Cytosolic phospholipase A2

Journal of Lipid Mediators and Cell Signalling

Volumn 12, Issue 2-3, 1995, Pages 83-117

  Clark, James D ^a   Schievella, Andrea R ^a   Nalefski, Eric A ^a   Lin, Lih Ling ^a  

^a PFIZER INC   (United States)

Author keywords

Arachidonic acid; Ca2+; Ca2+ dependent lipid binding domain; Mitogen activated protein kinase; Phospholipase A2, cytosolic; Phosphorylation

Indexed keywords

ARACHIDONIC ACID; CALCIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHOLIPASE A; PROTEIN KINASE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ADENOSINE TRIPHOSPHATE; CALCIMYCIN; COLONY STIMULATING FACTOR 1; DIACYLGLYCEROL; EPIDERMAL GROWTH FACTOR; INOSITOL TRISPHOSPHATE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PERTUSSIS TOXIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE A2; PHOSPHOLIPID; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; STAUROSPORINE; THROMBIN; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR; UNINDEXED DRUG; ZYMOSAN;

AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMISTRY; CYTOSOL; ENZYME ACTIVATION; ENZYME SPECIFICITY; ENZYMOLOGY; HUMAN; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; REVIEW; ARACHIDONIC ACID METABOLISM; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL MEMBRANE; CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME REGULATION; GENETIC TRANSCRIPTION; INFLAMMATION; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SECOND MESSENGER;

AMINO ACID SEQUENCE; ANIMALS; ARACHIDONIC ACID; BINDING SITES; CALCIUM; CYTOSOL; ENZYME ACTIVATION; GTP-BINDING PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHOLIPASES A; PHOSPHORYLATION; PROTEIN KINASES; SUBSTRATE SPECIFICITY;

EID: 0028970907     PISSN: 09297855     EISSN: None     Source Type: Journal    
DOI: 10.1016/0929-7855(95)00012-F     Document Type: Article

References (139)

