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Volumn 52, Issue 11, 1995, Pages 1074-1079

Apolipoprotein e ε4 allele and the lifetime risk of alzheimer's disease: What physicians know, and what they should know

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4; APOLIPOPROTEIN E; APOLIPOPROTEIN E 4; APOLIPOPROTEIN E-4;

EID: 0028973776     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneur.1995.00540350068018     Document Type: Article
Times cited : (148)

References (55)
  • 1
    • 0027407565 scopus 로고
    • Apolipoprotein E: high avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease
    • Strittmatter WJ, Saunders AN, Schmechel D, et al. Apolipoprotein E: high avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer's disease. Proc Natl Acad Sci U S A. 1993;90:1977-1981.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 1977-1981
    • Strittmatter, W.J.1    Saunders, A.N.2    Schmechel, D.3
  • 2
    • 0027327267 scopus 로고
    • Association of apolipoprotein E ε4 with late-onset familial and sporadic Alzheimer's disease
    • Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 1993;43:1462-1472.
    • (1993) Neurology , vol.43 , pp. 1462-1472
    • Saunders, A.M.1    Strittmatter, W.J.2    Schmechel, D.3
  • 3
    • 0027337858 scopus 로고
    • Apolipoprotein E ε4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases
    • Saunders AM, Schmader K, Breitner JCS, et al. Apolipoprotein E ε4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases. Lancet. 1993;342:710-711.
    • (1993) Lancet , vol.342 , pp. 710-711
    • Saunders, A.M.1    Schmader, K.2    Breitner, J.C.S.3
  • 5
    • 0027339923 scopus 로고
    • The apolipoprotein ε4 allele in patients with Alzheimer's disease
    • Mayeux R, Stern Y, Ottman R, et al. The apolipoprotein ε4 allele in patients with Alzheimer's disease. Ann Neurol. 1993;34:752-754.
    • (1993) Ann Neurol , vol.34 , pp. 752-754
    • Mayeux, R.1    Stern, Y.2    Ottman, R.3
  • 6
    • 0028167193 scopus 로고
    • Confirmation of the ε4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease
    • Brousseau T, Legrain S, Berr C, Gourlet V, Vidal O, Amouyel P. Confirmation of the ε4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease. Neurology. 1994;44:342-344.
    • (1994) Neurology , vol.44 , pp. 342-344
    • Brousseau, T.1    Legrain, S.2    Berr, C.3    Gourlet, V.4    Vidal, O.5    Amouyel, P.6
  • 7
    • 0028167195 scopus 로고
    • ApoE allelic association with Alzheimer's disease
    • Peacock ML, Fink JK. ApoE allelic association with Alzheimer's disease. Neurology. 1994;44:339-341.
    • (1994) Neurology , vol.44 , pp. 339-341
    • Peacock, M.L.1    Fink, J.K.2
  • 8
    • 0028301820 scopus 로고
    • Apolipoprotein E: risk factor for Alzheimer disease
    • Tsai MS, Tangalos EG, Petersen RC, et al. Apolipoprotein E: risk factor for Alzheimer disease. Am J Hum Genet. 1994;54:643-649.
    • (1994) Am J Hum Genet , vol.54 , pp. 643-649
    • Tsai, M.S.1    Tangalos, E.G.2    Petersen, R.C.3
  • 9
    • 23444438235 scopus 로고
    • The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease
    • Yu C, Payami H, Olson JM, et al. The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease. Am J Hum Genet. 1994;54:631-642.
    • (1994) Am J Hum Genet , vol.54 , pp. 631-642
    • Yu, C.1    Payami, H.2    Olson, J.M.3
  • 10
    • 0028178047 scopus 로고
    • Apolipoprotein E, ε4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region
    • Chartier-Harlin M, Parfitt M, Legrain S, et al. Apolipoprotein E, ε4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region. Hum Mol Genet. 1994;3:569-574.
    • (1994) Hum Mol Genet , vol.3 , pp. 569-574
    • Chartier-Harlin, M.1    Parfitt, M.2    Legrain, S.3
  • 11
    • 0027703587 scopus 로고
    • Unraveling Alzheimer's: a major cause of the disease yields to researchers
    • Beardsley T. Unraveling Alzheimer's: a major cause of the disease yields to researchers. Sci Am. 1993;11:28-30.
    • (1993) Sci Am , vol.11 , pp. 28-30
    • Beardsley, T.1
  • 12
    • 0023628422 scopus 로고
    • The prevalence of dementia: a quantitative integration of the literature
    • Jorm AF, Korten AE, Henderson AS. The prevalence of dementia: a quantitative integration of the literature. Acta Psychiatr Scand. 1987;76:465-479.
