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Volumn 13, Issue 7, 1995, Pages 1663-1670

Response to fluorouracil therapy in cancer patients: The role of tumoral dihydropyrimidine dehydrogenase activity

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; THYMIDYLATE SYNTHASE;

EID: 0028982820     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1995.13.7.1663     Document Type: Article
Times cited : (316)

References (47)
  • 1
    • 0025069924 scopus 로고
    • Induction chemotherapy with cisplatin, fluorouracil and high-dose leucovorin for locally advanced head and neck cancer: A clinical and pharmacological analysis
    • Vokes EE, Schilsky RL, Weichselbaum RR, et al: Induction chemotherapy with cisplatin, fluorouracil and high-dose leucovorin for locally advanced head and neck cancer: A clinical and pharmacological analysis. J Clin Oncol 8:214-247, 1990
    • (1990) J Clin Oncol , vol.8 , pp. 214-247
    • Vokes, E.E.1    Schilsky, R.L.2    Weichselbaum, R.R.3
  • 2
    • 0024413739 scopus 로고
    • Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer
    • Swain SM, Lippman ME, Egan EG, et al: Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer. J Clin Oncol 7:890-899, 1989
    • (1989) J Clin Oncol , vol.7 , pp. 890-899
    • Swain, S.M.1    Lippman, M.E.2    Egan, E.G.3
  • 3
    • 0025815823 scopus 로고
    • Clinical relevance of biochemical modulation of 5-fluorouracil
    • Peters GJ, Van Groeningen CJ: Clinical relevance of biochemical modulation of 5-fluorouracil. Ann Oncol 2:469-480, 1991
    • (1991) Ann Oncol , vol.2 , pp. 469-480
    • Peters, G.J.1    Van Groeningen, C.J.2
  • 4
    • 0025261244 scopus 로고
    • Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy
    • Doroshow JH, Multhauf P, Leong L, et al: Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy. J Clin Oncol 8:491-501, 1990
    • (1990) J Clin Oncol , vol.8 , pp. 491-501
    • Doroshow, J.H.1    Multhauf, P.2    Leong, L.3
  • 5
    • 0025068882 scopus 로고
    • Continuous infusion high-dose leucovorin with 5-fluorouracil and cisplatin for untreated stage IV carcinoma of the head and neck
    • Dreyfuss AI, Clark JR, Wright JR, et al: Continuous infusion high-dose leucovorin with 5-fluorouracil and cisplatin for untreated stage IV carcinoma of the head and neck. Ann Intern Med 112:167-172, 1990
    • (1990) Ann Intern Med , vol.112 , pp. 167-172
    • Dreyfuss, A.I.1    Clark, J.R.2    Wright, J.R.3
  • 6
    • 0022345778 scopus 로고
    • Treatment of squamous cell carcinoma of the head and neck with cisplatin and 5 fluorouracil
    • Amrein PC, Weitzman SA: Treatment of squamous cell carcinoma of the head and neck with cisplatin and 5 fluorouracil. J Clin Oncol 3:1632-1639, 1985
    • (1985) J Clin Oncol , vol.3 , pp. 1632-1639
    • Amrein, P.C.1    Weitzman, S.A.2
  • 7
    • 0019979498 scopus 로고
    • Clinical trial of cisplatin and 5FU infusion as initial treatment for advanced squamous cell carcinoma of the head and neck
    • Kish J, Drelichman A, Jacobs J, et al: Clinical trial of cisplatin and 5FU infusion as initial treatment for advanced squamous cell carcinoma of the head and neck. Cancer Treat Rep 66:471-476, 1982
    • (1982) Cancer Treat Rep , vol.66 , pp. 471-476
    • Kish, J.1    Drelichman, A.2    Jacobs, J.3
  • 8
    • 0023009728 scopus 로고
    • Induction chemotherapy with cis platinum and 5-fluorouracil for squamous cell carcinoma of the head and neck
    • Thyss A, Schneider M, Santini J, et al: Induction chemotherapy with cis platinum and 5-fluorouracil for squamous cell carcinoma of the head and neck. Br J Cancer 54:755-760, 1986
    • (1986) Br J Cancer , vol.54 , pp. 755-760
    • Thyss, A.1    Schneider, M.2    Santini, J.3
  • 9
    • 0025611018 scopus 로고
    • Metabolism and mechanism of action of 5-fluorouracil
    • Parker WB, Cheng YC: Metabolism and mechanism of action of 5-fluorouracil. Pharm Ther 48:381-395, 1990
    • (1990) Pharm Ther , vol.48 , pp. 381-395
