Carazolol: a potent, selective β3-adrenoceptor agonist

European Journal of Pharmacology: Molecular Pharmacology

Volumn 291, Issue 3, 1995, Pages 359-366

  Méjean, Annick ^a   Guillaume, Jean Luc ^a   Strosberg, A Donny ^a  

^a CNRS   (France)

Author keywords

Adenylyl cyclase; Carazolol; Lipolyse; Adrenoceptor antagonist; 3 Adrenoceptor agonist

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; ADENYLATE CYCLASE; ADRENALIN; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; BUPRANOLOL; CARAZOLOL; CYANOPINDOLOL I 125; DITHIOTHREITOL; ISOPRENALINE; RECEPTOR SUBTYPE; REDUCING AGENT;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; LIPOLYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ANIMAL; BINDING, COMPETITIVE; CELLS, CULTURED; CHO CELLS; COMPARATIVE STUDY; DITHIOTHREITOL; HAMSTERS; LIPOLYSIS; PROPANOLAMINES; RECEPTORS, ADRENERGIC, BETA; SUPPORT, NON-U.S. GOV'T;

EID: 0028972934     PISSN: 09224106     EISSN: None     Source Type: Journal    
DOI: 10.1016/0922-4106(95)90077-2     Document Type: Article

References (40)

1. Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs
2. Cardiac action of carazolol and methypranol in comparison with other β-receptor blockers
3. Comparative investigation on the cardio-protective action of the β-blockers carazolol, propranolol and pindolol in rats
4. Body composition of animal treated with partitioning agents: implication for human health
5. 3-adrenergic receptor
6. 3-adrenoceptor
7. Atypical characteristics of the β-adrenoceptor mediating cyclic AMP generation and lipolysis in the rat adipocyte
8. Agonist and antagonist characterization of a putative adrenoceptor with distinct pharmacological properties form the α and β subtypes
9. Changes in renal functions during β-blocker carazolol administration in acute heat-stressed pigs
10. An investigation of the β-adrenoreceptor that mediates metabolic responses to the novel agonist BRL 28410 in rat soleus muscle
11. Structural features required for ligand binding to the β-adrenergic receptor
12. 2-adrenergic receptor
13. 3-adrenoceptor: the search for a physiological function
14. 3-adrenergic receptor - Relationship with atypical receptors
15. 3-adrenergic receptor
16. Atypical β-adrenergic receptor in 3T3-F442A adipocytes
17. Site-directed mutagenesis of β-adrenergic receptors
18. 3-adrenergic receptor
19. CGP 1277A modulates brown fat adenylate cyclase by interacting with two distinct receptor sites
20. Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells
21. The effect of carazolol on the cardiovascular responses to adrenaline in stress sensitive pigs
22. Investigations on the exogenous influencing of the spontaneous tumour rate in rats
23. Synthesis of iodine 125 labeled (+/-)-15(4-azidobenzyl) carazolol: a potent beta-adrenergic photoaffinity probe
24. Control of prostaglandin-induced parturition in sows by injection of the β-adrenergic blocking agent carazolol or carazolol and oxytocin
25. Treatment of arterial hypertension. Efficacy and tolerance of the beta receptor blocker carazolol in a field study
26. 3-adrenergic receptor mRNA in man
27. Photoaffinity labeling of the β-adrenergic receptor
28. The affinity of carazolol for myocardial and tracheal β-adrenoceptors activated by (−)-isoprenaline
29. 3-adrenergic recetors rential agonist activation of recombinant receptors in chinese hamster ovary cells
30. Recent advances in beta-adrenergic blocking agents
31. 3H]CGP-12177, generally classified as an antagonist, is a thermogenic agonist in brown adipose tissue
32. 1-adrenergic receptor: structural evidence for existence of disulfide bridges essential for ligand binding
33. An adipose tissue-specific β-adrenergic receptor
34. 3-adrenergic receptor: relationship with the atypical receptor of adipocytes
35. Structure, function and regulation of adrenergic receptors
36. Expression of three human β-adrenergic-receptor subtypes in transfected Chinese hamster ovary cells
37. Characterization of the binding domain of the β-adrenergic receptor with the fluorescent antagonist carazolol
38. 1-adrenergic receptors of turkey erythrocyte membranes
39. The rat lipolytic β-adrenoceptor: studies using novel β-adrenoceptor agonists
40. 3-adrenoceptor’?