne MC, Chéradame S, et al: A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to fluorouracil. Eur J Cancer 30:1517-1522, 1994
-
(1994)
Eur J Cancer
, vol.30
, pp. 1517-1522
-
-
Beck, A.1
Etienne, M.C.2
Chéradame, S.3
-
25
-
-
0642319762
-
Biochemical determinants of tumor sensitivity to 5-fluoro-2′deoxyuridilate, 2′deoxyuridine and thymidylate synthase
-
Moran RG, Spears CP, Heidelberger C: Biochemical determinants of tumor sensitivity to 5-fluoro-2′deoxyuridilate, 2′deoxyuridine and thymidylate synthase. Proc Natl Acad Sci USA 76:1456-1460, 1979
-
(1979)
Proc Natl Acad Sci USA
, vol.76
, pp. 1456-1460
-
-
Moran, R.G.1
Spears, C.P.2
Heidelberger, C.3
-
26
-
-
0025058867
-
Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion
-
Harris BE, Song R, Soong S, et al: Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion. Cancer Res 50:197-201, 1990
-
(1990)
Cancer Res
, vol.50
, pp. 197-201
-
-
Harris, B.E.1
Song, R.2
Soong, S.3
-
27
-
-
0020451764
-
Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high-performance liquid chromatography
-
Sommadossi JP, Gewirtz DA, Diasio RB, et al: Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high-performance liquid chromatography. J Biol Chem 257:8171-8176, 1982
-
(1982)
J Biol Chem
, vol.257
, pp. 8171-8176
-
-
Sommadossi, J.P.1
Gewirtz, D.A.2
Diasio, R.B.3
-
28
-
-
0024200997
-
Methods for thymidylate synthase pharmacodynamics: Serial biopsy, free and total TS, FdUMP and dUMP, and H4 Pteglu and CH2-H4 Pteglu assays
-
Rustum Y, McGuire JJ (eds) New York, NY, Plenum
-
Spears CP, Gustavsson BG: Methods for thymidylate synthase pharmacodynamics: Serial biopsy, free and total TS, FdUMP and dUMP, and H4 Pteglu and CH2-H4 Pteglu assays, in Rustum Y, McGuire JJ (eds): The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy. New York, NY, Plenum, 1988, pp 97-104
-
(1988)
The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy
, pp. 97-104
-
-
Spears, C.P.1
Gustavsson, B.G.2
-
30
-
-
0027458280
-
Overview of combined modality therapies for head and neck cancer
-
Dimery IW, Hong WK: Overview of combined modality therapies for head and neck cancer. J Natl Cancer Inst 86:95-111, 1993
-
(1993)
J Natl Cancer Inst
, vol.86
, pp. 95-111
-
-
Dimery, I.W.1
Hong, W.K.2
-
31
-
-
0025974254
-
Dose reduction without loss of efficacy for 5-fluorouracil and cisplatin combined with folinic acid. In vitro study on human head and neck carcinoma cell lines
-
Etienne MC, Bernard S, Fischel JL, et al: Dose reduction without loss of efficacy for 5-fluorouracil and cisplatin combined with folinic acid. In vitro study on human head and neck carcinoma cell lines. Br J Cancer 63:372-377, 1991
-
(1991)
Br J Cancer
, vol.63
, pp. 372-377
-
-
Etienne, M.C.1
Bernard, S.2
Fischel, J.L.3
-
32
-
-
0022886092
-
Biochemical basis for cisplatin and 5-fluorouracil synergisin in human ovarian carcinoma cells
-
Scanlon KJ, Newman EM, Lu Y, et al: Biochemical basis for cisplatin and 5-fluorouracil synergisin in human ovarian carcinoma cells. Proc Natl Acad Sci USA 83:8923-8925, 1986
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 8923-8925
-
-
Scanlon, K.J.1
Newman, E.M.2
Lu, Y.3
-
33
-
-
0027285520
-
Metabolic basis of the synergistic antitumor activities of 5-fluorouracil and cisplatin in rodent tumor models in vivo
-
Shirasaka T, Shimamoto Y, Cheshimo H, et al: Metabolic basis of the synergistic antitumor activities of 5-fluorouracil and cisplatin in rodent tumor models in vivo. Cancer Chemother Pharmacol 32:167-172, 1993
-
(1993)
Cancer Chemother Pharmacol
, vol.32
, pp. 167-172
-
-
Shirasaka, T.1
Shimamoto, Y.2
Cheshimo, H.3
-
34
-
-
84908830444
-
Fluorouracil and folinic acid in advanced colorectal cancer resistant to fluoropyrimidines, a study by the Italian Trials in Medical Oncology group
-
abstr
-
De Braud F, Bajetta E, Colleoni M, et al: Fluorouracil and folinic acid in advanced colorectal cancer resistant to fluoropyrimidines, a study by the Italian Trials in Medical Oncology group. Ann Oncol 3:132, 1992 (suppl 5) (abstr)
-
(1992)
Ann Oncol
, vol.3
, Issue.5 SUPPL.
