ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans

Proceedings of the National Academy of Sciences of the United States of America

Volumn 92, Issue 7, 1995, Pages 2484-2488

  Kempf, Dale J ^a   Marsh, Kennan C ^a   Denissen, Jon F ^a   McDonald, Edith ^a   Vasavanonda, Sudthida ^a   Flentge, Charles A ^a   Green, Brian E ^a   Fino, Lynnmarie ^a   Park, Chang H ^a   Kong, Xiang Peng ^a   Wideburg, Norman E ^a   Saldivar, Ayda ^a   Ruiz, Lisa ^a   Kati, Warren M ^a   Sham, Hing L ^a   Robins, Terry ^a   Stewar, Kent D ^a   Hsu, Ann ^a   Plattner, Jacob J ^a   Leonard, John M ^a   Norbeck, Daniel W ^a   more..

^a ABBOTT LABORATORIES   (United States)

Author keywords

acquired immunodeficiency syndrome; antiviral; peptidomimetic

Indexed keywords

A 77003; A 80987; A 81525; A 82200; A 83962; ANTIVIRUS AGENT; PROTEINASE INHIBITOR; RITONAVIR; UNCLASSIFIED DRUG; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CLINICAL TRIAL; DOG; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG POTENCY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MONKEY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

ADMINISTRATION, ORAL; ANIMAL; ANTIVIRAL AGENTS; BILE; BILE DUCTS; BINDING SITES; BIOLOGICAL AVAILABILITY; CAPSULES; COMPARATIVE STUDY; FEMALE; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HIV-2; HUMAN; INJECTIONS, INTRAVENOUS; MACACA FASCICULARIS; MALE; METABOLIC CLEARANCE RATE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RITONAVIR; SUPPORT, U.S. GOV'T, P.H.S.; TABLETS; THIAZOLES; TISSUE DISTRIBUTION; VALINE;

ANIMALIA; CANIS FAMILIARIS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2;

EID: 0028968902     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.92.7.2484     Document Type: Article

References (23)