Rigid Analogs of Camptothecin as DNA Topoisomerase I Inhibitors

Journal of Medicinal Chemistry

Volumn 38, Issue 6, 1995, Pages 906-911

  Lackey, Karen ^a   Besterman, Jeffrey M ^a   Fletcher, Wade ^b   Leitner, Peter ^a   Morton, Bradley ^a   Sternbach, Daniel D ^a  

^a GLAXOSMITHKLINE   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10,11 ETHYLENEDIOXY 7 [(4 METHYL 1 PIPERAZINYL)METHYL]CAMPTOTHECIN; 8 ETHYL 2 (2 OXO 1,2 DIHYDROINDOL 3 YLIDENE) 8 HYDROXY 2,3,5,8 TETRAHYDRO 6 OXA 3A AZACYCLOPENTA[B]NAPHTHALENE 1,4,7 TRIONE; CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; GYRASE INHIBITOR; IRINOTECAN; TOPOTECAN; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; DRUG DNA INTERACTION; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

ALKALOIDS; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; COMPARATIVE STUDY; DNA; DNA TOPOISOMERASES, TYPE I; ISOMERISM; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0028956776     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00006a008     Document Type: Article

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