    • Parker, W.B.1    Cheng, Y.C.2
  • 10
    • 0002685062 scopus 로고
    • Fluorinated pyrimidine
    • Chabner BA, Collins JM (eds) Philadelphia, PA, Lippincott
    • Grem JL: Fluorinated pyrimidine, in Chabner BA, Collins JM (eds): Cancer Chemotherapy, Principles and Practice. Philadelphia, PA, Lippincott 1990, pp 180-225
    • (1990) Cancer Chemotherapy, Principles and Practice , pp. 180-225
    • Grem, J.L.1
  • 11
    • 0008865908 scopus 로고
    • Studies on resistance against 5-fluorouracil. Enzymes of the uracil pathway during development of resistance
    • Reichard, Sköld O, Klein G, Revesz L, et al: Studies on resistance against 5-fluorouracil. Enzymes of the uracil pathway during development of resistance. Cancer Res 22:235-243, 1962
    • (1962) Cancer Res , vol.22 , pp. 235-243
    • Reichard1    Sköld, O.2    Klein, G.3    Revesz, L.4
  • 12
    • 0018886366 scopus 로고
    • Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil
    • Ardalan B, Cooney DA, Jayaram HN, et al: Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil. Cancer Res 40:1431-1437, 1980
    • (1980) Cancer Res , vol.40 , pp. 1431-1437
    • Ardalan, B.1    Cooney, D.A.2    Jayaram, H.N.3
  • 13
    • 0019349301 scopus 로고
    • Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinoma in mice
    • Houghton JA, Maroda SJ, Phillips JO, et al: Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinoma in mice. Cancer Res 41:144-149, 1981
    • (1981) Cancer Res , vol.41 , pp. 144-149
    • Houghton, J.A.1    Maroda, S.J.2    Phillips, J.O.3
  • 14
    • 0020027506 scopus 로고
    • Biochemical characterisation of fluoropyrimidine-resistant murine leukemic cell lines
    • Mulkins MA, Heidelberg C: Biochemical characterisation of fluoropyrimidine-resistant murine leukemic cell lines. Cancer Res 42:965-972, 1982
    • (1982) Cancer Res , vol.42 , pp. 965-972
    • Mulkins, M.A.1    Heidelberg, C.2
  • 15
    • 0023111335 scopus 로고
    • Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy
    • Clark JL, Berger SH, Mittelman A, et al: Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy. Cancer Treat Rep 71:261-265, 1987
    • (1987) Cancer Treat Rep , vol.71 , pp. 261-265
    • Clark, J.L.1    Berger, S.H.2    Mittelman, A.3
  • 16
    • 10544225765 scopus 로고
    • Thymidylate synthase gene expression predicts response of primary gastric cancer to 5-fluorouracil-leucovorin-cisplatin
    • abstr
    • Lenz HJ, Leichman CG, Danenberg P, et al: Thymidylate synthase gene expression predicts response of primary gastric cancer to 5-fluorouracil-leucovorin-cisplatin. Proc Am Soc Clin Oncol 199:585, 1993 (abstr)
    • (1993) Proc Am Soc Clin Oncol , vol.199 , pp. 585
    • Lenz, H.J.1    Leichman, C.G.2    Danenberg, P.3
  • 17
    • 85035154792 scopus 로고
    • Thymidylate synthase protein and gene expression predicts for response to 5fluorouracil-leucovorin chemotherapy in patients with colorectal and gastric cancer
    • abstr
    • Johnston PG, Lenz HJ, Danenberg KD, et al: Thymidylate synthase protein and gene expression predicts for response to 5fluorouracil-leucovorin chemotherapy in patients with colorectal and gastric cancer. Proc Am Soc Clin Oncol 196:569, 1994 (abstr)
    • (1994) Proc Am Soc Clin Oncol , vol.196 , pp. 569
    • Johnston, P.G.1    Lenz, H.J.2    Danenberg, K.D.3
  • 18
    • 84921211131 scopus 로고
    • Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer resistance to protracted infusion 5-fluorouracil and weekly leucovorin
    • abstr
    • Leichman CG, Lenz HJ, Leichman L, et al: Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer resistance to protracted infusion 5-fluorouracil and weekly leucovorin. Proc Am Soc Clin Oncol 201:592, 1994 (abstr)
    • (1994) Proc Am Soc Clin Oncol , vol.201 , pp. 592
    • Leichman, C.G.1    Lenz, H.J.2    Leichman, L.3
  • 19
    • 85035154300 scopus 로고
    • Thymidylate synthase gene expression in normal and malignant gastrointestinal tissues in relation to in vivo response to 5FU based therapy
