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Volumn 3, Issue 3, 1995, Pages 263-272

Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; SERINE PROTEINASE; TRANSCRIPTION FACTOR;

EID: 0028972845     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/1074-7613(95)90112-4     Document Type: Review
Times cited : (385)

References (101)
  • 3
    • 0024294357 scopus 로고
    • Activation of DNA binding activity in an apparently cytoplasmic precursor of the NFKB transcription factor
    • (1988) Cell , vol.53 , pp. 211-217
    • Baeuerle1    Baltimore2
  • 4
    • 0023724778 scopus 로고
    • IκB: a specific inhibitor of the NFκB transcription factor
    • (1988) Science , vol.242 , pp. 540-546
    • Baeuerle1    Baltimore2
  • 5
    • 0024759789 scopus 로고
    • A 65-kD subunit of active NF-κB is required for inhibition of NF-κB by lκB
    • (1989) Genes Dev. , vol.3 , pp. 1689-1698
    • Baeuerle1    Baltimore2
  • 7
    • 0027332498 scopus 로고
    • The IκB proteins: multifunctional regulators of Rel/NF-κB transcription factors
    • (1993) Genes Dev. , vol.7 , pp. 2064-2070
    • Beg1    Baldwin2
  • 9
    • 0027207242 scopus 로고
    • Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of lκBα: a mechanism for NF-KB activation
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3301-3310
    • Beg1    Finco2    Nantermet3    Baldwin4
  • 10
    • 0025149657 scopus 로고
    • Cloning of a mitogen-inducible gene encoding a κB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs
    • (1990) Nature , vol.348 , pp. 76-80
    • Bours1    Villalobos2    Burd3    Kelly4    Siebenlist5
  • 16
    • 0024414477 scopus 로고
    • Transcriptional induction of the murine c-rel gene with serum and phorbol-12-myristate-13-acetate in fibroblasts
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 5239-5243
    • Bull1    Hunter2    Verma3
  • 20
    • 0028018268 scopus 로고
    • The ubiquitin-proteasome proteolytis pathway
    • (1994) Cell , vol.79 , pp. 13-21
    • Ciechanover1
  • 22
    • 0027317849 scopus 로고
    • IκBα can localize in the nucleus but shows no direct transactivation potential
    • (1993) Oncogene , vol.8 , pp. 2567-2573
    • Cressman1    Taub2
  • 23
    • 0028097037 scopus 로고
    • Physiologic turnover of nuclear factor κB by nuclear proteolysis
    • (1994) J. Biol. Chem. , vol.269 , pp. 26594-26597
    • Cressman1    Taub2
  • 24
    • 0027212534 scopus 로고
    • Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-κB proteins in human monocytic THP-1 cells
    • (1993) J. Biol. Chem. , vol.268 , pp. 11803-11810
    • Cordle1    Donald2    Read3    Hawinger4
  • 30
    • 0028172869 scopus 로고
    • Inducible phosphorylation of IκBα is not sufficient for its dissociation from NF-κB and is inhibited by protease inhibitors
    • (1994) Proc. NatL Acad. Sci. USA , vol.91 , pp. 11884-11888
    • Finco1    Beg2    Baldwin3
  • 31
    • 0027184023 scopus 로고
    • The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-κB p50 homodimers
    • (1993) Genes Dev. , vol.7 , pp. 1354-1363
    • Fujita1    Nolan2    Liou3    Scott4    Baltimore5
  • 32
    • 0027078835 scopus 로고
    • IκB/MAD-3 masks the nuclear localization signal of NF-κB p65 and requires the transactivation domain to inhibit NF-κB p65 DNA binding
    • (1992) Mol. Biol. Cell , vol.3 , pp. 1339-1352
    • Ganchi1    Sun2    Greene3    Ballard4
  • 33
    • 0026486817 scopus 로고
    • cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates
    • (1992) Cell , vol.71 , pp. 613-621
    • Geisler1    Bergmann2    Hiromi3    Nusslein-Volhard4
  • 34
    • 0025266685 scopus 로고
    • Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB
    • (1990) Nature , vol.344 , pp. 678-682
    • Ghosh1    Baltimore2
  • 38
    • 0025599398 scopus 로고
    • Structure and autoregulation of the c-rel promoter
    • (1990) Oncogene , vol.5 , pp. 1843-1850
    • Hannink1    Temin2
  • 41
    • 0027165587 scopus 로고
    • Common structural constituents confer IκB activity to NF-κB p105 and IκB/ Mad-3
    • (1993) EMBO J. , vol.12 , pp. 2781-2788
    • Hatada1    Naumann2    Scheidereit3
  • 48
  • 49
    • 0343755626 scopus 로고
    • Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-κB) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 4700-4704
    • Kawakami1    Scheidereit2    Roeder3
  • 50
    • 0026491071 scopus 로고
    • Characterization of the Drosophilia cactus locus and analysis of interactions between cactus and dorsal proteins
    • (1992) Cell , vol.71 , pp. 623-635
    • Kidd1
  • 53
    • 0027453548 scopus 로고
    • Promoter analysis of the gene encoding the IκBα/MAD3 inhibitor of NF-κB: positive regulation by members of the rel/NF-κ8 family
    • (1993) EMBO J. , vol.12 , pp. 5043-5049
    • Le Bail1    Schmidt-Ullrich2    Israel3
  • 55
    • 0028032241 scopus 로고
    • Phosphorylation of NF-κB1-p50 is involved in NF-κ8 activation and stable DNA binding
    • (1994) J. Biol. Chem. , vol.269 , pp. 30089-30092
    • Li1    Dai2    Chen3    Longo4
  • 56
    • 0028981050 scopus 로고
    • Activation of NF-κB requires proteolysis of the inhibitor IκBa: signal-induced phosphorylation of lκBα alone does not release active NF-κB
