Structural basis for explaining open-channel blockade of the NMDA receptor

Journal of Neuroscience

Volumn 15, Issue 2, 1995, Pages 1446-1454

  Zarei, Masoud M ^a   Dani, John A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

glutamate receptors; hippocampal neurons; ion channel; ion permeation; ion selectivity; Mg2+ blockade; NMDA receptors; structure and function

Indexed keywords

AMMONIUM DERIVATIVE; CATION; ION CHANNEL; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; HIPPOCAMPUS; NERVE CELL; NEWBORN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; VOLTAGE CLAMP;

EID: 0028961509     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.15-02-01446.1995     Document Type: Article

References (40)

1. Adams DJ, Dwyer TM, Hille B (1980) The permeability of endplate channels to monovalent and divalent metal cations. J Gen Physiol 75:493-510.
2. Adams DJ, Nonner W, Dwyer TM, Hille B (1981) Block of endplate channels by permeant cations in frog skeletal muscle. J Gen Physiol 78:593-615.
3. Aimers W, McCleskey EW (1984) Non-selective conductance in calcium channels of frog muscle: calcium selectivity in a single-file pore. J Physiol (Lond) 353:585-608.
4. Amador M, Dani JA (1991a) Protein kinase inhibitor, H-7, directly affects N-methyl-D-aspartate receptor channels. Neurosci Lett 124: 251-255.
5. Amador M, Dani JA (1991b) MK-801 inhibition of nicotinic acetylcholine receptor channels. Synapse 7:207-215.
6. Armstrong CM (1969) Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons. J Gen Physiol 54:553-575.
7. Ascher P, Nowak L (1988) The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture. J Physiol (Lond) 399:247-266.
8. Bliss TVP, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
9. Burnashev N, Schoepfer R, Monyer H, Ruppersberg JP, Gunther W, Seeburg PH, Sakmann B (1992) Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor. Science 257:1415-1419.
10. 2+ block of NMDA receptor channels as a mechanism of modulation. Nature 356: 521-523.
11. Dani JA (1989) Open channel structure and ion binding sites of the nicotinic acetylcholine receptor channel. J Neurosci 9:884-892.
12. Dani JA, Eisenman G (1987) Monovalent and divalent cation permeation in acetylcholine receptor channels: ion transport related to structure. J Gen Physiol 89:959-983.
13. Decker ER, Dani JA (1990) Calcium permeability of the nicotinic acetylcholine receptor: the single-channel calcium influx is significant. J Neurosci 10:3413-3420.
14. Dwyer TM, Adams DJ, Hille B (1980) The permeability of the endplate channel to organic cations in frog muscle. J Gen Physiol 75: 469-492.
15. French RJ, Shoukimas JJ (1985) An ion's view of the potassium channel. The structure of the permeation pathway as sensed by a variety of blocking ions. J Gen Physiol 85:669-698.
16. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pfluegers Arch 391:85-100.
17. Hess P, Tsien RW (1984) Mechanism of ion permeation through calcium channels. Nature 309:453-456.
18. Honore T, Davies SN, Drejer J, Fletcher EJ, Jacobsen P, Lodge D, Nielsen FE (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241:701-703.
19. Huettner JE, Baughman RW (1986) Primary culture of identified neurons from the visual cortex of postnatal rats. J Neurosci 6:3044-3060.
20. Jahr CE, Stevens CF (1990) A quantitative description of NMDA receptor-channel kinetic behavior. J Neurosci 10:1830-1837.
21. 2+ on NMDA-activated channels. Biophys J 57:1085-1090.
22. 2+. Voltage and concentration dependence of calcium entry into the pore. J Gen Physiol 88:321-347.
23. MacDermott AB, Mayer ML, Westbrook GL, Smith SJ, Barker JL (1986) NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 321:519-522.
24. Madison DV, Malenka RC, Nicoll RA (1991) Mechanisms underlying long-term potentiation of synaptic transmission. Annu Rev Neurosci 14:379-397.
25. Mayer ML, Westbrook GL (1987) Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones. J Physiol (Lond) 394:501-527.
26. 2+ of NMDA responses in spinal cord neurones. Nature 309:261-263.
27. Mayer ML. Westbrook GL, Vyklicky L Jr (1988) Sites of antagonist action on N-methyl-D-aspartic acid receptors studied using fluctuation analysis and a rapid perfusion technique. J Neurophysiol 60:645-663.
28. 2+ channel in skeletal muscle is a large pore. Proc Natl Acad Sci USA 82:7149-7153.
29. 2+-block site of the NMDA receptor channel. Nature 358:673-675.
30. Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A (1984) Magnesium gates glutamate-activate channels in mouse central neurones. Nature 307:462-465.
31. + channel. Neuron 9:307-313.
32. 3H]MK801 binding to the N-methyl-D-aspartate receptor reveals drug interactions with the zinc and magnesium binding sites. J Pharmacol Exp Ther 247:1025-1031.
33. Sanchez JA, Dani JA, Siemen D, Hille B (1986) Slow permeation of organic cations in acetylcholine receptor channels. J Gen Physiol 87: 985-1001.
34. Sernagor E, Kuhn D, Vyklicky L Jr, Mayer ML (1989) Open channel block of NMDA receptor responses evoked by tricyclic antidepressants. Neuron 2:1221-1227.
35. Unwin N (1993) Neurotransmitter action: opening of ligand-gated ion channels. Neuron Rev [Suppl] 10:31-41.
36. Vyklicky L Jr, Krusek J, Edwards C (1988) Differences in the pore sizes of the NMDA and kainate cation channels. Neurosci Lett 89: 313-318.
37. Wong EHF, Kemp JA, Priestley T, Knight AR, Woodruff GN, Iversen LL (1986) The anticonvulsant MK-801 is a potent NMDA antagonist. Proc Natl Acad Sci USA 83:7104-7108.
38. Woodhull AM (1973) Ionic blockage of sodium channels in nerve. J Gen Physiol 61:687-708.
39. 2+ channels. Nature 366:158-161.
40. Zarei MM, Dani JA (1994) Ionic permeability characteristics of the N-methyl-D-aspartate receptor. J Gen Physiol 103:231-248.