Cellular interactions and metabolism of aflatoxin: An update

Pharmacology and Therapeutics

Volumn 65, Issue 2, 1995, Pages 163-192

  McLean, Michelle ^a   Dutton, Michael F ^a  

^a UNIVERSITY OF NATAL   (South Africa)

Author keywords

Aflatoxin; anti mutagenic; cytochrome P450; glutathione S transferase; metabolism; mycotoxin

Indexed keywords

AFLATOXIN B1; CYTOCHROME P450; GLUTATHIONE TRANSFERASE; MYCOTOXIN;

ANIMAL CELL; ANIMAL TISSUE; BIOSYNTHESIS; CARCINOGENICITY; CHEMICAL STRUCTURE; DETOXIFICATION; DRUG METABOLISM; ENZYME ACTIVITY; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; LIPID METABOLISM; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ABNORMALITIES, DRUG-INDUCED; AFLATOXIN B1; AFLATOXINS; ANIMAL; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; CYTOCHROME P-450 ENZYME SYSTEM; DNA; HUMAN; LIVER NEOPLASMS; MUTATION; MYCOTOXICOSIS; PROTEINS; RNA; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0028965135     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/0163-7258(94)00054-7     Document Type: Review

References (224)

1. 1 in the presence of a microsomal fraction
2. 1 in human lymphocytes
3. 1
4. Research priorities for assessing the risk of multiple mycotoxin exposure to domestic animals and man: what we know and what we need to know!
5. Potential mechanisms of food-related carcinogens and anticarcinogens
6. 1-DNA adducts in cultured mammalian tracheal epithelium
7. Oncogene activation in chemical carcinogenesis
8. Aflatoxin and glutathione in domestic fowl (Gallus domesticus). I. Glutathione elevation and attenuation by high dietary methionine
9. 1-DNA binding and glutathione conjugate formation by liver preparations from rats of different ages
10. 1 with guanines in different DNA sequences
11. 1 on histamine release from human mast cells
12. The pathology of mycotoxins
13. 1-8,9-epoxide conjugating activities of two bacterially expressed alpha class glutathione S-transferase isozymes from mouse and rat
14. Structure elucidation of the fumonisins mycotoxins from Fusarium moniliforme
15. 1 leading to activation and DNA adduct formation
16. Sex specific binding of steroid hormones to microsomal membranes of rat liver
17. Transient intervention with oltipraz protects against aflatoxin-induced hepatic tumorigenesis
18. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
19. Antimutagenicity profiles of some natural substances
20. Co-induction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics
21. 1 in rats
22. Aflatoxin
23. 1-DNA adducts in smeared tumor tissue from patients with hepatocellular carcinoma
24. 1 in isolated hepatocytes
25. 1-protein complex
26. 1
27. Interrelationships of cellular antioxidants defense systems
28. 1 and its implications to quantitative cancer-risk assessment
29. Mutagenicity and antimutagenicity of hispidulin and hortensin, the flavonoids from Millingtonia hortensis L
30. Etiology of Turkey ‘X’ disease in retrospect: a case for the involvement of cyclopiazonic acid
31. 1 by glutathione and glutathione transferases in vitro
32. Fumonisin-induced pulmonary edema and hydrothorax in swine
33. Biological action of mycotoxins
34. 1 and comparison to CYP1A2 and CYP2A3
35. 1
36. Quantitative comparison of covalent aflatoxin-DNA adducts formed in rat and mouse livers and kidneys
37. 1-DNA adduct formed in vivo in rat liver
38. 1 on myelopoiesis in vitro
39. 1 administered in vivo on the growth of bone marrow CFU-GM and the production of some cytokines in rats
40. 1
41. 1 and two heterocyclic amines in the Salmonella assay
42. 1
43. 1 in the rat is a glutathione conjugate
44. 1-epoxide
45. 1
46. Aflatoxin inhibition of rat liver mitochondria
47. 2a
48. 1 in two cases of lung cancer in man
49. 1 and sterigmatocystin
50. 1: patterns of DNA adduct formation, removal, and excretion in relation to carcinogenesis
