Molecular and cellular aspects of the insulin-like growth factor I receptor

Endocrine Reviews

Volumn 16, Issue 2, 1995, Pages 143-163

  Leroith, Derek ^a   Werner, Haim ^a   Beitner Johnson, Dana ^a   Roberts, Andcharles T ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN C; SOMATOMEDIN RECEPTOR;

GENE EXPRESSION REGULATION; GENE STRUCTURE; GROWTH REGULATION; HUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVIEW;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; CARRIER PROTEINS; GENE EXPRESSION REGULATION; HUMAN; INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN 1; MOLECULAR SEQUENCE DATA; NERVOUS SYSTEM; SIGNAL TRANSDUCTION;

EID: 0028957113     PISSN: 0163769X     EISSN: 0163769X     Source Type: Journal    
DOI: 10.1210/edrv-16-2-143     Document Type: Article

References (292)

1. Sussenbach JS, Steenbergh PH, Holthuizen P 1992 Structure and expression of the human insulin-like growth factor genes. Growth Regul 2:1-9
2. Daughaday WH, Rotwein P 1989 Insulin-like growth factors I and Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr Rev 10:68-91
3. Sara VR, Hall K 1990 Insulin-like growth factors and their binding proteins. Physiol Rev 70:591-614
4. Humbel RE 1990 Insulin-like growth factors I and II. Eur J Biochem 190:445-462
5. LeRoith D, Adamo M, Werner H, Roberts Jr CT 1991 Insulin-like growth factors and their receptors as growth regulators in normalphysiology and pathological states. Trends Endocrinol Metab 2:134-139
6. Nissley P, Lopaczynski W 1991 Insulin-like growth factor receptors. Growth Factors 5:29-49
7. Werner H, Woloschak M, Stannard B, Shen-Orr Z, Roberts Jr CT, LeRoith D 1991 Insulin-like growth factor I receptor: molecular biology, heterogeneity, and regulation. In: LeRoith D (ed) InsulinLike Growth Factors. CRC Press, Boca Raton, FL, pp 17-47
8. Cohick WS, Clemmons DR 1993 The insulin-like growth factors. Annu Rev Physiol 55:131-153
9. Clemmons DR 1992 IGF binding proteins: regulation of cellular actions. Growth Regul 2:80-87
10. Rechler MM 1993 Insulin-like growth factor binding proteins. Vitam Horm 47:1-114
11. Baxter RC 1991 Insulin-like growth factor (IGF) binding proteins: the role of serum IGFBPs in regulating IGF availability. Acta Paediatr Scand 372:107-114
12. Abbott AM, Bueno R, Pedrini MT, Murray JM, Smith RJ 1992 Insulin-like growth factor I receptor gene structure. J Biol Chem 267:10759-10763
13. Ullrich A, Bell JR, Chen EY, Herrera R, Petruzzeli LM, Dull TJ, Gray A, Coussens L, Liao Y-C, Tsubokawa M, Mason A, Seeburg PH, Grunfeld C, Rosen OM, Ramachandran J 1985 Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes. Nature 313:756-761
14. Ebina Y, Ellis L, Jamagin K, Edery M, Graf L, Clauser E, Qu J, Masiarz F, Kan YW, Goldfine ID, Roth RA, Rutter WJ 1985 The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signaling. Cell 40:747-758
15. Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubowka M, Collins Henzel W, LeBon T, Kathuria S, Chen F, Jacobs S, Francke U, Ramachandran J, Fujita-Yamaguchi Y 1986 Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests determinants that define functional specificity. EMBO J 5:2503-2512
16. Pedrini MT, Giorgino F, Smith RJ 1994 cDNA cloning of the rat IGF-I receptor: structural analysis of rat and human IGF-I and insulin receptors reveals differences in alternative splicing and receptor-specific domain conservation. Biochem Biophys Res Commun 202:1038-1046
17. Lowe Jr WL, Adamo M, Werner H, Roberts Jr CT, LeRoith D 1989 Regulation by fasting of rat insulin-like growth factor I and its receptor. Effects on gene expression and binding. J Clin Invest 84:619-626
18. Bondy CA, Werner H, Roberts Jr CT, LeRoith D 1990 Cellular pattern of insulin-like growth factor I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression. Mol Endocrinol 4:1386-1398
19. Werner H, Woloschak M, Adamo M, Shen-Orr Z, Roberts Jr CT, LeRoith D 1989 Developmental regulation of the rat insulin-like growth factor I receptor gene. Proc Natl Acad Sci USA 86:7451-7455
20. Werner H, Stannard B, Bach MA, LeRoith D, Roberts Jr CT 1990 Cloning and characterization of the proximal promoter region of the rat insulin-like growth factor I (IGF-I) receptor gene. Biochem Biophys Res Commun 169:1021-1027
21. Werner H, Bach MA, Stannard B, Roberts Jr CT, LeRoith D 1992 Structural and functional analysis of the insulin-like growth factor I receptor gene promoter. Mol Endocrinol 6:1545-1558
22. Mamula PW, Goldfine ID 1992 Cloning and characterization of the human insulin-like growth factor-I receptor gene 5’-flanking region. DNA Cell Biol 11:43-50
23. Cooke DW, Bankert LA, Roberts Jr CT, LeRoith D, Casella SJ 1991 Analysis of the human type I insulin-like growth factor receptor promoter region. Biochem Biophys Res Commun 177:1113-1120
24. Smale ST, Baltimore D 1989 The “initiator” as a transcription control element. Cell 57:103-113
25. McKeon C, Moncada V, Pham T, Salvatore P, Kadowaki T, Accili Taylor S 1990 Structural and functional analysis of the insulin receptor promoter. Mol Endocrinol 4:647-656
26. Mamula PW, Wong W-Y, Maddux BA, McDonald AR, Goldfine ID 1988 Sequence and analysis of promoter region of the human insulin receptor gene. Diabetes 37:1241-1246
27. Araki E, Shimada F, Uzawa H, Mori M, Ebina Y 1987 Characterization of the promoter region of the human insulin receptor gene. J Biol Chem 262:16186-16191
28. Sibley E, Kastelic T, Kelly TJ, Lane MD 1989 Characterization of the mouse insulin receptor gene promoter. Proc Natl Acad Sci USA 86:9732-9736
29. Kozak M 1991 An analysis of vertebrate mRNA sequences: intimations of translational control. J Cell Biol 115:887-903
30. Courey AJ, Tjian R 1992 Mechanisms of transcriptional control as revealed by studies of human transcription factor Spl. In: Transcriptional Regulation. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp 743-769
31. Brown MS, Goldstein JC 1986 A receptor-mediated pathway for cholesterol homeostasis. Science 232:34-47
32. Backer JM, Kahn CR, Cahill DA, Ullrich A, White MF 1990 Receptor-mediated internationalization of insulin requires a 12-aftuno acid sequence in the juxtamembrane region of the insulin receptor beta-subunit. J Biol Chem 265:16450-16454
33. Hsu D, Knudson PE, Zapf A, Rolband GC, Olefsky JM 1994 NPXY motif in the insulin-like growth factor-I receptor is required for efficient ligand-mediated receptor internalization and biological signaling. Endocrinology 134:744-754
34. Prager D, Li H-L, Yamasaki H, Melmed S 1994 Human insulin-like growth factor I receptor internalization. J Biol Chem 269:11934-11937
35. Hanks SK, Quinn AM, Hunter T 1988 The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241:42-52
36. Knighton DR, Zheng J, Ten Eyck LF, Ashford VA, Xuong N-H, Taylor SS, Sowadski JM 1991 Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 253:407-414
37. Knighton DR, Zheng J, Ten Eyck LF, Xuong N-H, Taylor SS, Sowadski JM 1991b Structure of a peptide inhibition bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 253:414-420
38. Yee D, Lebovic GS, Marcus RR, Rosen N 1989 Identification of an alternate type I insulin-like growth factor receptor β subunit in mRNA transcript. J Biol Chem 264:21439-21441
