HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

Cell

Volumn 82, Issue 1, 1995, Pages 155-165

  Denzin, Lisa K ^a   Cresswell, Peter ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN; HLA DM ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; DIMERIZATION; HLA SYSTEM; HUMAN; HUMAN CELL; LYSOSOME; MAJOR HISTOCOMPATIBILITY COMPLEX; PH; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

EID: 0028981178     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(95)90061-6     Document Type: Article

References (39)

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3. Binding of immunogenic peptides to Is histocompatibility molecules
4. MHC class II-associated invariant chain contains a sorting signal for endosomal compartments
5. Monoclonal antibody to HLA-A3
6. Role for intracellular proteases in the processing and transport of class II HLA antigens
7. MHC class II deletion mutant expresses normal levels of transgene encoded class II molecules that have abnormal conformation and impaired antigen presentation ability
8. A segment of the MHC Class II β chain plays a critical role in targeting class II molecules to the endocytic pathway
9. Assembly, transport and function of MHC class II molecules
10. Getting peptides into MHC class II molecules
11. Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells
12. HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells
13. Binding of a major T cell epitope of mycobacteria to a specific pocketwithin HLA-DRw17 (DR3) molecules
14. MHC class 11 structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding
15. Differential expression and serologically distinct subpopulations of human la antigens detected with monoclonal antibodies to la α and β chains
16. Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells
17. A new human HLA class II-related locus, DM
18. Two populations of la-like molecules on a human cell line
19. Monensin prevents terminal glycosylation of the N- and O-linked oligosaccharides of the HLADR-associated invariant chain and inhibits its dissociation from the α-β chain complex
20. Supermotifs enable natural invariant chain-derived peptides to interact with many major histocompatibility complex-class II molecules
21. Endosomal aspartic proteinases are required for invariant chain processing
22. Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes
23. A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides
24. An essential role for HLA-DM in antigen presentation by class 11 major histocompatibility molecules
25. Characterization of endogenous peptides bound to purified HLA-DR molecules and their absence from invariant chain-associated αβ dimers
26. Structural analysis of proteolytic products of MHC class II-invariant chain complexes generated in vivo
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28. Intracellular transport and localization of major histocompatibility complex class II molecules and associated invariant chain
29. The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation
30. HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides
31. Transport and intracellular distribution of MHC class 11 molecules and associated invariant chain in normal and antigen-processing mutant cell lines
32. Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding
33. Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain
34. Sequence analysis of peptides bound to MHC class II molecules
35. A role for peptide in determining MHC class II structure
36. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids
37. Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments
38. Invariantchain peptides in most HLA-DR molecules of an antigen-processing mutant
39. Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II