51. 1 in rat liver
52. Mycotoxicoses
53. 1 metabolism in human liver
54. 1: in vitro effect of plant flavonoids
55. 1 in nonhuman primates
56. 1
57. 1 in rats
58. Effect of aflatoxin on the humoral and cell mediated immune systems of the chicken
59. Solution structure of the covalent sterigmatocystin-DNA adduct
60. 1-8,9-oxide by purified glutathione S-transferases from rats
61. Molecular dosimetry of urinary aflatoxin-N7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats
62. Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in Guangxi Autonomous Region, People's Republic of China
63. Molecular epidemiology of aflatoxin exposures: validation of aflatoxin-N7-guanine levels in urine as a biomarker in experimental rat models and humans
64. 1 activation in human liver microsomes by naringenin and other flavonoids
65. Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology
66. Lipid and vitamin metabolism during mycotoxicoses
67. 1 and actinomycin D on HeLa cells
68. Role of free radicals in mutation, cancer, aging, and the maintenance of life
69. Does aflatoxin exposure in the United Kingdom constitute a cancer risk?
70. Biological activities of mycotoxins
71. 1
72. 1-8,9-epoxide
73. 1 exposure in hepatocellular carcinoma patients from Thailand
74. The role of aflatoxin in human cancer
75. Mode of action of mycotoxins
76. Metabolism and toxicity of aflatoxins
77. Comparative metabolism of aflatoxin
78. Correlates of liver cancer mortality in China
79. Mutational hotspot in the p53 gene in human hepatocellular carcinomas
80. Degree of protein deficiency affects the extent of the depression of the antioxidative enzyme activities and the enhancement of tissue lipid peroxidation in rats
81. Mycotoxin interactions in poultry and swine
82. 1-induced rat hepatic hyperplastic nodules do not exhibit a site-specific mutation with the p53 gene
83. 1 by pulmonary, renal, and hepatic cytochrome P450s from rats
84. 1 adduction within the ribosomal RNA gene sequences of rat liver DNA
85. Worldwide occurrence in foods and feeds — an update
86. The nuclear envelope in relation to the metabolic activation of chemical carcinogens
87. 1
88. Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer 1,2-dithiole-3-thione
89. Biochemical mechanisms of action of mycotoxins
90. Stable expression of cytochrome P450IIIA7 cDNA in human breast cancer cell line MCF-7 and its application to cytotoxicity testing
91. Aflatoxin and hepatocellular carcinoma: a useful paradigm for environmentally induced carcinogenesis
92. 3-450 gene
93. Inhibition of nucleoside transport by aflatoxins and sterigmatocystin
94. 1 on in vitro production of interleukin-1 by bovine mononuclear phagocytes
95. Binding affinity of aflatoxins on the uterine estrogen receptor
96. The reversibility of inhibition of RNA and DNA synthesis induced by aflatoxin in rat liver. A tentative explanation for carcinogenic metabolism
97. 1 metabolites in extrahepatic tissues in fetal and infant mice and in adult mice with depleted glutathione levels
98. 1 in the marmoset monkey (Callithrix jacchus)
99. 1 in the rainbow trout (Oncorhynchus mykiss)
100. 1—DNA adducts in human fibroblasts
101. 1
102. Case-control study of cigarette smoking and primary hepatoma in an aflatoxin-endemic region of China: a protective effect
103. Glutathione S-transferase μ in human lymphocyte and liver: role in modulating formation of carcinogen-derived DNA adducts
104. 1 actions in the liver of weanling rats
105. Oxygen free radicals and tumor cells
106. Characterisation of c-Ki-ras oncogene alleles by direct sequencing of enzymatically amplified DNA from carcinogen-induced tumours
107. 1, a selective inhibitor of DNA synthesis in mammalian cells
108. 1 on rat liver macrophages (Kupffer cells)