39. Condorelli G, Smith RJ 1993 Two alternatively spliced forms of the IGF-I receptor have distinct biological activities and hormone-induced internalization rates. Exp Clin Endocrinol 101:95-97
40. Condorelli G, Bueno R, Smith R 1994 Two alternatively spliced forms of the human insulin-like growth factor I receptor have distinct biological activities and internalization kinetics. J Biol Chem 269:8510-8516
41. Alexandrides TK, Chen J-H, Bueno R, Giorgino F, Smith RJ 1993 Evidence for two insulin-like growth factor I receptors with distinct primary structure that are differentially expressed during development. Regul Pept 48:279-290
42. Alexandrides TK, Smith RJ 1989 A novel fetal insulin-like growth factor (IGF) I receptor. Mechanism for increased IGF-I and insulin-stimulated tyrosine kinase activity in fetal muscle. J Biol Chem 264:12922-12930
43. Alexandrides T, Moses AC, Smith RJ 1989 Developmental expression of receptors for insulin, insulin-like growth factor I (IGF-I), and IGF-II in rat skeletal muscle. Endocrinology 124:1064-1076
44. Garofalo RS, Rosen OM 1989 Insulin and insulin-like growth factor I (IGF-I) receptors during central nervous system development: expression of two immunologically distinct IGF-I receptor β subunits. Mol Cell Biol 9:2806-2817
45. Moss AM, Livingston JN 1993 Distinct β-subunits are present in hybrid insulin-like-growth-factor-I receptors in the central nervous system. Biochem J 294:685-692
46. Barenton B, Domeyne A, Garandel V, Garofalo RS 1993 A developmentally regulated form of insulin-like growth factor receptor β-subunit in C2 myoblasts exhibiting altered requirements for differentiation. Endocrinology 133:651-660
47. Shemer J, Adamo M, Wilson GL, Heffez D, Zick Y, LeRoith D 1987 Insulin and insulin-like growth factor-I stimulate a common endogenous phosphoprotein substrate (ppl85) in intact neuroblastoma cells. J Biol Chem 262:15476-15482
48. Ota A, Wilson G, LeRoith D 1988 Insulin-like growth factor I receptors in mouse neuroblastoma cells. Two β subunits are derived from differences in glycosylation. Eur J Biochem 174:521-530
49. Kellerer M, Obemmaier-Kusser B, Ermel B, Wallner U, Haring H-U, Petrides P1990 An altered IGF-I receptor is present in human leukemic cells. J Biol Chem 265:9340-9345
50. Garofalo RS, Barenton B 1992 Functional and immunological distinction between insulin-like growth factor I receptor subtypes in KB cells. J Biol Chem 276:11470-11475
51. Domeyne A, Pinset C, Montarras D, Garandel V, Rosenfeld RG, Barenton B 1992 Preferential binding of insulin-like growth factor-II (IGF-II) to a putative a2β2 IGF-II receptor type C2 myoblasts. Eur J Biochem 208:273-279
52. Sasaki N, Nakamura K, Kabota K, Uchimura H 1991 Characterization of receptors for insulin-like factors in human brain. Gerontology 37:3-11
53. Kull FC, Jacobs S, Su Y-F, Svoboda ME, Van Wyk JJ, Cuatrecasas P 1983 Monoclonal antibodies to receptors for insulin and somatomedin-c. J Biol Chem 258:6561-6566
54. Flier JS, Moses AC 1985 Characterization of monoclonal antibodies to the IGF-I receptor that inhibit IGF-I binding to human cells. Biochem Biophys Res Commun 127:929-936
55. Wada J, Liu ZZ, Alvares K, Kumar A, Wallner E, Makino H, Kanwar YS 1993 Cloning of cDNA for the alpha subunit of the mouse insulin-like growth factor I receptor and the role of the receptor in metanephric development. Proc Natl Acad Sci USA 90:10360-10364
56. Moxham CP, Jacobs S 1992 Insulin/IGF-I receptor hybrids: a mechanism for increasing receptor diversity. J Cell Biochem 48: 136-140
57. Moxham CP, Duronio V, Jacobs S 1989 Insulin-like growth factor I receptor β subunit heterogeneity. Evidence for hybrid tetramers composed of insulin-like growth factor I and insulin receptor heterodimers. J Biol Chem 264:13238-13244
58. Soos MA, Siddle K 1989 Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors. Biochem J 263: 553-563
59. Soos MA, Whittaker J, Lammers R, Ullrich A, Siddle K 1990 Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterization of hybrid receptors in transfected cells. Biochem J 270:383-390
60. Treadway JL, Morrison BD, Goldfine ID, Pessin JE 1989 Assembly of insulin/insulin-like growth factor-I hybrid receptors in vitro. J Biol Chem 264:21450-21453
61. Soos MA, Field CE, Siddle K 1993 Purified hybrid insulin/insulinlike growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem J 290:419-425
62. Kasuya J, Paz B, Maddux BA, Goldfine ID, Hefta SA, Fujita-Yamaguchi Y 1993 Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification. Biochemistry 32:13531-13536
63. Frattali AL, Pessin JE 1993 Relationship between a subunit ligand occupancy and j3 subunit autophosphorylation in insulin/insulinlike growth factor-I hybrid receptors. J Biol Chem 268:7393-7400
64. Shier P, Watt VM 1989 Primary structure of a putative receptor for a ligand of the insulin family. J Biol Chem 264:14605-14608
65. -Shier P, Watt VM 1992 Tissue-specific expression of the rat insulin receptor-related receptor gene. Mol Endocrinol 6:723-729
66. Kurachi H, Jobo K, Ohta M, Kawasaki T, Itoh N 1992 A new member of the insulin receptor family, insulin receptor-related receptor, is expressed preferentially in the kidney. Biochem Biophys Res Commun 187:934-939
67. Reinhardt RR, Chin E, Zhang B, Roth RA, Bondy CA 1993 Insulin receptor-related receptor messenger ribonucleic acid is focally expressed in sympathetic and sensory neurons and renal distal tubule cells. Endocrinology 133:3-10
68. Zhang B, Roth RA 1992 The insulin receptor-related receptor. J Biol Chem 267:18320-18328
69. Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J 1992 The SH2 and SH3 domain-containing proteins GRB2 links receptor tyrosine kinases to ras signaling. Cell 70:431-442
70. Gale NW, Kaplan S, Lowenstein EJ, Schlessinger J, Bar-Sagi D 1993 Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Nature (London) 363:88-92
71. Rozakis-Adcock M, Femley R, Wade J, Pawson T, Bowtell D 1993 The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSosl. Nature 363:83-84
72. Olivier JP, Raabe T, Henkemeyer M, Dickson B, Mbamalu G, Margolis B, Schlessinger J, Hafen E, Pawson T 1993 A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine exchange, Sos. Cell 73:179-191
73. Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA 1993 Association of Sos ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363:45-51
74. Crews CM, Erikson RL 1993 Extracellular signals and reversible protein phosphorylation: what to Mek of it all. Cell 74:215-217
75. Boguski MS, McCormick F 1993 Proteins regulating Ras and its relatives. Nature 366:643-653
76. Kato H, Faria TN, Stannard B, Roberts Jr CT, LeRoith D 1993 Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. J Biol Chem 265:2655-2661
77. Kato H, Faria TN, Stannard B, Roberts Jr CT, LeRoith D 1994 Essential role of tyrosine residues 1131, 1135, and 1136 of the insulin-like growth factor-I (IGF-I) receptor in IGF-I action. Mol Endocrinol 8:40-50
78. Gronborg M, Wulff BS, Rasmussen JS, Kjeldsen T, Gammeltoft S 1993 Structure-function relationship of the insulin-like growth factor-I receptor tyrosine kinase. J Biol Chem 258:23435-23440
