Impaired function of inhibitory G proteins during acute myocardial ischemia of canine hearts and its reversal during reperfusion and a second period of ischemia: Possible implications for the protective mechanism of ischemic preconditioning

Circulation Research

Volumn 76, Issue 5, 1995, Pages 861-870

  Niroomand, Feraydoon ^a   Weinbrenner, Christof ^a   Weis, Angelika ^a   Bangert, Matthias ^a   Schwencke, Carsten ^a   Marquetant, Rainer ^a   Beyer, Thorsten ^a   Strasser, Ruth H ^a   Kübler, Wolfgang ^a   Rauch, Bernhard ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Adenylyl cyclase; G proteins; Ischemic preconditioning; Muscarinic receptors; Myocardial ischemia; Reperfusion

Indexed keywords

ADENYLATE CYCLASE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION;

ANIMAL; CARBACHOL; DOGS; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; SARCOLEMMA; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T;

EID: 0028968259     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.76.5.861     Document Type: Article

References (42)

1. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1982;66:1150-1153.
2. Murry CE, Richard VJ, Reimer KA, Jennings RB. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode. Circ Res. 1990;66: 913-931.
3. Shiki K, Hearse DJ. Preconditioning of ischemic myocardium: reperfusion induced arrhythmias. Am J Physiol. 1987;253:H1470-H1476.
4. 1 adenosine receptors in rabbit heart. Circulation. 1991;84:350-356.
5. Thornton JD, Liu GS, Downey JM. Pretreatment with pertussis toxin blocks the protective effects of preconditioning: evidence for a G-protein mechanism. J Mol Cell Cardiol. 1993;25:311-320.
6. 1-selective adenosine analogues protects the heart against infarction. Circulation. 1992;85:659-667.
7. Toombs CF, McGee DS, Johnston WE, Vinten-Johanson J. Myocardial protective effects of adenosine: infarct size reduction with pretreatment and continued receptor stimulation during ischemia. Circulation. 1992;86:986-994.
8. Olsson RA. Changes in content of purine nucleoside in canine myocardium during coronary occlusion. Circ Res. 1970;26:301-306.
9. Londos C, Cooper DMF, Schlegel W, Rodbell M. Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis. Proc Natl Acad Sci U S A. 1978;75:5362-5366.
10. Maroko PR, Kjekshus JK, Sobel BE, Watanabe T, Covell JW, Ross J Jr, Braunwald E. Factors influencing infarct size following experimental coronary artery occlusions. Circulation. 1971;43:67-82.
11. +)-ATPase, beta-adrenergic receptor-coupled adenylate cyclase, and cAMP-dependent protein kinase activities of cardiac sarcolemmal vesicles. J Biol Chem. 1980;255: 9971-9980.
12. Colvin RA, Ashavaid TF, Herbette LG. Structure-function studies of canine cardiac sarcolemmal membranes, I: estimation of receptor site densities. Biochim Biophys Acta. 1985;812:601-608.
13. Fleming JW, Watanabe AM. Muscarinic cholinergic-receptor stimulation of specific GTP hydrolysis related to adenylate cyclase activity in canine cardiac sarcolemma. Circ Res. 1988;64:340-350.
14. Jakobs KH, Saur W, Schultz G. Reduction of adenylate cyclase activity in lysates of human platelets by the alpha-adrenergic component of epinephrine. J Cyclic Nucl Res. 1976;2:381-392.
15. Holmer RH, Stevens S, Homey CJ. Tissue- and species-specific expression of inhibitory guanine nucleotide-binding proteins: cloning of a full-length complementary DNA from canine heart. Circ Res. 1989;65:1136-1140.
16. Niroomand F, Bangert M, Beyer T, Rauch B. Reduced adenylyl cyclase inhibition by carbachol and GTP during acute myocardial ischemia. J Mol Cell Cardiol. 1992;24:471-475.
17. Schömig A, Dart AM, Dietz R, Mayer E, Kübler W. Release of endogenous catecholamines in the ischemic myocardium of the rat. Circ Res. 1984;55:689-701.
18. Corr PB, Shayman JA, Kramer JB, Kipnis RJ. Increased alpha-adrenergic receptors in ischemic cat myocardium. J Clin Invest. 1981;67:1232-1236.
19. Mukherjee A, Wong TM, Buja M, Lefkowitz RJ. Beta adrenergic and muscarinic cholinergic receptors in canine myocardium: effects of ischemia. J Clin Invest. 1979;64:1423-1428.
