Age-related spatial reference and working memory deficits assessed in the water maze

Neurobiology of Aging

Volumn 16, Issue 2, 1995, Pages 149-160

  Frick, Karyn M ^a   Baxter, Mark G ^a   Markowska, Alicja L ^a   Olton, David S ^a   Price, Donald L ^b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Principal components analysis; Reference memory; Spatial memory; Variable interval probe trial; Working memory

Indexed keywords

ADOLESCENT; AGED; AGING; AMNESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SENESCENCE;

AGING; ANIMAL; DISCRIMINATION (PSYCHOLOGY); INDIVIDUALITY; MALE; MAZE LEARNING; MEMORY; MEMORY, SHORT-TERM; PSYCHOMOTOR PERFORMANCE; RATS; RATS, INBRED F344; SPACE PERCEPTION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0028954228     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-4580(94)00155-3     Document Type: Article

References (53)

1. Working memory in aged rats
2. Temporally graded, age-related impairments in spatial memory in the rat
3. Morphologic alterations of choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized Fisher 344 rats
4. Memory changes with age: Neurobiological correlates
5. Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat
6. Spatial memory deficits in senescent rats
7. D-Cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats
8. Effects of linopirdine (DuP 996) and X9121 on age-related memory impairments and on the cholinergic system
9. The need for multiple time points in aging studies
10. Acetyl-L-Carnitine: Behavioral, electrophysiological, and neurochemical effects
11. Individual differences in hippocampal synaptic plasticity as a function of aging: Behavioral, electrophysiological and morphological evidence
12. Electrophysiological markers of aging and memory loss in rats
13. Age related deficits in spatial memory and hippocampal plasticity
14. Cognitive mapping and elderly adults: Verbal and location memory for urban landmarks
15. Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging
16. Degenerative changes in forebrain cholinergic nuclei correlate with cognitive impairments in aged rats
17. Neuron numbers and sizes in aging brain: Comparisons of human, monkey, and rodent data
18. Age-related impairments in spatial memory are independent of those in sensorimotor skills
19. Spatial learning and motor deficits in aged rats
20. Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats
21. Relationship of age-related decline across several behavioral domains
22. Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze
23. Markers for biogenic amines in the aged rat brain: Relationship to decline in spatial learning ability
24. Aged rats need a preserved complement of perforated axospinous synapses per hippocampal neuron to maintain good spatial memory
25. Loss of perforated synapses in the dentate gyrus: Morphological substrate of memory deficit in aged rats
26. Aging and stress-induced changes in choline and glutamate uptake in hippocampus and septum of two rat strains differing in longevity and reactivity to stressors
27. Cholinergic and GABAergic modulation of medial septal area: Effect on working memory
28. Working memory and cholinergic auto-regulation in the medial septal area
29. Inbred strains of rats and mutants
30. Survival distributions for selected laboratory rat strains and stocks
31. Age-related structural changes in the rat hippocampus: Correlation with working memory deficiency
32. Short forms of the “reference-” and “working-memory” Morris water maze for assessing age-related deficits
33. Aging and atropine effects on spatial navigation in the Morris water maze
34. Memory and sensorimotor skills in aging rats: Effects of age, strain, gender and diet restriction
35. Variable-interval probe test as a tool for repeated measurements of spatials memory in the water maze
36. Working memory and the aged rat: Deficient two-choice win-stay water-escape acquisition and retention
37. How many memory systems? Evidence from aging
38. Developmentsof a water-maze procedure for studying spatial learning in the rat
39. Spatial localization does not require the presence of local cues
40. Place navigation impaired in rats with hippocampal lesions
41. Does variability increase with age? An archival study of cognitive measures
42. Hippocampus, space, and memory
43. Mazes: Their use in delayed conditional discriminations and place discriminations
44. Within-subjects, parametric manipulations to investigate aging
45. Spatial memory and hippocampal function
46. Individual differences in the cognitive and neurobiological consequences of normal aging
47. An evaluation of spatial information processing in aged rat
48. Memory for object locations in young and elderly adults
49. Effects of age on water escape behavior and on repeated acquisition in rats
50. Cognitive maps of environmental knowledge and preference in nursing home patients