79. Yamasaki H, Prager D, Gebremedhin S, Melmed S 1992 Human insulin-like growth factor I receptor 950tyrosine is required for somatotroph growth factor signal transduction. J Biol Chem 267: 20953-20958
80. LeRoith D, Lowe Jr WL, Shemer J, Raizada M, Ota A 1988 Development of brain insulin receptors. Int J Biochem 20:225-230
81. Myers Jr MG, Sun X-J, Cheatham B, Jachna BR, Glasheen EM, Backer JM, White MF 1993 IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3’-kinase. Endocrinology 132:1421-1430
82. Myers Jr MG, White MF 1993 The new elements of insulin signalling: insulin receptor substrate-1 and proteins with SH2 domains. Diabetes 42:643-650
83. Sun XJ, Crimmins DL, Myers Jr MG, Miralpeix M, White MF 1993 Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol Cell Biol 13:7418-7428
84. Pawson T, Schlessinger J 1993 SH2 and SH3 domains. Curr Biol 3:434-442
85. Backer JM, Myers Jr MG, Shoelson SE, Chin DJ, Sun X-J, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J, White MF 1992 The phosphatidylinositol 3’-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J 11:3469-3479
86. Myers Jr MG, Backer JM, Sun X-J, Shoelson SE, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, White MF 1992 IRS-1 activates the phosphatidylinositol 3’-kinase by associating with the src homology 2 domains of p85. Proc Natl Acad Sci USA 89:10350-10354
87. Kotani K, Yonezawa K, Hara K, Ueda H, Kitamura Y, Sakaue H, Ando A, Chavanieu A, Calas B, Grigorescu F, Nishiyama M, Waterfield MD, Kasuga M 1994 Involvement of phosphoinositide 3-kinase in insulin- or IGF-I-induced membrane ruffling. EMBO J 13:2313-2321
88. Kuhne MR, Pawson T, Lienhard GE, Feng G-S 1993 The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J Biol Chem 2:11479-11481
89. Lechleider RJ, Sugimoto S, Bennett AM, Kashishian AS, Cooper AM, Shoelson SE, Walsh CT, Neel BG 1993 Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor β. J Biol Chem 268:21478-21481
90. Feng G-S, Hui C-C, Pawson T 1993 SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259:1607-1611
91. Vogel W, Lammers R, Huang J, Ullrich A 1993 Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science 259:1611-1614
92. Sugimoto S, Wandless TJ, Shoelson SE, Neel BG, Walsh CT 1994 Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1. J Biol Chem 269:13614-13622
93. Pronk GJ, McGlade J, Pelicci G, Pawson T, Bos JL 1993 Insulin-induced phosphorylation of the 46- and 52-kDa She proteins. J Biol Chem 268:5748-5769
94. Sasaoka T, Draznin B, Leitner JW, Langlois WJ, Olefsky JM 1994 She is the predominant signaling molecular coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation. J Biol Chem 269:10734-10736
95. Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Fomi G, Pawson T, Pelicci PG 1992 A novel transforming protein (She) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70:93-104
96. Yokote K, Mori S, Hansen K, McGlade J, Pawson T, Heldin C-H, Claesson-Welsh L 1994 Direct interaction between She and the platelet-derived growth factor β-receptor. J Biol Chem 269:15337-15343
97. Sasaoka T, Rose DW, Juhn BH, Saltiel AR, Draznin B, Olefsky JM 1994 Evidence for a functional role of She proteins in mitogenic signaling induced by insulin, insulin-like growth factor-I, and epidermal growth factor. J Biol Chem 269:13689-13694
98. Skolnik EY, Lee CH, Batzer AG, Vincentini M, Zhou M, Daly RJ, Myers Jr MG, Backer JM, Ullrich A, White MF, Schlessinger J 1993 The SH2/SH3 domain containing protein GRB2 interacts with tyrosine phosphorylated IRS-1 and She: implications for insulin control of ras signaling. EMBO J 12:1929-1936
99. Yonezawa K, Ando A, Kaburagi Y, Yamamoto-Honda R, Kiamura T, Hara K, Nakafuku M, Okabayashi Y, Kasowaki T, Kaziro Y, Kasuga M 1994 Signal transduction pathways from insulin receptors to Ras. J Biol Chem 269:4634-4640
100. Songyang Z, Shoelson SE, McGlade J, Olivier T, Pawson XR, Bustelo M, Barbacid M, Sabe H, Hanafusa H, Yi T, Ren R, Baltimore D, Ratnofsky S, Feldman A, Cantley LC 1994 Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, She, Syk, and Vav. Mol Cell Biol 14:2777-2785
101. Condorelli G, Formisano P, Villone G, Smith RJ, Beguinot F 1989 Insulin and insulin-like growth factor-I (IGF-I) stimulate phosphorylation of a Mr 175, 000 cytoskeleton-associated protein in intact FRTL-5 cells. J Biol Chem 264:12633-12638
102. Lamphere L, Lienhard GE 1992 Components of signaling pathways for insulin and insulin-like growth factor-I in muscle myoblasts and myotubes. Endocrinology 131:2196-2202
103. Oemar BS, Law NM, Rosensweig SA 1991 Insulin-like growth factor-I induces tyrosyl phosphorylation of nuclear proteins. J Biol Chem 266:24241-24244
104. Way BA, Mooney RA 1993 Activation of phosphatidylinositol-3-kinase by platelet-derived growth factor and insulin-like growth factor-I is inhibited by a transmembrane phosphotyrosine phosphatase. J Biol Chem 269:26409-26415
105. Peraldi P, Hauguel-de Mouzon S, Alengrin F, Van Obberghen E 1992 Dephosphorylation of human insulin-like growth factor I (IGF-I) receptors by membrane-associated tyrosine phosphatases. Biochem J 285:71-78
106. Li W, Nishimura R, Kashishian A, Batzer AG, Kim WJH, Cooper JA, Schlessinger J 1994 A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol Cell Biol 14:509-517
107. Milarski KL, Saltiel AR 1994 Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin. J Biol Chem 269:21239-21243
108. Xiao S, Rose DW, Sasaoka T, Maegawa H, Burke Jr TR, Roller PP, Shoelson SE, Olefsky JM 1994 Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. J Biol Chem 269:21244-21248
109. Case RD, Piccione E, Wolf G, Benett AM, Lechleider RJ, Neel BG, Shoelson SE 1994 SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor β-receptor, epidermal growth factor receptor, and insulin receptor substrate-1-derived phosphopeptides. J Biol Chem 269:10467-10474
110. Kuhne MR, Zhao Z, Rowles J, Lavan BE, Shen S-H, Fischer EH, Lienhard GE 1994 Dephosphorylation of insulin receptor substrate 1 by the tyrosine phosphatase PTP2C. J Biol Chem 269:15833-15837
111. Begum N, Robinson LJ, Draznin B, Heidenreich KA 1993 Protein phosphatase-1 and *-2a activities in cultured fetal chick neurons: differential regulation by insulin and insulin-like growth factor-I. Endocrinology 133:2085-2090
112. 538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains. J Biol Chem 269:12220-12228
113. Cook SJ, McCormick F 1993 Inhibition by cAMP of Ras-dependent activation of Raf. Science 262:1069-1072
114. Sevetson BR, Kong X, Lawrence Jr JC 1993 Increasing cAMP attenuates activation of mitogen-activated protein kinase. Biochemistry 90:10305-10309
115. Graves LM, Bomfeldt KE, Raines EW, Potts BC, MacDonald SG, Ross R, Krebs EG 1993 Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. Proc Natl Acad Sci USA 90:10300-10304
116. Wu J, Dent P, Jelinek T, Wolfman A, Weber MJ, Sturgill TW 1993 Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3’, 5’-monophosphate. Science 262:1065-1069
117. Burgering BMT, Pronk GJ, van Weeren PC, Chardin P, Bos JL 1993 cAMP antagonizes p21ras-directed kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J 12:4211-4220
