The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

Immunity

Volumn 2, Issue 4, 1995, Pages 331-339

  Lin, Jian Xin ^a   Migone, Thi Sau ^a   Tseng, Monica ^b   Friedmann, Michael ^a   Weatherbee, James A ^b   Zhou, Li ^b   Yamauchi, Akira ^c   Bloom, Eda T ^c   Mietz, Judy ^a   John, Susan ^a   Leonard, Warren J ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b R and D Systems Inc   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 7; INTERLEUKIN RECEPTOR; STAT PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NORMAL HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING, COMPETITIVE; DNA PROBES; DNA-BINDING PROTEINS; HUMAN; INTERLEUKIN-13; INTERLEUKIN-15; INTERLEUKIN-2; INTERLEUKIN-4; INTERLEUKIN-7; INTERLEUKINS; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MOLECULAR SEQUENCE DATA; RECEPTORS, INTERLEUKIN; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; TRANS-ACTIVATORS;

EID: 0028962572     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/1074-7613(95)90141-8     Document Type: Article

References (53)

1. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
2. Structural design and molecular evolution of a cytokine receptor superfamily
3. Activation of JAK kinases and STAT proteins by interleukin-2 and interferon a, but not the T cell antigen receptor, in human T lymphocytes
4. The γ subunit of the interleukin-2 receptor is expressed in human monocytes and modulated by interleukin-2, interferon γ, and transforming growth factor β1
5. c chain of the IL-2 receptor
6. IL-4 induces IL-2 receptor p75 β-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes
7. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
8. Interleukin-4 receptor regulation in human monocytic cells
9. Expression of interleukin-2 receptor y on human monocytes: characterization of lineage specific post-translational modifications
10. Molecular cloning of a cDNA encoding the human interleukin 4 receptor
11. Receptor to nucleus signaling by prolactin and interleukin 2 via activation of latent DNA-binding factors
12. Utilization of the 9 and y chains of the IL-2 receptor by the novel cytokine IL-15
13. Human interleukin 2 receptor β-chain gene: chromosomal localization and identification of 5′ regulatory sequences
14. Ligand-induced IFN y receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)
15. A restricted cytoplasmic region of IL-2 receptor d chain is essential for growth signal transduction but not for ligand binding and internalization
16. Stoichiometry of the complex of human interleukin-4 with its receptor
17. An interleukin-4-induced transcription factor: IL-4 Stat
18. Signaling by the cytokine receptor superfamily: JAKs and STATs
19. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2
20. Cytokine signal transduotion
21. Sharing of the interleukin-2 (IL-2) receptor y chain between receptors for IL-2 and IL-4
22. Functional participation of the IL-2 receptor γ chain in IL-7 receptor complexes
23. Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4
24. Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement
25. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
26. The defective gene in X-linked severe combined immunodeficiency encodes a shared interleukin receptor subunit: implications for cytokine pleiotropy and redundancy
27. The interleukin-2 receptor complex and its role in the induction of a nonspecific cytotoxicity
28. c
29. Characterization of the human interleukin-2 receptor β-chain gene promoter: regulation of promoter activity by ets gene products
30. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits
31. Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes
32. Heterodimerization of the IL-2 receptor 6- and y-chain cytoplasmic domains is required for signalling
33. Cytoplasmic domains of the interleukin-2 receptor B and y chains mediate the signal for T-cell proliferation
34. Interleukin-2 receptor y chain: a functional component of the interleukin-7 receptor
35. Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans
36. Ack
37. Pleiotropy and redundancy: T cell-derived lymphokines in the immune response
38. Independent regulation of interleukin 4 (IL-4)-induced expression of human B cell surface CD23 and IgM: functional evidence for two IL-4 receptors
39. Cytokines and growth factors signal through tyrosine phosphorylation of a family of related transcription factors
40. Interleukin-2 receptor y chain: a functional component of the interleukin-4 receptor
41. Interaction of IL-2R0 and Y, chains with Jaki and Jak3: implications for XSCID and XCID
42. STF-IL-4: a novel 11-4-induced signal transducing factor
43. The IL-2 receptor β chain (p70): role in mediating signals for LAK, NK, and proliferative activities
44. The alphas, betas, and kinases of cytokine receptor complexes
45. Cloning of the y chain of the human IL-2 receptor
46. The IL-2/IL-2 receptor system: a current overview
47. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response
48. The multi-subunit interleukin-2 receptor
49. Involvement of the Jak-3 Janus kinase in signalling by intedeukins 2 and 4 in lymphoid and myeloid cells
50. Requirement of thiol compounds as reducing agents for IL-2-mediated induction of LAK activity and proliferation of human NK cells
51. Stat3: A STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin 6
52. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells
53. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction