Probing the Active Sites of Rat and human cytochrome-P450 2E1 with alcohols and carboxylic acids

Archives of Biochemistry and Biophysics

Volumn 317, Issue 1, 1995, Pages 299-304

  Wang, Mong Heng ^a   Wade, David ^a   Chen, Laishun S ^a,b   White, Steven ^a,c   Yang, Chung S ^a  

^a Rutgers University   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

Active site dynamics; Competitive inhibition; Cytochrome P450 2E1

Indexed keywords

ALCOHOL; CYTOCHROME P450; DIMETHYLNITROSAMINE; LAURIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ALCOHOLS; ANIMAL; BINDING SITES; BINDING, COMPETITIVE; CARBOXYLIC ACIDS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME REPRESSION; HUMAN; MICROSOMES, LIVER; MODELS, CHEMICAL; RATS; SUPPORT, U.S. GOV'T, P.H.S.;

ANIMALIA;

EID: 0028954947     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1006/abbi.1995.1166     Document Type: Article

References (24)

1. Yang, C. S., Yoo, J.S.H., Ishizaki, H., and Hong, J.-Y. (1990) Drug Metab. Rev. 22, 147-160.
2. Yang, C. S., Brady, J. F., and Hong, J.-Y. (1992) FASEB J. 6, 737-744.
3. Koop, D. R. (1992) FASEB J. 6, 724-730.
4. Guengerich, F. P., Kim, D.-H., and Iwasaki, M. (1991) Chem. Res. Toxicol. 4, 168-179.
5. Fukuda, T., Imai, Y., Komori, M., Nakamura, E., Satouchi, K., and Kusunose M. (1993) J. Biochem. 113, 7-12.
6. Laethem, R. M., Balazy, M., Laethem, C., and Koop, D. R. (1992) In Fourth North American ISSX Meeting, Abstract 17, Bar Harbor, FL.
7. Lucas, D., Berthou, F., Dreano, Y., Floch, H. H., and Menez, J. F. (1990) Alcoholism: Clin. Exp. Res. 14, 590-594.
8. Sipes, I. G., Stripp, B., Krishna, G., Maling, H. M., and Gillette, J. R. (1973) Proc. Soc. Exp. Biol. Med. 142, 237-240.
9. Patten, C., Ishizaki, H., Aoyama, T., Lee, M. J., Ning, S. M., Gonzalez, F., and Yang, C. S. (1992) Arch. Biochem. Biophys. 299, 163-171.
10. Yang, C. S., Patten, C., Ishizaki, H., and Yoo, J-S.H. (1991) Methods Enzymol. 206, 595-603.
11. Brady, J. F., Wang, M.-H., Hong, J.-Y., Xiao, F., Li, Y., Yoo, J.-S.H., Ning, S. M., Lee, M. J., Fukuto, J. M., Gapac, J. M., and Yang, C. S. (1991) Toxicol. Appl. Pharmacol. 108, 342-354.
12. Barton, A. F. M. (1984) Solubility Data Series: Alcohols with Water, Vol. 15, Pergamon Press, New York.
13. Stephen, H., and Stephen, T. (1963) Solubilities of Inorganic and Organic Compounds, Vol. 1, Pergamon, New York.
14. Lin, I. J. (1971) Israel J. Tech. 9, 621-624.
15. Yang, C. S., Ishizaki, H., Lee, M. J., Wade, D., and Fadel, A. (1991) Chem. Res. Toxicol. 4, 408-413.
16. Bergman, F., and Segal, R. (1954) Biochem. J. 58, 692-698.
17. Webb, J. L. (1963) Enzyme and Metabolic Inhibitors, Vol. 1, Academic Press, New York.
18. Tanford, C. (1973) The Hydrophobic Effect: Formation of Micelles and Biological Membranes, Wiley, New York.
19. Backes, W. L., Means, M., and Canady, W. J. (1984) J. Biol. Chem. 259, 10092-10099.
20. Cohen, G. M., and Mannering, G. J. (1973) Mol. Pharmacol. 9, 383-397.
21. Koop, D. R., and Coon, M. J. (1986) Acoholism: Clin. Exp. Res. 10 (6 suppl.), 40-49.
22. Boddupalli, S. S., Pramanik, B. C., Slaughter, C. A., Estabrook, R. W., and Peterson, J. A. (1992) Arch. Biochem. Biophys. 292, 20-28.
23. Ravichandran, K. G., Boddupalli, S. S., Hasemann, C. A., Peterson, J. A., and Deisenhofer, J. (1993) Science 261, 731-736.
24. Swanson, B. A., Dutton, D. R., Lunetta, J. M., Yang, C. S., and Ortiz de Montellano, P. R. (1991) J. Biol. Chem. 266, 19258-19264.