118. Webster J, Prager D, Melmed S 1994 Insulin-like growth factor-I activation of extracellular signal-related kinase-1 and *-2 in growth hormone-secreting cells. Mol Endocrinol 8:539-544
119. Faure M, Voyno-Yasenetskaya TA, Bourne HR 1994 cAMP and βk subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J Biol Chem 269: 7851-7854
120. Schumacher R, Mosthaf L, Schlessinger J, Brandenburg D, Ullrich A 1991 Insulin and insulin-like growth factor-I binding specificity is determined by distinct regions of their cognate receptors. J Biol Chem 266:19288-19295
121. Kjeldsen T, Andersen AS, Wiberg FC, Rasmussen JS, Schaffer L, Balschmidt P, Moller KB, Moller NPH 1991 The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site. Proc Natl Acad Sci USA 88:4404-4408
122. Andersen AS, Kjeldsen T, Wiberg FC, Christensen PM, Rasmussen JS, Norris K, Moller KB, Moller NPH 1990 Changing the insulin receptor to possess insulin-like growth factor I ligand specificity. Biochemistry 29:7363-7366
123. Andersen AS, Kjeldsen T, Wiberg FC, Vissing H, Schaffer L, Rasmussen JS, De Meyts P, Moller NP 1992 Identification of determinants that confer ligand specificity on the insulin receptor. J Biol Chem 267:13681-13686
124. Soos MA, Field CE, Lammers R, Ullrich A, Zhang B, Roth RA, Andersen AS, Kjeldsen T, Siddle K 1992 A panel of monoclonal antibodies for the type I insulin-like growth factor receptor. J Biol Chem 267:12955-12963
125. Liu D, Rutter WJ, Wang L-H 1992 Enhancement of transforming potential of human insulin-like growth factor I receptor by N-terminal truncation and fusion to avian sarcoma virus UR2 gag sequence. J Virol 66:374-385
126. Liu D, Rutter WJ, Wang L-H 1993 Modulating effects of the extracellular sequence of the human insulin-like growth factor I receptor on its transforming and tumorigenic potential. J Virol 67: 9-18
127. Shoelson SE, White MF, Kahn CR 1988 Tryptic activation of the insulin receptor. Proteolytic truncation of the a subunit releases the β-subunit from inhibitory control. J Biol Chem 263:4852-4860
128. Germain-Lee EL, Janicot M, Lammers R, Ullrich A, Casella SJ 1992 Expression of a type I insulin-like growth factor receptor with low affinity for insulin-like growth factor II. Biochem J 281:413-417
129. Kishimoto M, Hashiramoto M, Yonezawa K, Shii K, Kazumi T, Kasuga M 1994 Substitution of glutamine for arginine 1131: A newly identified mutation in the catalytic loop of the tyrosine kinase domain of the human insulin receptor. J Biol Chem 269: 11349-11356
130. Chen J, Hanafusa T, Wang L-H 1994 Ala—>Gly mutation in the putative catalytic loop confers temperature sensitivity on Ros, insulin receptor, and insulin-like growth factor I receptor protein-tyrosine kinases. Proc Natl Acad Sci USA 91:321-325
131. Prager D, Yamasaki H, Weber MM, Gebremedlin S, Melmed S 1992 Human insulin-like growth factor-I receptor function in pituitary cells is suppressed by a dominant negative mutant. J Clin Invest 90:2117-2122
132. Hsu D, Knudson PE, Zapf A, Rolband GC, Olefsky JM 1994 NPXY motif in the insulin-like growth factor-I receptor is required for efficient ligand-mediated receptor internalization and biological signaling. Endocrinology 134:744-750
133. Surmacz E, Sell C, Swantek J, Kato H, Roberts Jr CT, LeRoith D, Baserga R, Dissociation of mitogenesis and transforming activity by C-terminal truncation of the insulin-like growth factor-I receptor. Exp Cell Res, in press
134. Liu D, Zong CS, Wang L-H 1993 Distinctive effects of the carboxy-terminal sequence of the insulin-like growth factor I receptor on its signaling functions. J Virol 67:6835-6840
135. Prager D, Li H-L, Asa S, Melmed S 1994 Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant. Proc Natl Acad Sci USA 91:2181-2185
136. Tartare S, Mothe I, Kowalski-Chauvel A, Breittmayer J-P, Ballotti R, Van Obberghen E 1994 Signal transduction by a chimeric insulin-like growth factor-I (IGF-I) receptor having the carboxy-terminal domain of the insulin receptor. J Biol Chem 269:11449-11455
137. Faria TN, Blakesley VA, Kato H, Stannard B, LeRoith D, Roberts Jr CT 1994 Role of the carboxy-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function. J Biol Chem 269:1-7
138. Enoch T, Nurse P 1991 Coupling M phase and S phase: control maintaining the dependence of mitosis on chromosome replication. Cell 65:921-923
139. Hartwell LH, Weinert TA 1989 Checkpoints: controls that ensure the order of cell cycle events. Science 246:629-634
140. Mitchison JM 1974 Sequences, pathways and timers in the cell cycle. In: Padilla GM, Cameron IL, Zimmerman A (eds) Cell Cycle Controls. Academic Press, New York, pp 125-142
141. Furlanetto RW, Harwell SE, Frick KK 1994 Insulin-like growth factor-I induces cyclin-Dl expression in MG63 human osteosarcoma cells in vitro. Mol Endocrinol 8:510-517
142. Baserga R, Sell C, Porcu P, Rubini M 1994 The role of the IGF-I receptor in the growth and transformation of mammalian cells. Cell Prolif 27:63-71
143. Baserga R, Rubin R 1993 Cell cycle and growth control. Crit Rev. Eukaryotic Gene Expression 3:47-61
144. Coppola D, Ferber A, Miura M, Sell C, D’Ambrosio C, Rubin R, Baserga R 1994 A functional insulin-like growth factor-I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor. Mol Cell Biol 14:4588-4595
145. Liu J-P, Baker J, Perkins AS, Robertson EJ, Efstratiadis A 1993 Mice carrying null mutations of the genes encoding insulin-like ^growth factor I (IGF-I) and Type I IGF receptor (IGF-IR). Cell 75:59-72
146. Baker J, Liu J-P, Robertson EJ, Efstratiadis A 1993 Role of insulinlike growth factors in embryonic and postnatal growth. Cell 75: 73-82
147. Porcu P, Ferber A, Pietrzkowski Z, Roberts Jr CT, Adamo M, LeRoith D, Baserga R 1992 The growth-stimulatory effect of Simian virus 40 T antigen requires the interaction of insulin-like growth factor I with its receptor. Mol Cell Biol 12:5069-5077
148. Baserga R 1992 The double life of the IGF-I receptor. Receptor 2:261-266
149. Sell C, Rubini M, Rubin R, Liu J-P, Efstratiadis A, Baserga R 1993 Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc Natl Acad Sci USA 90:11217-11221
150. Kaleko M, Rutter WJ, Miller AD 1990 Overexpression of the human insulin-like growth factor I receptor promotes ligand-dependent neoplastic transformation. Mol Cell Biol 10:464-473
151. Macauley VM, Teale J, Everard MJ, Joshi GP, Smith IE, Millar JL 1988 Somatomedin-C/insulin-like growth factor I is a mitogen for human small cell lung cancer. Br J Cancer 57:91-98
152. Freed KA, Herington AC 1989 Insulin-like growth factor-I and its autocrine role in growth of MCF-7 human breast cancer cells in culture. J Mol Endocrinol 3:183-188
153. Yee D, Paik S, Lebovic GS, Marcus RR, Favoni RE, Cullen KJ, Lippman ME, Rosen N 1989 Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer. Mol Endocrinol 3:509-514
154. Nakanishi Y, Mulshine JI, Kasprzyk PG, Natale RB, Maneckjee R, Avis I, Treston AM, Gazdar AF, Minna JD, Cuttitta F 1988 Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines. J Clin Invest 82: 354-359