    • (1987) Acta Psychiatr Scand , vol.76 , pp. 465-479
    • Jorm, A.F.1    Korten, A.E.2    Henderson, A.S.3
  • 13
    • 0028030867 scopus 로고
    • Prevalence and types of dementia in the very old
    • Ebly EM, Parhad IM, Hogan DB, Fung TS. Prevalence and types of dementia in the very old. Neurology. 1994;44:1593-1600.
    • (1994) Neurology , vol.44 , pp. 1593-1600
    • Ebly, E.M.1    Parhad, I.M.2    Hogan, D.B.3    Fung, T.S.4
  • 15
    • 0027921553 scopus 로고
    • Apolipoprotein E ε4 allele and Alzheimer's disease
    • Ben-Shlomo Y, Lewis G, McKeigue PM. Apolipoprotein E ε4 allele and Alzheimer's disease. Lancet. 1993;342:1310.
    • (1993) Lancet , vol.342 , pp. 1310
    • Ben-Shlomo, Y.1    Lewis, G.2    McKeigue, P.M.3
  • 16
    • 0028289658 scopus 로고
    • Diagnosis of Alzheimer's disease by apolipoprotein E genotyping
    • Van Gool WA, Hijdra A. Diagnosis of Alzheimer's disease by apolipoprotein E genotyping. Lancet. 1994;344:275.
    • (1994) Lancet , vol.344 , pp. 275
    • Van Gool, W.A.1    Hijdra, A.2
  • 17
    • 0027369055 scopus 로고
    • Is the incidence of dementing illness changing? a 25-year time trend study in Rochester, Minnesota (1960-1984)
    • Kokmen E, Beard CM, O’Brein PC, Offord MS, Kurland LT. Is the incidence of dementing illness changing? a 25-year time trend study in Rochester, Minnesota (1960-1984). Neurology. 1993;43:1887-1892.
    • (1993) Neurology , vol.43 , pp. 1887-1892
    • Kokmen, E.1    Beard, C.M.2    O’Brein, P.C.3    Offord, M.S.4    Kurland, L.T.5
  • 18
    • 0027457545 scopus 로고
    • Incidence of dementia and probable Alzheimer's disease in a general population: The Framingham Study
    • Bachman DL, Wolf PA, Linn RT, et al. Incidence of dementia and probable Alzheimer's disease in a general population: The Framingham Study. Neurology. 1993;43:515-519.
    • (1993) Neurology , vol.43 , pp. 515-519
    • Bachman, D.L.1    Wolf, P.A.2    Linn, R.T.3
  • 19
    • 0028057995 scopus 로고
    • Estimating the probability for major gene Alzheimer disease
    • Farrer LA, Cupples LA. Estimating the probability for major gene Alzheimer disease. Am J Hum Genet. 1994;54:374-383.
    • (1994) Am J Hum Genet , vol.54 , pp. 374-383
    • Farrer, L.A.1    Cupples, L.A.2
  • 20
    • 0022506213 scopus 로고
    • Rates of senile dementia-Alzheimer's type in the Baltimore longitudinal study
    • Sayetta RB. Rates of senile dementia-Alzheimer's type in the Baltimore longitudinal study. J Chron Dis. 1986;39:271-286.
    • (1986) J Chron Dis , vol.39 , pp. 271-286
    • Sayetta, R.B.1
  • 23
    • 0028286934 scopus 로고
    • Lack of association between apolipoprotein E allele ε4 and sporadic Alzheimer's disease
    • Lannfelt L, Lilius L, Nastase M, et al. Lack of association between apolipoprotein E allele ε4 and sporadic Alzheimer's disease. Neurosci Lett. 1994;169:175-178.
    • (1994) Neurosci Lett , vol.169 , pp. 175-178
    • Lannfelt, L.1    Lilius, L.2    Nastase, M.3
  • 24
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261:921-923.
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 25
    • 0027919960 scopus 로고
    • Apolipoprotein E genotype and Alzheimer's disease
    • Payami H, Kaye J, Heston LL, et al. Apolipoprotein E genotype and Alzheimer's disease. Lancet. 1993;342:738.
    • (1993) Lancet , vol.342 , pp. 738
    • Payami, H.1    Kaye, J.2    Heston, L.L.3
  • 27
    • 0027921538 scopus 로고
    • Apolipoprotein E-ε4 allele and Alzheimer's disease
    • Czech C, Monning U, Tienari P, et al. Apolipoprotein E-ε4 allele and Alzheimer's disease. Lancet. 1993;342:1309-1310.
    • (1993) Lancet , vol.342 , pp. 1309-1310
    • Czech, C.1    Monning, U.2    Tienari, P.3
  • 28
    • 0028289326 scopus 로고
    • Confirmation of association between the ε4 allele of apolipoprotein E and Alzheimer's disease
    • Liddell M, Williams J, Bayer A, Kaiser F, Owen M. Confirmation of association between the ε4 allele of apolipoprotein E and Alzheimer's disease. J Med Genet. 1994;31:197-200.