109. Do aflatoxin and polycyclic hydrocarbon carcinogens delete genes in the regions of chromosomes acted on by steroid hormones?
110. 1 by human liver
111. 1 in vitro by rat liver microsomes
112. 1 by control and 3-methylcholanthrene stimulated rat and quail microsomes
113. Human AH locus polymorphism and cancer: inducibility of CYP1A1 and other genes by combustion products and dioxin
114. 1 on chicken peritoneal macrophages in vitro
115. Interaction of nutrients and other factors with mycotoxins
116. Contribution of nutritional sciences to food safety: control of mycotoxins
117. 1 carcinogenesis
118. 1 activation
119. 1 during hepatocarcinogenesis
120. Cytotoxic and mutagenic effects of sterigmatocystin on cultured Chinese hamster cells
121. p53 Gene mutation and 17p allelic deletion in hepatocellular carcinoma from Japan
122. p53 Mutation in hepatocellular carcinoma after aflatoxin exposure
123. Effects of aflatoxins on oxidative phosphorylation by rat liver mitochondria
124. Transcriptional activation of cytochrome P450 2B1/2 genes in rat liver by diallyl sulfide, a compound derived from garlic
125. ser mutations in hepatocellular carcinoma patients with low aflatoxin exposure
126. Metabolism as a factor in determining the toxic action of the aflatoxins in different animal species
127. Alteration of immune function following dietary mycotoxin exposure
128. Immunotoxic effects of mycotoxins
129. An overview of the mycotoxicoses in domestic animals
130. Immunomodulation in aflatoxicosis
131. Major biological consequences of aflatoxicosis in animal production
132. Mycotoxic suppression of immunity
133. Effect of aflatoxin on immunity in turkeys. II. Reversal of impaired resistance to bacterial infection by passive supplementation
134. Effects of aflatoxin on the cellular immune system
135. Effects of mycotoxins on immunity and resistance of animals
136. Aflatoxin suppression of cell mediated immune response and interaction with T-2 toxin
137. 1. Effects on rat liver RNA polymerase and ultrastructure
138. 1-induced sister chromatid exchanges and cytotoxicity in differentiating B and T lymphocytes in vivo
139. 1: role of copper on the catalytic activity of liver microsome
140. 1
141. Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens
142. 1-induced precancerous enzyme-altered hepatocellular foci in rats
143. Alteration of the aflatoxin cyclopentenone ring to a delta-lactone reduces intercalation with DNA and decreases formation of guanine N7 adducts by aflatoxin epoxides
144. 1 exo- and endo-epoxides by rat and human glutathione SM-transferases
145. 1
146. 32P-postlabelling analysis
147. 1
148. Activated oncogenes in B6C3F1 mouse liver tumours: implications for risk assessment
149. Effects of mycotoxins on immunity
150. 1
151. 1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry
152. Aflatoxin biomarkers
153. 1 on polysomal profiles and RNA synthesis in rat liver
154. The co-mutagenic effect of metabolic extracts of fungi grown on the main grain in high incidence liver cancer areas — Fusui County
155. 1 and extracts of fungi
156. Antimutagenic effect of eight natural foods on moldy foods in a high liver cancer incidence area
157. 1-DNA adducts and hepatitis B virus antigens in hepatocellular carcinoma and nontumorous liver tissue
158. 1
159. 1 catalysed by isolated rat liver parenchymal, Kupffer and endothelial cells
160. Immunotoxicity of mycotoxins
161. Activation of ras oncogene in aflatoxin-induced rat liver carcinogenesis
162. 1-induced hepatocellular carcinoma and adenoma in the rat: detection by denaturing gradient gel electrophoresis
163. Inhibition of aflatoxin-induced liver damage in ducklings by food additives
164. 1: binding to DNA in vitro and alteration of RNA metabolism in vivo
165. Aflatoxin is not a probable human carcinogen: the published evidence is sufficient