1. Expression and properties of two distinct classes of the phorbol ester receptor family, four conventional protein kinase C types, and a novel protein kinase
2. Conformational analysis of the polar head group in phosphatidylcholine bilayers: a structural change induced by cations
3. Pro-Leu-Ser/Thr-Pro is a cnsensus primary sequence for substrate protein phosphorylation
4. 2 in rat renal medullary interstitial cells
5. 2 inhibit release of free arachidonate in thrombin-stimulated human platelets
6. Association of protein kinase C with phospholipid vesicles
7. 2 produced in baculovirus-infected insect cells
8. 2: determination of the interfacial kinetic rate constants
9. Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release, and activation of the mitogen-activated protein kinase cascade
10. 2 activity
11. Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells
12. Synaptotagmin: a calcium sensor on the synaptic vesicle surface
13. 2 with membrane in the macrophage cell line RAW 264.7
14. Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes
15. 2 genes in embryonic mouse cells
16. 2+-dependent translocation domain with homology to PKC and GAP
17. 2 from the human monocytic cell line U937
18. Extracellular signal-regulated kinases ERKs in progress
19. Synergistic membrane interaction of the two C2 domains of synaptotagmin
20. 2 from snake venom to human secreted forms
21. 2+/phospholipid binding
22. 2 is expressed as an activated phosphoprotein in Sf9 cells
23. Synaptic transmission persists in synaptotagmin mutants of Drosophila
24. Fatty acid and phospholipid selectivity of different phospholipase A 2 enzymes studied by using a mammalian membrane as substrate
25. 2 in a mixed vesicle model
26. Platelet-derived growth factor stimulates a biphasic mobilization of arachidonic acid in Swiss 3T3 cells
27. 2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein kinase
28. 2
29. Inositol-1345-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin 11
30. The role of rab3A in neurotransmitter release
31. 2+ sensor for transmitter release at a central synapse
32. Kinetic analysis of a high molecular weight phospholipase A 2 from rat kidney: divalent metal-dependent trapping of enzyme on product-containing vesicles
33. Mastoparan, a novel mitogen for Swiss 3T3 cells, stimulates pertussis toxin-sensitive arachidonic acid release without inositol phosphate accumulation
34. Bacterial liposaccharide priming of P388DI macrophage-like cells for enhanced arachidonic acid metabolism
35. Inhibition of expression of protein kinase C by antisense cDNA inhibits phorbol ester-mediated arachidonate release
36. 2 activation
37. 2 in rat renal mesangial cells
38. Purification of a high-molecular-mass form of phospholipase AZ from rat kidney activated at physiological calcium concentrations
39. 2
40. Mitogenic signaling by epidermal growth factor (EGF), but not platelet-derived growth factor, requires arachidonic acid metabolism in BALB/c 3T3 cells
41. 2 enzymes on product-containing vesicles: application to the determination of substrate preferences
42. Signal transduction by interferon-a through arachidonic acid metabolism
43. Evidence for glomerular actions of epidermal growth factor in the rat
44. Mediation of renal vascular effects of epidermal growth factor by arachidonate metabolites
45. 2 is crucial in the cytotoxic action of tumor necrosis factor
46. Cytoplasmic phospholipase AZ activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced sythesis
47. 2
48. 2
49. 2 in rheumatoid synovial fibroblasts
50. A role for protein kinase C-α in zymosan-stimulated eicosanoid systhesis in mouse peritoneal macrophages
51. How is the level of free arachidonic acid controlled in mammalian cells?
52. Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor α
53. 2 activity in bovine rod outer segments by the βγ subunits of transducin and its inhibition by the a subunit
54. 2 by transforming growth factor-α in HEL-30 keratinocytes
55. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling
56. 2
57. 2 is a 100-kDa protein in human monoblast U937 cells
58. 2 in human platelets
59. 2 that exhibits lysophospholipase activity
60. 2 from a macrophage cell line, Raw 264.7
61. 2 in human fibroblasts
62. 2 is coupled to hormonally regulated release of arachidonic acid
63. 2 is phosphorylated and activated by MAP kinase
64. 2+-activated neurotransmitter release
65. Microdomains of high calcium concentration in a presynaptic terminal
66. 2 activity
67. Epidermal growth factor is synergistic with phorbol esters and vasopressin in stimulating arachidonate release and prostaglandin production in renal glomerular mesangial cells
68. A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans
69. Primary structure of protein moiety of Penicillium notatum phospholipase B deduced from the cDNA
70. 2 in glomerular mesangial cells
71. Potentiation of NMDA receptor currents by arachidonic acid
72. p65 fragments, homologous to the CZ region of protein kinase C, bind to the intracellular receptors for protein kinase C
73. 1-O-Alkyl-linked glycerophospholipids of human neutrophils: distribution of arachidonate and other acyl residues in the ether-linked and diacyl species
74. 2
75. Tyrosine phosphorylation and activation of mitogen-activated protein kinases by thrombin in human platelets: possible involvement in late arachidonic acid release
76. 2 activation
77. 2+-independent catalytic domain
78. 2 in alveolar type II epithelial cells: biochemical and immunologic characterization
79. 2 by p42 microtubule-associated protein 2 kinase and protein kinase C
80. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
81. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
82. Role of arachidonic acid metabolism in the mitogenic response of BALB/c 3T3 fibroblasts to epidermal growth factor
83. Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin
84. The α/β hydrolase fold
85. Direct regulation of ion channels by fatty acids
86. q-independent activation of phospholipase C-β2
87. Removal of the carboxyl-terminal region of phospholipase C-β1 by calpain abolishes activation by Gaq
88. Thromboxane biosynthesis and metabolism in relation to cardiovascular risk-factors
89. SH2 and SH3 domains: from structure to function
90. Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans
91. 2 to the nuclear fraction upon macrophage activation
92. Lipoxygenase metabolites of arachidonic acid in neuronal transmembrane signalling
93. Molecular signal integration: interplay between serine, threonine and tyrosine phosphorylation
94. 2 activation by phosphorylation in mouse peritoneal macrophages
95. 2
96. 2 in human neutrophil cytosol
97. Platelet-activating factor and leukotriene biosynthesis is inhibited in polymorphonuclear leukocytes depleted of arachidonic acid
98. Subcellular localization of prostaglandin endoperoxide synthase-2 in murine 3T3 cells
99. 2
100. Regulation of inositol phospholipid-specific phospholipase C isozymes
101. 2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets
102. 2 in human leukocytes by lipopolysaccharide
103. Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene
104. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects
105. 2 activity and protein synthesis is blocked by dexamethasone in rat mesangial cells
106. 2
107. 2
108. 2: mRNA levels and potential for transcriptional regulation. 1. Lipid
109. 2
110. Role of stimulation of arachidonic acid release in the proliferative response of 3T3 mouse fibroblasts to platelet-derived growth factor
111. Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin
112. 2 activity in isolated human platelet membranes
113. The eicosanoids and their biochemical mechanism of action
114. Prostaglandin and thromboxane biosynthesis
115. Sequence similarity of phospholipase C with the non-catalytic region of src
116. 2
117. 2 activity regulates the synthesis of platelet-activating factor in granulocytic HL-60 cells
118. 2 in macrophages in response to bacteria
119. 2 which preferentially hydrolyzes an arachidonoyl residue
120. 2
121. 2 complexed with a substrate-derived inhibitor
122. Molecular cloning of two types of GAP complementary DNA from human placenta
123. 2
124. Ras GTPase-activating protein physically associates with mitogenically active phospholipids
125. 3H]alkyl-2-arachidonyl-sn-glycero-3-phosphorylcholine to lyso platelet-activating factor by the CoA-independent transacylase in membrane fractions of human neutrophils
126. Platelet-activating factor: a phospholipid autacoid with diverse actions
127. Stimulation of arachidonic-acid release from Swiss 3T3 cells by recombinant basic fibroblast growth factor: independence from phosphoinositide turnover
128. Low molecular weight human pulmonary surfactant protein SP5: isolation, characterization, and cDNA and amino acid sequences
129. Function and regulation of expression of pulmonary surfactant-associated proteins
130. 2 in mouse spleen and the macrophage cell line J774
131. 2+ for membrane binding but not for catalytic activity
132. 2+ and mitogen-activation protein kinase regulation
133. 2 activity in the human neutrophil
134. 5-lipoxgenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes
135. Identification of critical regions on phospholipase C-β1 required for activation by G-proteins
136. 2+ in HL-60 granulocytes
137. 2+-binding domains
138. 2the cytosol to membranes in rat brain induced by calcium ions