Contribution of proteasome-mediated proteolysis to the hierarchy of epitopes presented by major histocompatibility complex class I molecules

Immunity

Volumn 2, Issue 3, 1995, Pages 289-299

  Niedermann, Gabrlele ^a   Butz, Stefan ^a   Ihlenfeldt, Hans Georg ^b   Grimm, Rudolf ^c   Lucchlarl, Maria ^a   Hoschotzky, Heinz ^a   Jung, Günther ^b   Maier, Bernhard ^a   Elchmann, Klaus ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c Hewlett Packard GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; OVALBUMIN; PROTEASOME; SYNTHETIC PEPTIDE;

ALLOGENEIC RESTRICTION; ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CYTOTOXIC T LYMPHOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMAL; ANTIGEN PRESENTATION; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; CYTOTOXICITY TESTS, IMMUNOLOGIC; EPITOPES; H-2 ANTIGENS; IMMUNODOMINANT EPITOPES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; OVALBUMIN; PEPTIDE FRAGMENTS; SUPPORT, NON-U.S. GOV'T;

EID: 0028968217     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/1074-7613(95)90053-5     Document Type: Article

References (71)

1. Human transporters associated with antigen processing possess a promiscuous peptide-binding site
2. Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules
3. The essence of epitopes
4. Improved silver staining of plant proteins RNA and DNA in polyacrylamide gels
5. Interferon gamma stimulation modulates the proteolytic activity and cleavage site preference of 208 mouse proteasomes
6. Structural and serological similarity of MHC-linked LMP and proteasome (multicatalytic proteinase) complexes
7. A 3,4-dichloroisocoumarin-resistant component of the multicatalytic proteinase complex
8. Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues
9. Recognition of oligonucleotide-encoded T cell epitopes introduced into a gene unrelated to the original antigen
10. Efficient processing of an antigenic sequence for presentation by MHC class 1 molecules depends on its neighboring residues in the protein
11. Design of (ω-N(O-acyl)hydroxy amid) aminodicarboxylic acid pyrrolidides as potent inhibitors of proline-specific peptidases
12. Proteolytic processing of ovalbumin and β-galactosidase by the proteasome to yield antigenic peptides
13. MHC-linked LMP gene products specifically alter peptidase activities of the proteasome
14. Flanking sequences influence the presentation of an endogenously synthesized peptide to cytotoxic T lymphocytes
15. Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes
16. Peptide selection by class I molecules of the major histocompatibility complex
17. Structure of peptides associated with MHC class I molecules
18. Consensus motifs and peptide ligands of MHC class I molecules
19. Allele-specific motifs revealed by sequencing of selfpeptides eluted from MHC molecules
20. MHC class I expressionin mice lacking the proteasome subunit LMP-7
21. Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillo-mavirus type 16-transformed cells
22. Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes
23. A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC
24. The mechanism and functions of ATP-dependent proteases in bacterial and animal cells
25. Proteolysis, protessomes and antigen presentation
26. Presentation of viral antigen to class I major histocompatibility complex-restricted cytotoxic T lymphocytes: recognition of an immunodominant influenza hemagglutinin site by cytotoxic T lymphocytes is independent of the position of this site in the hemagglutinin translation product
27. + T cell recognition of an endogenously processed epitope is regulated primarily by residues within the epitope
28. Liposome-encapsulated antigens engender lysosomal processing for class II MHC presentation and cytosolic processing for class I presentation
29. Substrate specificity of allelic variants of the TAP peptide transporter
30. Peptide translocation by variants of the transporter associated with antigen processing
31. In vitro induction of human cytotoxic T lymphocyte responses against peptides of mutant and wild-type p53
32. Antigen processing: peptides and the proteasome
33. Dissection of major histocompatibility complex (MHC) and T cell receptor contact residues in a Kb-restricted ovalbumin peptide and an assessment of the predictive power of MHC-binding motifs
34. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy
35. Second proteasome-related gene in the human MHC clan: II region
36. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
37. Primary in vivo responses to ovalbumin: probing the predictive value of the Kb binding motif
38. Host resistance directed selectively against H-2-deficient lymphoma variants
39. Intracellular processing of hapten-modified protein for MHC class I presentation: cytoplasmic delivery by liposomes
40. Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene
41. Purification and characterization of a high molecular weight proteinase (macropain) from human erythrocytes
42. A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation
43. Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation
44. Selectivity of MHC-encoded peptide transporters from human, mouse and rat
45. Peptide size selection by the major histocompatibility complex-encoded peptide transporter
46. A molecular model of MHC class-I-restricted antigen processing
47. Introduction of soluble protein into the class 1 pathway of antigen processing and presentation
48. Carboxyacyl derivatives of cardiolipin as four-tailed hydrophobic anchors for the covalent coupling of hydrophilic proteins to liposomes
49. Mechanisms of mouse spleen dendritic cell function in the generation of influenza-specific, cytolytic T lymphocytes
50. Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation
51. Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex: properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids
52. Subunit of the ‘20S’ proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex
53. A nonimmunodominant nucleoprotein-derived peptide is presented by influenza A virus-infected H-2b cells
54. Precise prediction of a dominant class 1 MHC-restricted epitope of Listeria monocytogenes
55. pH sensitive liposomes provide an efficient means of sensitizing target cells to class I restricted CTL recognition of a soluble protein
56. Exact prediction of a natural T cell epitope
57. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented by MHC class I molecules
58. Limitations of predictive motifs revealed by cytotoxic T lymphocyte epitope mapping of the human papilloma virus E7 protein
59. Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator
60. Dominance and crypticity of T cell antigenic determinants
61. Identification of an autologous insulin B chain peptide as a target antigen for H-2Kb-restricted cytotoxic T lymphocytes
62. TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective
63. Immunodominant mink cell focus-inducing murine leukemia virus (MuLV)-encoded CTL epitope identified by its MHC class I-binding motif explains MuLV-type specificity of MCF-directed cytotoxic T lymphocytes
64. Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen
65. Altered peptidase and viral-specific T cell response in LMP2 mutant mice
66. + cytolytic T lymphocytes
67. Variable binding affinities of listeriolysin O peptides for the H-2Kd class I molecule
68. Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes
69. MHC-encoded proteasome subunits LMP2 and LMP7 are not required for efficient antigen presentation
70. An improved method of loading pH-sensitive liposomes with soluble proteins for class I restricted antigen presentation
71. d in proteasome subunit LMP2- and LMP7- deficient cells