166. 1 in cultured human and animal tracheobronchial and bladder tissues
167. Role for steroid hormones in the interaction of ribosomes with the endoplasmic membranes of rat liver
168. 1-2,3-oxide: evidence for its formation in rat liver in vivo and by human liver microsomes in vitro
169. Natural occurrence of some Fusarium toxins in corn from low and high oesophageal cancer prevalence areas of the Transkei
170. Fumonisins in Argentinian field-trial corn
171. 1 to DNA inhibited by ajoene and diallyl sulfide
172. Morphological and functional damage to cells and tissues
173. An investigation into the passage of natural toxins across the digestive tract wall using the everted sac technique
174. Effect of aflatoxin on complement activity in guinea pigs
175. 1 in the bovine olfactory mucosa: DNA binding, mutagenicity and induction of sister chromatid exchanges
176. The role of oxygen radicals as a possible mechanism of tumor promotion
177. 1-induced genotoxicity in CH310T1/2 cells
178. 1-induced glutathione S-transferase placental form in single hepatocytes
179. Altered lipid transport during aflatoxicosis
180. Diet/toxin interactions
181. Toxicology and biochemistry of mycotoxins
182. A limited survey of fumonisins in corn and corn-based products in Asian countries
183. Tumour-reducing and anti-carcinogenic activity of selected spices
184. Hepatocellular carcinoma and dietary aflatoxin in Mozambique and Transkei
185. 1 alters protein phosphorylation in rat livers
186. 1-induced hepatotoxic lesions by crocetin (a natural carotenoid)
187. 1 in rats
188. Penta-acetyl geniposide inhibits the growth and development of C-6 glioma cells in rats
189. The repair of large DNA adducts in mammalian cells
190. Role of cytochromes P450 in drug metabolism and hepatotoxicity
191. Toxic fungal metabolites in food
192. Chemoprevention of cancer
193. Field studies of aflatoxin exposure, metabolism and induction of genetic alterations in relation to HBV infection and hepatocellular carcinoma in the Gambia and Thailand
194. Molecular dosimetry of aflatoxin exposure: contribution to understanding the multifactorial etiopathogenesis of primary hepatocellular carcinoma with particular reference to hepatitis B virus
195. 1-2-3-epoxide
196. 1 and steroid hormones on polysome binding to microsomal membranes as measured by activity of an enzyme catalysing disulphide interchange
197. Experimental reproduction of ELEM
198. Inhibition of DNA methylation by chemical carcinogens
199. Chemical nature and biological effects of the aflatoxins
200. Aflatoxins as risk factors for hepatocellular carcinoma in humans
201. 1 of hydrocortisone induction of rat liver tryptophan pyrrolase and tyrosine transaminase
202. Aflatoxin-DNA interactions: qualitative, quantitative and kinetic features in relation to carcinogenesis
203. 1
204. Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential
205. 1 metabolite in rat plasma
206. 1 in monkey, rat and mouse
207. Environmental Health Criteria 11
208. 1: a modelling approach
209. Dietary lipids coinduce xenobiotic metabolizing enzymes in rat liver
210. p53 Codon 249ser hot-spot mutation in HBV-negative hepatocellular carcinoma
211. Modulation of the levels of cytochromes P450 in rat liver and lung by dietary lipid
212. 1 inhibition of rat hepatic nuclear RNA synthesis
213. 1 inhibition of rat liver nucleolar RNA synthesis
214. 1 to the transcriptionally active regions of rat liver nucleolar chromatin in vivo and in vitro
215. The aflatoxins and liver cancer in Guangxi, China
216. 1 in rats neonatally exposed to diethylstilbestrol. Alterations in alpha-class glutathione
217. 1-DNA adducts and hepatitis B virus antigens in hepatocellular carcinoma and non-tumorous liver tissue
218. Potential anticarcinogenic natural products isolated from lemongrass oil and galanga root oil