    • (1994) J Med Genet , vol.31 , pp. 197-200
    • Liddell, M.1    Williams, J.2    Bayer, A.3    Kaiser, F.4    Owen, M.5
  • 29
    • 0028274248 scopus 로고
    • Association of apolipoprotein E ε4 with vascular dementia
    • Frisoni GB, Bianchetti A, Govoni, S et al. Association of apolipoprotein E ε4 with vascular dementia. JAMA. 1994;271:1317.
    • (1994) JAMA , vol.271 , pp. 1317
    • Frisoni, G.B.1    Bianchetti, A.2    Govoni, S.3
  • 30
    • 0028167740 scopus 로고
    • Association of apolipoprotein E phenotypes with late onset Alzheimer's disease
    • Kuusisto J, Koivisto K, Kervinen K, et al. Association of apolipoprotein E phenotypes with late onset Alzheimer's disease. BMJ. 1994;309:636-638.
    • (1994) BMJ , vol.309 , pp. 636-638
    • Kuusisto, J.1    Koivisto, K.2    Kervinen, K.3
  • 31
    • 0027921538 scopus 로고
    • Apolipoprotein E-ε4 allele and Alzheimer's disease
    • Lucotte G, David F, Visvikis S, et al. Apolipoprotein E-ε4 allele and Alzheimer's disease. Lancet. 1993;342:1309.
    • (1993) Lancet , vol.342 , pp. 1309
    • Lucotte, G.1    David, F.2    Visvikis, S.3
  • 32
    • 0027203749 scopus 로고
    • Apolipoprotein E genotype and Alzheimer's disease
    • Noguchi S, Murakami K, Yamada N. Apolipoprotein E genotype and Alzheimer's disease. Lancet. 1993;342:737.
    • (1993) Lancet , vol.342 , pp. 737
    • Noguchi, S.1    Murakami, K.2    Yamada, N.3
  • 33
    • 0027146623 scopus 로고
    • A high frequency of apolipoprotein ε4 isoprotein in Japanese patients with late-onset nonfamilial Alzheimer's disease
    • Ueki A, Kawano M, Namba Y, Kawakami M, Ikeda K. A high frequency of apolipoprotein ε4 isoprotein in Japanese patients with late-onset nonfamilial Alzheimer's disease. Neurosci Lett. 1993;163:166-168.
    • (1993) Neurosci Lett , vol.163 , pp. 166-168
    • Ueki, A.1    Kawano, M.2    Namba, Y.3    Kawakami, M.4    Ikeda, K.5
  • 34
    • 0028364004 scopus 로고
    • Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein C genes due to linkage disequilibrium?
    • Tsuda T, Lopez R, Rogaeva EA, et al. Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein C genes due to linkage disequilibrium? Ann Neurol. 1994;36:97-100.
    • (1994) Ann Neurol , vol.36 , pp. 97-100
    • Tsuda, T.1    Lopez, R.2    Rogaeva, E.A.3
  • 36
    • 0027946816 scopus 로고
    • Predictive value of apolipoprotein E genotyping in Alzheimer's disease
    • Nalbantoglu J, Gilfix BM, Bertrand P, et al. Predictive value of apolipoprotein E genotyping in Alzheimer's disease. Ann Neurol. 1994;36:889-895.
    • (1994) Ann Neurol , vol.36 , pp. 889-895
    • Nalbantoglu, J.1    Gilfix, B.M.2    Bertrand, P.3
  • 37
    • 0028026997 scopus 로고
    • Apolipoprotein ε4 allele in a population-based study of early-onset Alzheimer's disease
    • van Duijn C, de Knijff P, Cruts M, et al. Apolipoprotein ε4 allele in a population-based study of early-onset Alzheimer's disease. Nat Genet. 1994;7:74-78.
    • (1994) Nat Genet , vol.7 , pp. 74-78
    • Van Duijn, C.1    De, K.2    Cruts, M.3
  • 38
    • 17444451748 scopus 로고
    • ApoE-ε4 and early-onset Alzheimer's
    • Okuizumi K, Onodera O, Tanaka H, et al. ApoE-ε4 and early-onset Alzheimer's. Nat Genet. 1994;7:10-11.
    • (1994) Nat Genet , vol.7 , pp. 10-11
    • Okuizumi, K.1    Onodera, O.2    Tanaka, H.3
  • 41
    • 0028359655 scopus 로고
    • Genetic associations with human longevity at the APOE and ACE loci
    • Schachter F, Faure-Delanef L, Guenot F, et al. Genetic associations with human longevity at the APOE and ACE loci. Nat Genet. 1994;6:29-32.
