Specific lesions in the extrapyramidal system of the rat brain induced by 3-nitropropionic acid (3-NPA)

Experimental Neurology

Volumn 132, Issue 1, 1995, Pages 105-115

  Pei, Geng ^a   Ebendal, Ted ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROPROPIONIC ACID; APOMORPHINE; OXIDOPAMINE; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; FEMALE; MALE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

ANIMAL; BASE SEQUENCE; BEHAVIOR, ANIMAL; BRAIN DISEASES; CORPUS STRIATUM; DOPAMINE; FEMALE; MALE; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTORS; OXIDOPAMINE; PROPIONIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NERVE GROWTH FACTOR; RNA, MESSENGER; SUBSTANTIA NIGRA; SUPPORT, NON-U.S. GOV'T; TEGMENTUM MESENCEPHALI; TYROSINE 3-MONOOXYGENASE;

EID: 0028965432     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/0014-4886(95)90064-0     Document Type: Article

References (69)

1. Hyperactivity of remaining dopaminergic neurons after partial destruction of the nigrostriatal dopaminergic system in rat
2. 3-Nitropropionate, the toxic substance of Indigofera, is a suicide inactivator of succinate dehydrogenase
3. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
4. Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid
5. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
6. Complete sequence of a cDNA encoding an active rat choline acetyltransferase: A tool to investigate the plasticity of cholinergic phenotype expression
7. Striatal damage caused by 3NP induced energy compromise is potentiated by aging
8. Neonatal hypoxic-ischemic or excitotoxic striatal injury results in a decreased adult number of substantia nigra neurons
9. Partial lesion of the substantia nigra: Relation between extent of lesion and rotational behavior
10. Glutamate neurotoxicity and disease of the nervous system
11. Inactivation of succinate dehydrogenase by 3-nitropropionate
12. Dopamine receptor binding enhancement accompanies lesion-induced behavioral supersensitivity
13. Function and evolution of the NGF family and its receptors
14. Striatal degeneration induced by mitochondrial blockade is prevented by biologically delivered NGF
15. MPTP-induced neurotoxicity and the quest for a preventative therapy for Parkinson's disease
16. Neural transplants in Parkinson's disease
17. Kinetic studies of enzymatic dopamine β-hydroxylation reaction
18. Basal ganglia degeneration, myelin alterations, and enzyme inhibition induced in mice by the plant toxin 3-nitropropanoic acid
19. Complete coding sequence of rat tyrosine hydroxylase mRNA
20. Nature and distribution of brain lesions in rats intoxicated with 3-nitropropionic acid: a type of hypoxic (energy deficient) brain damage
21. Extrapyramidal lesions induced by mildewed sugar cane poisoning
22. Mycotoxin induced encephalopathy and dystonia in children
23. Partial lesions of the dopaminergic nigrostriatal system in rat brain: Biochemical characterization
24. The relationship between loss of dopamine nerve terminal striatal (3H)spiroperidol binding and rotational behavior in unilaterally 6-hydroxydopamine-lesioned rats
25. Specificity of 6-hydroxydopamine induced degeneration of central monoamine neurons: An electron and fluorescence microscopic study with special reference to intracerebral injection on the nigrostriatal dopamine system
26. The isolation and structure identification of a toxic substance, 3-nitropropionic acid, produced by Arthrinium from mildewed sugar cane
27. The clinical practice of neurotransplantations on treatment of Parkinson's disease
28. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
29. trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development
30. Intrastriatal 3-nitropropionic acid: a behavioral assessment
31. Human and rat brain-derived neurotrophic factor and neurotrophin-3: Gene structures, distributions, and chromosomal localizations
32. Degeneration of adrenergic nerves produced by 6-hydroxy-dopamine
33. Supersensitivity of apomorphine following destruction of the ascending dopamine neurons: Quantification using the rotational model
34. Molecular and biochemical characterization of the human trk proto-oncogene
35. Methemoglobinemia in rats injected with 3-nitropropionic acid, sodium nitrite, and nitroethane
36. Mechanism of action of levodopa
37. TrkB, a neural protein-tyrosine kinase: Evidence for a full-length and two truncated receptors
38. Enhancement of dopamine-stimulated adenylate cyclase activity in rat caudate after lesion in sustantia nigra: Evidence for denervation supersensitivity
39. Intraputaminal infusion of nerve growth factor to support adrenal medullary autografts in Parkinson's disease: One-year follow-up of first clinical trial
40. Effect of β-nitropropionic acid on rat brain acetylcholinesterase
41. Chronic lesions differentially decrease tyrosine hydroxylase messenger RNA in dopaminergic neurons of the substantia nigra
42. Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system
43. 3-Carbanionic substrate analogues bind very tightly to fumarase and aspartase
44. Gene transfer and molecular cloning of the rat nerve growth factor receptor
45. Interaction of 1-methyl-4-phenylpyridinium ion (MPP+) and its analogues with the rotenone/piericidin binding site of NMDA dehydrogenase
46. High correlations between number of dopamine cells, dopamine levels and motor performance
47. 3-Nitropropionic acid-excitotoxic lesion of the hippocampus induced by an inhibitor of chemical energy metabolism
48. Inhibition of energy metabolism by 3-nitropropionic acid activates ATP-sensitive potassium channels
49. Inbibition of isocitrate lyase by 3-nitropropionate, a reaction-intermediate analogue
50. Lesions of nigrostriatal pathway reduce expression of tyrosine hydroxylase gene in residual dopaminergic neurons of substantia nigra
51. Electrophysiological evidence for involvement of cyclic adenosine monophosphate in dopamine responses of caudate neurons
52. Mitochondrial impairment reduces the threshold for in vivo NMDA-mediated neuronal death in the striatum
53. Mechanism of the neurotoxicity of MPTP
54. Differential expression of tyrosine hydroxylase mRNA in the developing rat mesencephalon
55. Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinium ion toxicity: Involvement of the glutathione system
56. The ultrapathological study of caudate nucleus in toxic cerebropathy induced by deteriorated sugarcane poisoning
57. The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat
58. Increased resistance to chronic oral 3-nitropropionic acid (3NPA) neurotoxicity in aged mice: EM and histochemical studies
59. Supersensitivity to dopamine agonists following unilateral, 6-hydroxydopamine-induced striatal lesions in mice
60. Hippocampal pyramidal cell response to 6-hydroxydopamine lesions of the rat ventral tegmental area
61. An electron microscopic study of selective, acute degeneration of sympathetic nerve terminals after administration of 6-hydroxydopamine
62. Protection of substantia nigra from MPP+neurotoxicity by N-methyl-D-aspartate antagonists
63. 6-Hydroxy-dopamine induced degeneration of central monoamine neurons
64. Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system
65. Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system
66. Dopaminergic supersensitivity in the striatum
67. Messenger RNAs for trk and the low-affinity NGF receptor in rat basal forebrain
68. Compensations after lesions of central dopaminergic neurons: Some clinical and basic implications