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 552-556
    • Lin1    Brown2    Siebenlist3
  • 60
    • 0028007144 scopus 로고
    • Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers
    • (1994) J. Biol. Chem. , vol.269 , pp. 26363-26367
    • Mackman1
  • 61
    • 0027520473 scopus 로고
    • Proteolytic degradation of MAD3 (IκBa) and enhanced processing of the NF-κB precursor p105 are obligatory steps in the activation of NF-κ8
    • (1993) Nucl. Acid Res. , vol.21 , pp. 5059-5066
    • Mellits1    Hay2    Goodbourn3
  • 62
    • 0026675781 scopus 로고
    • Molecular cloning and characterization of a novel ReI/NF-κB family member displaying structural and functional homology to NF-κB p50/p105
    • (1992) DNA Cell. Biol. , vol.12 , pp. 685-695
    • Mercurio1    Didonato2    Rosette3    Karin4
  • 64
    • 0028181648 scopus 로고
    • Enhanced IκBa degradation is responsible for constitutive NF-κB activity in mature murine B-cell lines
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3276-3282
    • Miyamoto1    Chiao2    Verma3
  • 67
    • 0023176085 scopus 로고
    • An inducible transcription factor activates expression of human immunodeficiency virus in T cells
    • (1987) Nature , vol.326 , pp. 711-713
    • Nabel1    Baltimore2
  • 68
    • 0028170265 scopus 로고
    • Activation of NF-κB in vivo is regulated by multiple phosphorylations
    • (1994) EMBO J. , vol.13 , pp. 4597-4607
    • Naumann1    Scheidereit2
  • 69
    • 0027472317 scopus 로고
    • The NF-κB precursor p105 and the proto-oncogene product Bcl-3 are IκB molecules and control nuclear translocation of NF-κB
    • (1993) EMBO J. , vol.12 , pp. 213-222
    • Naumann1    Wulczyn2    Scheidereit3
  • 70
    • 0026476683 scopus 로고
    • Identification of complex formation between two intracellular tyrosine kinase substrates; human c-Rel and the p105 precursor of p50 NF-κB
    • (1992) Oncogene , vol.7 , pp. 2095-2104
    • Neumann1    Tsapos2    Scheppler3    Ross4    Franza5
  • 71
    • 0025975795 scopus 로고
    • DNA binding and IκB inhibition of the cloned p65 subunit of NF-κB, a rel-related polypeptide
    • (1991) Cell , vol.60 , pp. 961-969
    • Nolan1    Ghosh2    Liou3    Tempst4    Baltimore5
  • 72
    • 0027980321 scopus 로고
    • The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
    • (1994) Cell , vol.78 , pp. 773-785
    • Palombella1    Rando2    Goldberg3    Maniatis4
  • 73
    • 0027451924 scopus 로고
    • In vivo control of NF-κB activation by IκBa
    • (1993) EMBO J. , vol.12 , pp. 4685-4695
    • Rice1    Ernst2
  • 74
    • 0026742527 scopus 로고
    • The precursor of NF-κB p50 has IκBα like functions
    • (1992) Cell , vol.71 , pp. 243-253
    • Rice1    MacKichan2    Israel3
  • 77
    • 0024834128 scopus 로고
    • A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo
    • (1989) Cell , vol.59 , pp. 1189-1202
    • Roth1    Stein2    Nusslein-Volhard3
  • 79
    • 0024839859 scopus 로고
    • The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila
    • (1989) Cell , vol.59 , pp. 1165-1177
    • Rushlow1    Han2    Manley3    Levine4
  • 84
    • 0022930702 scopus 로고
    • Inducibility of κ immunoglobulin enhancer-binding protein NF-κ8 by a posttranslational mechanism
    • (1986) Cell , vol.47 , pp. 921-928
    • Sen1    Baltimore2
  • 85
    • 0028804551 scopus 로고
    • Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
    • (1995) Cell , vol.80 , pp. 321-330
    • Sha1    Liou2    Tuomanen3    Baltimore4
  • 86
    • 0024355977 scopus 로고
    • In vitro activation and nuclear translocation of NF-κB catalyzed by cyclic AMP-dependent protein kinase and protein kinase C
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 725-735
    • Shirakawa1    Mizel2
  • 88
    • 0024814230 scopus 로고
    • Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function
    • (1989) Cell , vol.59 , pp. 1179-1188
    • Steward1
  • 89
    • 0027168447 scopus 로고
    • NF-κB controls expression of inhibitor IκBα: evidence for an inducible autoregulatory pathway
    • (1993) Science , vol.259 , pp. 1912-1915
    • Sun1    Ganchi2    Ballard3    Greene4
  • 91
    • 0027960533 scopus 로고
    • Human T-cell leukemia virus type I tax activation of NF-κB/Rel involves phosphorylation and degradation of IκBa and ReIA (p65)mediated induction of the c-rel gene
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7377-7384
    • Sun1    Elwood2    Beraud3    Greene4
  • 93
  • 94
    • 0025812701 scopus 로고
    • Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complex
    • (1991) Science , vol.253 , pp. 762-768
    • Thompson1    Brown2    McKnight3
  • 96
    • 0028148227 scopus 로고
    • A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of lκBα that is still bound to NF-κB
    • (1994) EMBO J. , vol.13 , pp. 5433-5441
    • Traenckner1    Wilk2    Baeuerle3
  • 97
  • 100
    • 0025304791 scopus 로고
    • Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA
    • (1990) Cell , vol.61 , pp. 255-265
    • Zabel1    Baeuerle2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.