Optically Active Antifungal Azoles. IV.1) Synthesis and Antifungal Activity of (2R,3R)-3-Azolyl-2-(substituted phenyl)-l-(1H-1,2,4-triazol-1 -yl)-2-butanols

Chemical and Pharmaceutical Bulletin

Volumn 43, Issue 3, 1995, Pages 432-440

  Tasaka, Akihiro ^a   Tamura, Norikazu ^a   Matsushita, Yoshihiro ^a   Kitazaki, Tomoyuki ^a   Hayashi, Ryogo ^a   Okonogi, Kenji ^a   Itoh, Katsumi ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

1,3 bis(azolyl) 2 butanol; antifungal activity; candidosis; chiral synthesis; optically active antifungal azole; triazolylbutanol

Indexed keywords

1,2,4 TRIAZOLE DERIVATIVE; 2 (2,4 DIFLUOROPHENYL) 3 (2H TETRAZOL 1 YL) 1 (1H 1,2,4 TRIAZOL 1 YL) 2 BUTANOL; ANTIFUNGAL AGENT; FLUCONAZOLE; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CONTROLLED STUDY; DRUG SYNTHESIS; INFRARED SPECTROPHOTOMETRY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTIFUNGAL AGENTS; AZOLES; BUTANOLS; CANDIDA ALBICANS; CANDIDIASIS; CHEMISTRY, PHYSICAL; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED STRAINS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0028951363     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.43.432     Document Type: Article

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