155. Minuto F, Del Monte P, Barreca A, Alama A, Cariola G, Giordano G 1988 Evidence for autocrine mitogenic stimulation by somatomedin-C insulin-like growth factor I on an established human lung cancer cell line. Cancer Res 48:3716-3723
156. Macauley VM, Everard MJ, Teale JD, Trott PA, Van Wyk JJ, Smith IE, Millar JL 1990 Autocrine function for insulin-like growth factor I in human small cell lung cancer cell lines and fresh tumor cells. Cancer Res 50:2511-2517
157. Jaques G, Rotsch M, Wegmann C, Worsch U, Maasberg M, Havemann K 1988 Production of immunoreactive insulin-like growth factor I and response to exogenous IGF-I in small cell lung cancer cell lines. Exp Cell Res 176:336-345
158. Nielsen FC, Orskov C, Haselbacher G, Ramlau J, Christiansen J, Schmiegelow K, Rehfeld JF 1994 Insulin-like growth factor II mRNA, peptides, and receptors in a thoracopulmonary malignant small round cell tumor. Cancer 73:1312-1319
159. Kaiser U, Schardt C, Brandscheidt D, Wollmer E, Havemann K 1993 Expression of insulin-like growth factor receptors I and II in normal human lung and in lung cancer. J Cancer Res Clin Oncol 119:665-668
160. Rotsch M, Maasberg M, Erbil C, Jaques G, Worsch U, Havemann K 1992 Characterization of insulin-like growth factor I receptors and growth effects in human lung cancer cell lines. J Cancer Res Clin Oncol 118:502-508
161. Furlanetto RW, DiCarlo JN 1984 Somatomedin-C receptors and growth effects in human breast cells maintained in long-term tissue culture. Cancer Res 44:2122-2128
162. Peyrat J-P, Bonneterre J, Beuscart R, Dijane J, Demaille A 1988 Insulin-like growth factor I receptors in human breast cancer and their relation to estradiol and progesterone receptors. Cancer Res 48:6429-6436
163. Poliak MN, Perdue JF, Margolese RG, Raer K, Richard M 1987 Presence of somatomedin receptor on primary human breast and colon carcinomas. Cancer Lett 38:223-230
164. Poliak MN, Polychronakos C, Yousefi S, Richard M 1988 Characterization of insulin-like growth factors I (IGF-I) receptors of human breast cancer cells. Biochem Biophys Res Commun 154: 326-332
165. Foekens JA, Portengen H, Janssen M, Klijn JGM 1989 Insulin-like growth factor-1 receptors and insulin-like growth factor-1-like activity in human primary breast cancer. Cancer 63:2139-2146
166. Foekens JA, Protengen H, Van Putten WL, Trapman AMAC, Reubi J-C, Alexieva-Figusch J, Klijn JGM 1989 Prognostic value of receptors for insulin-like growth factor I, somatostatin, and epidermal growth factor in human breast cancer. Cancer Res 49:7002-7009
167. Cullen KI, Yee D, Sly WS, Perdue J, Hampton B, Lippman ME, Rosen N 1990 Insulin-like growth factor receptor expression and function in human breast cancer. Cancer Res 50:48-53
168. Pekonen F, Partanen S, Makinen T, Rutanen E-M 1988 Receptors for epidermal growth factor and insulin-like growth factor I and their relation to steroid receptors in human breast cancer. Cancer Res 48:1343-1348
169. Pezzino V, Milazzo G, Frittitta L, Vigneri R, Ezaki O, Kasahara M, LeBon TR, Goldfine ID, Fujita-Yamaguchi Y 1991 Radioimmunoassay for human insulin-like growth factor-I receptor: applicability to breast carcinoma specimens and cell lines. Metabolism 40:861-865
170. Jammes H, Peyrat JP, Ban E, Vilain MO, Haour F, Djiane J, Bonneterre J 1992 Insulin-like growth factor I receptors in human breast tumour: localization and quantification by histo-autoradiographic analysis. Br J Cancer 66:248-253
171. De Leon DD, Bakker B, Wilson DM, Hintz RL, Rosenfeld RG 1988 Demonstration of insulin-like growth factor (IGF-I and -II) receptors and binding protein in human breast cancer cell lines. Biochem Biophys Res Commun 152:398-406
172. Verland S, Gammeltoft S 1989 Functional receptors for insulin-like growth factors I and II in rat thymocytes and mouse thymoma cells. Mol Cell Endocrinol 67:207-215
173. Chung CK, Antoniades HN 1992 Expression of c-sis/platelet-derived growth factor B, insulin-like growth factor I, and transforming growth factor alpha messenger RNAs and their respective receptor messenger RNAs in primary human gastric carcinomas: in vivo studies with in situ hybridization and immunocytochemistry. Cancer Res 52:3453-3459
174. Remaole-Bennet MM, Culouscou JM, Garrouste FL, Rabenandrasana C, Marvaldi JL, Pommier GJ 1992 Expression of type I, but not type II insulin-like growth factor receptor on both undifferentiated and differentiated HT29 human colon carcinoma cell line. J Clin Endocrinol Metab 75:609-616
175. Guo YS, Narayan S, Yallampalli C, Singh P 1992 Characterization of insulin-like growth factor I receptors in human colon cancer. Gastroenterology 102:1101-1108
176. Minuto F, Barreca A, Del Monte P, Cariola C, Torn GC, Giordano G 1989 Immunoreactive insulin-like growth factor I (IGF-I) and IGF-I binding protein content in human thyroid tissue. J Clin Endocrinol Metabol 68:621-628
177. Yashiro T, Ohba Y, Murakami H, Ohara T, Tsushima T, Fujimoto Y, Shizume K, Ito K 1989 Expression of insulin-like growth factor receptors in primary human thyroid neoplasms. Acta Endocrinol (Copenh) 121:112-118
178. Kohn EC, Francis EA, Liotta LA, Schiffmann E 1990 Heterogeneity of the motility responses in malignant tumor cells: a biological basis for the diversity and homing of metastatic cells. Int J Cancer 46: 287-296
179. Caro JF, Poulos J, Ittoop O, Pories WJ, Flickinger EG, Sinha MK 1988 Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma and normal, regenerating and fetal rat liver. J Clin Invest 81:976-985
180. Ohmura E, Okada M, Onoda N, Kamiya Y, Murakami H, Tsushima T, Shizume K 1990 Insulin-like growth factor I and transforming growth factors as autocrine growth factors in human pancreatic cancer cell growth. Cancer Res 50:103-107
181. Pekonen F, Partanen S, Rutanen E-M 1989 Binding of epidermal growth factor and insulin-like growth factor I in renal carcinoma and adjacent normal kidney tissues. Int J Cancer 43:1029-1035
182. Talavera F, Reynolds RK, Roberts JA, Menon KMJ 1990 Insulinlike growth factor I receptors in normal and neoplastic human endometrium. Cancer Res 50:3019-3026
183. Glick RP, Gettleman R, Patel K, Lakshman R, Tsibris JCM 1989 Insulin and insulin-like growth factor I in brain tumors: binding and in vitro effects. Neurosurgery 24:791-806
184. Kurihara M, Tokunaga Y, TsuTsumi K 1989 Characterization of insulin-like growth factor I and epidermal growth factor receptors in meningioma. J Neurosurg 71:538-546
185. Martin DM, Yee D, Carlson RO, Feldman EL 1992 Gene expression of the insulin-like growth factors and their receptors in human neuroblastoma cell lines. Brain Res Mol Brain Res 15:241-246
186. Antoniades HN, Galanopoulos T, Neville-Golden J, Maxwell M 1992 Expression of insulin-like growth factors I and II and their receptor mRNAs in primary human astrocytomas and meningiomas; in vivo studies using in situ hybridization and immunocytochemistry. Int J Cancer 50:215-222
187. Ritvos O, Ranta T, Jalkanen J, Suikkari A-M, Vourilainen R, Bohn H, Rutanen E-M 1988 Insulin-like growth factor binding protein from human decidua inhibits the binding and biological action of IGF-I in cultured choriocarcinoma cells. Endocrinology 122:2150-2157
