Anti-DNA antibodies bind to DNase I

Journal of Experimental Medicine

Volumn 181, Issue 5, 1995, Pages 1797-1804

  Puccetti, Antonio ^a   Madaio, Michael P ^b   Bellese, Grazia ^a   Migliorini, Paola ^c  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOPHAGE DNA; DEOXYRIBONUCLEASE I; DNA ANTIBODY; DOUBLE STRANDED DNA; MONOCLONAL ANTIBODY; SINGLE STRANDED DNA;

ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DNA DEGRADATION; ETIOLOGY; HUMAN; IMMUNOPATHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

AMINO ACID SEQUENCE; ANIMAL; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; BINDING SITES; DEOXYRIBONUCLEASE I; DNA; HUMAN; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; SUPPORT, NON-U.S. GOV'T;

EID: 0028952166     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.181.5.1797     Document Type: Article

References (37)

1. Madaio, M.P., S. Hodder, R.S. Schwartz, and B.D. Stollar. 1984. Responsiveness of autoimmune and normal mice to nucleic acid antigens. J. Immunol. 132: 872-876.
2. Schoenfeld, Y., J. Rauch, H. Massicotte, S.K. Datta.J. AndreSchwartz, B.D. Stollar, and R.S. Schwartz. 1983. Polyspecificity of monoclonal lupus autoantibodies produced by human-human hybridoma. N. Engl. J. Med. 308: 414-420.
3. Andrezejewski, C., J. Rauch, E. Lafer, B.D. Stollar, and R.S. Schwartz. 1981. Antigen-binding diversity and idiotypic crossreactions among hybridoma autoantibodies to DNA. J. Immunol. 126: 226-231.
4. Pisetsky, D.E., and S.A. Caster. 1982. Binding specificity of a monoclonal anti-DNA antibody. Mol. Immunol. 19: 645-650.
5. Lafer, E.A., J. Rauch, C. Andrezejewski, D. Mudd, B. Furie, R.S. Schwartz, and B.D. Stollar. 1981. Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids. J. Exp. Med. 153: 897-909.
6. Naparstek, Y., D. Duggan, A. Schattner, M.P. Madaio, F. Goni, B. Frangione, B.D. Stollar, E.A. Rabat, and R.S. Schwartz. 1985. Immunochemical similarities between monoclonal antibacterial Waldenstrom’s macroglobulins and monoclonal anti-DNA lupus autoantibodies. J. Exp Med. 161: 1525-1538.
7. Schwartz, R.S., and B.D. Stollar. 1985. Origins of anti-DNA autoantibodies. J. Clin. Invest. 75: 321-327.
8. Faaber, P., T.P.M. Rijke, L.B.A. van de Putte, P.J.A. Capel, andJ.H.M. Berden. 1986. Crossreactivity of human and murine anti-DNA antibodies with heparan sulphate. The major glycosaminoglycan in glomerular basement membranes. J. Clin. Invest. 77: 1824-1830.
9. Jacob, L., D. Lety, D. Lorward, and J.F. Bach. 1985. Binding of a monoclonal anti-DNA autoantibody to identical proteins present at the surface of several cell types involved in lupus pathogenesis. J. Clin. Invest. 75: 315-317.
10. Madaio, M.P., J. Carlson, J. Cataldo, A. Ucci, P. Migliorini, and O. Pankewycz. 1987. Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits. J. Immunol. 138: 2883-2889.
11. Pankewycz, O., P. Migliorini, and M.P. Madaio. 1987. Polyreactive autoantibodies are nephritogenic in murine lupus nephritis. J. Immunol. 139: 3287-3294.
12. Madaio, M.P., A. Schattner, M. Schattner, and R.S. Schwartz. 1986. Lupus serum and normal human serum contain anti-DNA antibodies with the same idiotypic markers. J. Immunol. 137: 2535-2540.
13. Migliorini, P., B. Ardman, J. Kaburaki, and R.S. Schwartz. 1987. Parallel sets of autoantibodies in MLR -Ipr/lpr mice. An anti-DNA, anti-SmRNP, anti-gp70 network. J. Exp. Med. 165: 483-499.
14. Koizumi, T., A. Puccetti, P. Migliorini, K. Barret, and R.S. Schwartz. 1991. Molecular heterogeneity of auto-anti-idiotypic antibodies in MLR-lpr/lpr mice. Eur. J. Immunol 21: 2185-2193.
15. Puccetti, A., T. Koizumi, P. Migliorini, J. Andre-Schwartz, K.J. Barrett, and R.S. Schwartz. 1990. An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice. J. Exp Med. 171: 1919-1930.
