Vaccination against lyme disease caused by diverse Borrelia burgdorferi

Journal of Experimental Medicine

Volumn 181, Issue 1, 1995, Pages 215-221

  Fikrig, Erol ^a   Telford, Sam R ^e   Wallich, Reinhard ^f   Chen, Manchuan ^c   Lobet, Yves ^g   Matuschka, Franz R ^h   Kimsey, Robert B ⁱ   Kantor, Fred S ^b   Barthold, Stephen W ^d   Spielman, Andrew ^a   FlavellS, Richard A ^c  

^a Section of Rheumatology   (United States)

^b Allergy and Immunology   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^g GLAXOSMITHKLINE BIOLOGICALS   (Belgium)

^h CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL VACCINE; HYBRID PROTEIN; OUTER MEMBRANE PROTEIN; RECOMBINANT VACCINE;

ANIMAL EXPERIMENT; ARTICLE; BORRELIA BURGDORFERI; CONTROLLED STUDY; DISEASE CARRIER; DISEASE TRANSMISSION; DRUG EFFICACY; FEMALE; GENE MUTATION; GEOGRAPHIC DISTRIBUTION; IMMUNOBLOTTING; LYME DISEASE; MOUSE; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SUBCUTANEOUS DRUG ADMINISTRATION; TICK; VACCINATION;

ANIMAL; ANTIGENS, BACTERIAL; ANTIGENS, SURFACE; ARACHNID VECTORS; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL VACCINES; BORRELIA BURGDORFERI GROUP; DNA, BACTERIAL; FEMALE; IMMUNIZATION, PASSIVE; LYME DISEASE; MICE; MICE, INBRED C3H; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TICKS; VACCINATION;

EID: 0028966088     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.181.1.215     Document Type: Article

References (25)