20. 1-receptor-independent activation of protein kinase C in acute myocardial ischemia: mechanisms for sensitization of the adenylyl cyclase system. Circ Res. 1992;70:1304-1312.
21. Schulz R, Guth BD, Pieper K, Martin C, Heusch G. Recruitment of an inotropic reserve in moderately ischemic myocardium at the expense of metabolic recovery: a model of short-term hibernation. Circ Res. 1992;70:1282-1295.
22. Corr PB, Witkowski FX, Sobel BE. Mechanisms contributing to malignant dysrhythmias induced by ischemia in the cat. J Clin Invest. 1987;61:109-119.
23. Podzuweit T, Dalby AJ, Cherry GW, Opie LH. Cyclic AMP levels in ischemic and non-ischemic myocardium following coronary artery ligation: relation to ventricular fibrillation. J Mol Cell Cardiol. 1978;10:81-94.
24. Hjalmarson A, Elmfeldt D, Herlitz J, Holmberg S, Málek I, Nyberg G, Rydén L, Swedberg K, Vedin A, Waagstein F, Waldenström A, Waldenström J, Wedel H, Wilhelmsen L, Wilhelmsson C. Effect on mortality of metoprolol in acute myocardial infarction: a double blind randomised trial. Lancet. 1981;2:823-827.
25. k opens atrial potassium channels. Science. 1987;236:442-445.
26. + channels to A1 receptors by G proteins in rat ventricular myocytes. Am J Physiol. 1990;259:H820-H826.
27. Keung CE, Karliner JS. Complex regulation of calcium current in cardiac cells. J Clin Invest. 1990;85:950-954.
28. Matsuda JJ, Lee HC, Shibata EF. Acetylcholine reversal of isoproterenol-stimulated sodium currents in rabbit ventricular myocytes. Circ Res. 1993;72:517-525.
29. Gross GJ, Auchampach JA. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res. 1992;70:223-233.
30. Thornton JD, Thornton CS, Sterling DL, Downey JM. Blockade of ATP-sensitive potassium channels increases infarct size but does not prevent preconditioning in rabbit hearts. Circ Res. 1993;72: 44-49.
31. Myers RW, Pearlman AS, Hyman RM, Goldstein RA, Kent KM, Goldstein RE, Epstein SE. Beneficial effects of vagal stimulation and bradycardia during experimental acute myocardial ischemia. Circulation. 1974;49:943-947.
32. Corr PB, Gillis RA. Role of the vagus nerve in cardiovascular changes induced by coronary occlusion. Circulation. 1974;49:86-97.
33. Zuanetti G, De Ferrari GM, Priori SG, Schwartz PJ. Protective effect of vagal stimulation on reperfusion arrhythmias in cats. Circ Res. 1987;61:429-435.
34. Bigger TJ, Kleiger RE, Fleiss JL, Rolnitzky LM, Steinman AB, Miller JP. The multicenter post-infarction research group: components of heart rate variability measured during healing of acute myocardial infarction. Am J Cardiol. 1988;61:208-215.
35. Collins MN, Billman GE. Autonomie response to coronary occlusion in animals susceptible to ventricular fibrillation. Am J Physiol. 1989;257:H1886-H1894.
36. Billman GE. Effect of carbachol and cyclic GMP on susceptibility to ventricular fibrillation. FASEB J. 1990;4:1668-1673.
37. Yoon MS, Han J, Tse WW, Rogers R. Effects of vagal stimulation, atropine, and propranolol on fibrillation threshold of normal and ischemic ventricles. Am Heart J. 1977;93:60-65.
38. Du XJ, Dart AM, Riemersma RA, Oliver MF. Failure of the cholinergic modulation of norepinephrine release during acute myocardial ischemia in the heart. Circ Res. 1990;66:950-956.
39. Asano T, Pedersen SE, Scott CW, Ross EM. Reconstitution of catecholamine-stimulated binding of guanosine 5́-O-(3-thiotriphosphate) to the stimulatory GTP-binding protein of adenylate cyclase. Biochemistry. 1984;23:5460-5467.
40. Bourne HR, Masters SB, Miller RT, Sullivan KA, Heideman W. Mutations probe structure and function of G-protein α chains. Cold Spring Harb Symp Quant Biol. 1988;53:221-228.
41. Li Y, Kloner RA. Ischemic preconditioning is not mediated by adenosine receptors in the rat heart. Circulation. 1992;86(suppl I):I-24. Abstract.
42. Wappel M, Zalewski A, Savage M, Hessen S, Goldberg S, Maroko PR. Myocardial salvage after regional beta adrenergic blockade. Am Heart J. 1989;117:37-42.