    • (1994) Nat Genet , vol.6 , pp. 29-32
    • Schachter, F.1    Delanef, F.2    Guenot, F.3    et, A.L.4
  • 42
    • 0028064688 scopus 로고
    • The association between apolipoprotein E allele epsilon 4 and late-onset Alzheimer's disease
    • Riggs JE, Keefover RW. The association between apolipoprotein E allele epsilon 4 and late-onset Alzheimer's disease. Arch Neurol. 1994;51:750.
    • (1994) Arch Neurol , vol.51 , pp. 750
    • Riggs, J.E.1    Keefover, R.W.2
  • 43
    • 0028345557 scopus 로고
    • Prevalence of dementia in old age: clinical diagnoses in subjects aged 95 years and older
    • Wernicke TF, Reischies FM. Prevalence of dementia in old age: clinical diagnoses in subjects aged 95 years and older. Neurology. 1994;44:250-253.
    • (1994) Neurology , vol.44 , pp. 250-253
    • Wernicke, T.F.1    Reischies, F.M.2
  • 44
    • 0027994071 scopus 로고
    • If we live long enough, will we all be demented?
    • Drachman DA. If we live long enough, will we all be demented? Neurology. 1994;44:1563-1565.
    • (1994) Neurology , vol.44 , pp. 1563-1565
    • Drachman, D.A.1
  • 45
    • 0029037609 scopus 로고
    • Lack of association of apolipoprotein E allele ε4 with late-onset Alzheimer's disease among Finnish centenarians
    • Sobel E, Louhija J, Sulkava R, et al. Lack of association of apolipoprotein E allele ε4 with late-onset Alzheimer's disease among Finnish centenarians. Neurology. 1995;45:903-907
    • (1995) Neurology , vol.45 , pp. 903-907
    • Sobel, E.1    Louhija, J.2    Sulkava, R.3
  • 46
    • 0028169648 scopus 로고
    • Reduced apolipoprotein ε4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals
    • Rebeck GW, Perls TT, West HL, Sodhi P, Lipsitz LA, Hyman BT. Reduced apolipoprotein ε4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals. Neurology. 1994;44:1513-1516.
    • (1994) Neurology , vol.44 , pp. 1513-1516
    • Rebeck, G.W.1    Perls, T.T.2    West, H.L.3    Sodhi, P.4    Lipsitz, L.A.5    Hyman, B.T.6
  • 47
    • 0028325294 scopus 로고
    • Alzheimer's disease, apolipoprotein ε4 and gender
    • Payami H, Montee KR, Kaye JA, et al. Alzheimer's disease, apolipoprotein ε4 and gender. JAMA. 1994;271:1316-1317.
    • (1994) JAMA , vol.271 , pp. 1316-1317
    • Payami, H.1    Montee, K.R.2    Kaye, J.A.3
  • 48
    • 0028305380 scopus 로고
    • Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
    • Corder EH, Saunders AM, Risch NJ, et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet. 1994;7:180-184.
    • (1994) Nat Genet , vol.7 , pp. 180-184
    • Corder, E.H.1    Saunders, A.M.2    Risch, N.J.3
  • 49
    • 18744430888 scopus 로고
    • Protective effect of apo epsilon 2 in Alzheimer's disease
    • Smith AD, Johnson C, Sim E, et al. Protective effect of apo epsilon 2 in Alzheimer's disease. Lancet. 1994;344:473-474.
    • (1994) Lancet , vol.344 , pp. 473-474
    • Smith, A.D.1    Johnson, C.2    Sim, E.3
  • 51
    • 0026453496 scopus 로고
    • Lipoprotein and apolipoprotein profile in men with ischemic stroke
    • Pedro-Botet J, Senti M, Nogues X, et al. Lipoprotein and apolipoprotein profile in men with ischemic stroke. Stroke. 1992;23:1556-1562.
    • (1992) Stroke , vol.23 , pp. 1556-1562
    • Pedro-Botet, J.1    Senti, M.2    Nogues, X.3
  • 52
    • 0027178862 scopus 로고
    • Apolipoprotein ε4 allele frequency, ischemic cerebrovascular disease, and Alzheimer's disease
    • Saunders AM, Roses AD. Apolipoprotein ε4 allele frequency, ischemic cerebrovascular disease, and Alzheimer's disease. Stroke 1993;24:1416-1417.
    • (1993) Stroke , vol.24 , pp. 1416-1417
    • Saunders, A.M.1    Roses, A.D.2
  • 53
    • 0027365822 scopus 로고
    • Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease
    • Schmechel DE, Saunders AM, Strittmatter WJ, et al. Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci U S A. 1993;90:9649-9653.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 9649-9653
    • Schmechel, D.E.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 54
    • 0028133025 scopus 로고
    • ApoE: new risk factor for Alzheimer's
    • Butler RN. ApoE: new risk factor for Alzheimer's. Geriatrics. 1994;49:10-11.
    • (1994) Geriatrics , vol.49 , pp. 10-11
    • Butler, R.N.1


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