1. Fikrig, E., S.W. Barthold, F.S. Kantor, and R.A. Flavell. 1990. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science (Wash. DC). 250: 553-556.
2. Fikrig, E., H. Tao, F.S. Kantor, S.W. Barthold, and R.A. Flavell. 1993. Evasion of protective immunity by Borrelia burgdorferi by truncation of OspB. Proc Nat. Acad. Sci. USA. 90: 4092-4096.
3. Simon, M.M., U.E. Schaible, M.D. Kramer, C. Eckerskorn, C. Museteanu, H.K. Muller-Hermelink, and R. Wallich. 1991. Recombinant outer surface protein A from Borrelia burgdorferi induces antibodies protective against spirochetal infection in mice. J. Infect. Dis. 164: 123-132.
4. Schaible, U.E., M.D. Kramer, E. Eichmann, M. Modolell, C. Museteanu, and M.M. Simon. 1990. Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proc Natl. Acad. Sci. USA. 87: 3768-3772.
5. Fikrig, E., S.W. Barthold, D.H. Persing, X. Sen, F.S. Kantor, and R.A. Flavell. 1992. Borrelia burgdorferi strain 25015: characterization of OspA and vaccination against infection. J. Immunol. 148: 2256-2260.
6. Jonnson, M., L. Noppa, A.G. Barbour, and S. Bergstrom. 1993. Heterogeneity of outer membrane proteins in Borrelia burgdorferi: comparison of osp operons of three isolates of different geographic origins. Infect. Immun. 60: 1845-1853.
7. Sadziene, A., P.A. Rosa, P.A. Thompson, D.M. Hogan, and A.G. Barbour. 1992. Antibody-resistant mutants of Borrelia burgdorferi-. in vitro selection and characterization. J. Exp Med. 176: 799-809.
8. Schaible, U.E., R. Wallich, M.D. Kramer, L. Gem, J.F. Anderson, C. Museteanu, and M.M. Simon. 1993. Immune sera to individual Borrelia burgdorferi isolates or recombinant OspA thereof protect SCID mice against infection with the homologous strains but only partially or not at all against those of different OspA/OspB genotypes. Vaccine. 11: 1049-1054.
9. Dykhuizen, D.E., D.S. Folin, J.J. Dunn, B. Wilske, V. Preac-Mursic, R.N. Dattwyler, and B.J. Luft. 1993. Borrelia burgdorferi is clonal: implications for taxonomy and vaccine development. Proc. Natl. Acad. Sci. USA. 90: 10163-10167.
10. Coleman, J.L., R.C. Rogers, and J.L. Benach. 1992. Selection of an escape variant of Borrelia burgdorferi by use of bactericidal monoclonal antibodies to OspB. Infect. Immun. 60: 3098-3104.
11. Coleman, J.L., R.C. Rogers, P.A. Rosa, and J.L. Benach. 1994. Variations in the OspB gene of Borrelia burgdorferi result in differences in monoclonal antibody reactivity and in production of escape variants. Infect. Immun. 62: 303-307.
12. Rosa, P., D. Hogan, and T. Schwan. 1992. Recombination between major surface protein genes of Borrelia burgdorferi. Mol. Microbiol. 6: 3031-3040.
13. Wilske, B., V. Preac-Mursic, U.B. Gobel, B. Graf, S. Jauris, E. Soutschek, E. Schwab, and G. Zumstein. 1993. An OspA serotyping system for Borrelia burgdorferi based on reactivity with monoclonal antibodies and OspA sequence analysis. J. Clin. Microbiol. 31: 340-350.
14. Postic, D., C. Edlinger, C. Richaud, F. Grimont, Y. Dufresne, P. Perolat, G. Baranton, and P.A.D. Grimont. 1990. Two genomic species in Borrelia burgdorferi. Res. Microbiol. 141: 465-475.
15. Wallich, R., C. Helmes, U.E. Schaible, Y. Lobet, S.E. Moter, M.D. Kramer, and M.M. Simon. 1992. Evaluation of genetic divergence among Borrelia burgdorferi isolates by use of OspA, Fla, HSP60 and HSP70 gene probes. Infect. Immun. 60: 4856-4866.
16. Baranton, G., D. Postic, I. Saint Girons, J.C. Boerlin, J.C. Piffaretti, M. Assous, and P.A.D. Girmont. 1992. Delineation of Borrelia burgdorferi sensu stricto, Borrelia garinii sp nov., and group VS461 associated with Lyme borreliosis. Int.J. Syst. Bacteriol. 42: 378-383.
17. Boerlin, P., A.G. Bretz, D. Postic, G. Baranton, and J.C. Piffaretti. 1992. Population genetic analysis of Borrelia burgdorferi isolates by multilocus enzyme electrophoresis. Infect. Immun. 60: 1677-1683.
18. Lovrich, S.D., S.M. Callister, L.C.L. Lim, and R.F. Schell. 1993. Seroprotective groups among isolates of Borrelia burgdorferi. Infect. Immun. 61: 4367-4374.
19. Telford, S.R. Ill, E. Fikrig, S.W. Barthold, L.R. Brunet, A. Spielman, and R.A. Flavell. 1993. Protection against antigenically variable Borrelia burgdorferi conferred by recombinant vaccines. J. Exp Med. 178: 755-758.
20. Fikrig, E.F., S.R. Telford, S.W. Barthold, F.S. Kantor, A. Spielman, and R.A. Flavell. 1992. Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proc. Natl. Acad. Sci. USA. 89: 5418-5421.
21. Piesman, J., T.N. Mather, R.J. Sinsky, and A. Spielman. 1987. Duration of tick attachment and Borrelia burgdorferi transmission. J. Clin. Microbiol. 25: 557-558.
22. Anderson, J.F., J.M. Doby, A. Couatarmanac’h, F.W. Hyde, and R.C. Johnson. 1986. Differences antigeniques entre des souches de Borrelia burgdorferi. Medecine et Maladies Infectieuses. 16: 171-175.
23. Wilske, B., V. Preac-Mursic, G. Schierz, R. Kuhbeck, A.G. Barbour, and M. Kramer. 1988. Antigenic variability of Borrelia burgdorferi. Ann. N.Y. Acad. Sci. 539: 126-131.
24. Sears, J., E. Fikrig, T. Nakagawa, K. Deponte, N. Marcantonio, F. Kantor, and R.A. Flavell. 1991. Molecular mapping of OspA-mediated protection against Borrelia burgdorferi, the Lyme disease agent. J. Immunol. 147: 1995-2001.
25. Sadziene, A., A.G. Barbour, P.A. Rosa, and D.D. Thomas. 1993. An OspB mutant of Borrelia burgdorferi has reduced invasiveness in vitro and reduced infectivity in vivo. Infect. Immun. 61: 3590-3596.