Preischaemic as well as postischaemic application of a Na+/H+ exchange inhibitor reduces infarct size in pigs

Cardiovascular Research

Volumn 30, Issue 6, 1995, Pages 945-951

  Rohmann, Sven ^a   Weygandt, Heinrich ^a   Minck, Klaus Otto ^a  

^a MERCK KGAA   (Germany)

Author keywords

Anesthetized; HOE 694; Myocardial infarct size; Myocardial ischemia; Na+ H+ exchange; Pig

Indexed keywords

3 METHYLSULFONYL 4 PIPERIDINOBENZOYL GUANIDINE; 3-METHYLSULFONYL-4-PIPERIDINOBENZOYL GUANIDINE; GUANIDINE DERIVATIVE; SODIUM PROTON EXCHANGE PROTEIN; SULFONE; (3 METHYLSULFONYL 4 PIPERIDINOBENZOYL)GUANIDINE METHANESULFONATE;

ANIMAL; ARTICLE; DRUG ANTAGONISM; FEMALE; HEART INFARCTION; HEART MUSCLE; MALE; METABOLISM; PATHOLOGY; REPERFUSION INJURY; SWINE; ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; HEART MUSCLE ISCHEMIA; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; FEMALE; GUANIDINES; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; SODIUM-HYDROGEN ANTIPORTER; SULFONES; SWINE;

EID: 0028972681     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1016/S0008-6363(95)00154-9     Document Type: Article

References (42)

