BCL-2: Prevention of apoptosis as a mechanism of drug resistance

Hematology/Oncology Clinics of North America

Volumn 9, Issue 2, 1995, Pages 451-473

  Reed, J C ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; CISPLATIN; CLADRIBINE; CYCLOPHOSPHAMIDE; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; DNA BINDING PROTEIN; DOXORUBICIN; ETOPOSIDE; FLUDARABINE; FLUOROURACIL; GENE PRODUCT; METHOTREXATE; MITOXANTRONE; PACLITAXEL; PROTEIN P53; RETINOID; TRANSCRIPTION FACTOR; VINCRISTINE;

ACUTE LYMPHOCYTIC LEUKEMIA; APOPTOSIS; B CELL LYMPHOMA; CANCER RESISTANCE; CELL CYCLE; CELL ONCOGENE; CHROMOSOME 18; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE;

EID: 0028958030     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0889-8588(18)30104-7     Document Type: Review

References (91)

1. G. Baffy T. Miyashita J.R. Williamson J.C. Reed Apoptosis induced by withdrawal of interleukin-3 [IL-3] from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production J Biol Chem 268 1993 6511 6519
2. A. Bedi B.A. Zehnbauer J.P. Barber Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia Blood 83 1994 2038 2044
3. L.H. Boise M. González-Garcia C.E. Postema bcl-x, a bcl-2 related gene that functions as a dominant regulator of apoptotic cell death Cell 74 1993 597 608
4. D. Bradbury Y.-M. Zhu N. Russel Regulation of Bcl-2 expression and apoptosis in acute myeloblastic leukaemia cells by granulocyte-macrophage colony-stimulating factor Leukemia 8 1994 786 791
5. Bronner M, Culin C, Reed JC, Furth EE: Bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model. Am J Pathol, in press.
6. L. Campos J.-P. Roualut O. Sabido High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy Blood 81 1993 3091 3096
7. L. Campos O. Sabido J.-P. Rouault D. Guyatat Effects of BCL-2 antisense oligodeoxy- nucleotides on in vitro proliferation and survival of normal marrow progenitors and leukemic cells Blood 84 1994 595 600
8. A.R. Clarke C.A. Purdie D.J. Harison Thymocyte apoptosis induced by p53- dependent and independent pathways Nature 362 1993 849 852
9. V.P. Castle K.P. Heidelberger J. Bromberg Expression of the apoptosis-suppressing protein bcl-2 in neuroblastoma is associated with unfavorable histology and N-mi/c amplification Am J Pathol 143 1993 1543 1550
10. M. Colombel F. Symmans S. Gil Detection of the apoptosis-suppressing oncoprotein bcl-2 in hormone-refractory human prostate cancers Am J Pathol 143 1993 390 400
11. M.K.L. Collins J. Marvel P. Malde A. Lopez-Rivas Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents J Exp Med 176 1992 1043 1051
12. E. Cuende J.E. Alés-Martinez L. Ding Programmed cell death by bcl-2- dependent and independent mechanisms in B lymphoma cells EMBO J 12 1993 1555 1560
13. D. de Jong F.A. Prins D.Y. Mason Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells Cancer Res 54 1994 256 260
14. M. Dole G. Nunez A.K. Merchant Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma Cancer Res 54 1994 3253 3259
15. D.R. Dowd P.N. MacDonald B.S. Komm Stable expression of the calbindin-D28K complementary DNA interferes with the apoptotic pathway in lymphocytes Mol Endocrinol 6 1992 1843 1848
16. A. Eastman Activation of programmed cell death by anticancer agents: cis-platin as a model system Cancer Cells (Cold Spring Harbor) 2 1990 275 280
17. R.E. Ellis J. Yuan H.R. Horvitz Mechanisms and functions of cell death Annu Rev Cell Biol 7 1991 663 668
18. M.W. Epperly M.A. Santucci J.C. Reed Expression of the human Bcl-2 transgene increases the radiation resistance of a hematopoietic progenitor cell line Radiation Oncology Investigations 2 1994 77 83
19. C.A. Evans P.J. Owen-Lynch A.D. Whetton C. Dive Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells Cancer Res 53 1993 1735 1738
20. E. Feinstem G. Cimino R.P. Gale p53 in chronic myelogenous leukemia in acute phase Proc Natl Acad Sci USA 88 1991 6293 6297
21. M.J. Fernandez-Sarbia J.R. Bischoff Bcl-2 associates with the ras-related protein R-ras p23 Nature 366 1993 274 275
22. T.C. Fisher A.E. Milner C.D. Gregory bcl-2 modulation of apoptosis induced by anticancer drugs: Resistance to thymidylate stress is independent of classical resistance pathways Cancer Res 53 1993 3321 3326
23. R. Gascoyne S. Adornat A. Toleher Prognostic relevance of the Bcl-2 translocation in diffuse large cell lymphomas Mod Pathol 7 1994 A630
24. A.R. Gottschalk L.H. Boise C.B. Thompson J. Quintans Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2 Proc Natl Acad Sci USA 91 1994 7350 7354
25. S.D. Griffiths D.T. Goodhead S.J. Marsden Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis J Exp Med 179 1994 1789 1797
26. M. Hanada D. Delia A. Aiello bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia Blood 82 1993 1820 1828
27. M. Hanada S. Krajewski S. Tanaka Production of the p26-Bcl-2 protein in human neuroblastoma cell lines correlates with neuroblastic differentiation and resistance to chemotherapy Cancer Res 53 1993 4978 4986
28. D. Hockenbery Z. Oltvai X-M. Yin Bcl-2 functions in an antioxidant pathway to prevent apoptosis Cell 75 1993 241 251
29. J.O. Jacobson B.M. Wilkes D.J. Kwiatkowski bcl-2 rearrangements in de novo diffuse large cell lymphoma Cancer 72 1993 231 236
30. M.D. Jacobson J.F. Burne M.P. King Apoptosis and Bcl-2 protein in cells without mitochondrial DNA Nature 361 1993 365 368
31. M.D. Jacobson J.F. Burne M.C. Raff Programmed cell death and Bcl-2 protection in the absence of a nucleus EMBO J 13 1994 1899 1910
32. S. Kamesaki H. Kamesaki T.J. Jorgensen bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced F D.N.A. strand breaks and their repair Cancer Res 53 1993 4251 4256
33. D.J. Kane T.A. Sarafin S. Auton Bcl-2 inhibition of neural cell death: Decreased generation of reactive oxygen species Science 262 1993 1274 1276
34. S.H. Kaufmann Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: A cautionary note Cancer Res 49 1989 5870 5878
35. S. Kitada S. Takayama K. DeRiel Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression Antisense Res Dev 4 1994 71 79
36. S. Kondo D. Yin T. Morimura Transfection with a bcl-2 expression vector protects transplanted bone marrow from chemotherapy-induced myelosuppression Cancer Res 54 1994 2928 2933
37. Krajewski S, Chatten J, Kanada M, et al: Immunohistochemical analysis of Bcl-2 oncoprotein in human neuroblastoma: Correlations with tumor cell differentiation and N-myc protein. Lab Invest, in press.
38. S. Krajewski S. Tanaka S. Takayama Investigations of the subcellular distribution of the BCL-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes Cancer Res 53 1993 4701 4714
39. Kühl J-S, Krajewski S, Durán GE, et al: A spontaneously resistant variant of murine P388 leukemia with broad cross-resistance to cytotoxins and overexpression of the long form of the Bcl-X protein. Submitted.
40. M. Lam G. Dubyak C.W. Distelhorst Effect of glucocorticosteroid treatment on intracellular calcium homeostasis in mouse lymphoma cells Mol Endocrinol 7 1993 686 693
41. F. Lo Coco G. Gaidano D.C. Louie p53 mutations are associated with histologic transformation of follicular lymphoma Blood 82 1993 2289 2295
