Identification of a Gs coupling domain in the amino terminus of the third intracellular loop of the α2A-adrenergic receptor: Evidence for distinct structural determinants that confer Gs versus Gi coupling

Journal of Biological Chemistry

Volumn 270, Issue 42, 1995, Pages 24753-24760

  Eason, Margaret G ^a   Liggett, Stephen B ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRICETINAE; CRICETULUS GRISEUS;

ALPHA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; GTP BINDING PROTEINS; GUANINE NUCLEOTIDE BINDING PROTEIN; RECEPTORS, ADRENERGIC, ALPHA 2; SEROTONIN RECEPTOR; ADENYLATE CYCLASE; ADRENALIN; ALPHA 2A ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BRIMONIDINE; CHOLERA TOXIN; FORSKOLIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; PERTUSSIS TOXIN; SEROTONIN; SEROTONIN 1A RECEPTOR; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOSYNTHESIS; CHEMISTRY; CHO CELL; HAMSTER; HUMAN; METABOLISM; MOLECULAR GENETICS; STRUCTURE ACTIVITY RELATION; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; CONTROLLED STUDY; DELETION MUTANT; ENZYME ACTIVATION; FIBROBLAST CULTURE; GENE EXPRESSION; GENETIC RECOMBINATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMAL; CHO CELLS; CYCLIC AMP; GTP-BINDING PROTEINS; HAMSTERS; HUMAN; MOLECULAR SEQUENCE DATA; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028973233     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.270.42.24753     Document Type: Article

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