    • abstr
    • Ardalan B, Reddy KR, Livingstone A, et al: Thymidylate synthase gene expression in normal and malignant gastrointestinal tissues in relation to in vivo response to 5FU based therapy. Proc Am Assoc Cancer Res 549:3271, 1994 (abstr)
    • (1994) Proc Am Assoc Cancer Res , vol.549 , pp. 3271
    • Ardalan, B.1    Reddy, K.R.2    Livingstone, A.3
  • 20
    • 0026560328 scopus 로고
    • Quantification of thymidylate synthase, dihydrofolate reductase and DT-diaphorase gene expression in human tumors using the polymerase chain reaction
    • Horikoshi T, Danenberg KD, Stadlbauer THW, et al: Quantification of thymidylate synthase, dihydrofolate reductase and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Res 52:108-116, 1992
    • (1992) Cancer Res , vol.52 , pp. 108-116
    • Horikoshi, T.1    Danenberg, K.D.2    Stadlbauer, T.H.W.3
  • 21
    • 0022656553 scopus 로고
    • Sensitivity of human, murine and rat cells to 5-fluorouracil and 5′-deoxy-5fluorouridine in relation to drug metabolizing enzymes
    • Peters GJ, Laurensse E, Leyva A, et al: Sensitivity of human, murine and rat cells to 5-fluorouracil and 5′-deoxy-5fluorouridine in relation to drug metabolizing enzymes. Cancer Res 46:20-28, 1986
    • (1986) Cancer Res , vol.46 , pp. 20-28
    • Peters, G.J.1    Laurensse, E.2    Leyva, A.3
  • 22
    • 0026637845 scopus 로고
    • Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules
    • Aschele C, Sobrero A, Faderan MA, et al: Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules. Cancer Res 52:1855-1864, 1992
    • (1992) Cancer Res , vol.52 , pp. 1855-1864
    • Aschele, C.1    Sobrero, A.2    Faderan, M.A.3
  • 23
    • 0022400840 scopus 로고
    • Enzymes of uracil catabolism in normal and neoplastic human tissues
    • Naguib FNM, El Kouni AM, Cha S: Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res 45:5405-5412, 1985
    • (1985) Cancer Res , vol.45 , pp. 5405-5412
    • Naguib, F.N.M.1    El Kouni, A.M.2    Cha, S.3
  • 24
    • 0028097137 scopus 로고
    • A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to fluorouracil
    • Beck A, Etienne MC, Chéradame S, et al: A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumor sensitivity to fluorouracil. Eur J Cancer 30:1517-1522, 1994
    • (1994) Eur J Cancer , vol.30 , pp. 1517-1522
    • Beck, A.1    Etienne, M.C.2    Chéradame, S.3
  • 25
    • 0642319762 scopus 로고
    • Biochemical determinants of tumor sensitivity to 5-fluoro-2′deoxyuridilate, 2′deoxyuridine and thymidylate synthase
    • Moran RG, Spears CP, Heidelberger C: Biochemical determinants of tumor sensitivity to 5-fluoro-2′deoxyuridilate, 2′deoxyuridine and thymidylate synthase. Proc Natl Acad Sci USA 76:1456-1460, 1979
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 1456-1460
    • Moran, R.G.1    Spears, C.P.2    Heidelberger, C.3
  • 26
    • 0025058867 scopus 로고
    • Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion
    • Harris BE, Song R, Soong S, et al: Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion. Cancer Res 50:197-201, 1990
    • (1990) Cancer Res , vol.50 , pp. 197-201
    • Harris, B.E.1    Song, R.2    Soong, S.3
  • 27
    • 0020451764 scopus 로고
    • Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high-performance liquid chromatography
    • Sommadossi JP, Gewirtz DA, Diasio RB, et al: Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high-performance liquid chromatography. J Biol Chem 257:8171-8176, 1982
    • (1982) J Biol Chem , vol.257 , pp. 8171-8176
    • Sommadossi, J.P.1    Gewirtz, D.A.2    Diasio, R.B.3
  • 28
    • 0024200997 scopus 로고
    • Methods for thymidylate synthase pharmacodynamics: Serial biopsy, free and total TS, FdUMP and dUMP, and H4 Pteglu and CH2-H4 Pteglu assays
    • Rustum Y, McGuire JJ (eds) New York, NY, Plenum
