Telomeres and telomerase in aging and cancer

Current Opinion in Genetics and Development

Volumn 5, Issue 2, 1995, Pages 249-255

  Harley, Calvin B ^a   Villeponteau, Bryant ^a  

^a GERON CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; RIBONUCLEOPROTEIN; RNA; TELOMERASE;

AGING; CARCINOGENESIS; CHROMATIN STRUCTURE; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; MITOSIS; MOLECULAR CLONING; PRIORITY JOURNAL; REVIEW; TELOMERE;

AGING; ANIMAL; BASE SEQUENCE; DNA; DNA NUCLEOTIDYLEXOTRANSFERASE; HUMAN; MOLECULAR SEQUENCE DATA; NEOPLASMS; STEM CELLS; TELOMERE;

EID: 0028958708     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-437X(95)80016-6     Document Type: Article

References (56)

1. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
2. The telomere terminal transferase of tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity
3. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
4. Telomerases
5. Telomeres and telomerases
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7. Telomeres: no end in sight
8. Characterization of a G-quartet formation reaction promoted by the beta-subunit of the Oxytricha telomere-binding protein
9. Structure and function of telomeres
10. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
11. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
12. Human telomeres contain at least three types of G-rich repeat distributed non-randomly
13. Stringent sequence requirements for the formation of human telomeres
14. Unusual chromatin in human telomeres
15. Nucleosomal organization of telomere-specific chromatin in rat
16. Nucleosome spacing is compressed in active chromatin domains of chick erythroid cells
17. Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription
18. Telomere-proximal DNA in Saccharomyces cerevisiae is refractory to methyltransferase activity in vivo
19. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
20. Human telomeres are attached to the nuclear matrix
21. Interphase chromosomes of Friend-S cells are attached to the matrix structures through the centromeric/telomeric regions
22. The in vitro DNA-binding properties of purified nuclear lamin proteins and vimentin
23. A mammalian factor that binds telomeric TTAGGG repeats in vitro
24. RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decrease chromosome stability
25. C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae
26. RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae
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28. Functional reconstitution of wild-type and mutant Tetrahymena telomerase
29. A conserved secondary structure for telomerase RNA
30. Telomerase RNAs of different ciliates have a common secondary structure and a permuted template
31. TLC1: template RNA component of Saccharomyces cerevisiae telomerase
32. A mutant with a defect in telomere elongation leads to senescence in yeast
33. RNA-dependent polymerase motifs in EST1: tentative identification of a protein component of an essential yeast telomerase
34. Structure and variability of human chromosome ends
35. Telomere length predicts replicative capacity of human fibroblasts
36. Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes
37. Genetic determination of telomere size in humans: a twin study of three age groups
38. Telomeres shorten during ageing of human fibroblasts
39. Telomere reduction in human colorectal carcinoma and with ageing
40. Telomere loss: mitotic clock or genetic time bomb?
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45. Loss of telomeric DNA during aging may predispose cells to cancer
46. Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes
47. Telomerase activity in human ovarian carcinoma
48. A theory of marginotomy
49. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age
50. Hypervariable ultra-long telomeres in mice
51. Extensive telomere repeat arrays in mouse are hypervariable
52. Identification of a non-processive telomerase activity from mouse cells
53. Developmental and tissue-specific regulation of mouse telomerase and telomere length.
54. Chromosome ends catch fire
55. A role for both RB and p53 in the regulation of human cellular senescence
56. In vivo loss of telomeric repeats with age in humans