188. Ritvos O, Rutanen E-M, Pekonen F, Jalkanen J, Suikkari A-M, Ranta T 1988 Characterization of functional type insulin-like growth factor receptors from human choriocarcinoma cells. Endocrinology 122:395
189. Weima SM, Stet LH, Van Rooijen MA, Van Raul-Offers SC, Van Zoelen EJJ, DeLaat SW, Mummery CL 1989 Human teratocarcinoma cells express functional insulin-like growth factor I receptors. Exp Cell Res 184:427-436
190. Biddle C, Li CH, Schofield PN, Tate VE, Hopkins B, Engstrom W, Huskisson NS, Graham CF 1988 Insulin-like growth factors and the multiplication of tera-2, a human teratoma-derived cell line. J Cell Sci 90:475-484
191. Chandrasekhar Y, Heiner J, Dsuamkpe C, Nagamani M 1992 Insulin-like growth factor I and II binding in human myometrium and leiomyomas. Am J Obstet Gynecol 166:64-69
192. Giudice LC, Irwin JC, Dsupin BA, Pannier EM, Jin IH, Vtr TH, Hoffman AR 1993 Insulin-like growth factor (IGF), IGF binding protein (IGFBP), and IGF receptor gene expression and IGFBP synthesis in human uterine leiomyomata. Hum Reprod 8: 1796-1806
193. Kamio T, Shigematsu K, Kawai K, Tsuchiyama H 1991 Immunoreactivity and receptor expression of insulin-like growth factor I and insulin in human adrenal tumors. An immunohistochemical study of 94 cases. J Clin Endocrinol Metab 138:83-91
194. van Valen F, Winkelmann W, Jurgens H 1992 Type I and type II insulin-like growth factor receptors and their function in human Ewing’s sarcoma cells. J Cancer Res Clin Oncol 118:269-275
195. Baier TG, Ludwig WD, Schonberg D, Hartmann KK 1992 Characterization of insulin-like growth factor I receptors of human acute lymphoblastic leukemia (ALL) cell lines and primary ALL cells. Eur J Cancer 28:1105-1110
196. Pepe MG, Ginzton NH, Lee PDK, Mintz RL, Greenberg PL 1987 Receptor binding and mitogenic effects of insulin and insulin-like growth factors I and II for human myeloid leukemic cells. J Cell Physiol 133:219-226
197. Lee PDK, Rosenfeld RG, Hintz RL, Smith SD 1986 Characterization of insulin, insulin-like growth factors I and II and growth hormone receptors on human leukemic lymphoblasts. J Clin Endocrinol Metab 62:28-36
198. Hizuka N, Sukegawa I, Takano K, Asakawa K, Horikawa, R, Tsushima T, Shizume K 1987 Characterization of insulin-like growth factor I receptors on human erythroleukemia cell line (K-562 cells). Endocrinol Jpn 34:81-90
199. Cooke DW, Casella SJ 1994 The 5’-untranslated region of the IGF-I receptor gene modulates reporter gene expression by both pre- and post-transcriptional mechanisms. Mol Cell Endocrinol 101:77-84
200. Beitner-Johnson D, Werner H, LeRoith D, Roberts Jr CT, Regulation of IGF-I receptor gene expression by Spl and by products of the retinoblastoma and p53 tumor suppressor genes. Program of the 76th Annual Meeting of the Endocrine Society, Anaheim, CA, 1994 (Abstract 439)
201. Saffer JD, Jackson SP, Annarella MB 1991 Developmental expression of Spl in the mouse. Mol Cell Biol 11:2189-2199
202. Ammendola R, Mesuraca M, Russo T, Cimino F 1992 Spl DNA binding efficiency is highly reduced in nuclear extracts from aged rat tissues. J Biol Chem 267:17944-17948
203. Sukhatme VP 1992 The EGR transcription factor family: from signal transduction to kidney differentiation. Kidney Int 41:550553
204. Madden SL, Cook DM, Morris JF, Gashler A, Sukhatme VP, Rauscher III FJ 1991 Transcriptional repression mediated by the WT1 Wilms’ tumor gene product. Science 253:1550-1553
205. Drummond IA, Madden SL, Rohwer-Nutter P, Bell GI, Sukhatme VP, Rauscher III FJ 1992 Repression of the insulin-like growth factor II gene by the Wilms’ tumor suppressor WT1. Science 257: 674-678
206. Gashler AL, Bonthron DT, Madden SL, Rauscher III FJ, Collins T, Sukhatme VP 1992 Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms’ tumor suppressor WT1. Proc Natl Acad Sci USA 89:10984-10988
207. Harrington MA, Konicek B, Song A, Xia X-L, Fredericks WJ, Rauscher III FJ 1993 Inhibition of colony-stimulating factor-1 promoter activity by the product of the Wilms’ tumor locus. J Biol Chem 268:21271-21275
208. Werner H, Re GG, Drummond IA, Sukhatme VP, Rauscher III FJ, Sens DA, Garvin AJ, LeRoith D, Roberts Jr CT 1993 Increased expression of the insulin-like growth factor-I receptor gene, IGFIR, in Wilms’ tumor is correlated with modulation of IGFIR promoter activity by the WT1 Wilms’ tumor gene product. Proc Natl Acad Sci USA 90:5828-5832
209. Werner H, Rauscher III FJ, Sukhatme VP, Drummond IA, Roberts Jr CT, LeRoith D 1994 Transcriptional repression of the insulin-like growth factor I receptor (IGF-I-R) gene by the tumor suppressor WT1 involves binding to sequences both upstream and downstream of the IGF-I-R gene transcription start site. J Biol Chem 269:12577-12582
210. Call KM, Glaser T, Ito CY, Buckler AJ, Pelletier J, Haber DA, Rose EA, Kral A, Yeger H, Lewis WH, Jones C, Housman DE 1990 Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms’ tumor locus. Cell 60:509-520
211. Rose EA, Glaser T, Jones C, Smith CL, Lewis WH, Call KM, Minden M, Champagne E, Bonetta L, Yeger H, Housman DE 1990 Complete physical map of the WAGR region of 11 pi 3 localizes a candidate Wilms’ tumor gene. Cell 60:495-508
212. Gessler M, Poustka A, Cavence W, Neve RL, Orkin SH, Bruns GAP 1990 Homozygous deletion in Wilms’ tumors of a zinc-finger gene identified by chromosome jumping. Nature 343:774-778
213. Gansler T, Furlanetto R, Gramling TS, Robinson KA, Blocker N, Buse MG, Sens DA, Garvin AJ 1989 Antibody to type I insulin-like growth factor receptor inhibits growth of Wilms’ tumor in culture and in athymic mice. Am J Pathol 135:961-966
214. Maheswaran S, Park S, Bernard A, Morris JF, Rauscher III FJ, Hill DE, Haber DA 1993 Physical and functional interaction between WT1 and p53 proteins. Proc Natl Acad Sci USA 90:5100-5104
215. Thissen JP, Ketelslegers J-M, Underwood LE 1994 Nutritional regulation of the insulin-like growth factors. Endocr Rev 15: 80-163
216. Eshet R, Werner H, Klinger B, Silbergeld A, Laron Z, LeRoith D, Roberts Jr CT 1993 Up-regulation of insulin-like growth factor-I (IGF-I) receptor gene expression in patients with reduced serum IGF-I levels. J Mol Endocrinol 10:115-120
217. Werner H, Shen-Orr Z, Stannard B, Burguera B, Roberts Jr CT, LeRoith D 1990 Experimental diabetes increases insulin-like growth factor I and II receptor concentration and gene expression in the kidney. Diabetes 39:1490-1497
218. Mulroney SE, Haramati A, Werner H, Bondy C, Roberts Jr CT, LeRoith D 1992 Altered expression of insulin-like growth factor-I (IGF-I) and IGF-I receptor genes after unilateral nephrectomy in immature rats. Endocrinology 130:249-256
219. Rosenfeld RG, Hintz RL 1980 Characterization of a specific receptor for somatomedin C (Sm-C) on cultured human lymphoblasts: Evidence that Sm-C modulates homologous receptor concentration. Endocrinology 107:1841-1848
220. Rosenfeld RG 1982 Characterization of the somatomedin-c/insulin-like growth factor I (SM-C/IGF-I) receptor on cultured human fibroblast monolayers: regulation of receptor concentration by SM-C/IGF-I and insulin. J Clin Endocrinol Metab 55:434-440