, pp. 132
-
-
De Braud, F.1
Bajetta, E.2
Colleoni, M.3
-
35
-
-
0026795489
-
Immunological quantification of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil sensitive and resistant human cancer cell lines
-
Johnston PG, Drake JC, Trepel J, et al: Immunological quantification of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil sensitive and resistant human cancer cell lines. Cancer Res 52:4306-4312, 1992
-
(1992)
Cancer Res
, vol.52
, pp. 4306-4312
-
-
Johnston, P.G.1
Drake, J.C.2
Trepel, J.3
-
36
-
-
0026788343
-
Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors
-
Van der Wilt CL, Pinedo HM, Smid K, et al: Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors. Cancer Res 52:2922-2928, 1992
-
(1992)
Cancer Res
, vol.52
, pp. 2922-2928
-
-
Van Der Wilt, C.L.1
Pinedo, H.M.2
Smid, K.3
-
37
-
-
0008840454
-
Thymidylate synthase expression is an independent predictor of survival/disease free survival in patients with rectal cancer
-
abstr
-
Johnston PG, Fischer E, Rockette HE, et al: Thymidylate synthase expression is an independent predictor of survival/disease free survival in patients with rectal cancer. Proc Am Soc Clin Oncol 202:599, 1993 (abstr)
-
(1993)
Proc Am Soc Clin Oncol
, vol.202
, pp. 599
-
-
Johnston, P.G.1
Fischer, E.2
Rockette, H.E.3
-
38
-
-
0026557953
-
Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin
-
Peters GJ, Van Groeningen CJ, Van der Wilt C, et al: Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin. Semin Oncol 19:26-35, 1992
-
(1992)
Semin Oncol
, vol.19
, pp. 26-35
-
-
Peters, G.J.1
Van Groeningen, C.J.2
Van Der Wilt, C.3
-
39
-
-
0019773249
-
Metabolism of 5-fluorouracil in various human normal and tumor tissues
-
Maehara Y, Nagayama S, Okazaki H, et al: Metabolism of 5-fluorouracil in various human normal and tumor tissues. Gann 72:824-827, 1981
-
(1981)
Gann
, vol.72
, pp. 824-827
-
-
Maehara, Y.1
Nagayama, S.2
Okazaki, H.3
-
40
-
-
0022448330
-
Distribution and inhibition of dihydrouracil dehydrogenase activities in human tissues using 5-fluorouracil as a substrate
-
Ho DH, Townsend L, Luna MA, et al: Distribution and inhibition of dihydrouracil dehydrogenase activities in human tissues using 5-fluorouracil as a substrate. Anticancer Res 6:781-784, 1986
-
(1986)
Anticancer Res
, vol.6
, pp. 781-784
-
-
Ho, D.H.1
Townsend, L.2
Luna, M.A.3
-
41
-
-
0024267360
-
Circadian rhythm of rat liver dihydropyrimidine dehydrogenase. Possible relevance to fluoropyrimidine chemotherapy
-
Harris BE, Song R, He YJ, et al: Circadian rhythm of rat liver dihydropyrimidine dehydrogenase. Possible relevance to fluoropyrimidine chemotherapy. Biochem Pharmacol 37:4759-4762, 1988
-
(1988)
Biochem Pharmacol
, vol.37
, pp. 4759-4762
-
-
Harris, B.E.1
Song, R.2
He, Y.J.3
-
43
-
-
0026490284
-
Decreased catabolism of fluorouracil in peripheral blood mononuclear cells during combination therapy with fluorouracil, leucovorin and interferon α-2a
-
Yee LK, Allegra CS, Steinberg SM, et al: Decreased catabolism of fluorouracil in peripheral blood mononuclear cells during combination therapy with fluorouracil, leucovorin and interferon α-2a. J Natl Cancer Inst 84:1820-1825, 1992
-
(1992)
J Natl Cancer Inst
, vol.84
, pp. 1820-1825
-
-
Yee, L.K.1
Allegra, C.S.2
Steinberg, S.M.3
-
44
-
-
0028307399
-
Inhibition of dihydropyrimidine dehydrogenase by α-interferon: Experimental data on human tumor cell lines
-
Milano G, Fischel JL, Etienne MC, et al: Inhibition of dihydropyrimidine dehydrogenase by α-interferon: Experimental data on human tumor cell lines. Cancer Chemother Pharmacol 34:147-152, 1994
-
(1994)
Cancer Chemother Pharmacol
, vol.34
, pp. 147-152
-
-
Milano, G.1
Fischel, J.L.2
Etienne, M.C.3
-
45
-
-
0025774575
-
Inhibition of fluoropyrimidine catabolism by benzyloxybenzyluracil. Possible relevance to regional chemotherapy
-
Daher GC, Naguib FNM, El Kouni MH, et al: Inhibition of fluoropyrimidine catabolism by benzyloxybenzyluracil. Possible relevance to regional chemotherapy. Biochem Pharmacol 41:1887-1893, 1991
-
(1991)
Biochem Pharmacol
, vol.41
, pp. 1887-1893
-
-
Daher, G.C.1
Naguib, F.N.M.2
El Kouni, M.H.3
-
46
-
-
3142561033
-
Potentiation of 5-fluorouracil efficacy by the dihydrouracil dehydrogenase inhibitor, 5 benzyloxybenzyluracil
-
Naguib FNM, Hao SN: Potentiation of 5-fluorouracil efficacy by the dihydrouracil dehydrogenase inhibitor, 5 benzyloxybenzyluracil. Proc Am Assoc Cancer Res 34:438, 1993
-
(1993)
Proc Am Assoc Cancer Res
, vol.34
, pp. 438
-
-
Naguib, F.N.M.1
Hao, S.N.2
-
47
-
-
0028281781
-
5-Ethynyluracil (776C85): Modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma
-
Cao S, Rustum YM, Spector T: 5-Ethynyluracil (776C85): Modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma. Cancer Res 54:1507-1510, 1994
-
(1994)
Cancer Res
, vol.54
, pp. 1507-1510
-
-
Cao, S.1
Rustum, Y.M.2
Spector, T.3
|