The 5-HT4 receptor: Molecular cloning and pharmacological characterization of two splice variants

EMBO Journal

Volumn 14, Issue 12, 1995, Pages 2806-2815

  Gerald, Christophe ^a   Adham, Nika ^a   Kao, Hung Teh ^b   Oisen, Michael A ^c   Laz, Thomas M ^a   Schechter, Lee E ^d   Bard, Jonathan A ^a   Vaysse, Pierre J J ^a   Hartig, Paul R ^e   Branchek, Theresa A ^a   Weinshank, Richard L ^a  

^a Synaplic Pharmacculical Corporation ^*  (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^c WYETH AYERST RESEARCH   (United States)

^d CNS Biology ^*  (United States)

^e DUPONT COMPANY   (United States)

Author keywords

5 HT4 receptor; G protein coupled receptor; Splice variants; Stimulation of cAMP

Indexed keywords

ADENYLATE CYCLASE; BENZAMIDE DERIVATIVE; CISAPRIDE; COMPLEMENTARY DNA; DNA FRAGMENT; MESSENGER RNA; OLIGONUCLEOTIDE; PRIMER DNA; RECEPTOR PROTEIN; SEROTONIN 4 RECEPTOR; TROPISETRON; AMINO ACID; INDOLE DERIVATIVE; PIPERIDINE DERIVATIVE; SEROTONIN; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; BRAIN; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CORPUS STRIATUM; DNA LIBRARY; ENZYME ACTIVATION; HEART ATRIUM; MALE; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN VARIANT; RAT; TISSUE DISTRIBUTION; ANIMAL; ANTIBODY SPECIFICITY; BRAIN LEVEL; CELL LINE; CHEMISTRY; DNA SEQUENCE; DRUG EFFECT; GENE EXPRESSION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; RNA SPLICING; SIGNAL TRANSDUCTION;

ANIMALIA;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; AMINO ACIDS; ANIMAL; BASE SEQUENCE; BRAIN CHEMISTRY; CELL LINE; CISAPRIDE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; GENE EXPRESSION; HEART ATRIUM; INDOLES; MOLECULAR SEQUENCE DATA; ORGAN SPECIFICITY; PIPERIDINES; RATS; RECEPTORS, SEROTONIN; RNA SPLICING; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; SEROTONIN; SEROTONIN ANTAGONISTS; SIGNAL TRANSDUCTION; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028978023     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1995.tb07280.x     Document Type: Article

References (19)

1. Adham,N., Rumanienko,R., Hanig,P. Weinsbank,R.L. and Branchek,T.A. (1992) Mol. pharmarol., 41, 1-7.
2. Adham,N. et al. (1993) Proc. Natl Acad. Sci. USA, 90, 408-412.
3. Albcrt,P.R., Zhon,Q.Y., VonTol,H.H.M., Bunzow,J.R. and Civelli,O. (1990) J. Biol. Chem., 265, 5825-5832.
4. Amlaiky,N., Ramboz,S., Beschert,U., Plassat,J.L. and Hen,R. (1992) J. Biol. Chem., 267, 19761-19764.
5. Bard,J.A., Zgombick,J., Adham,N., Vaysse,P.J.-J., Branchek,T.A. and Weinshank,R.L. (1993) J. Biol Chem., 268, 23422-23426.
6. Baxter,G.S., Craig,D.A. and Clarke,D.E. (1991) Naunyn-SfhmieJeberg's Arch. Pharmacol., 343, 439-450.
7. Bockaert,J., Sehhen,M. and Dumuis,A. (1990) Mol pharmacol., 37, 408-411.
8. Shen,Y., Monsma,F.J., Metcalf,M.A., Jose,P.A., Hamblin,M.W. and Sibley,D.R. (1993) J. Biol. Chem., 268, 18200-18204.
9. Shenkcr,A., Maayani,S., Weinstein,H. and Green,J.P. (1987) Mol. pharmacol., 31, 357-367.
10. Vanelti,M., Kouba,M., Wang,X., Vogt,G. and Hollt,V. (1992) FEBS lett., 311, 290-294.
11. Vanetti,M., Vogt,G. and Hollt,V. (1993) FEBS Lstt., 331, 260-266.
12. Voigt,M.M., Laurie,D.J., Seeburg,P.H. and Bach,A. (1991) EMBO J., 10, 4017-4023.
13. Waeber,C., Sebben,M., Grossman,C., Javoy-Agid.K, Bockaert,J. and Dumuis,A. (1993) Neumreporl, 4, 1239-1242.
14. Warden,D. and Thorne,H.V. (1968) J Gen. Virol., 3, 371-377.
15. Wardle,K.A., Ellis,E.S., Baxter,G.S., Kennett,G.A., Gaster,L.M. and Sanger,G.J. (1994) Br. J. pharmacol., 112, 789-794.
16. Weinshank,R.L., Zgombick,J.M., Macchi,M., Branchek,T.A. and Hartig,P.R. (1992) Proc. Nutl Acad. Sci. USA. 89, 3630-3634.
17. Whaley,B.S., Yuan,N., Birnbaumer,L., Clark,R.B. and Barber,R. (1994) Mol. Pharmacol. 45, 481-489.
18. Zgombick,J.M., Schechter,L.E., Macchi,M., Hartig,P.R., Branchek,T.A. and Weinshank,R.L. (1992) Mol. Pharmacol. 42, 180-185.
19. Zhao,D., Yang,J., Jones,K.E., Gerald,C., Suzuki,Y., Hogan,P.G., Chin,W.W. and Tashjian,A.H.,Jr (1992) Endocrinology. 130, 3529-3536.