221. Yamamoto H, Prager D, Yamasaki H, Melmed S1993 Rat pituitary GC cell insulin-like growth factor I receptor regulation. Endocrinology 133:1420-1425
222. Rosenthal SM, Brown EJ, Brunetti A, Goldfine ID 1991 Fibroblast growth factor inhibits insulin-like growth factor II (IGF-II) gene expression and increases IGF-I receptor abundance in BC3H-1 muscle cells. Mol Endocrinol 5:678-684
223. Clemmons DR, Shaw DS 1983 Variables controlling somatomedin production by cultured human fibroblasts. J Cell Physiol 115:137-142
224. Rubini M, Werner H, Gandini E, Roberts Jr CT, LeRoith D, Baserga R 1994 Platelet-derived growth factor increases the activity of the promoter of the IGF-I receptor gene. Exp Cell Res 211:374-379
225. Papa V, Hartmann KKP, Rosenthal SM, Maddux BA, Siiteri PK, Goldfine ID 1991 Progestins induce down-regulation of insulinlike growth factor (IGF-I) receptors in human breast cancer cells; potential autocrine role of IGF-II. Mol Endocrinol 5:709-717
226. Goldfine ID, Papa V, Vigneri R, Siiteri P, Rosenthal SM 1992 Progestin regulation of insulin and insulin-like growth factor I receptors in cultured human breast cancer cells. Mol Endocrinol 6:1665-1672
227. Reiss K, Meggs LG, Li P, Olivetti G, Capasso JM, Anversa P 1994 Upregulation of IGF1, IGF1-receptor, and late growth related genes in ventricular myocytes acutely after infarction in rats. J Cell Physiol 158:160-168
228. Engelmann GL, Boehm KD, Haskell JF 1989 Insulin-like growth factors and neonatal cardiomyocyte development: ventricular gene expression and membrane receptor variations in normotensive and hypertensive rats. Mol Cell Endocrinol 63:1-14
229. Toyozaki T, Hiroe M, Hasumi M, Horie T, Hosoda S, Tsushima T, Sekiguchi M 1993 Insulin-like growth factor I receptors in human cardiac myocytes and their relation to myocardial hypertrophy. Jpn Circ J 57:1120-1127
230. Pfeifle B, Boeder H, Ditschuneit H 1987 Interaction of receptors for insulin-like growth factor I, platelet-derived growth factor, and fibroblast growth factor in rat aortic cells. Endocrinology 120:2251-2258
231. Bassas L, Girbau M, Lesniak MA, Roth J, DePablo F 1989 Development of receptors for insulin-like growth factor-I in head and brain of chick embryos: autoradiographic localization. Endocrinology 125:2320-2326
232. Bassas L, DePablo F, Lesniak MA, Roth J 1985 Ontogeny of receptors for insulin-like peptides in chick embryo tissues: early dominance of insulin-like growth factor over insulin receptors in brain. Endocrinology 117:2321-2329
233. Scavo L, Shuldiner AR, Serrano J, Dashner R, Roth J, dePablo F 1991 Genes encoding receptors for insulin and insulin-like growth factor I are expressed in Xenopus oocytes and embryos. Proc Natl Acad Sci USA 88:6214-6218
234. Rappolee DA, Werb Z 1991 Endogenous insulin-like growth factor II mediates growth in preimplantation mouse embryos. In: Spencer EM (ed) Modem Concepts of Insulin-Like Growth Factors. Elsevier, New York, pp 3-8
235. Schultz GA, Hahnel A, Arcellana-Panlilio M, Wang L, Goubau S, Watson A, Harvey M 1993 Expression of IGF ligand and receptor genes during preimplantation mammalian development. Mol Reprod Dev 35:414-420
236. Kaye PL, Bell KL, Beebe LF, Dunglison GF, Gardner HG, Harvey MB 1992 Insulin and the insulin-like growth factors (IGFs) in preimplantation development. Reprod Fertil Dev 4:373-386
237. Kapur S, Tamada H, Dey SK, Andrews GK 1992 Expression of insulin-like growth factor-I (IGF-I) and its receptor in the peri-implantation mouse uterus, and cell-specific regulation of IGF-I gene expression by estradiol and progesterone. Biol Reprod 46: 208-219
238. Bondy CA, Wemer H, Roberts Jr CT, LeRoith D 1992 Cellular pattern of Type I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulinlike growth factors I and II. Neuroscience 46:909-923
239. Nilsson C, Blay P, Neilsen FC, Gammeltoft S 1992 Gene expression and receptor binding of insulin-like growth factor-II in pig choroid plexus epithelial cells. J Neurochem 58:923-930
240. Liu ZZ, Wada J, Alvares K, Kumar A, Wallner EI, Kanwar YS 1993 Distribution and relevance of insulin-like growth factor I receptor in metanephric development. Kidney Int 44:1242-1250
241. Pomerance M, Gavaret J-M, Jacquemin C, Matricon C, Toru-Delbauffe D, Pierre M 1988 Insulin and insulin-like growth factor I receptors during postnatal development of rat brain. Dev Brain Res 42:77-82
242. Bohannon NJ, Corp ES, Wilcox BJ, Figlewicz DP, Dorsa DM, Baskin DG 1988 Localization of binding sites for insulin-like growth factor I (IGF-I) in the rat brain by quantitative autoradiography. Brain Res 444:205-213
243. Lesniak MA, Hill JM, Kiess W, Rojeski M, Pert CB, Roth J 1988 Receptors for insulin-like growth factors I and II: autoradiographic localization in rat brain and comparison to receptors for insulin. Endocrinology 123:2089-2099
244. Werther GA, Hogg A, Oldfield BJ, McKinley MJ, Figdor R, Mendelsohn D 1989 Localization and characterization of IGF-I receptors in rat brain and pituitary gland using in vitro autoradiographyand computerized densitometry: distinct distribution from insulin receptors. J Endocrinol 1:369-377
245. Matsuo K, Niwa M, Kurihara M, Shigematsu K, Yamashita S, Ozaki M, Nagataki S 1989 Receptor autoradiographic analysis of IGF-I binding in the rat forebrain and pituitary gland. Cell Mol Neurobiol 9:357-367
246. Marks JL, Porte D, Baskin DG 1991 Localization of type I IGF receptor mRNA in the adult rat brain by in situ hybridization. Mol Endocrinol 5:1158-1168
247. Recio-Pinto E, Rechler MM, Ishii DN 1986 Effects of insulin, insulin-like growth factor II, nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons. J Neurosci 6:1211-1216
248. Nielsen FC, Wang E, Gammeltoft S 1991 Receptor binding, endocytosis, and mitogenesis of insulin-like growth factors I and II in fetal rat brain neurons. J Neurochem 56:12-21
249. DiCicco-Bloom E, Black IB 1988 Insulin growth factors regulate the mitogenic cycle in cultured rat sympathetic neuroblasts. Proc Natl Acad Sci USA 85:4066-4070
250. Heidenreich KA 1993 Insulin and IGF-I receptor signaling in cultured neurons. In: Raizada MK, LeRoith D (eds) The Role of InsulinLike Growth Factors in the Nervous System. Ann NY Acad Sci 692:72-88
251. Burgess SK, Jacobs S, Cuatrecasas P, Sahyoun N 1987 Characterization of a neuronal subtype of insulin-like growth factor I receptor. J Biol Chem 262:1618-1622
252. Heidenreich KA, Freidenberg GR, Figlewicz DP, Gilmore PR 1986 Evidence for a subtype of insulin-like growth factor I receptor in brain. Regul Pept 15:301-310
253. McElduff A, Poronnik P, Baxter RC, Williams P 1988 A comparison of the insulin and insulin-like growth factor I receptors from rat brain and liver. Endocrinology 122:1933-1939
254. Shemer J, Raizada MK, Masters BA, Ota A, LeRoith D 1987 Insulin-like growth factor I receptors in neuronal and glial cells. Characterization and biological effects in primary culture. J Biol Chem 262:7693-7699
255. Zick Y, Speigel AM, Sagi-Eisenberg R 1987 IGF-I receptors in retinal rod outer segments. J Biol Chem 262:10259-10264
256. Shemer J, Adamo M, Raizada MK, Heffez D, Zick Y, LeRoith D 1989 Insulin and IGF-I stimulate phosphorylation of their respective receptors in intact neuronal and glial cells in primary culture. J Mol Neurosci 1:3-8