    • Spears CP, Gustavsson BG: Methods for thymidylate synthase pharmacodynamics: Serial biopsy, free and total TS, FdUMP and dUMP, and H4 Pteglu and CH2-H4 Pteglu assays, in Rustum Y, McGuire JJ (eds): The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy. New York, NY, Plenum, 1988, pp 97-104
    • (1988) The Expanding Role of Folates and Fluoropyrimidines in Cancer Chemotherapy , pp. 97-104
    • Spears, C.P.1    Gustavsson, B.G.2
  • 30
    • 0027458280 scopus 로고
    • Overview of combined modality therapies for head and neck cancer
    • Dimery IW, Hong WK: Overview of combined modality therapies for head and neck cancer. J Natl Cancer Inst 86:95-111, 1993
    • (1993) J Natl Cancer Inst , vol.86 , pp. 95-111
    • Dimery, I.W.1    Hong, W.K.2
  • 31
    • 0025974254 scopus 로고
    • Dose reduction without loss of efficacy for 5-fluorouracil and cisplatin combined with folinic acid. In vitro study on human head and neck carcinoma cell lines
    • Etienne MC, Bernard S, Fischel JL, et al: Dose reduction without loss of efficacy for 5-fluorouracil and cisplatin combined with folinic acid. In vitro study on human head and neck carcinoma cell lines. Br J Cancer 63:372-377, 1991
    • (1991) Br J Cancer , vol.63 , pp. 372-377
    • Etienne, M.C.1    Bernard, S.2    Fischel, J.L.3
  • 32
    • 0022886092 scopus 로고
    • Biochemical basis for cisplatin and 5-fluorouracil synergisin in human ovarian carcinoma cells
    • Scanlon KJ, Newman EM, Lu Y, et al: Biochemical basis for cisplatin and 5-fluorouracil synergisin in human ovarian carcinoma cells. Proc Natl Acad Sci USA 83:8923-8925, 1986
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 8923-8925
    • Scanlon, K.J.1    Newman, E.M.2    Lu, Y.3
  • 33
    • 0027285520 scopus 로고
    • Metabolic basis of the synergistic antitumor activities of 5-fluorouracil and cisplatin in rodent tumor models in vivo
    • Shirasaka T, Shimamoto Y, Cheshimo H, et al: Metabolic basis of the synergistic antitumor activities of 5-fluorouracil and cisplatin in rodent tumor models in vivo. Cancer Chemother Pharmacol 32:167-172, 1993
    • (1993) Cancer Chemother Pharmacol , vol.32 , pp. 167-172
    • Shirasaka, T.1    Shimamoto, Y.2    Cheshimo, H.3
  • 34
    • 84908830444 scopus 로고
    • Fluorouracil and folinic acid in advanced colorectal cancer resistant to fluoropyrimidines, a study by the Italian Trials in Medical Oncology group
    • abstr
    • De Braud F, Bajetta E, Colleoni M, et al: Fluorouracil and folinic acid in advanced colorectal cancer resistant to fluoropyrimidines, a study by the Italian Trials in Medical Oncology group. Ann Oncol 3:132, 1992 (suppl 5) (abstr)
    • (1992) Ann Oncol , vol.3 , Issue.5 SUPPL. , pp. 132
    • De Braud, F.1    Bajetta, E.2    Colleoni, M.3
  • 35
    • 0026795489 scopus 로고
    • Immunological quantification of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil sensitive and resistant human cancer cell lines
    • Johnston PG, Drake JC, Trepel J, et al: Immunological quantification of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil sensitive and resistant human cancer cell lines. Cancer Res 52:4306-4312, 1992
    • (1992) Cancer Res , vol.52 , pp. 4306-4312
    • Johnston, P.G.1    Drake, J.C.2    Trepel, J.3
  • 36
    • 0026788343 scopus 로고
    • Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors
    • Van der Wilt CL, Pinedo HM, Smid K, et al: Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors. Cancer Res 52:2922-2928, 1992
    • (1992) Cancer Res , vol.52 , pp. 2922-2928
    • Van Der Wilt, C.L.1    Pinedo, H.M.2    Smid, K.3
  • 37
    • 0008840454 scopus 로고
    • Thymidylate synthase expression is an independent predictor of survival/disease free survival in patients with rectal cancer
    • abstr
    • Johnston PG, Fischer E, Rockette HE, et al: Thymidylate synthase expression is an independent predictor of survival/disease free survival in patients with rectal cancer. Proc Am Soc Clin Oncol 202:599, 1993 (abstr)
    • (1993) Proc Am Soc Clin Oncol , vol.202 , pp. 599
