Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

Immunity

Volumn 2, Issue 3, 1995, Pages 271-279

  Sad, Subash ^a   Marcotte, Rita ^a   Mosmann, Tim R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CD8 ANTIGEN; CYTOKINE;

ANIMAL CELL; ARTICLE; CYTOTOXIC T LYMPHOCYTE; FEMALE; HELPER CELL; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; STEM CELL; T LYMPHOCYTE;

ANIMAL; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINE; CYTOTOXICITY TESTS, IMMUNOLOGIC; FEMALE; FLOW CYTOMETRY; IMMUNOGLOBULIN ISOTYPES; INTERLEUKIN-4; INTERLEUKINS; LYMPHOCYTE COOPERATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS; TH2 CELLS;

EID: 0028960040     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/1074-7613(95)90051-9     Document Type: Article

References (53)

1. Cytotoxic T cells both produce and respond to interleukin 2
2. Molecular and biological characterization of a murine ligand for CD40
3. Characterization of murine thymocytes with CD3-associated T-cell receptor structures
4. Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by Th1 clones
5. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies
6. A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma
7. Purified protein derivative (PPD) of mycobacterium tuberculosis and excretory-secretory antigen(s) (TES) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profiles of cytokine production
8. Cellular immune responses to the murine nematode parasite Trichuris muris. II. Differential induction of Th-cell subsets in resistant versus susceptible mice
9. − cells that make Th2 cytokines and help B cells
10. A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes
11. Participation of lymphocyte activating factor (interleukin 1) in the induction of cytotoxic T cell responses
12. + T cell subset with an unrestricted cytokine profile
13. + T cell clones secrete the Th1 pattern of cytokines
14. Serologic and functional characterization of a panel of antigen-presenting cell lines expressing mutant I-A class II molecules
15. Selection of a human T helper type 1-like T cell subset by mycobacteria
16. Reciprocal expression of interferon gamma or IL-4 during the resolution or progression of murine leishmaniasis: evidence for expansion of distinct helper T cell subsets
17. IL-4 (B cell-stimulatory factor 1) regulates multiple aspects of influenza virus-specific cell-mediated immunity
18. + T cells through IL-12 produced by Listeria-induced macrophages
19. T cell-derived B cell differentiation factor(s): effect on the isotype switch of murine B cells
20. Secretion of interleukin 2, macrophage-activating factor, interferon, and colony-stimulating factor by alloreactive T lymphocyte clones
21. Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes
22. Generation of interleukin-4 (II-4)-producing cells in vivo and in vitro: II-2 and II-4 are required for in vitro generation of II-4-producing cells
23. Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities
24. IL10 inhibits cytokine production, vascular leakage and swelling during Th1-induced delayed type hypersensitivity
25. + T cells from ab transgenic mice: IL12 substitution for macrophages to stimulate IFNγ production is IFNγ-dependent
26. + cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type I infection
27. + T lymphocytes
28. + cytolytic clones
29. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties
30. Specific assays for cytokine production by T cells
31. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
32. Isolation of MAbs specific for IL-4, IL5, and IL6, and a new Th2-specific cytokine, cytokine synthesis inhibitory factor (CSIF, IL10), using a solid phase radioimmunoadsorbent assay
33. Production of a monoclonal antibody to and molecular characterization of Bell stimulatory factor-1
34. + T cell clones
35. B cell stimulatory factor 1(interleukin 4) is sufficient for the proliferation and differentiation of lectin-stimulated cytolytic T lymphocyte precursors
36. Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo
37. Alloreactive cloned T cell lines. VI. Multiple lymphokine activities secreted by helper and cytolytic cloned T lymphocytes
38. A single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype
39. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones
40. Eosinophil differentiation factor also has B-cell growth factor activity: proposed name interleukin 4
41. Immunoregulation of cutaneous leishmaniasis: T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens
42. + T cells can be primed in vitro to produce IL-4
43. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming
44. Role of T-cell derived cytokines in the downregulation of immune responses in parasiticand retroviral infection
45. Monoclonal antibodies to interferon-gamma inhibit interleukin 2-dependent induction of growth and maturation in lectin/antigen-reactive cytolytic T lymphocyte precursors
46. Heterogeneity of mouse helper T cells: evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells
47. + T cell subsets: lymphokine secretion of memory cells and of effector cells which develop from precursors in vitro
48. Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype
49. + resting murine T lymphocytes
50. Regulation of cytolytic T-lymphocyte generation by B-cell stimulatory factor
51. + T lymphocytes in atopic patients
52. Molecular biology of interleukin 4 and interleukin 5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells
53. Alterations in the amino-terminal third of mouse interleukin 2: effects on biological activity and immunoreactivity