257. Duffy KR, Pardridge WM, Rosenfeld RG 1988 Human blood-brain barrier insulin-like growth factor receptor. Metabolism 37: 136-140
258. Frank HJL, Pardridge WM, Morris WL, Rosenfeld RG, Choi TB Binding and internalization of insulin and insulin-like growth factors by isolated brain microvessels. Diabetes 35:654-661
259. Rosenfeld RG, Pham H, Keller BT, Borchardt RT, Pardridge WM Demonstration and structural comparison of receptors for insulin-like growth factor-I and -II (IGF-I and -II) in brain and blood brain barrier. Biochem Biophys Res Commun 149:159-166
260. Kiess W, Lee L, Graham DE, Greenstein L, Tseng LYH, Rechler MM, Nissley SP 1989 Rat C6 glial cells synthesize insulin-like growth factor I (IGF-I) and express IGF-I receptors and IGF-II/Mannose-6-Phosphate receptors. Endocrinology 124:1727
261. Sturm MA, Conover CA, Pham H, Rosenfeld RG 1989 Insulin-like growth factor receptors and binding protein in rat neuroblastoma cells. Endocrinology 124:388-396
262. Ota A, Wilson GL, LeRoith D 1988 Insulin-like growth factor I receptors on mouse neuroblastoma cells. Two β subunits are derived from differences in glycosylation. Eur J Biochem 174:521-530
263. Von Eye Corleta H, Strowitzki T, Kellerer M, Haring HU 1992 Insulin-like growth factor I-dependent tyrosine kinase activity in stromal cells of human endometrium in vitro. Am J Physiol 262: 863-868
264. Hofig A, Michel FJ, Simmen FA, Simmen RC 1991 Constitutive expression of uterine receptors for insulin-like growth factor-I during the peri-implantation period in the pig. Biol Reprod 45:533-539
265. Stevenson KR, Gilmour RS, Wathes DC 1994 Localization of insulin-like growth factor-I (IGF-I) and -II messenger ribonucleic acid and type I IGF receptors in the ovine uterus during the estrous cycle and early pregnancy. Endocrinology 134:1655-1664
266. Ryan J, Mantle T, Costigan DC 1991 Comparison of type I insulinlike growth factor (IGF) receptor binding in ovine tissue and human placental membranes. Biochem Soc Trans 19:63-68
267. Cissewski K, Wolf M, Moses AC 1992 Characterization of insulinlike growth factor receptors in human thyroid tissue. Receptor 2:145-153
268. Cotton EW, Means Jr RT, Cline SM, Rrantz SB 1991 Quantitation of insulin-like growth factor-I binding to highly purified human erythroid colony-forming units. Exp Hematol 19:278-281
269. Zhao X, McBride BW, Trouten-Radford LM, Burton JH 1992 Specific insulin-like growth factor-I receptors on circulating bovine mononuclear cells. J Recept Res 12:117-129
270. Johnson EW, Jones LA, Kozak RW 1992 Expression and function of insulin-like growth factor receptors on anti-CD3-activated human T lymphocytes. J Immunol 148:63-71
271. Stuart CA, Meehan RT, Neale LS, Cintron NM, Furlanetto RW 1991 Insulin-like growth factor-I binds selectively to human peripheral blood monocytes and B-lymphocytes. J Clin Endocrinol Metab 72:1117-1122
272. Cantrell PR, Frolik CA, Ellis LF, Williams DC 1991 Binding of insulin-like growth factors to cultured rat calvarial cells with differing biologic responses. J Bone Miner Res 6:851-857.
273. Dor’e S, Pelletier JP, DiBattista JA, Tardif G, Brazeau P, Martel-Pelletier J 1994 Human osteoarthritic chondrocytes possess an increased number of insulin-like growth factor I binding sites but are unresponsive to its stimulation. Possible role of IGF-I-binding proteins. Arthritis Rheum 37:253-263
274. Obasiolu CC, Khan-Dawood FS, Dawood MY 1992 Insulin-like growth factor I receptors in human corpora lutea. Fertil Steril 57: 1235-1240
275. Talavera F, Menon KM 1991 Studies on rat luteal cell response to insulin-like growth factor I (IGF-I): identification of a specific cell membrane receptor for IGF-I in the luteinized rat ovary. Endocrinology 129:1340-1346
276. Hernandez ER, Hurwitz A, Vera A, Pellicer A, Adashi EY, LeRoith D, Roberts Jr CT 1992 Expression of the genes encoding the insulin-like growth factors and their receptors in the human ovary. J Clin Endocrinol Metab 74:419-425
277. El-Roeiy A, Chen X, Roberts VJ, LeRoith D, Roberts Jr CT, Yen SSC 1993 Expression of insulin-like growth factor-I (IGF-I) and IGF-II and the IGF-I, IGF-II, and insulin receptor genes and localization of the gene products in the human ovary. J Clin Endocrinol Metab 77:1411-1418
278. Zhou J, Bondy C 1993 Anatomy of the insulin-like growth factor system in the human testis. Fertil Steril 60:897-904
279. Hainaut P, Kowalski A, Giorgetti S, Baron V, Van Obberghen E 1991 Insulin and insulin-like-growth-factor-I (IGF-I) receptors in Xenopus laevis oocytes. Comparison with insulin receptors from liver and muscle. Biochem J 273:673-678
280. Arafah BM 1991 Insulin-like growth factor-I receptors in the rat adrenals. J Lab Clin Med 118:531-537
281. Serck-Hanssen G, Sovik O 1991 Binding of insulin and insulin-like growth factor I in bovine chromaffin cells in primary culture. Int J Biochem 23:85-91
282. Lamas E, Zindy F, Seurin D, Guguen-Guillouzo C, Brechot C 1991 Expression of insulin-like growth factor II and receptors for insulinlike growth factor II, insulin-like growth factor I and insulin in isolated and cultured rat hepatocytes. Hepatology 13:936-940
283. Krane JF, Murphy DP, Carter DM, Krueger JG 1991 Synergistic effects of epidermal growth factor (EGF) and insulin-like growth factor I/somatomedin C (IGF-I) on keratinocyte proliferation may be mediated by IGF-I transmodulation of the EGF receptor. J Invest Dermatol 96:419-424
284. Neely EK, Morhenn VB, Hintz RL, Wilson DM, Rosenfeld RG 1991 Insulin-like growth factors are mitogenic for human keratinocytes and a squamous cell carcinoma. J Invest Dermatol 96:104-110
285. Elliott JL, Oldham JM, Ambler GR, Bass JJ, Spencer GS, Hodgkinson SC, Breier BH, Gluckman PD, Suttle JM 1992 Presence of insulin-like growth factor-I receptors and absence of growth hormone receptors in the antler tip. Endocrinology 130:2513-2520
286. Duclos MJ, Wilkie RS, Goddard C 1991 Stimulation of DNA synthesis in chicken muscle satellite cells by insulin and insulin-likegrowth factors: evidence for exclusive mediation by a type-I insulin-like growth factor receptor. J Endocrinol 128:35-42
287. MacDonald RS, Park JH, Thornton Jr WH 1993 Insulin, IGF-I, and IGF-2 receptors in rat small intestine following massive small bowel resection. Analysis by binding, flow cytometry, and immunohistochemistry. Dig Dis Sci 38:1658-1659
288. Ryan J, Costigan DC 1993 Determination of the histological distribution of insulin-like growth factor I receptors in the rat gut. Gut 34:1693-1697
289. Wilton P 1992 Treatment with recombinant human insulin-like growth factor-I of children with Laron syndrome. Acta Paediatr Scand Suppl 323:137-141
290. Ishii DN, Glazner GW, Whalen LR 1993 Regulation of peripheral nerve regeneration by insulin-like growth factors. Ann NY Acad Sci 692:172-182
291. Apfel SC, Arezzo JC, Lewis ME, Kessler JA 1993 The use of insulin-like growth factor I in the prevention of vincristine neuropathy in mice. Ann NY Acad Sci 692:243-245
292. Barinaga M 1994 Neurotrophic factors enter the clinic. Science 264:772-774