16. Puccetti, A., P. Migliorini, J. Sabbaga, and M.P. Madaio. 1990. Human and murine anti-DNA antibodies induce the production of anti-idiotypic antibodies with autoantigen-binding properties (epibodies) through immune-network interactions. J. Immunol. 145: 4229-4237.
17. Blake, M.S., K.H. Johnston, G.J. Russell-Jones, and E.C. Gotschlich. 1984. A rapid, sensitive method for detection of alkaline-phosphatase conjugated anti-antibody on western blots. Anal. Biochem. 136: 175-179.
18. Matsudaira, P. 1987. Sequence from picomole quantities of protein electroblotted onto polyvinylidenedifluoride membranes. J. Biol. Chem. 262: 10035-10038.
19. Atherton, E., C.J. Logan, and R.C. Sheppard. 1979. Peptide synthesis. Part 2. Bioorg. Chem. 8: 351-370.
20. Price, P.A., W.H. Stein, and S. Moore. 1969. Effect of divalent cations on the reduction and re-formation of the disulfide bonds of deoxyribonuclease. J. Biol. Chem. 244: 929-932.
21. Price, P.A., T.Y. Liu, W.H. Stein, and S. Moore. 1969. Properties of chromatographically purified bovine pancreatic deoxyribonuclease. J. Biol. Chem. 244: 917-923.
22. Suck, D., and C. Oefner. 1986. Structure of DNase I at 2.0A resolution suggests a mechanism for binding and cutting DNA. Nature (Lottd). 312: 620-625.
23. Kabsch, W., H.G. Mannherz, D. Suck, E.F. Pai, and K.C. Holmes. 1990. Atomic structure of the actin-DNase I complex. Nature (Lond). 347: 37-44.
24. Suck, D., A. Lahm, and C. Oefner. 1988. Structure refined to 2A of a nicked DNA octanucleotide complex with DNase I. Nature (Lond). 332: 464-468.
25. Lahm, A., and D. Suck. 1991. DNase I induced DNA conformation. 2A structure of a DNase I-octamer complex. J. Mol. Biol. 221: 645-667.
26. Brendel, V., J. Dohlman, B.E. Blaisdell, and S. Karlin. 1991. Very long charge runs in systemic lupus-associated autoantigens. Proc. Natl. Acad. Sci. USA. 88: 1536-1540.
27. Shuster, A.M., G.V. Gololobov, O.A. Kvashuk, A.E. Bogomolova, I.V. Smirnov, and A.G. Gabibov. 1992. DNA hydrolyzing autoantibodies. Science (Wash. DC). 256: 665-667.
28. Daoust, R. 1965. Histochemical localization of enzyme activities by substrate film methods: ribonucleases, deoxyribonucleases, proteases, amylase and hyaluronidase. Int. Rev. Cytol. 18: 191-221.
29. Lacks, S.A. 1981. Deoxyribonuclease I in mammalian tissues. Specificity of inhibition by actin. J. Biol. Chem. 256: 2644-2648.
30. Peitsch, M.C., B. Polzar, H. Stephan, T. Crompton, H.R. MacDonald, H.G. Mannherz, andj. Tschopp. 1993. Characterization of the endogenous deoxyribonuclease involved in nuclear DNA fragmentation during apoptosis (programmed cell death). EMBO (Eur. Mol. Biol. Organ.) J. 12: 371-377.
31. Ando, D.G., E.E. Sercarz, and B.H. Hahn. 1987. Mechanism of T and B collaboration in the in vitro production of anti-DNA antibodies in the NZB/NZW FI murine SLE model. J. Immunol. 138: 3185-3190.
32. Naiki, M., B.L. Chiang, D. Cawley, A. Ansari, S.J. Rozzo, B.L. Kotzin, A. Zlotnik, and M.E. Gershwin. 1992. Generation and characterization of cloned helper T cell lines for anti-DNA responses in NZB.H-2bm12 mice. J. Immunol. 149:4109-4115.
33. Datta, S.K., H. Patel, and D. Berry. 1987. Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritis. J. Exp. Med. 165: 1252-1268.
34. Mohan, C., S. Adams, V. Stanik, and S.K. Datta. 1993. Nucleosome: a major immunogen for pathogenic autoantibody inducing T cells of lupus. J. Exp. Med. 177: 1367-1381.
35. Pisetsky, D.S., S.O. Hoch, C.L. Klatt, M.A. O’Donnell, and J.D. Keene. 1985. Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activity. J. Immunol. 135: 4080-4085.
36. Bloom, D.D., J.L. Davignon, P.L. Cohen, R.A. Eisenberg, and S.H. Clarke. 1993. Overlap of the anti-Sm and anti-DNA responses of MRL/Mp-lpr/lpr mice. J. Immunol. 150:1579-1590.
37. Desai, D.D., M.R. Krishnan, J.T. Swindle, and T.N. Marion. 1993. Antigen-specific induction of antibodies against native mammalian DNA in nonautoimmune mice. J. Immunol. 151: 1614-1626.