Vesicle-mediated protein transport: Regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast

Journal of Cell Biology

Volumn 129, Issue 2, 1995, Pages 321-334

  Stack, Jeffrey H ^a   DeWald, Daryll B ^a   Takegawa, Kaoru ^a,b   Emr, Scott D ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b KAGAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; INOSITOL; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL KINASE; PROTEIN KINASE; SERINE CARBOXYPEPTIDASE;

ARTICLE; CELL VACUOLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; MEMBRANE VESICLE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PROTEIN TRANSPORT; SACCHAROMYCES CEREVISIAE; TEMPERATURE SENSITIVE MUTANT; TEMPERATURE SENSITIVITY;

SACCHAROMYCES CEREVISIAE;

EID: 0028964232     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.129.2.321     Document Type: Article

References (45)

1. Auger, K. R., C. L. Carpenter, L. C. Cantley, and L. Varticovski. 1989. PhosPhatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae. J. Biol. Chem. 264: 20181-20184.
2. Auger, K. R., L. A. Serunian, S. P. Soltoff, P. Libby, and L. C. Cantley. 1989. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell. 57:167-175.
3. Bankaitis, V. A., L. M. Johnson, and S. D. Emr. 1986. Isolation of yeast mutants defective in protein targeting to the vacuole. Proc. Natl. Acad. Sci. USA. 83:9075-9079.
4. Cantley, L. C., K. R. Auger, C. Carpenter, B. Duckworth, A. Graziani, R. Kapeller, and S. Soltoff. 1991. Oncogenes and signal transduction. Cell. 64:281-302.
5. Carlberg, K., P. Tapley, C. Haystead, and L. Rohrschneider. 1991. The role of kinase activity and the kinase insert region in ligand-induced internalization and degradation of the c-fms protein. EMBO (Eur. Mol. Biol. Organ.) J. 10:877-883.
6. Carpenter, C. L., K. R. Auger, M. Chanudhuri, M. Yoakim, B. Schaffhausen, S. Shoelson, and L. C. Cantley. 1993. Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. J. Biol. Chem. 268:9478-9483.
7. Carpenter, C. L., and L. C. Cantley. 1990. Phosphoinositide kinases. Biochemistry. 29:11147-11156.
8. Cowles, C. R., S. D. Emr, and B. F. Horazdovsky. 1994. Mutations in the VPS45 gene, a SEC1 homologue, result in vacuolar protein sorting defects and accumulation of membrane vesicles. J. Cell Sci. 107:3449-3459.
9. Downing, J. R., M. F. Roussel, and C. J. Sherr. 1989. Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms. Mol. Cell. Biol. 9:2890-2896.
10. Fantl, W. J., J. A. Escobedo, G. A. Martin, C. W. Turck, M. del Rosario, F. McCormick, and L. T. Williams. 1992. Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell. 69:413-423.
11. Giorgetti, S., R. Ballotti, A. Kowalski-Chauvel, S. Tartare, and E, Van Obberghen. 1993. The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro. J. Biol. Chem. 268:7358-7364.
12. Hawkins, P. T., L. R. Stephens, and J. R. Piggott. 1993. Analysis of inositol metabolites produced by Saccharomyces cerevisiae in response to glucose stimulation. J. Biol. Chem. 268:3374-3383.
13. Herman, P. K., and S. D. Emr. 1990. Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol. Cell. Biol. 10:6742-6754.
14. Herman, P. K., J. H. Stack, J. A. DeModena, and S. D. Emr. 1991a. A novel protein kinase homolog essential for protein sorting to the yeast lysosomelike vacuole. Cell. 64:425-437.
15. Herman, P. K., J. H. Stack, and S. D. Emr. 1991b. A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery. EMBO (Eur. Mol. Biol. Organ.) J. 13:4049-4060.
16. Herskowitz, I. 1987. Functional inactivation of genes by dominant negative mutations. Nature (Lond.). 329:219-222.
17. Hiles, I. D., M. Otsu, S. Volinia, M. J. Fry, I. Gout, R. Dhand, G. Panayotou, F. Ruiz-Larrea, A. Thompson, and N. F. Totty. 1992. Phosphatidylinositol 3-kinase. Structure and expression of the 110kd catalytic subunit. Cell. 70:419-429.
18. Horazdovsky, B. F., G. R. Busch, and S. D. Emr. 1994. VPS21 encodes a rab5-like GTP binding protein that is required for the sorting of yeast vacuolar proteins. EMBO (Eur. Mol. Biol. Organ.) J. 13:1297-1309.
19. Ito, H., Y. Fukuda, K. Murata, and A. Kimura. 1983. Transformation of intact yeast cells with alkali cations. J. Bacteriol. 153:163-168.
20. Johnson, L. M., V. A. Bankaitis, and S. D. Emr. 1987. Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protein. Cell. 48:875-885.
