2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced anorexia and wasting syndrome in rats: aggravation after ventromedial hypothalamic lesion

European Journal of Pharmacology: Environmental Toxicology and

Volumn 293, Issue 4, 1995, Pages 309-317

  Tuomisto, Jouni T ^a   Pohjanvirta, Raimo ^a   Unkila, Mikko ^a   Tuomisto, Jouko ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

(Rat); 2,3,7,8 Tetrachlorodibenzo p dioxin; Appetite; Body weight; Eating; Ventromedial hypothalamic nucleus

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; GLUCOSE; INSULIN; METIROSINE; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARTICLE; BODY WEIGHT; BRAIN INJURY; CACHEXIA; CONTROLLED STUDY; FEMALE; FOOD INTAKE; HISTOLOGY; HYPERPHAGIA; HYPOPHAGIA; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; WEIGHT REDUCTION; HYPOTHALAMUS LESION; WASTING SYNDROME;

ANIMAL; BLOOD GLUCOSE; CACHEXIA; EATING DISORDERS; FEMALE; HYPOTHALAMUS; INSULIN; MALE; NOREPINEPHRINE; RATS; SUPPORT, NON-U.S. GOV'T; TETRACHLORODIBENZODIOXIN;

EID: 0028973335     PISSN: 09266917     EISSN: None     Source Type: Journal    
DOI: 10.1016/0926-6917(95)90050-0     Document Type: Article

References (43)

1. Central receptors and recognition sites mediating the effects on monoamines and anorectic drugs on feeding behavior
2. Pharmacological approaches to appetite suppression
3. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis
4. Experimental obesity: a homeostatic failure due to defective nutrient stimulation of the sympathetic nervous system
5. Effects of 2,4-dichlorophenoxyacetic acid (2,4-D) on biogenic amines and their metabolites in brain and cerebrospinal fluid of rats
6. Molecular mapping of obesity genes
7. Dose-response and time course of hypothyroxinemia and hypoinsulinemia and characterization of insulin hypersensitivity in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats
8. Reduced gluconeogenesis in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated rats
9. Hypothalamic lesions and adiposity in the rat
10. The regulation of body weight
11. The role of a depot fat in the hypothalamic control of food intake in the rat
12. Hypothalamic monoamine systems for control of food intake, analysis of meal patterns and macronutrient selection
13. Opioids: Are they regulators of feeding
14. Application of high performance liquid chromatography with electrochemical detection to neurochemical analysis: Measurements of catecholamines, serotonin and metabolites in rat brain
15. Appetite regulation: The role of peptides and hormones
16. The pharmacology of eating behavior
17. Neuronal histamine in the hypothalamus suppresses food intake in rats
18. The wasting syndrome in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity: basic features and their interpretation
19. Letter to the Editor
20. Remarkable residual alterations in responses to feeding regulatory challenges in Han/Wistar rats after recovery from the acute toxicity of TCDD
21. 2,3,7,8-Tetrachlorodibenzo-p-dioxin enhances responsiveness to post-ingestive satiety signals
22. Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals: effects, mechanisms, and animal models
23. Han/Wistar rats are exceptionally resistant to TCDD. I
24. Target tissue morphology and serum biochemistry following 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in a TCDD-susceptible and a TCDD-resistant rat strain
25. The loss of glucoprivic feeding is an early-stage alteration in TCDD-treated Han/Wistar rats
26. 14C-TCDD in a TCDD-susceptible and TCDD-resistant rat strain
27. Characterization of the enhanced responsiveness to postingestive satiety signals in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated Han/Wistar rats
28. Comparative acute lethality of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 1,2,3,7,8-pentachlorodibenzo-p-dioxin and 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin in the most TCDD-susceptible and the most TCDD-resistant rat strain
29. TCDD-induced hypophagia is not explained by nausea
30. Accelerated norepinephrine turnover in peripheral tissues after ventromedial hypothalamic stimulation in rats
31. Neurochemical mechanism of action of anorectic drugs
32. Body weight regulation in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin
33. Body weight regulation in rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin
34. Acute neurobehavioural effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Han/Wistar rats
35. Depletion of brain serotonin does not alter 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced starvation syndrome in the rat
36. Changes in rat brain monoamines, monoamine metabolites and histamine after a single administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
37. Effect of a single dose of TCDD on the level of histamine in discrete nuclei in rat brain
38. Effect of a single lethal dose of TCDD on the levels of monoamines, their metabolites and tryptophan in discrete brain nuclei and peripheral tissues of Long-Evans rats
39. Dose response and time course of alterations in tryptophan metabolism by 2378-tetrachlorodibenzo-p-dioxin (TCDD) in the most TCDD-susceptible and the most TCDD-resistant rat strain relationship with TCDD lethality
40. Ventromedial hypothalamic lesions abolish compensatory reduction in energy expenditure to weight loss
41. 2-adrenergic receptors
42. Positional cloning of the mouse obese gene and its human homologue