1. Williamson JR, Schaffer SW, Ford C, Safer B. Contribution of tissue acidosis to ischemic injury in the perfused rat heart. Circulation 1976;53(suppl l):1-3–1-16.
2. 2+ exchange. Circ Res 1989;65:1045–1056.
3. Barry WH. Calcium and ischemic injury. Trends Cardiovasc Med 1991;1:162–166.
4. Lazdunski M, Freiin C, Vigne P. The sodium/hydrogen exchange system in cardiac cells: its biological and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J Mol Cell Cardiol 1985;17:1029–1042.
5. Mahnensmith RL, Aronson PS. The plasma membrane sodium-hydrogen exchanger and its role in physiological and pathophysiological processes. Circ Res 1985;56:773–778.
6. + exchange in isolated myocytes from adult rat heart. Am J Physiol 1989;257:C207–C213.
7. Dennis SC, Gevers W, Opie LH. Protons in ischaemia: where do they come from; where do they go? J Mol Cell Cardiol 1991;23: 1077–1086.
8. MacLeod KT. Regulation and interaction of intracellular calcium, sodium and hydrogen ions in cardiac muscle. Cardioscience 1991;2:71–85.
9. + exchange inhibitors in cardiac ischaemia. J Mol Cell Cardiol 1992;24:731–740.
10. + exchange in the sheep cardiac Purkinje fibre. J Physiol (Lond) 1990;428:441–466.
11. Yan G-H, Kleber AG. Changes in extracellular and intracellular pH and in ischemic rabbit papillary muscle. Circ Res 1992;71:460–470.
12. 2+ overload in reperfused ischemic myocardium. Annu Rev Physiol 1990;52:543–559.
13. 2+ exchange in the development of cardiac abnormalities due to calcium paradox. Eur Heart J 1983;4(suppl H):51–56.
14. Poole-Wilson PA, Harding DP, Bourdillon PDV, Tones MA. Calcium out of control. J Mol Cell Cardiol 1984;16:175–187.
15. + exchange inhibitor and its effects in cardiac ischaemia. Br J Pharmacol 1993;109:562–568.
16. + antiporter inhibitor on post-ischemic reperfusion in pig heart. J Cardiovasc Pharmacol 1994;23:72–78.
17. Nakazawa HK, Roberts DL, Klocke FJ. Quantitation of anterior descending vs. circumflex venous drainage in the canine great cardiac vein and coronary sinus. Am J Physiol 1978;234:H163–H166.
18. Laxson DD, Homans DC, Dai XZ, Sublet E, Bache RJ. Oxygen consumption and coronary reactivity in postischemic myocardium. Circ Res 1989;64:9–20.
19. Opie LH. Reperfusion injury and its pharmacologic modification. Circulation 1989;80:1049–1062.
20. + exchange in reperfusion arrhythmogeesis. Eur Heart J 1993; 14: 86(Abstract).
21. + exchange inhibition during either the ischaemic or the reperfusion period decreases reperfusion damage in rat heart. Eur Heart J 1993;14:95(Abstract)
22. Jennings RB, Reimer KA, Steenberg C. Myocardial ischaemia revisited: the osmolar load, membrane damage, and reperfusion. J Mol Cell Cardiol 1986;18:769–780.
23. + exchange in porcine brain capillary cells by EIPA and HOE 694. Pflügers Arch 1991;119(Supplement 6):R115(Abstract).
24. + antiporter isoforms using amiloride analogs and a new inhibitor exhibiting antiischemic properties. Mol Pharmacol 1993;44:1041–1046
25. Schott RJ, Rohmann S, Braun ER, Schaper W. Ischemic preconditioning reduces infarct size in swine. Circ Res 1990;66:1133–1142
26. + exchange regulates receptor-mediated phospholipase A: activation in human platelets. J Biol Chem 1986;261:8667–8673.
27. 2+ mobilization in human platelets stimulated by ADP and the tromboxane mimetic U 46619. J Biol Chem 1990;264:719–725.
28. Simehowitz L, Cragoe EJ. Regulation of human neutrophil Chemotaxis by intracellular pH. J Biol Chem 1986;261:6492–6500.
29. Kloner RA. Does reperfusion injury exist in humans? J Am Coll Cardiol 1993;21:537–545.
30. Steenbergen C, Perlman ME, London RE, Murphy E. Mechanism of preconditioning: ionic alterations. Circ Res 1993;72:112–125.
31. Kida M, Fujiwara H, Ishida M, et al. Ischemic preconditioning preserves creatine phosphate and intracellular pH. Circulation 1991;84:2495–2503.
32. 2 contributes to loss of plasma integrity during chemical hypoxia in rat hepatocytes. Biochem Biophys Res Commun 1991;174:654–659.
33. Jahangir A, Terzic A, Kurachi Y. Intracellular acidification and ADP enhance nicorandil induction of ATP sensitive potassium channel current in cardiomyocytes. Cardiovasc Res 1994;28:831–835.
34. Rohmann S, Weygandt H, Schelling P, Soei LK, Verdouw PD, Lues I. Involvement of ATP-sensitive potassium channels in preconditioning protection. Basic Res Cardiol 1994;in press.
35. Rohmann S, Weygandt H, Schelling P, et al. Effect of bimakalim (EMD 52692), an opener of ATP sensitive potassium channels, on infarct size, coronary blood flow, regional wall function, and oxygen consumption in swine. Cardiovasc Res 1994;28:858–863.
36. 2+ overload in isolated perfused rabbit heart. Circulation 1994;89:2787–2798.
37. Bugge E, Ytrehus K. Inhibition of sodium–hydrogen exchange reduces infarct size in the isolated rat heart—a protective additive to ischaemic preconditioning. Cardiovasc Res 1995;29:269–274.
38. Weis RG, Lakatta EG, Gerstenblith G. Effects of amiloride on metabolism and contractility during oxygenation in perfused rat hearts. Circ Res 1990;66:1012–1022.
39. + exchange. Am J Physiol 1993;265:H2017–H2026.
40. Murphy E, Perlman M, London RE, Steenberg C. Amiloride delays the ischaemia-induced rise in cytosolic free calcium. Circ Res 1991;68:1250–1258.
41. Orchard CH, Kentish JC. Effects of changes in pH on the contractile function of cardiac muscle. Am J Physiol 1990;258:C967–C981.
42. Vaughan Jones RD. Regulation of intracellular pH in cardiac muscle. In: Proton Passage across Cell Membranes. Chichester: John Wiley and Sons. 1988;23–46 (Ciba Foundation Symposium 139).