21. Joly, M., A. Kazlauskas, F. S. Fay, and S. Corvera. 1994. Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites. Science (Wash. DC). 263:684-687.
22. Kapeller, R., R. Chakrabarti, L. Cantley, F. Fay, and S. Corvera. 1993. Internalization of activated platelet-derived growth factor receptor-phosphatidylinositol-3′ kinase complexes: potential interactions with the microtubule cytoskeleton. Mol. Cell. Biol. 13:6052-6063.
23. Klionsky, D. J., and S. D. Emr. 1989. Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase. EMBO (Eur. Mol. Biol. Organ.) J. 8:2241-2250.
24. Klionsky, D. J., P. K. Herman, and S. D. Emr. 1990. The fungal vacuole: Composition, function and biogenesis. Microbiol. Rev. 54:266-292.
25. Kornfeld, S. 1992. Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors. Annu. Rev. Biochem. 61:307-330.
26. Kornfeld, S., and I. Mellman. 1989. The biogenesis of lysosomes. Annu. Rev. Cell Biol. 5:483-525.
27. Marcusson, E. G., B. F. Horazdovsky, J. Lin Cereghino, E. Gharakhanian, and S. D. Emr. 1994. The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Cell. 77:579-586.
28. Miller, J. 1972. Experiments in Molecular Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
29. Muhlrad, D., R. Hunter, and R. Parker. 1992. A rapid method for localized mutagenesis of yeast genes. Yeast. 8:79-82.
30. Paravicini, G., B. F. Horazdovsky, and S. D. Emr. 1992. Alternative pathways The Journal of Cell Biology, Volume 129, 1995 for the sorting of soluble vacuolar proteins in yeast: a vps35 null mutant missorts and secretes only a subset of vacuolar hydrolases. Mol. Biol. Cell. 3:415-427.
31. Pleiman, C. M., W. M. Hertz, and J. C. Cambier. 1994. Activation of phosphatidylinositol-3′ kinase by Src-family kinase SH3 binding to the p85 subunit. Science (Wash. DC). 263:1609-1612.
32. Robinson, J. S., D. J. Klionsky, L. M. Banta, and S. D. Emr. 1988. Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol. Cell. Biol. 8:4936-4948.
33. Rothman, J. H., I. Howald, and T. H. Stevens. 1989. Characterization of genes required for protein sorting and vacuolar function in the yeast Saccharomyces cerevisiae. EMBO (Eur. Mol. Biol. Organ.) J. 8:2057-2065.
34. Rothman, J. H., and T. H. Stevens. 1986. Protein sorting in yeast: mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway. Cell. 47:1041-1051.
35. Schu, P. V., K. Takegawa, M. J. Fry, J. H. Stack, M. D. Waterfield, and S. D. Emr. 1993. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science (Wash. DC). 260:88-91.
36. Serunian, L. A., K. R. Auger, and L. C. Cantley. 1991. Identification and quantification of polyphosphoinositides produced in response to plateletderived growth factor stimulation. Methods Enzymol. 198:78-87.
37. Sherman, F., G. R. Fink, and W. L. Lawrence. 1979. Methods in Yeast Genetics: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
38. Soltoff, S. P., C. L. Carpenter, K. R. Auger, R. Kapeller, B. Schaffhausen, and L. C. Cantley. 1992. Phosphatidylinositol-3 kinase and growth regulation. Cold Spring Harbor Symp. Quant. Biol. 57:75-80.
39. Stack, J. H., and S. D. Emr. 1994. Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities. J. Biol. Chem. 269: 31552-31562.
40. Stack, J. H., P. K. Herman, P. V. Schu, and S. D. Emr. 1993. A membraneassociated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole. EMBO (Eur. Mol. Biol. Organ.) J. 12:2195-2204.
41. Stephens, L., F. T. Cooke, R. Walters, T. Jackson, S. Volinia, I. Gout, M. D. Waterfield, and P. T. Hawkins. 1994. Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells. Curr. Biol. 4:203-214.
42. Valls, L. A., C. P. Hunter, J. H. Rothman, and T. H. Stevens. 1987. Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide. Cell. 48:887-897.
43. Valls, L. A., J. R. Winther, and T. H. Stevens. 1990. Yeast carboxypeptidase Y vacuolar targeting signal is defined by four propeptide amino acids. J. Cell Biol. 111:361-368.
44. Walsh, J. P., K. K. Caldwell, and P. W. Majerus. 1991. Formation of phosphatidylinositol 3-phosphate by isomerization from phosphatidylinositol 4-phosphate. Proc. Natl. Acad. Sci. USA. 88:9184-9187.
45. Whitman, M., C. P. Downes, M. Keeler, T. Keller, and L. Cantley. 1988. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol 3-phosphate. Nature (Lond.). 332:644-646.