42. J. Lotem L. Sachs Control of sensitivity to induction of apoptosis in myeloid leukemic cells by differentiation and bcl-2 dependent and independent pathways Cell Growth Differ 5 1994 321 327
43. S.W. Lowe H.E. Ruley T. Jacks D.E. Houseman p53-dependent apoptosis modulates the cytotoxicity of anticancer agents Cell 74 1993 957 967
44. S.W. Lowe E.M. Schmitt S.W. Smith p53 is required for radiation-induced apoptosis in mouse thymocytes Nature 362 1993 847 849
45. Q.-L. Lu G. Elia S. Lucas J.A. Thomas Bcl-2 proto-oncogene expression in Epstein- Barr-virus associated nasopharyngeal carcinoma Int J Cancer 53 1993 29 35
46. D. Makover M. Cuddy K. Bradley Phorbol ester-mediated inhibition of growth and regulation of proto-oncogene expression in the human T cell leukemia line JURKAT Oncogene 6 1991 455
47. J. Marx How p53 suppresses cell growth Science 262 1993 1644 1645
48. T.J. McDonnell P. Troncoso S.M. Brisbay Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer Cancer Res 52 1992 6940 6944
49. A. McGahon R. Bissonnette M. Schmitt BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death Blood 83 1994 1179 1187
50. W. Meikrantz S. Gisselbrecht S.W. Tam R. Schlegel Activation of cyclin A-dependent protein kinases during apoptosis Proc Natl Acad Sci USA 91 1994 3754 3758
51. A.J. Merritt C.S. Pötten C.J. Kemp The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice Cancer Res 54 1994 614 617
52. T. Miyashita J.C. Reed BCL-2 gene transfer increases relative resistance of S49.1 and WEH17.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs Cancer Res 52 1992 5407 5411
53. T. Miyashita J.C. Reed Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line Blood 81 1993 151 157
54. Miyashita T, Reed JC: Tumor suppressor p 53 is a direct transcriptional activator of BAX gene. Cell, In press.
55. T. Miyashita M. Harigai M. Hanada J.C. Reed Identification of a p53-dependent negative response element in the bcl-2 gene Cancer Res 54 1994 3131 3135
56. T. Miyashita S. Krajewski M. Krajewska Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo Oncogene 9 1994 1799 1805
57. K.-I. Nakayama K. Nakayama I. Negishi Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice Science 261 1993 1584 1588
58. L. Naumovski M.L. Clearly Bcl-2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells Blood 83 1994 2261 2267
59. K. Offit P.R.K. Koduru R. Hollis 18q21 rearrangement in diffuse large cell lymphoma: Incidence and clinical significance Br J Haematol 72 1989 178 183
60. K. Offit G. Wong D.A. Filippa Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin’s lymphoma: Clinical correlations Blood 77 1991 1508 1515
61. Z. Oltvai C. Milliman S.J. Korsmeyer Bcl-2 heterodimerizes in vivo with a conserved homolog Bax, that accelerates programmed cell death. Cell 74 1993 609 619
62. F. Pezzella M. Jones E. Ralfkiaer Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma Br J Cancer 65 1992 87 89
63. F. Pezzella H. Turley I. Kuzu bcl-2 protein in non-small-cell lung carcinoma N Engl J Med 329 1993 690 694
64. M.A. Piris F. Pezella J.C. Martinez-Montero p53 and bcl-2 expression in high- grade B-cell lymphomas: Correlation with survival time Br J Cancer 69 1994 337 341
65. J.C. Reed Bcl-2 and the regulation of programmed cell death J Cell Biol 124 1994 1
66. J.C. Reed S. Kitada S. Takayama T. Miyashita Regulation of chemoresistance by the bcl-2 oncoprotein in non-Hodgkin’s lymphoma and lymphocytic leukemia cell lines Ann Oncol 5 Suppl 1 1994 S61 S65
67. J. Reed L. Meister M. Cuddy Differential expression of the BCL2 proto-oncogene in neuroblastomas and other human neural tumors Cancer Res 51 1991 6529 6538
