Contribution of O6‐methylguanine‐DNA methyltransferase to resistance to 1,3‐(2‐chloroethyl)‐1‐nitrosourea in human brain tumor‐derived cell lines

Molecular Carcinogenesis

Volumn 13, Issue 2, 1995, Pages 81-88

  Bobola, Michael S ^a   Berger, Mitchel S ^a   Silber, John R ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

chloroethylnitrosourea; DNA repair; O6 benzylguanine

Indexed keywords

6 O BENZYLGUANINE; CARMUSTINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLTRANSFERASE; O(6) METHYLGUANINE DNA METHYLTRANSFERASE;

ARTICLE; BRAIN TUMOR; CONTROLLED STUDY; DNA REPAIR; DRUG RESISTANCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR CELL LINE; CELL ADHESION; CELL CULTURE; COLON TUMOR; CULTURE MEDIUM; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; GLIOMA; MEDULLOBLASTOMA; PHYSIOLOGY;

BRAIN NEOPLASMS; CARMUSTINE; CELL ADHESION; COLONIC NEOPLASMS; CULTURE MEDIA; DRUG RESISTANCE; DRUG SCREENING ASSAYS, ANTITUMOR; GLIOMA; HUMAN; MEDULLOBLASTOMA; METHYLTRANSFERASES; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0028980765     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.2940130204     Document Type: Article

References (46)

1. Chemotherapy for malignant gliomas
2. Chemotherapy for malignant brain tumors
3. Efficacy of adjuvant chemotherapy for patients with poor‐risk medulloblastoma: A preliminary report
4. Medulloblastoma: Tumor biological and clinical perspectives
5. DNA alkylation by the halonitrosoureas: Nature of modifications produced and their enzymatic repair or removal
6. Chemical Mutagenesis
7. Differences in DNA alkylation products formed in sensitive and resistant human glioma cells treated with N‐(2‐chloroethyl)‐N‐nitrosourea
8. Isolation and purification of 06‐alkylguanine‐DNA alkyltransferase from human leukemic cells: Prevention of chloroethylnitrosourea‐induced cross‐links by purified enzymes
9. 6‐alkylguanine DNA adducts in glioma‐derived human cells resistant to the cytotoxic and cytogenetic effects of 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea
10. Mammalian 06‐alkylguanine‐DNA alkyltransferase: Regulation and importance in response to alkylating carcinogenic and therapeutic agents
11. Repair of DNA containing 06‐alkylguanine
12. 6‐alkylguanine‐DNA alkyltransferase reduces the toxic effects of alkylating agents
13. Effect of 06‐methylguanine‐DNA methyltransferase gene activity on repair in human cells transformed by a regulatable ada gene
14. Transfection and expression of human 06‐methylguanine‐DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: The role of MGMT in protection against the genotoxic effects of alkylating agents
15. 6‐methylguaniine‐DNA methyltransferase in Chinese hamster ovary cells and restoration of cellular resistance to certain N‐nitroso compounds
16. 6‐benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents
17. 6‐benzylguanine and its effect on the sensitivity of a human glioma tumor to 1‐(2‐chloroethyl)‐3‐(4‐methylcyclohexyl)‐1‐nitrosourea
18. 6‐benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents
19. 6‐benzylguanine
20. 6‐benzylguanine and hypoxia on the cytotoxicity of 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea in the nitrosourea‐resistant SF‐763 cells
21. Prevention of 1<3‐deoxy‐cytidyl),2‐(1‐deoxyguanosinyljethane crosslink formation in DNA by rat liver 06‐alkylguanine‐DNA alkyltransferase
22. 6‐alkylguanmne‐DNA alkyltransferase is not a major determinant of sensitivity to 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea in four medulloblastoma cell lines
23. Effect of 06‐benzylguanine on the sensitivity of human tumor xenografts to 1,3‐bis(2chloroethyl)‐1‐nitrosourea and on DNA interstrand cross‐link formation
24. 6‐benzylguanine and 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea
25. Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme
26. 6‐methylguanine‐DNA methyftransferase to monofunctional alkylating agent resistance in human brain tumor‐derived cell lines
27. 6‐benzylguanine with or without streptozotpcin enhances 1,3‐bis(2‐chloroethyl)‐1‐nitrosourea sensitivity in vitro
28. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
29. The MIT assay for chemosensitivity testing of human tumors of the central nervous system
30. Improved plating efficiencies for human tumors cloned in capillary tubes versus petri dishes
31. Positive correlation between the extent of cell proliferation and the regulation of base excision repair
32. A reduced rate of bulky DNA adduct removal is coincident with differentiation of human neuroblastoma cells induced by nerve growth factor
33. The regulation of DNA repair during development
34. Influence of proliferation on DNA repair rates in liver
35. Repair of haloethyl‐nitrosourea‐induced DNA damage in mutant and adapted bacteria
36. 6‐methylguanine‐DNA methyltransferase in a DNA excision repair‐deficient Chinese hamster ovary line and its response to certain alkylating agents
37. Isolation of two chloroethylnitrosourea‐sensitive Chinese hamster ovary cell lines
38. Mutagenic and recombinogenic consequences of DNA‐repair inhibition during treatment with 1,3‐bis(2chloroethyl)‐1‐nitrosounea in Saccnaromyces cerevisiae
39. Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3‐methyladenine DNA glycosylase
40. DNA repair
41. Glutathione‐associated enzymes in anticancer drug resistance
42. Overexpression of metallothionine confers resistance to anticancer drugs
43. Apoptosis induced by anticancer drugs
44. Checkpoints: Controls that ensure the order of cell cycle events
45. Applications of in vivo and in vitro pharmacokinetics for physiologically relevant drug exposure in a human'tumor clonogenic cell assay
46. 6‐methylguanine‐DNA methyltransferase in six medulloblastoma cell lines