Episelection: Novel Ki ~ Nanomolar Inhibitors of Serine Proteases Selected by Binding or Chemistry on an Enzyme Surface

Biochemistry

Volumn 34, Issue 26, 1995, Pages 8264-8280

  Katz, Bradley A ^a   Finer Moore, Janet ^b   Mortezaei, Reza ^c   Rich, Daniel H ^c   Stroud, Robert M ^a,b  

^a Arris Pharmaceutical Corporation   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORONIC ACID DERIVATIVE; SERINE PROTEINASE INHIBITOR; TRIPEPTIDE DERIVATIVE; BORON; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; OLIGOPEPTIDE; SERINE PROTEINASE; TRYPSIN; TRYPSIN INHIBITOR;

ARTICLE; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME MECHANISM; PRIORITY JOURNAL; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; COMPARATIVE STUDY; KINETICS; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; SENSITIVITY AND SPECIFICITY; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; BORON; COMPARATIVE STUDY; CRYSTALLOGRAPHY, X-RAY; INDICATORS AND REAGENTS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PROTEIN CONFORMATION; SENSITIVITY AND SPECIFICITY; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; SPECTRUM ANALYSIS, MASS; SUPPORT, U.S. GOV'T, P.H.S.; TRYPSIN; TRYPSIN INHIBITORS;

EID: 0028980848     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00026a008     Document Type: Article

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