68. J. Reed Y. Tsujimoto S. Epstein Regulation of bcl-2 gene expression in lymphoid cell lines containing t(14;18) or normal #18 chromosomes Oncogene Research 4 1989 271 282
69. J.E. Roumaguera W. Pugh R. Luthra The clinical relevance of t(14;18)/Bcl-2 rearrangement and Del 6q in diffuse large cell lymphoma and immunoblastic lymphoma Ann Oncol 4 1993 51 54
70. J.J. Ryan E. Prochownik C.A. Gottlieb c-myc anc bcl-2 modulates p53 function by altering p53 subcellular trafficking during the cell cycle Proc Natl Acad Sci USA 91 1994 5878 5882
71. C.A. Sander T. Yano H.M. Clark p53 mutation is associated with progression in follicular lymphomas Blood 82 1993 1994 2004
72. T. Sato M. Hanada S. Bodrug Interactions among members of the bcl-2 protein family analyzed with a yeast two-hybrid system Proc Natl Acad Sci USA 91 1994 9238 9242
73. M. Selvakumaran H.-K. Lin T. Miyashita Immediate early up-regulation of bax expression by p53 but not TGFbl: A paradigm for distinct apoptotic pathways Oncogene 9 1994 1791 1798
74. C.L. Sentman J.R. Shutter D. Hockenbery bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes Cell 67 1991 879 888
75. R. Siegel M. Katsumata T. Miyashita Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice Proc Natl Acad Sci USA 89 1992 7003
76. R. Silvestrini S. Veneroni M.G. Daidone The bcl-2 protein: A prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients J Natl Cancer Inst 86 1994 499 504
77. A. Strasser A.W. Harris S. Cory Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship Cell 67 1991 889
78. Takayama S, Sato T, Krajewski S, et al: Cloning and functional analysis of BAG-1: a novel Bcl-2 binding protein with anti-cell death activity. Cell, in press.
79. Y. Tsujimoto C.M. Croce Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma Proc Natl Acad Sci USA 83 1986 5214 5218
80. Y. Tsujimoto E. Louie M.M. Bashir C.M. Croce The reciprocal partners of both the t(14;18) and t(11;14) translocations involved in B-cell neoplasms are rearranged by the same mechanism Oncogene 2 1988 347 351
81. D.J. Veis C.M. Sorenson J.R. Shutter S.J. Korsmeyer Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair Cell 75 1993 229 240
82. B. Vogelstein K.W. Kinzler p53 function and dysfunction Cell 70 1992 523 526
83. W.I. Walton D. Whysong P.M. O’Connor Constitutive expression of human Bcl- 2 modulates nitrogen mustard and camptothecin induced apoptosis Cancer Res 53 1993 1853 1861
84. H.-G. Wang T. Miyashita S. Takayama Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase Oncogene 9 1994 2751 2756
85. Y. Wang L. Szekely I. Okan Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma line Oncogene 8 1993 3427 3431
86. L.M. Weiss R.A. Warnke J. Sklar M.L. Clearly Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas N Engl J Med 317 1987 1185 1189
87. A.H. Wyllie J.F.R. Kerr A.R. Currie Cell death, the significance of apoptosis Int Rev Cytol 68 1980 251 306
88. X.-M. Yin Z.N. Oltvai S.J. Korsmeyer BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax Nature 369 1994 321 333
89. J.J. Yunis M.G. Mayer M.A. Arensen Bcl-2 and other genomic alterations in the prognosis of large-cell lymphomas N Engl J Med 320 1989 1047 1054
90. A.D. Zelenetz G. Chu N. Galili Enhanced detection of the t(14;18) translocation in malignant lymphoma using pulsed-field gel electrophoresis Blood 178 1991 1552
91. Q. Zhan F. Carrier A.J. Fornace Jr. Induction of cellular p53 activity by DNA-damaging agents and growth arrest Mol Cell Biol 13 1993 4242 4250