Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus

Journal of Virology

Volumn 69, Issue 5, 1995, Pages 3206-3210

  Watanabe, Michiko ^a   Hirano, Akiko ^a   Stenglein, Stephen ^b   Nelson, Jay ^b   Thomas, Gary ^b   Wong, Timothy C ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FURIN; GLYCOPROTEIN; SERINE PROTEINASE INHIBITOR;

ARTICLE; ENZYME ACTIVATION; MEASLES; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; VIRUS ASSEMBLY; VIRUS INFECTIVITY; VIRUS REPLICATION;

EID: 0028960688     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.69.5.3206-3210.1995     Document Type: Article

References (30)

1. Alkhatib, G., S.-H. Shea, D. Briedis, C. Richardson, B. Massie, R. Weinberg, D. Smith, J. Taylor, E. Paoletti, and J. Roder. 1994. Functional analysis of N-linked glycosylation mutants of the measles virus fusion protein synthesized by recombinant vaccinia virus vectors. J. Virol. 68:1522-1531.
2. 1-antitrypsin variant. J. Biol. Chem. 268:24887-24891.
3. Bresnahan, P. A., R. Leduc, L. Thomas, J. Thorner, H. L. Gibson, A. J. Brake, P. J. Barr, and G. Thomas. 1990. Human furin gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo. J. Cell Biol. 111:2851-2859.
4. Decroly, E., M. Vanderbranden, J. M. Ruysschaert, J. Cogniaux, G. S. Jacob, S. C. Howard, G. Marshall, A. Kompelli, A. Basak, F. Jean, C. Lazure, S. Benjannet, M. Chretien, R. Day, and N. G. Seidah. 1994. The convertases furin and PC1 can both cleave the human immunodeficiency virus (HIV)-1 envelope glycoprotein gp160 into gp120 (HIV-1 SU) and gp41 (HIV-1 TM). J. Biol. Chem. 269:12240-12247.
5. Gotoh, B., Y. Ohnishi, N. M. Inocencio, E. Esaki, K. Nakayama, P. J. Barr, G. Thomas, and Y. Nagai. 1992. Mammalian subtilisin-related proteinases in cleavage activation of the paramyxovirus fusion glycoprotein: superiority of furin/PACE to PC2 or PC1/PC3. J. Virol. 66:6391-6397.
6. Hallenberger, S., V. Bosch, H. Angliker, E. Shaw, H.-D. Klenk, and W. Garten. 1992. Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160. Nature (London) 360:358-361.
7. Hirano, A. 1992. Subacute sclerosing panencephalitis virus dominantly interferes with replication of wild-type measles virus in a mixed infection: implication for viral persistence. J. Virol. 66:1891-1898.
8. Hosaka, M., M. Nagahama, W.-S. Kim, T. Watanabe, K. Hatsuzawa, J. Ikemizu, K. Murakami, and K. Nakayama. 1991. Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway. J. Biol. Chem. 266:12127-12130.
9. Matheson, N. R., H. van Halbeek, and J. Travis. 1991. Evidence for a tetrahedral intermediate complex during serpin-proteinase interactions. J. Biol. Chem. 266:13489-13491.
10. Misumi, Y., K. Oda, T. Fujiwara, N. Takami, K. Tashiro, and Y. Ikehara. 1991. Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3. J. Biol. Chem. 266:16954-16959.
11. Molloy, S. S., P. A. Bresnahan, S. H. Leppla, K. R. Klimpel, and G. Thomas. 1992. Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin pre-ventive antigen. J. Biol. Chem. 267:16396-16402.
12. Molloy, S. S., L. Thomas, J. K. VanSlyke, P. E. Stenberg, and G. Thomas. 1994. Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. EMBO J. 13:18-33.
13. Morikawa, Y., E. Barsov, and I. Jones. 1993. Legitimate and illegitimate cleavage of human immunodeficiency virus glycoproteins by furin. J. Virol. 67:3601-3604.
14. Morrison, T., and A. Portner. 1991. Structure, function, and intracellular processing of the glycoproteins of paramyxoviridae, p. 347-382. In D. W. Kingsbury (ed.), The paramyxoviruses. Plenum Press, New York.
15. Nagai, Y. 1993. Protease-dependent virus tropism and pathogenicity. Trends Microbiol. 1:81-87.
16. Norrby, E., and M. N. Oxman. 1990. Measles virus, p. 1013-1044. In B. N. Fields and D. M. Knipe (ed.), Virology. Raven Press, New York.
17. Ohnishi, Y., T. Shioda, K. Nakayama, S. Iwata, B. Gotoh, M. Hamaguchi, and Y. Nagai. 1994. A furin-defective cell line is able to process correctly the gpl60 of human immunodeficiency virus type 1. J. Virol. 68:4075-4079.
18. 1-antitrypsin Pittsburgh (358 Met-Arg), a fatal breeding disorder. N. Engl. J. Med. 309:694-698.
19. 1-antitrypsin gene and emphysema. Am. J. Physiol. 257:L147-L162.
20. Rehemtulla, A., P. J. Barr, C. J. Rhodes, and R. J. Kaufman. 1993. PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE. Biochemistry 32:11586-11590.
21. Richardson, C., D. Hull, P. Greer, K. W. Hasel, A. Berkovich, G. Englund, W. J. Bellini, B. Rima, and R. Lazzarini. 1986. The nucleotide sequence of the mRNA encoding the fusion protein of measles virus (Edmonston strain): a comparison of fusion proteins from several different paramyxoviruses. Virology 155:508-523.
22. Sato, T. A., T. Kohama, and A. Sugiura. 1988. Intracellular processing of measles virus fusion protein. Arch. Virol. 98:39-50.
23. Stieneke-Grober, A., M. Vey, H. Angliker, E. Shaw, G. Thomas, C. Roberts, H.-D. Klenk, and W. Garten. 1992. Influenza viras hemagglutinin with multi-basic cleavage site is activated by furin, a subtilisin-like endoprotease. EMBO J. 11:2407-2414.
24. Takahashi, S., K. Kasai, K. Halsuzawa, N. Kitamura, Y. Misumi, Y. Ikehara, K. Murakami, and K. Nakayama. 1993. A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells. Biochem. Biophys. Res. Commun. 195:1019-1026.
25. Thomas, G. Unpublished observations.
26. Tulchinsky, T. H., G. M. Ginsberg, Y. Abed, M. T. Angeles, C. Akukwe, and J. Bonn. 1993. Measles control in developing and developed countries: the case for a two-dose policy. Bull. W. H. O. 71:93-103.
27. Walker, J. A., S. S. Molloy, G. Thomas, T. Sakaguchi, T. Yoshida, T. M. Chambers, and Y. Kawaoka. 1994. Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus. J. Virol. 68:1213-1218.
28. Watanabe, M., A. Wang, J. Sheng, A. F. Gombart, M. Ayata, S. Ueda, A. Hirano, and T. C. Wong. Delayed activation of altered fusion glycoprotein in a chronic measles virus variant that causes subacute sclerosing panencephalitis. J. NeuroVirol., in press.
29. Weiss, R. 1992. Measles battle loses potent weapon. Science 258:546-547.
30. Wong, T. C., M. Ayata, S. Ueda, and A. Hirano. 1991. Role of biased hypermutation in evolution of subacute sclerosing panencephalitis virus from progenitor acute measles virus. J. Virol. 65:2191-2199.