    • Johnston, P.G.1    Fischer, E.2    Rockette, H.E.3
  • 38
    • 0026557953 scopus 로고
    • Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin
    • Peters GJ, Van Groeningen CJ, Van der Wilt C, et al: Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin. Semin Oncol 19:26-35, 1992
    • (1992) Semin Oncol , vol.19 , pp. 26-35
    • Peters, G.J.1    Van Groeningen, C.J.2    Van Der Wilt, C.3
  • 39
    • 0019773249 scopus 로고
    • Metabolism of 5-fluorouracil in various human normal and tumor tissues
    • Maehara Y, Nagayama S, Okazaki H, et al: Metabolism of 5-fluorouracil in various human normal and tumor tissues. Gann 72:824-827, 1981
    • (1981) Gann , vol.72 , pp. 824-827
    • Maehara, Y.1    Nagayama, S.2    Okazaki, H.3
  • 40
    • 0022448330 scopus 로고
    • Distribution and inhibition of dihydrouracil dehydrogenase activities in human tissues using 5-fluorouracil as a substrate
    • Ho DH, Townsend L, Luna MA, et al: Distribution and inhibition of dihydrouracil dehydrogenase activities in human tissues using 5-fluorouracil as a substrate. Anticancer Res 6:781-784, 1986
    • (1986) Anticancer Res , vol.6 , pp. 781-784
    • Ho, D.H.1    Townsend, L.2    Luna, M.A.3
  • 41
    • 0024267360 scopus 로고
    • Circadian rhythm of rat liver dihydropyrimidine dehydrogenase. Possible relevance to fluoropyrimidine chemotherapy
    • Harris BE, Song R, He YJ, et al: Circadian rhythm of rat liver dihydropyrimidine dehydrogenase. Possible relevance to fluoropyrimidine chemotherapy. Biochem Pharmacol 37:4759-4762, 1988
    • (1988) Biochem Pharmacol , vol.37 , pp. 4759-4762
    • Harris, B.E.1    Song, R.2    He, Y.J.3
  • 43
    • 0026490284 scopus 로고
    • Decreased catabolism of fluorouracil in peripheral blood mononuclear cells during combination therapy with fluorouracil, leucovorin and interferon α-2a
    • Yee LK, Allegra CS, Steinberg SM, et al: Decreased catabolism of fluorouracil in peripheral blood mononuclear cells during combination therapy with fluorouracil, leucovorin and interferon α-2a. J Natl Cancer Inst 84:1820-1825, 1992
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1820-1825
    • Yee, L.K.1    Allegra, C.S.2    Steinberg, S.M.3
  • 44
    • 0028307399 scopus 로고
    • Inhibition of dihydropyrimidine dehydrogenase by α-interferon: Experimental data on human tumor cell lines
    • Milano G, Fischel JL, Etienne MC, et al: Inhibition of dihydropyrimidine dehydrogenase by α-interferon: Experimental data on human tumor cell lines. Cancer Chemother Pharmacol 34:147-152, 1994
    • (1994) Cancer Chemother Pharmacol , vol.34 , pp. 147-152
    • Milano, G.1    Fischel, J.L.2    Etienne, M.C.3
  • 45
    • 0025774575 scopus 로고
    • Inhibition of fluoropyrimidine catabolism by benzyloxybenzyluracil. Possible relevance to regional chemotherapy
    • Daher GC, Naguib FNM, El Kouni MH, et al: Inhibition of fluoropyrimidine catabolism by benzyloxybenzyluracil. Possible relevance to regional chemotherapy. Biochem Pharmacol 41:1887-1893, 1991
    • (1991) Biochem Pharmacol , vol.41 , pp. 1887-1893
    • Daher, G.C.1    Naguib, F.N.M.2    El Kouni, M.H.3
  • 46
    • 3142561033 scopus 로고
    • Potentiation of 5-fluorouracil efficacy by the dihydrouracil dehydrogenase inhibitor, 5 benzyloxybenzyluracil
    • Naguib FNM, Hao SN: Potentiation of 5-fluorouracil efficacy by the dihydrouracil dehydrogenase inhibitor, 5 benzyloxybenzyluracil. Proc Am Assoc Cancer Res 34:438, 1993
    • (1993) Proc Am Assoc Cancer Res , vol.34 , pp. 438
    • Naguib, F.N.M.1    Hao, S.N.2
  • 47
    • 0028281781 scopus 로고
    • 5-Ethynyluracil (776C85): Modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma
    • Cao S, Rustum YM, Spector T: 5-Ethynyluracil (776C85): Modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma. Cancer Res 54:1507-1510, 1994
    • (1994) Cancer Res , vol.54 , pp. 1507-1510
    • Cao, S.1    Rustum, Y.M.2    Spector, T.3


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